Twf1 (twinfilin actin-binding protein 1) - Rat Genome Database

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Gene: Twf1 (twinfilin actin-binding protein 1) Rattus norvegicus
Analyze
Symbol: Twf1
Name: twinfilin actin-binding protein 1
RGD ID: 1311872
Description: Predicted to enable actin binding activity; anion binding activity; and protein tyrosine kinase activity. Involved in conditioned place preference; negative regulation of actin filament polymerization; and negative regulation of dendritic spine morphogenesis. Predicted to be located in several cellular components, including filopodium; perinuclear region of cytoplasm; and ruffle membrane. Predicted to be active in actin filament and myofibril. Orthologous to human TWF1 (twinfilin actin binding protein 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315265; MGC105817; protein tyrosine kinase 9; Ptk9; twinfilin, actin-binding protein, homolog 1; twinfilin, actin-binding protein, homolog 1 (Drosophila); twinfilin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Twf1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87127,595,210 - 127,607,821 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7127,595,210 - 127,607,105 (-)EnsemblGRCr8
mRatBN7.27125,715,938 - 125,727,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7127,501,266 - 127,513,176 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07129,727,164 - 129,739,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07129,628,398 - 129,640,309 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07135,838,647 - 135,850,542 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)Ensemblrn6Rnor6.0
Rnor_5.07135,495,109 - 135,507,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47133,089,255 - 133,101,150 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7122,105,689 - 122,117,583 (-)NCBICelera
RGSC_v3.17133,165,692 - 133,177,587 (-)NCBI
Cytogenetic Map7q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
lymphoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
quercetin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory. Wang YJ, etal., Mol Psychiatry. 2021 Nov;26(11):6218-6236. doi: 10.1038/s41380-021-01111-3. Epub 2021 May 7.
Additional References at PubMed
PMID:9249064   PMID:10406962   PMID:10669753   PMID:11604420   PMID:12477932   PMID:12807912   PMID:15489334   PMID:18837697   PMID:20571053   PMID:21423176   PMID:25468996   PMID:28493397  
PMID:33450132  


