TWF1 (twinfilin actin binding protein 1)

Gene: TWF1 (twinfilin actin binding protein 1) Canis lupus familiaris

Analyze

Symbol:

TWF1

Name:

twinfilin actin binding protein 1

RGD ID:

12294546

Description:

ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN actin filament depolymerization (inferred); barbed-end actin filament capping (inferred); negative regulation of actin filament polymerization (inferred); ASSOCIATED WITH lymphoma (ortholog); FOUND IN actin cytoskeleton (inferred); actin filament (inferred); cell-cell junction (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

twinfilin, actin-binding protein, homolog 1; twinfilin-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	10,281,249 - 10,295,550 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	10,246,746 - 10,293,543 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	36,012,669 - 36,026,965 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	10,470,479 - 10,484,783 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	10,470,517 - 10,484,924 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	10,281,754 - 10,296,048 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	10,316,285 - 10,330,591 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	36,254,132 - 36,268,471 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

lymphoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament depolymerization (IEA)

barbed-end actin filament capping (IEA)

negative regulation of actin filament polymerization (IEA)

positive regulation of cardiac muscle hypertrophy (IEA)

positive regulation of neuron projection development (IEA)

regulation of actin cytoskeleton organization (IEA)

regulation of actin phosphorylation (IEA)

regulation of lamellipodium assembly (IEA)

sequestering of actin monomers (IEA)

Cellular Component

actin cytoskeleton (IEA)

actin filament (IEA)

cell-cell junction (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IEA)

filopodium (IEA)

myofibril (IEA)

perinuclear region of cytoplasm (IEA)

ruffle membrane (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

actin monomer binding (IEA)

ATP binding (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IEA)

protein binding (ISO)

protein tyrosine kinase activity (IEA,ISO)

protein-containing complex binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TWF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	10,281,249 - 10,295,550 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	10,246,746 - 10,293,543 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	36,012,669 - 36,026,965 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	10,470,479 - 10,484,783 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	10,470,517 - 10,484,924 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	10,281,754 - 10,296,048 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	10,316,285 - 10,330,591 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	36,254,132 - 36,268,471 (-)	NCBI		UU_Cfam_GSD_1.0

TWF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	43,793,723 - 43,806,317 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	43,793,723 - 43,806,328 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	44,187,526 - 44,200,120 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	42,473,793 - 42,486,445 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	42,989,914 - 43,003,516 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI
HuRef	12	41,215,942 - 41,228,787 (-)	NCBI		HuRef
CHM1_1	12	44,152,507 - 44,165,159 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	43,752,448 - 43,765,042 (-)	NCBI		T2T-CHM13v2.0

Twf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	94,475,829 - 94,487,727 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	94,475,832 - 94,487,770 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	94,577,948 - 94,589,884 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	94,577,951 - 94,589,889 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	94,408,379 - 94,420,255 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	94,406,128 - 94,418,004 (-)	NCBI		MGSCv36	mm8
Celera	15	96,725,758 - 96,737,654 (-)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	48.59	NCBI

Twf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	127,595,210 - 127,607,821 (-)	NCBI		GRCr8
mRatBN7.2	7	125,715,938 - 125,727,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	125,716,015 - 125,727,894 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	127,501,266 - 127,513,176 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	129,727,164 - 129,739,074 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	129,628,398 - 129,640,309 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	135,838,647 - 135,850,542 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	135,838,648 - 135,850,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	135,495,109 - 135,507,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	133,089,255 - 133,101,150 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	133,165,692 - 133,177,587 (-)	NCBI
Celera	7	122,105,689 - 122,117,583 (-)	NCBI		Celera
Cytogenetic Map	7	q35	NCBI

Twf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955500	3,050,028 - 3,070,799 (-)	NCBI	ChiLan1.0	ChiLan1.0

TWF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	50,365,141 - 50,380,376 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	50,361,874 - 50,377,135 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	44,925,701 - 44,938,344 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	45,794,763 - 45,807,404 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	45,794,763 - 45,807,404 (+)	Ensembl	panpan1.1		panPan2

