Pole2 (DNA polymerase epsilon 2, accessory subunit) - Rat Genome Database

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Gene: Pole2 (DNA polymerase epsilon 2, accessory subunit) Rattus norvegicus
Analyze
Symbol: Pole2
Name: DNA polymerase epsilon 2, accessory subunit
RGD ID: 1311962
Description: Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to be located in chromosome and nuclear body. Predicted to be part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA polymerase epsilon subunit 2; LOC299112; polymerase (DNA directed), epsilon 2; polymerase (DNA directed), epsilon 2 (p59 subunit); polymerase (DNA directed), epsilon 2, accessory subunit; polymerase (DNA) epsilon 2, accessory subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,410,713 - 93,448,782 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,410,758 - 93,435,361 (-)EnsemblGRCr8
mRatBN7.2687,674,702 - 87,712,723 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,074,664 - 88,099,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,374,099 - 88,398,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,813,850 - 87,838,387 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,494,348 - 91,532,355 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)Ensemblrn6Rnor6.0
Rnor_5.06100,953,300 - 100,977,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,155,518 - 91,180,121 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,173,896 - 86,198,498 (-)NCBICelera
RGSC_v3.1691,158,976 - 91,183,577 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
Enterolactone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
epsilon DNA polymerase complex  (IBA,IEA,ISO)
nuclear body  (IEA,ISO)
nuclear lumen  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. DNA polymerase epsilon - more than a polymerase. Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10801849   PMID:22465957  


Genomics

Comparative Map Data
Pole2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,410,713 - 93,448,782 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,410,758 - 93,435,361 (-)EnsemblGRCr8
mRatBN7.2687,674,702 - 87,712,723 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,074,664 - 88,099,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,374,099 - 88,398,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,813,850 - 87,838,387 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,494,348 - 91,532,355 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)Ensemblrn6Rnor6.0
Rnor_5.06100,953,300 - 100,977,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,155,518 - 91,180,121 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,173,896 - 86,198,498 (-)NCBICelera
RGSC_v3.1691,158,976 - 91,183,577 (-)NCBI
Cytogenetic Map6q24NCBI
POLE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,643,555 - 49,688,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1449,643,555 - 49,688,422 (-)Ensemblhg38GRCh38
GRCh371450,110,273 - 50,154,932 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,180,028 - 49,224,685 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341449,180,027 - 49,224,685NCBI
Celera1429,970,096 - 30,014,595 (-)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,227,158 - 30,272,590 (-)NCBIHuRef
CHM1_11450,049,196 - 50,093,831 (-)NCBICHM1_1
T2T-CHM13v2.01443,841,772 - 43,886,260 (-)NCBIT2T-CHM13v2.0
Pole2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,248,547 - 69,274,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,248,547 - 69,274,969 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381269,201,773 - 69,228,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,201,773 - 69,228,195 (-)Ensemblmm10GRCm38
MGSCv371270,302,766 - 70,329,177 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361270,120,384 - 70,146,795 (-)NCBIMGSCv36mm8
Celera1270,293,615 - 70,320,108 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.73NCBI
Pole2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,983,586 - 13,014,578 (+)Ensembl
ChiLan1.0NW_00495540912,983,488 - 13,014,669 (+)NCBIChiLan1.0ChiLan1.0
POLE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21550,769,296 - 50,816,576 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11449,985,800 - 50,032,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,222,957 - 30,268,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,531,945 - 48,576,700 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,531,945 - 48,576,700 (-)EnsemblpanPan2panpan1.1
Pole2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,303,675 - 58,348,150 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583341,456 - 386,395 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936583340,428 - 386,633 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,495,214 - 179,529,896 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11179,495,278 - 179,529,891 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21199,880,871 - 199,916,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,682,627 - 26,736,266 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2426,682,723 - 26,736,171 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605314,999,103 - 15,051,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pole2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473119,027,721 - 19,063,113 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473119,027,668 - 19,063,268 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pole2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1782,862,022 - 82,886,596 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pole2
304 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000005835
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
RH143484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,676,924 - 87,677,060 (+)MAPPERmRatBN7.2
Rnor_6.0691,496,616 - 91,496,751NCBIRnor6.0
Rnor_5.06100,955,523 - 100,955,658UniSTSRnor5.0
RGSC_v3.4691,157,741 - 91,157,876UniSTSRGSC3.4
Celera686,176,119 - 86,176,254UniSTS
RH 3.4 Map6624.69UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 164 91 90 59 91 59 6 352 190 11 143 79 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001169108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ231562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005835   ⟹   ENSRNOP00000005835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,410,758 - 93,435,361 (-)Ensembl
mRatBN7.2 Ensembl687,674,702 - 87,699,305 (-)Ensembl
Rnor_6.0 Ensembl691,494,393 - 91,518,996 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104479   ⟹   ENSRNOP00000086117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,411,609 - 93,435,361 (-)Ensembl
mRatBN7.2 Ensembl687,675,513 - 87,699,305 (-)Ensembl
RefSeq Acc Id: NM_001169108   ⟹   NP_001162579
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,758 - 93,435,361 (-)NCBI
mRatBN7.2687,674,702 - 87,699,305 (-)NCBI
Rnor_6.0691,494,393 - 91,518,996 (-)NCBI
Rnor_5.06100,953,300 - 100,977,959 (-)NCBI
RGSC_v3.4691,155,518 - 91,180,121 (-)RGD
Celera686,173,896 - 86,198,498 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240154   ⟹   XP_006240216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,435,364 (-)NCBI
mRatBN7.2687,674,702 - 87,699,308 (-)NCBI
Rnor_6.0691,494,348 - 91,519,658 (-)NCBI
Rnor_5.06100,953,300 - 100,977,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111983   ⟹   XP_038967911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_039111988   ⟹   XP_038967916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
mRatBN7.2687,674,702 - 87,712,723 (-)NCBI
RefSeq Acc Id: XM_063261680   ⟹   XP_063117750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261681   ⟹   XP_063117751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261682   ⟹   XP_063117752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,781 (-)NCBI
RefSeq Acc Id: XM_063261683   ⟹   XP_063117753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,781 (-)NCBI
RefSeq Acc Id: XM_063261684   ⟹   XP_063117754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261685   ⟹   XP_063117755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261686   ⟹   XP_063117756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261687   ⟹   XP_063117757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261688   ⟹   XP_063117758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261689   ⟹   XP_063117759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,781 (-)NCBI
RefSeq Acc Id: XM_063261690   ⟹   XP_063117760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261691   ⟹   XP_063117761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,781 (-)NCBI
RefSeq Acc Id: XM_063261692   ⟹   XP_063117762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261693   ⟹   XP_063117763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261694   ⟹   XP_063117764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,781 (-)NCBI
RefSeq Acc Id: XM_063261695   ⟹   XP_063117765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261696   ⟹   XP_063117766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261697   ⟹   XP_063117767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261698   ⟹   XP_063117768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261699   ⟹   XP_063117769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261700   ⟹   XP_063117770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261701   ⟹   XP_063117771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
RefSeq Acc Id: XM_063261702   ⟹   XP_063117772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,410,713 - 93,448,782 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001162579 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240216 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967911 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967916 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117750 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117751 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117752 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117753 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117754 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117755 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117756 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117757 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117758 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117759 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117760 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117761 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117762 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117763 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117764 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117765 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117766 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117768 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117769 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117772 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005835
  ENSRNOP00000005835.5
  ENSRNOP00000086117.1
RefSeq Acc Id: NP_001162579   ⟸   NM_001169108
- UniProtKB: D4ABZ5 (UniProtKB/TrEMBL),   A0A8I6A566 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240216   ⟸   XM_006240154
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005835   ⟸   ENSRNOT00000005835
RefSeq Acc Id: XP_038967916   ⟸   XM_039111988
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967911   ⟸   XM_039111983
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086117   ⟸   ENSRNOT00000104479
RefSeq Acc Id: XP_063117771   ⟸   XM_063261701
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117756   ⟸   XM_063261686
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117767   ⟸   XM_063261697
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117769   ⟸   XM_063261699
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117768   ⟸   XM_063261698
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117766   ⟸   XM_063261696
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117755   ⟸   XM_063261685
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117757   ⟸   XM_063261687
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117765   ⟸   XM_063261695
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117772   ⟸   XM_063261702
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117758   ⟸   XM_063261688
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117750   ⟸   XM_063261680
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117760   ⟸   XM_063261690
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117770   ⟸   XM_063261700
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117754   ⟸   XM_063261684
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117763   ⟸   XM_063261693
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117751   ⟸   XM_063261681
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117762   ⟸   XM_063261692
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117764   ⟸   XM_063261694
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117752   ⟸   XM_063261682
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117761   ⟸   XM_063261691
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117759   ⟸   XM_063261689
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117753   ⟸   XM_063261683
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A566 (UniProtKB/TrEMBL)
Protein Domains
DNA polymerase alpha/delta/epsilon subunit B   DNA polymerase epsilon subunit B N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABZ5-F1-model_v2 AlphaFold D4ABZ5 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694633
Promoter ID:EPDNEW_R5157
Type:single initiation site
Name:Pole2_1
Description:DNA polymerase epsilon 2, accessory subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0691,518,980 - 91,519,040EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311962 AgrOrtholog
BioCyc Gene G2FUF-37255 BioCyc
Ensembl Genes ENSRNOG00000004242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005835 ENTREZGENE
  ENSRNOT00000005835.7 UniProtKB/TrEMBL
  ENSRNOT00000104479.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.60.21.60 UniProtKB/TrEMBL
InterPro DNA_pol_alpha/epsilon_bsu UniProtKB/TrEMBL
  DNA_pol_e_bsu_N UniProtKB/TrEMBL
  DNA_pol_epsilon_bsu UniProtKB/TrEMBL
KEGG Report rno:299112 UniProtKB/TrEMBL
NCBI Gene 299112 ENTREZGENE
PANTHER DNA POLYMERASE EPSILON SUBUNIT 2 UniProtKB/TrEMBL
  PTHR12708 UniProtKB/TrEMBL
Pfam DNA_pol_E_B UniProtKB/TrEMBL
  Dpoe2NT UniProtKB/TrEMBL
PhenoGen Pole2 PhenoGen
PIRSF DNA_pol_eps_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004242 RatGTEx
UniProt A0A8I6A566 ENTREZGENE, UniProtKB/TrEMBL
  D4ABZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Pole2  DNA polymerase epsilon 2, accessory subunit  Pole2  polymerase (DNA) epsilon 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pole2  polymerase (DNA) epsilon 2, accessory subunit  Pole2  polymerase (DNA directed), epsilon 2, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pole2  polymerase (DNA directed), epsilon 2, accessory subunit  Pole2  polymerase (DNA directed), epsilon 2 (p59 subunit)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pole2  polymerase (DNA directed), epsilon 2 (p59 subunit)   Pole2_predicted  polymerase (DNA directed), epsilon 2 (p59 subunit) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pole2_predicted  polymerase (DNA directed), epsilon 2 (p59 subunit) (predicted)      Symbol and Name status set to approved 70820 APPROVED