Or4c1 (olfactory receptor family 4 subfamily C member 1) - Rat Genome Database

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Gene: Or4c1 (olfactory receptor family 4 subfamily C member 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or4c1
Name: olfactory receptor family 4 subfamily C member 1
RGD ID: 1333350
Description: Predicted to enable olfactory receptor activity. Predicted to be active in plasma membrane; INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 694; olfactory receptor gene Olr694; olfactory receptor Olr694; Olr694; ratchr3-73533229-73532303_ORF
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8395,735,085 - 95,736,011 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl395,735,085 - 95,736,011 (-)EnsemblGRCr8
mRatBN7.2375,278,908 - 75,279,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl375,276,531 - 75,283,324 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx378,756,626 - 78,757,552 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0387,355,168 - 87,356,094 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0385,120,792 - 85,121,718 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd393,593,236 - 93,594,162 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive3100,527,454 - 100,528,380 (-)NCBILyon_Normotensive
Lyon_Hypertensive392,445,183 - 92,446,109 (-)NCBILyon_Hypertensive
F344_StmMcwi373,726,789 - 73,727,715 (-)NCBIF344_StmMcwi
Rnor_6.0378,111,844 - 78,112,770 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl378,111,844 - 78,112,770 (-)Ensemblrn6Rnor6.0
Rnor_5.0384,844,003 - 84,844,929 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4373,635,931 - 73,636,857 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera374,536,124 - 74,537,050 (-)NCBICelera
RGSC_v3.1373,532,302 - 73,533,229 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or4c1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000008396
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

ectoderm
nervous system
reproductive system
1 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000008396   ⟹   ENSRNOP00000008396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl378,111,844 - 78,112,770 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109365   ⟹   ENSRNOP00000086961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl375,276,531 - 75,283,324 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158333   ⟹   ENSRNOP00000111261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl395,735,085 - 95,736,011 (-)Ensembl
RefSeq Acc Id: NM_001000357   ⟹   NP_001000357
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8395,735,085 - 95,736,011 (-)NCBI
mRatBN7.2375,278,908 - 75,279,834 (-)NCBI
Dahl_SR_JrHsd393,593,236 - 93,594,162 (-)NCBI
Lyon_Normotensive3100,527,454 - 100,528,380 (-)NCBI
Lyon_Hypertensive392,445,183 - 92,446,109 (-)NCBI
F344_StmMcwi373,726,789 - 73,727,715 (-)NCBI
Rnor_6.0378,111,844 - 78,112,770 (-)NCBI
Rnor_5.0384,844,003 - 84,844,929 (-)NCBI
RGSC_v3.4373,635,931 - 73,636,857 (-)RGD
Celera374,536,124 - 74,537,050 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000357 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111261
  ENSRNOP00000111261.1
RefSeq Acc Id: NP_001000357   ⟸   NM_001000357
- UniProtKB: D3ZQ19 (UniProtKB/TrEMBL),   A6HN34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008396   ⟸   ENSRNOT00000008396
Ensembl Acc Id: ENSRNOP00000086961   ⟸   ENSRNOT00000109365
Ensembl Acc Id: ENSRNOP00000111261   ⟸   ENSRNOT00000158333
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ19-F1-model_v2 AlphaFold D3ZQ19 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333350 AgrOrtholog
BioCyc Gene G2FUF-48834 BioCyc
Ensembl Genes ENSRNOG00000006415 Ensembl
  ENSRNOG00000062761 Ensembl
  ENSRNOG00000083462 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000158333 ENTREZGENE
  ENSRNOT00000158333.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
NCBI Gene 295896 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4c1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006415 RatGTEx
  ENSRNOG00000062761 RatGTEx
  ENSRNOG00000083462 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0ABK0M7J5_RAT UniProtKB/TrEMBL
  A6HN34 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQ19 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4c1  olfactory receptor family 4 subfamily C member 1  Olr694  olfactory receptor 694  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr694  olfactory receptor 694   Olr694_predicted  olfactory receptor 694 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr694_predicted  olfactory receptor 694 (predicted)      Symbol and Name status set to approved 70820 APPROVED