Twf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	70,871,699 - 70,884,564 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	2,280,064 - 2,293,117 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	2,280,266 - 2,293,101 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TWF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	74,868,585 - 74,893,698 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	74,868,586 - 74,881,220 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	77,681,086 - 77,694,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TWF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	40,000,458 - 40,019,490 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	39,999,926 - 40,019,502 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	206,491,729 - 206,504,658 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Twf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	8,765,922 - 8,778,396 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	8,765,937 - 8,780,301 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TWF1
199 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5		16		6		6		12	8	10	6
Low		5	6	6		6		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038438431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038513125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038577401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038640894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_543726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000015336 ⟹ ENSCAFP00000014190

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	27	10,281,306 - 10,293,543 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000049290 ⟹ ENSCAFP00000036173

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	27	10,246,746 - 10,293,543 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845051592 ⟹ ENSCAFP00845040481

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	27	10,470,517 - 10,484,924 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845051613 ⟹ ENSCAFP00845040497

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	27	10,470,517 - 10,484,771 (+)	Ensembl

RefSeq Acc Id:

XM_038438431 ⟹ XP_038294359

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	27	10,470,479 - 10,484,783 (+)	NCBI

RefSeq Acc Id:

XM_038513125 ⟹ XP_038369053

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	27	10,281,754 - 10,296,048 (+)	NCBI

RefSeq Acc Id:

XM_038577401 ⟹ XP_038433329

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	27	36,254,132 - 36,268,471 (-)	NCBI

RefSeq Acc Id:

XM_038640894 ⟹ XP_038496822

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	27	10,316,285 - 10,330,591 (+)	NCBI

RefSeq Acc Id:

XM_543726 ⟹ XP_543726

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	27	10,281,249 - 10,295,550 (+)	NCBI
Dog10K_Boxer_Tasha	27	36,012,669 - 36,026,965 (-)	NCBI

Sequence:

show sequence

GGGTCGCAGCCCGATGACGCGCCGCGGCCGGCGGCGGAGCCACCACTTCCTGGAGGCGCCGGGC
CGGGCCGCTCTCAGCACTTAGCGCCGGAGCCGGGAGCCCCGCGTCGCCGCCATGTCCCATCAGA
CCGGCATCCAAGCAAGTGAAGATGTTAAGGATATCTTTGCCAGAGCAAGAAATGGAAAATACAG
ACTTCTAAAAATATCTATTGAAAATGAGAAACTTGTGATTGGATCATATAGTCAGCCTTCAGAT
TCCTGGGATAAAGATTATGATTCCTTTGTTTTACCCCTACTGGAGGACAAGCAACCGTGCTATA
TATTATTCAGGTTAGATTCTCAGAATGCCCAGGGATATGAATGGATATTTATTGCCTGGTCTCC
AGATCATTCTCATGTTCGTCAAAAAATGTTGTATGCAGCAACAAGAGCAACTCTGAAAAAGGAA
TTTGGAGGTGGCCACATTAAAGATGAAGTCTTTGGAACAGTAAAGGAAGATGTATCATTAAATG
GATATAAAAAATACTTGCTATCACAATCTTCTCCTGCCCCACTGACTGCAGCTGAGGAAGAATT
ACGACAGATTAAAATTAATGAGGTACAAACTGACGTGGGTGTGGACACTAAGCATCAAACACTA
CAAGGAGTAGCATTTCCTATTTCTCGAGAAGCTTTTCAGGCTTTGGAAAAATTAAGTAACAGAC
AGCTCAACTATGTGCAATTGGAAATAGATATAAAAAATGAAATTATAATTTTGGCCAACACAAC
AAATACAGAACTAAAAGATTTGCCAAAGAGGATTCCCAAGGATTCAGCACGTTACCATTTCTTC
CTGTATAAACATTCCCATGAAGGAGACTATTTGGAGTCCATAGTTTTTATTTATTCAATGCCTG
GATACACATGCAGTATAAGAGAACGGATGTTATATTCTAGCTGCAAGAGCCCTCTGCTAGAAAT
TGTAGAAAGACAACTACAAATGGATGTCATTAGAAAGATTGAGATAGACAATGGGGATGAGTTG
ACAGCAGACTTCCTTTATGAAGAAGTACACCCAAAGCAGCATGCACATAAGCAAAGTTTTGCAA
AACCAAAAGGTCCTGCAGGAAAAAGAGGAATTCGAAGACTTATAAGGGGTCCAGCTGAAAGTGA
AGCCGCTGCTGATTAAAGTCATTATATTAAGCATTACAATACTAGTTTTTTAAAAGTCCAGCTT
TTAGTACAGGAGAACTGAAATCATTCCATGTTGATACATAGTAGGGGAAAAATTGTACTTTTTG
AAAAATAGCACTTTTCACTTCTGTGTGTTTTTAAAATTAAGGTTATAGAAGACTCATGATTTCT
ATTTTTGAGTTACAGCTAGAAAAGCGTTCAACATAGTGATGTTTAATTTTGTCACACTCTTTTC
ACAGAGTAATAGTGATTCCATACTTTCACACACTTCTTAAAATTTTATACAGTTGGGCCAGTTC
CAGAAAGTAATGTCTCAAACTAAGATACACTCCTTACTACTTTTTAGTGAGACATCAAGTTTTT
TCTTGAAGGGAGAAAGACCTTAAAGTATTCATACCATTAAATGAATATGTTAAGGACCAGGTTA
GATTATTTTCTCAGCTGAGAACCTAGTGTGCCTAGGTAAAGGTAAAACGTTGCTGACTCTGAGA
AGCAGTGCTCTCAGACTGTGGGATCATGTCTGCAACTTTTAGAAACTGTGCTTTATTGCAGCAG
TCTTTTCTATTTGACATTTTTGGTTTTTTAAATGGCATTAAAATTTCAGAAGATCAGTTCATTC
TGAAACCTTAAAGGTACCATATATTTTCTATACTGCAGGATTTCTGATGACGTTGAAAGACATT
TAAACAGCTTTAGTAAATTCTCTTTCTAGTGCTTTAAAAAGTTTCATTTTCAAAAGTAAGTCAT
TCCATTATAAGTAGTTTGAGGCCAAATTTTTATGTTCAGATTGAATATTAAATTAATATTAAAA
AAACAAAACTAAAGTCAATAATGTTGAAAAAGTCTTAAACATCAAGATTGATTTTTCTCCAGAA
CCATATATTAATAGGCAGATTATTATGTTCTTTATTACTTCTGAGCAAATACTCAGATTTCATA
AAATTGTTTGAAAGTCCCAGTACTTAATCAGCCTAACAGAAATTAAACACTTAGGGATCTTGTT
TCAATTTATATCTTATTTCAGAGCACATTTAACTGTTTTAAAGGTTTGCATTTTCAGTACAACC
CATAGAAATTTTGAGCCTTTTTTTTTCTTTTTGGATACTTGAAATAGGGAAGGAGTTAGGACAC
TTCGTCATGTTAAATCTGATAAACCTGCTGCAAGAGCCATAACTTTGAGAGTTTTCTAAATGAA
CTGTGGGGATCCAGGATTTAGAATTTCTTGATCTAAACTTTATGCTGCATAAAACATTAGAAAT
GCACATTTCATAGTATAAAATATGAAACACATTTTATACCTTATTATCTAAGGTACTATATGCA
CCTTTCAAAAATTCAATGTGTGTTCAAGTAAAGCCTATTAGAATAATTATGGGTTGACAGGATT
TTTTTTCTAGAGTTAAGGGTATTTGTGTGGGGTTTGTTTGTTTACAAATAATCAGACTATACTA
TTTAAACATGCAAAGTGATTGGCAGTAATGTTGCACTTGTTTACTAAAGATACACTTTAGGTTG
TTTCATGGGTGCCCACATAGACACGCGCGCGCGCGCGCACACACACACACACACACACACACAC
ACACACACTACTGCATTGAGAATCCTAGAGCTGCATTGCAGACCATAGCTGAAGCTGTATTTTC
AATCAGAAAGAATGTAAAACCTGTCATGAAGGTATAAAATTAATTTGGTAGTGAATGTTTTTCT
GTACCATTCATGTGCAATTATAGTCTAAATTCTACTACACTACATGAAAGAAAATGGACATTCC
AGAATATAGATGTGATTATATAGTCTTAAACTAATTATTATTAAACCAAGATTGCTGAAAATCA
GTGATGCATTTGTTATAGAGTATAACTCATTGTTTACAGGATGTTTTAGGTGACATCATCATAA
CAATAGAAGGTGATTAAAGTATTCCCAGTAAATTTATATAGCAGTGAAGAATTACATGCCTTCT
GTGGACATTTTATAAAAGTGCATTTTATATTGCAATAAATTTTTTTCTCTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038294359	(Get FASTA)	NCBI Sequence Viewer
	XP_038369053	(Get FASTA)	NCBI Sequence Viewer
	XP_038433329	(Get FASTA)	NCBI Sequence Viewer
	XP_038496822	(Get FASTA)	NCBI Sequence Viewer
	XP_543726	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000014190.3
	ENSCAFP00000036173.3
	ENSCAFP00000072470.1
	ENSCAFP00030027981.1
	ENSCAFP00030031178.1
	ENSCAFP00040035233.1
	ENSCAFP00040035286.1
	ENSCAFP00845040481
	ENSCAFP00845040481.1
	ENSCAFP00845040497.1

RefSeq Acc Id:

XP_543726 ⟸ XM_543726

- UniProtKB:

A0A8C0TGD9 (UniProtKB/TrEMBL), A0A8I3QIT6 (UniProtKB/TrEMBL), A0A8C0NRK2 (UniProtKB/TrEMBL), A0A8I3Q7G2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSYSQPSDSWDKDYDSFVLPLLEDK
QPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKED
VSLNGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEK
LSNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFI
YSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHAHK
QSFAKPKGPAGKRGIRRLIRGPAESEAAAD

hide sequence

RefSeq Acc Id:

ENSCAFP00000014190 ⟸ ENSCAFT00000015336

RefSeq Acc Id:

ENSCAFP00000036173 ⟸ ENSCAFT00000049290

RefSeq Acc Id:

XP_038369053 ⟸ XM_038513125

RefSeq Acc Id:

XP_038496822 ⟸ XM_038640894

RefSeq Acc Id:	XP_038294359 ⟸ XM_038438431
- UniProtKB:	A0A8C0TGD9 (UniProtKB/TrEMBL), A0A8I3QIT6 (UniProtKB/TrEMBL), A0A8C0NRK2 (UniProtKB/TrEMBL), A0A8I3Q7G2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038433329 ⟸ XM_038577401
- UniProtKB:	A0A8C0NRK2 (UniProtKB/TrEMBL), A0A8C0TGD9 (UniProtKB/TrEMBL), A0A8I3Q7G2 (UniProtKB/TrEMBL), A0A8I3QIT6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845040497 ⟸ ENSCAFT00845051613

RefSeq Acc Id:

ENSCAFP00845040481 ⟸ ENSCAFT00845051592

Protein Domains

ADF-H

Promoters

RGD ID:

13688131

Promoter ID:

EPDNEW_C6200

Type:

initiation region

Name:

TWF1_1

Description:

twinfilin actin binding protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	27	10,281,325 - 10,281,385	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009652	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030017430	UniProtKB/TrEMBL
	ENSCAFG00030019341	UniProtKB/TrEMBL
	ENSCAFG00040021751	UniProtKB/TrEMBL
	ENSCAFG00845029147	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000015336.5	UniProtKB/TrEMBL
	ENSCAFT00000049290.4	UniProtKB/TrEMBL
	ENSCAFT00000107231.1	UniProtKB/TrEMBL
	ENSCAFT00030032090.1	UniProtKB/TrEMBL
	ENSCAFT00030035750.1	UniProtKB/TrEMBL
	ENSCAFT00040040384.1	UniProtKB/TrEMBL
	ENSCAFT00040040448.1	UniProtKB/TrEMBL
	ENSCAFT00845051592	ENTREZGENE
	ENSCAFT00845051592.1	UniProtKB/TrEMBL
	ENSCAFT00845051613.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/TrEMBL
InterPro	ADF-H	UniProtKB/TrEMBL
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/TrEMBL
	Twinfilin	UniProtKB/TrEMBL
KEGG Report	cfa:486600	UniProtKB/TrEMBL
NCBI Gene	TWF1	ENTREZGENE
PANTHER	PTHR13759	UniProtKB/TrEMBL
	TWINFILIN-1	UniProtKB/TrEMBL
Pfam	Cofilin_ADF	UniProtKB/TrEMBL
PROSITE	ADF_H	UniProtKB/TrEMBL
SMART	ADF	UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/TrEMBL
UniProt	A0A8C0NRK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TGD9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q7G2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3QIT6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NNC9_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:48001	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD