Or4c11 (olfactory receptor family 4 subfamily C member 11) - Rat Genome Database

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Gene: Or4c11 (olfactory receptor family 4 subfamily C member 11) Rattus norvegicus
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Symbol: Or4c11
Name: olfactory receptor family 4 subfamily C member 11
RGD ID: 1332834
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human OR4C11 (olfactory receptor family 4 subfamily C member 11); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 660; olfactory receptor gene Olr660; olfactory receptor Olr660; Olr660
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8395,055,005 - 95,055,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl395,055,005 - 95,055,928 (+)EnsemblGRCr8
mRatBN7.2374,598,809 - 74,599,732 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl374,579,912 - 74,603,428 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx377,978,246 - 77,979,169 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0386,576,791 - 86,577,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0384,393,453 - 84,394,376 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0377,431,389 - 77,432,312 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl377,431,389 - 77,432,312 (+)Ensemblrn6Rnor6.0
Rnor_5.0384,225,718 - 84,226,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4372,916,576 - 72,917,499 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera373,862,139 - 73,863,062 (+)NCBICelera
RGSC_v3.1372,812,947 - 72,813,871 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4c11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8395,055,005 - 95,055,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl395,055,005 - 95,055,928 (+)EnsemblGRCr8
mRatBN7.2374,598,809 - 74,599,732 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl374,579,912 - 74,603,428 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx377,978,246 - 77,979,169 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0386,576,791 - 86,577,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0384,393,453 - 84,394,376 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0377,431,389 - 77,432,312 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl377,431,389 - 77,432,312 (+)Ensemblrn6Rnor6.0
Rnor_5.0384,225,718 - 84,226,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4372,916,576 - 72,917,499 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera373,862,139 - 73,863,062 (+)NCBICelera
RGSC_v3.1372,812,947 - 72,813,871 (+)NCBI
Cytogenetic Map3q24NCBI
OR4C11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,602,360 - 55,607,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,602,360 - 55,607,645 (-)Ensemblhg38GRCh38
GRCh371155,369,836 - 55,375,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,127,493 - 55,128,425 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341155,127,492 - 55,128,425NCBI
Celera1152,712,746 - 52,713,678 (-)NCBICelera
Cytogenetic Map11q11NCBI
HuRef1151,700,199 - 51,701,243 (-)NCBIHuRef
CHM1_11155,236,089 - 55,237,133 (-)NCBICHM1_1
T2T-CHM13v2.01155,540,617 - 55,545,902 (-)NCBIT2T-CHM13v2.0
Or4c11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39288,694,951 - 88,695,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl288,693,575 - 88,698,097 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38288,864,607 - 88,865,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl288,863,231 - 88,867,753 (+)Ensemblmm10GRCm38
MGSCv37288,704,764 - 88,705,687 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36288,665,446 - 88,666,369 (+)NCBIMGSCv36mm8
Celera290,444,682 - 90,445,315 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.03NCBI
OR4C11K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11840,532,738 - 40,533,670 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1840,532,738 - 40,533,670 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.01841,210,479 - 41,211,413 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11840,744,067 - 40,744,999 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.01840,960,499 - 40,961,431 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100516851
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1214,176,715 - 14,177,647 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2214,943,686 - 14,944,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OR4C11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,844,670 - 16,847,734 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,845,776 - 16,846,708 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038114,152,468 - 114,153,499 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or4c11
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:8
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000042848
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
renal system
respiratory system
1 3 1 1 3 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001000635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042848   ⟹   ENSRNOP00000047869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl395,055,005 - 95,055,928 (+)Ensembl
mRatBN7.2 Ensembl374,579,912 - 74,599,820 (+)Ensembl
Rnor_6.0 Ensembl377,431,389 - 77,432,312 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106617   ⟹   ENSRNOP00000092350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl374,579,912 - 74,603,428 (+)Ensembl
RefSeq Acc Id: NM_001000635   ⟹   NP_001000635
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8395,055,005 - 95,055,928 (+)NCBI
mRatBN7.2374,598,809 - 74,599,732 (+)NCBI
Rnor_6.0377,431,389 - 77,432,312 (+)NCBI
Rnor_5.0384,225,718 - 84,226,641 (-)NCBI
RGSC_v3.4372,916,576 - 72,917,499 (+)RGD
Celera373,862,139 - 73,863,062 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047869
  ENSRNOP00000047869.3
RefSeq Acc Id: NP_001000635   ⟸   NM_001000635
- UniProtKB: D3ZRP2 (UniProtKB/TrEMBL),   A0A8I6ADH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047869   ⟸   ENSRNOT00000042848
Ensembl Acc Id: ENSRNOP00000092350   ⟸   ENSRNOT00000106617

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRP2-F1-model_v2 AlphaFold D3ZRP2 1-307 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332834 AgrOrtholog
BioCyc Gene G2FUF-48870 BioCyc
Ensembl Genes ENSRNOG00000034028 Ensembl
  ENSRNOG00000063322 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042848 ENTREZGENE
  ENSRNOT00000042848.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
NCBI Gene 404828 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4c11 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034028 RatGTEx
  ENSRNOG00000063322 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6ADH8 ENTREZGENE
  D3ZRP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4c11  olfactory receptor family 4 subfamily C member 11  Olr660  olfactory receptor 660  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr660  olfactory receptor 660   Olr660_predicted  olfactory receptor 660 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr660_predicted  olfactory receptor 660 (predicted)      Symbol and Name status set to approved 70820 APPROVED