Genomics

Comparative Map Data
Twf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87127,595,210 - 127,607,821 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7127,595,210 - 127,607,105 (-)EnsemblGRCr8
mRatBN7.27125,715,938 - 125,727,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7127,501,266 - 127,513,176 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07129,727,164 - 129,739,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07129,628,398 - 129,640,309 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07135,838,647 - 135,850,542 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)Ensemblrn6Rnor6.0
Rnor_5.07135,495,109 - 135,507,004 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47133,089,255 - 133,101,150 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7122,105,689 - 122,117,583 (-)NCBICelera
RGSC_v3.17133,165,692 - 133,177,587 (-)NCBI
Cytogenetic Map7q35NCBI
TWF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381243,793,723 - 43,806,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1243,793,460 - 43,806,328 (-)Ensemblhg38GRCh38
GRCh371244,187,526 - 44,200,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,473,793 - 42,486,445 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1242,989,914 - 43,003,516 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1241,215,942 - 41,228,787 (-)NCBIHuRef
CHM1_11244,152,507 - 44,165,159 (-)NCBICHM1_1
T2T-CHM13v2.01243,752,448 - 43,765,042 (-)NCBIT2T-CHM13v2.0
Twf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391594,475,829 - 94,487,727 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1594,475,832 - 94,487,770 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381594,577,948 - 94,589,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1594,577,951 - 94,589,889 (-)Ensemblmm10GRCm38
MGSCv371594,408,379 - 94,420,255 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361594,406,128 - 94,418,004 (-)NCBIMGSCv36mm8
Celera1596,725,758 - 96,737,654 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1548.59NCBI
Twf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555003,051,904 - 3,060,186 (-)Ensembl
ChiLan1.0NW_0049555003,050,028 - 3,070,799 (-)NCBIChiLan1.0ChiLan1.0
TWF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21050,365,141 - 50,380,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11250,361,874 - 50,377,135 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01244,925,701 - 44,938,344 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11245,794,763 - 45,807,404 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1245,794,763 - 45,807,404 (+)EnsemblpanPan2panpan1.1
TWF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12710,281,249 - 10,295,550 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2710,246,746 - 10,293,543 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2736,012,669 - 36,026,965 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02710,470,479 - 10,484,783 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2710,470,517 - 10,484,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12710,281,754 - 10,296,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02710,316,285 - 10,330,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02736,254,132 - 36,268,471 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Twf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494570,871,699 - 70,884,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365122,280,064 - 2,293,117 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365122,280,266 - 2,293,101 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl574,868,585 - 74,893,698 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1574,868,586 - 74,881,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2577,681,086 - 77,694,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11140,000,458 - 40,019,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1139,999,926 - 40,019,502 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037206,491,729 - 206,504,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248168,765,922 - 8,778,396 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248168,765,937 - 8,780,301 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Twf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,465,470 - 267,475,678 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Twf1
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:238
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000038032
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH128344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27125,716,164 - 125,716,351 (+)MAPPERmRatBN7.2
Rnor_6.07135,838,874 - 135,839,060NCBIRnor6.0
Rnor_5.07135,495,336 - 135,495,522UniSTSRnor5.0
RGSC_v3.47133,089,482 - 133,089,668UniSTSRGSC3.4
Celera7122,105,916 - 122,106,102UniSTS
Cytogenetic Map7q35UniSTS
RH142801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27125,725,733 - 125,725,836 (+)MAPPERmRatBN7.2
Rnor_6.07135,848,442 - 135,848,544NCBIRnor6.0
Rnor_5.07135,504,904 - 135,505,006UniSTSRnor5.0
RGSC_v3.47133,099,050 - 133,099,152UniSTSRGSC3.4
Celera7122,115,483 - 122,115,585UniSTS
RH 3.4 Map71022.0UniSTS
Cytogenetic Map7q35UniSTS
RH143291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,069,070 - 135,069,177 (+)MAPPERmRatBN7.2
Rnor_6.05140,486,160 - 140,486,266NCBIRnor6.0
Rnor_5.05144,276,897 - 144,277,003UniSTSRnor5.0
RGSC_v3.45142,100,959 - 142,101,065UniSTSRGSC3.4
Celera5133,607,813 - 133,607,919UniSTS
RH 3.4 Map5890.1UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000038032   ⟹   ENSRNOP00000030138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7127,595,210 - 127,605,821 (-)Ensembl
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)Ensembl
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145237   ⟹   ENSRNOP00000106097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7127,595,210 - 127,607,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173146   ⟹   ENSRNOP00000101868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7127,595,210 - 127,607,105 (-)Ensembl
RefSeq Acc Id: NM_001008521   ⟹   NP_001008521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,595,210 - 127,607,105 (-)NCBI
mRatBN7.27125,715,938 - 125,727,834 (-)NCBI
Rnor_6.07135,838,647 - 135,850,542 (-)NCBI
Rnor_5.07135,495,109 - 135,507,004 (-)NCBI
RGSC_v3.47133,089,255 - 133,101,150 (-)RGD
Celera7122,105,689 - 122,117,583 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263656   ⟹   XP_063119726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,595,218 - 127,607,233 (-)NCBI
RefSeq Acc Id: XM_063263657   ⟹   XP_063119727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,595,218 - 127,607,821 (-)NCBI
RefSeq Acc Id: XM_063263658   ⟹   XP_063119728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,595,218 - 127,602,566 (-)NCBI
RefSeq Acc Id: XM_063263659   ⟹   XP_063119729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,595,218 - 127,606,740 (-)NCBI
RefSeq Acc Id: NP_001008521   ⟸   NM_001008521
- UniProtKB: Q5RJR2 (UniProtKB/Swiss-Prot),   A6K7V2 (UniProtKB/TrEMBL),   A0A8L2QHU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030138   ⟸   ENSRNOT00000038032
RefSeq Acc Id: XP_063119727   ⟸   XM_063263657
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GGS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119726   ⟸   XM_063263656
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QHU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119729   ⟸   XM_063263659
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GGS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119728   ⟸   XM_063263658
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000101868   ⟸   ENSRNOT00000173146
Ensembl Acc Id: ENSRNOP00000106097   ⟸   ENSRNOT00000145237
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJR2-F1-model_v2 AlphaFold Q5RJR2 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695604
Promoter ID:EPDNEW_R6129
Type:initiation region
Name:Twf1_1
Description:twinfilin actin-binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07135,850,607 - 135,850,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311872 AgrOrtholog
BioCyc Gene G2FUF-32299 BioCyc
Ensembl Genes ENSRNOG00000022507 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000145237 ENTREZGENE
  ENSRNOT00000173146 ENTREZGENE
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106678 IMAGE-MGC_LOAD
InterPro ADF-H UniProtKB/Swiss-Prot
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot
  Twinfilin UniProtKB/Swiss-Prot
KEGG Report rno:315265 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105817 IMAGE-MGC_LOAD
NCBI Gene 315265 ENTREZGENE
PANTHER PTHR13759 UniProtKB/Swiss-Prot
  TWINFILIN-1 UniProtKB/Swiss-Prot
Pfam Cofilin_ADF UniProtKB/Swiss-Prot
PhenoGen Twf1 PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022507 RatGTEx
SMART ADF UniProtKB/Swiss-Prot
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot
UniProt A0A8I6GGS8 ENTREZGENE
  A0A8L2QHU7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9P1_RAT UniProtKB/TrEMBL
  A6K7V2 ENTREZGENE, UniProtKB/TrEMBL
  Q5RJR2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-01 Twf1  twinfilin actin-binding protein 1  Twf1  twinfilin, actin-binding protein, homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Twf1  twinfilin, actin-binding protein, homolog 1 (Drosophila)  Ptk9  protein tyrosine kinase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ptk9  protein tyrosine kinase 9  Ptk9_predicted  protein tyrosine kinase 9 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ptk9_predicted  protein tyrosine kinase 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED