Fermt2 (FERM domain containing kindlin 2) - Rat Genome Database

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Gene: Fermt2 (FERM domain containing kindlin 2) Rattus norvegicus
Analyze
Symbol: Fermt2
Name: FERM domain containing kindlin 2
RGD ID: 1311799
Description: Predicted to enable several functions, including phosphatidylinositol-3,4,5-trisphosphate binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within cell adhesion and protein localization to cell junction. Predicted to be located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and stress fiber. Predicted to be active in focal adhesion. Orthologous to human FERMT2 (FERM domain containing kindlin 2); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fermitin family homolog 2; fermitin family homolog 2 (Drosophila); fermitin family member 2; LOC289992; pleckstrin homology domain containing, family C (with FERM domain) member 1; Plekhc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81521,162,603 - 21,257,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1521,162,605 - 21,258,115 (-)EnsemblGRCr8
mRatBN7.21518,682,927 - 18,751,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1521,475,374 - 21,544,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01522,432,342 - 22,501,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,688,917 - 20,757,681 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,807,806 - 19,876,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,807,808 - 19,876,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01523,771,816 - 23,840,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41521,358,411 - 21,427,264 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1519,110,289 - 19,178,605 (-)NCBICelera
RGSC_v3.11521,358,412 - 21,427,264 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
inulin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
nobiletin  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction maintenance  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell-matrix adhesion  (IBA,IEA,ISO)
focal adhesion assembly  (IEA,ISO)
integrin activation  (IEA,ISO)
integrin-mediated signaling pathway  (IEA,ISO)
limb development  (ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of vascular permeability  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of integrin activation  (IEA,ISO)
positive regulation of mesenchymal stem cell proliferation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of Rho protein signal transduction  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
positive regulation of wound healing, spreading of epidermal cells  (IEA,ISO)
protein localization to cell junction  (ISO)
protein localization to membrane  (ISO)
regulation of cell morphogenesis  (IEA,ISO)
substrate adhesion-dependent cell spreading  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component
adherens junction  (IEA,ISO)
anchoring junction  (IEA)
cell junction  (IEA,ISO)
cell projection  (IEA)
cytoplasm  (IEA,ISO)
cytoplasmic side of plasma membrane  (IEA,ISO)
cytosol  (IEA,ISO)
focal adhesion  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IEA,ISO)
stress fiber  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, etal., Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. [Expression of Kindlins and angiopoietins in acute myeloid leukemia]. Wu WB, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):7-11.
Additional References at PubMed
PMID:12477932   PMID:16876785   PMID:18483218   PMID:21325030   PMID:21423176   PMID:22030399   PMID:22699938   PMID:26143257   PMID:26676966   PMID:29162887   PMID:29496737  


Genomics

Comparative Map Data
Fermt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81521,162,603 - 21,257,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1521,162,605 - 21,258,115 (-)EnsemblGRCr8
mRatBN7.21518,682,927 - 18,751,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1521,475,374 - 21,544,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01522,432,342 - 22,501,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,688,917 - 20,757,681 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,807,806 - 19,876,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,807,808 - 19,876,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01523,771,816 - 23,840,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41521,358,411 - 21,427,264 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1519,110,289 - 19,178,605 (-)NCBICelera
RGSC_v3.11521,358,412 - 21,427,264 (-)NCBI
Cytogenetic Map15p14NCBI
FERMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,857,273 - 52,951,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,857,267 - 52,952,435 (-)Ensemblhg38GRCh38
GRCh371453,323,991 - 53,417,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,393,743 - 52,487,460 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341452,393,742 - 52,487,460NCBI
Celera1433,373,704 - 33,467,553 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1433,486,674 - 33,581,054 (-)NCBIHuRef
CHM1_11453,262,863 - 53,356,715 (-)NCBICHM1_1
T2T-CHM13v2.01447,065,165 - 47,158,990 (-)NCBIT2T-CHM13v2.0
Fermt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,696,252 - 45,767,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,696,252 - 45,767,575 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381445,458,792 - 45,530,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1445,458,795 - 45,530,118 (-)Ensemblmm10GRCm38
MGSCv371446,078,467 - 46,149,740 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361444,380,669 - 44,451,942 (-)NCBIMGSCv36mm8
Celera1441,642,480 - 41,713,283 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.97NCBI
Fermt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,285,793 - 10,327,468 (+)Ensembl
ChiLan1.0NW_00495540910,285,780 - 10,327,286 (+)NCBIChiLan1.0ChiLan1.0
FERMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,988,488 - 54,082,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11453,205,000 - 53,298,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01433,453,983 - 33,547,721 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,737,188 - 51,830,109 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,737,188 - 51,829,766 (-)EnsemblpanPan2panpan1.1
FERMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,083,538 - 29,135,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,084,531 - 29,133,391 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha828,829,003 - 28,907,889 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0829,250,020 - 29,326,046 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl829,250,010 - 29,395,871 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,924,206 - 29,004,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,996,473 - 29,076,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0829,325,136 - 29,405,152 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fermt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,153,793 - 76,234,113 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,927,812 - 2,008,268 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FERMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1182,519,684 - 182,606,869 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11182,519,681 - 182,606,890 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,790,224 - 202,816,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FERMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,954,706 - 30,053,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605318,220,669 - 18,321,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fermt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,168,207 - 16,246,778 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473116,168,179 - 16,247,747 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fermt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11277,507,364 - 77,575,160 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fermt2
545 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:659
Count of miRNA genes:280
Interacting mature miRNAs:351
Transcripts:ENSRNOT00000012400
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat

Markers in Region
AA960555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,058 - 18,683,155 (+)MAPPERmRatBN7.2
Rnor_6.01519,807,938 - 19,808,034NCBIRnor6.0
Rnor_5.01523,771,948 - 23,772,044UniSTSRnor5.0
RGSC_v3.41521,358,543 - 21,358,639UniSTSRGSC3.4
Celera1519,110,421 - 19,110,517UniSTS
Cytogenetic Map15p14UniSTS
RH134534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,035 - 18,683,246 (+)MAPPERmRatBN7.2
Rnor_6.01519,807,915 - 19,808,125NCBIRnor6.0
Rnor_5.01523,771,925 - 23,772,135UniSTSRnor5.0
RGSC_v3.41521,358,520 - 21,358,730UniSTSRGSC3.4
Celera1519,110,398 - 19,110,608UniSTS
RH 3.4 Map15149.4UniSTS
Cytogenetic Map15p14UniSTS
AI179101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,992 - 18,684,087 (+)MAPPERmRatBN7.2
Rnor_6.01519,808,872 - 19,808,966NCBIRnor6.0
Rnor_5.01523,772,882 - 23,772,976UniSTSRnor5.0
RGSC_v3.41521,359,477 - 21,359,571UniSTSRGSC3.4
Celera1519,111,355 - 19,111,449UniSTS
RH 3.4 Map15156.3UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 80 189 91 90 59 133 59 6 448 255 21 167 110 124 31 25 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001011915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012400   ⟹   ENSRNOP00000012400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1521,162,605 - 21,258,115 (-)Ensembl
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)Ensembl
Rnor_6.0 Ensembl1519,807,808 - 19,876,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086368   ⟹   ENSRNOP00000069828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1521,162,605 - 21,231,450 (-)Ensembl
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)Ensembl
Rnor_6.0 Ensembl1519,807,815 - 19,876,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094711   ⟹   ENSRNOP00000080201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1521,162,605 - 21,232,263 (-)Ensembl
mRatBN7.2 Ensembl1518,683,895 - 18,751,791 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114951   ⟹   ENSRNOP00000083293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1521,162,605 - 21,231,450 (-)Ensembl
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168503   ⟹   ENSRNOP00000099200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1521,162,605 - 21,232,263 (-)Ensembl
RefSeq Acc Id: NM_001011915   ⟹   NP_001011915
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,450 (-)NCBI
mRatBN7.21518,682,927 - 18,751,778 (-)NCBI
Rnor_6.01519,807,806 - 19,876,389 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
RGSC_v3.41521,358,411 - 21,427,264 (-)RGD
Celera1519,110,289 - 19,178,605 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251755   ⟹   XP_006251817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,497 (-)NCBI
mRatBN7.21518,682,927 - 18,751,838 (-)NCBI
Rnor_6.01519,807,806 - 19,876,414 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251756   ⟹   XP_006251818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
mRatBN7.21518,682,927 - 18,751,959 (-)NCBI
Rnor_6.01519,807,806 - 19,876,557 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251757   ⟹   XP_006251819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,497 (-)NCBI
mRatBN7.21518,682,927 - 18,751,838 (-)NCBI
Rnor_6.01519,807,806 - 19,876,414 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251759   ⟹   XP_006251821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,497 (-)NCBI
mRatBN7.21518,682,927 - 18,751,837 (-)NCBI
Rnor_6.01519,807,806 - 19,876,414 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251760   ⟹   XP_006251822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,497 (-)NCBI
mRatBN7.21518,682,927 - 18,751,837 (-)NCBI
Rnor_6.01519,807,806 - 19,876,414 (-)NCBI
Rnor_5.01523,771,816 - 23,840,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093097   ⟹   XP_038949025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
mRatBN7.21518,682,927 - 18,751,956 (-)NCBI
RefSeq Acc Id: XM_063274084   ⟹   XP_063130154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,257,995 (-)NCBI
RefSeq Acc Id: XM_063274085   ⟹   XP_063130155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,257,995 (-)NCBI
RefSeq Acc Id: XM_063274086   ⟹   XP_063130156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,257,995 (-)NCBI
RefSeq Acc Id: XM_063274087   ⟹   XP_063130157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
RefSeq Acc Id: XM_063274088   ⟹   XP_063130158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
RefSeq Acc Id: XM_063274090   ⟹   XP_063130160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,257,995 (-)NCBI
RefSeq Acc Id: XM_063274091   ⟹   XP_063130161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
RefSeq Acc Id: XM_063274092   ⟹   XP_063130162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81521,162,603 - 21,231,660 (-)NCBI
RefSeq Acc Id: NP_001011915   ⟸   NM_001011915
- UniProtKB: Q5XI19 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251818   ⟸   XM_006251756
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251822   ⟸   XM_006251760
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251821   ⟸   XM_006251759
- Peptide Label: isoform X8
- UniProtKB: F7ERM0 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251819   ⟸   XM_006251757
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G699 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251817   ⟸   XM_006251755
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012400   ⟸   ENSRNOT00000012400
Ensembl Acc Id: ENSRNOP00000069828   ⟸   ENSRNOT00000086368
RefSeq Acc Id: XP_038949025   ⟸   XM_039093097
- Peptide Label: isoform X10
- UniProtKB: Q5XI19 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083293   ⟸   ENSRNOT00000114951
Ensembl Acc Id: ENSRNOP00000080201   ⟸   ENSRNOT00000094711
RefSeq Acc Id: XP_063130160   ⟸   XM_063274090
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130156   ⟸   XM_063274086
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130155   ⟸   XM_063274085
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130154   ⟸   XM_063274084
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130162   ⟸   XM_063274092
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130158   ⟸   XM_063274088
- Peptide Label: isoform X6
- UniProtKB: A0A0G2JWC7 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130161   ⟸   XM_063274091
- Peptide Label: isoform X8
- UniProtKB: F7ERM0 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130157   ⟸   XM_063274087
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G699 (UniProtKB/TrEMBL),   A0A8I5ZZ14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099200   ⟸   ENSRNOT00000168503
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWC7-F1-model_v2 AlphaFold A0A0G2JWC7 1-695 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699598
Promoter ID:EPDNEW_R10122
Type:initiation region
Name:Fermt2_1
Description:fermitin family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01519,876,369 - 19,876,429EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311799 AgrOrtholog
BioCyc Gene G2FUF-14214 BioCyc
Ensembl Genes ENSRNOG00000009102 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012400 ENTREZGENE
  ENSRNOT00000012400.8 UniProtKB/TrEMBL
  ENSRNOT00000086368 ENTREZGENE
  ENSRNOT00000086368.3 UniProtKB/TrEMBL
  ENSRNOT00000094711.2 UniProtKB/TrEMBL
  ENSRNOT00000114951 ENTREZGENE
  ENSRNOT00000114951.2 UniProtKB/TrEMBL
  ENSRNOT00000168503.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129898 IMAGE-MGC_LOAD
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  Kindlin/fermitin UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PH_Kindlin/fermitin UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:289992 UniProtKB/TrEMBL
MGC_CLONE MGC:95154 IMAGE-MGC_LOAD
NCBI Gene 289992 ENTREZGENE
PANTHER FERMITIN FAMILY HOMOLOG 2 UniProtKB/TrEMBL
  PTHR16160 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Fermt2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009102 RatGTEx
SMART B41 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A0G2JWC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G699 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L568_RAT UniProtKB/TrEMBL
  F7ERM0 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Fermt2  FERM domain containing kindlin 2  Fermt2  fermitin family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fermt2  fermitin family member 2  Fermt2  fermitin family homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Fermt2  fermitin family homolog 2 (Drosophila)  Plekhc1  pleckstrin homology domain containing, family C (with FERM domain) member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Plekhc1  pleckstrin homology domain containing, family C (with FERM domain) member 1  Plekhc1_predicted  pleckstrin homology domain containing, family C (with FERM domain) member 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Plekhc1_predicted  pleckstrin homology domain containing, family C (with FERM domain) member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED