Amfr (autocrine motility factor receptor) - Rat Genome Database

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Gene: Amfr (autocrine motility factor receptor) Rattus norvegicus
Analyze
Symbol: Amfr
Name: autocrine motility factor receptor
RGD ID: 1311551
Description: Predicted to enable several functions, including BAT3 complex binding activity; ubiquitin-specific protease binding activity; and ubiquitin-ubiquitin ligase activity. Involved in learning or memory. Located in dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH bisphenol A; gentamycin; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: autocrine motility factor receptor, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase AMFR; LOC361367
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,002,451 - 11,038,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,002,101 - 11,038,364 (+)EnsemblGRCr8
mRatBN7.21910,996,705 - 11,032,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,996,099 - 11,032,247 (+)EnsemblmRatBN7.2
Rnor_6.01911,473,538 - 11,509,500 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,473,541 - 11,508,102 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,447,902 - 11,483,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,434,553 - 11,467,592 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,881,564 - 10,916,023 (+)NCBICelera
RGSC_v3.11911,417,443 - 11,471,813 (+)NCBI
Cytogenetic Map19p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of the AMF/neuroleukin receptor in developing and adult brain cerebellum. Leclerc N, etal., J Neurosci Res. 2000 Jun 1;60(5):602-12.
4. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. Luo Y, etal., J Neurochem. 2002 Jan;80(2):354-61.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1649192   PMID:11724934   PMID:12477932   PMID:12847084   PMID:16168377   PMID:16275660   PMID:17043353   PMID:17157811   PMID:17310145   PMID:17681147   PMID:17872946   PMID:19103148  
PMID:19223579   PMID:19946888   PMID:20819951   PMID:21636303   PMID:22728137   PMID:23246001   PMID:23382219   PMID:23942235   PMID:24424410   PMID:24810856   PMID:26459914   PMID:28528366  
PMID:31073040  


Genomics

Comparative Map Data
Amfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,002,451 - 11,038,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1911,002,101 - 11,038,364 (+)EnsemblGRCr8
mRatBN7.21910,996,705 - 11,032,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,996,099 - 11,032,247 (+)EnsemblmRatBN7.2
Rnor_6.01911,473,538 - 11,509,500 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,473,541 - 11,508,102 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,447,902 - 11,483,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,434,553 - 11,467,592 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,881,564 - 10,916,023 (+)NCBICelera
RGSC_v3.11911,417,443 - 11,471,813 (+)NCBI
Cytogenetic Map19p12NCBI
AMFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,361,452 - 56,425,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,361,449 - 56,425,545 (-)Ensemblhg38GRCh38
GRCh371656,395,364 - 56,459,457 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,952,865 - 55,016,945 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341654,952,864 - 55,016,804NCBI
Celera1640,892,193 - 40,957,463 (-)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,266,003 - 42,329,606 (-)NCBIHuRef
CHM1_11657,802,735 - 57,866,433 (-)NCBICHM1_1
T2T-CHM13v2.01662,156,498 - 62,220,616 (-)NCBIT2T-CHM13v2.0
Amfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,698,216 - 94,739,301 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,698,216 - 94,739,470 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38893,971,588 - 94,012,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,971,588 - 94,012,842 (-)Ensemblmm10GRCm38
MGSCv37896,495,488 - 96,536,540 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36896,861,055 - 96,901,971 (-)NCBIMGSCv36mm8
Celera898,301,641 - 98,335,290 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.96NCBI
Amfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,172,808 - 14,212,110 (-)Ensembl
ChiLan1.0NW_00495543314,172,871 - 14,205,484 (-)NCBIChiLan1.0ChiLan1.0
AMFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,843,225 - 65,907,259 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,762,368 - 71,826,081 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,647,792 - 36,711,782 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,780,633 - 55,843,738 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,780,633 - 55,843,744 (-)EnsemblpanPan2panpan1.1
AMFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,766,910 - 59,803,292 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,767,324 - 59,801,883 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha256,392,079 - 56,436,972 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0260,303,688 - 60,348,369 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,303,780 - 60,348,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,133,765 - 57,178,394 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,142,842 - 58,187,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,035,835 - 59,080,467 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,861,780 - 50,896,114 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,692,844 - 8,727,385 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,692,969 - 8,727,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,366,827 - 29,413,697 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1629,366,812 - 29,417,800 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,739,205 - 26,753,523 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,276,672 - 42,334,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,275,584 - 42,334,207 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604734,030,673 - 34,088,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624757136,283 - 179,138 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624757136,289 - 179,743 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amfr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v117890,749 - 925,638 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amfr
171 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:94
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000026340
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH70754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,032,009 - 11,032,151 (+)MAPPERmRatBN7.2
Rnor_6.01911,509,255 - 11,509,396NCBIRnor6.0
Rnor_5.01911,483,632 - 11,483,773UniSTSRnor5.0
RGSC_v3.41911,468,137 - 11,468,278UniSTSRGSC3.4
Celera1910,915,587 - 10,915,728UniSTS
Cytogenetic Map19p12UniSTS
RH130371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,993,508 - 10,993,697 (+)MAPPERmRatBN7.2
Rnor_6.01911,470,305 - 11,470,493NCBIRnor6.0
Rnor_5.01911,444,738 - 11,444,926UniSTSRnor5.0
RGSC_v3.41911,431,359 - 11,431,547UniSTSRGSC3.4
Celera1910,878,063 - 10,878,251UniSTS
RH 3.4 Map19112.3UniSTS
Cytogenetic Map19p12UniSTS
RH134309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,031,675 - 11,031,858 (+)MAPPERmRatBN7.2
Rnor_6.01911,508,921 - 11,509,103NCBIRnor6.0
Rnor_5.01911,483,298 - 11,483,480UniSTSRnor5.0
RGSC_v3.41911,467,803 - 11,467,985UniSTSRGSC3.4
Celera1910,915,253 - 10,915,435UniSTS
RH 3.4 Map19110.7UniSTS
Cytogenetic Map19p12UniSTS
BF386544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,019,743 - 11,019,895 (+)MAPPERmRatBN7.2
Rnor_6.01911,496,990 - 11,497,141NCBIRnor6.0
Rnor_5.01911,471,367 - 11,471,518UniSTSRnor5.0
RGSC_v3.41911,455,872 - 11,456,023UniSTSRGSC3.4
Celera1910,903,304 - 10,903,455UniSTS
RH 3.4 Map19110.7UniSTS
Cytogenetic Map19p12UniSTS
Amfr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,031,032 - 11,031,815 (+)MAPPERmRatBN7.2
Rnor_6.01911,508,278 - 11,509,060NCBIRnor6.0
Rnor_5.01911,482,655 - 11,483,437UniSTSRnor5.0
RGSC_v3.41911,467,160 - 11,467,942UniSTSRGSC3.4
Celera1910,914,610 - 10,915,392UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 212 91 90 59 157 59 6 486 284 22 190 112 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000082066   ⟹   ENSRNOP00000072893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1911,002,101 - 11,038,364 (+)Ensembl
mRatBN7.2 Ensembl1910,996,099 - 11,032,247 (+)Ensembl
Rnor_6.0 Ensembl1911,473,541 - 11,508,102 (+)Ensembl
RefSeq Acc Id: NM_001427144   ⟹   NP_001414073
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,002,451 - 11,038,182 (+)NCBI
RefSeq Acc Id: XM_063278104   ⟹   XP_063134174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81911,003,382 - 11,038,059 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414073 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134174 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87358 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072893
  ENSRNOP00000072893.2
Ensembl Acc Id: ENSRNOP00000072893   ⟸   ENSRNOT00000082066
RefSeq Acc Id: NP_001414073   ⟸   NM_001427144
RefSeq Acc Id: XP_063134174   ⟸   XM_063278104
- Peptide Label: isoform X1
- UniProtKB: A6JY80 (UniProtKB/TrEMBL)
Protein Domains
CUE   RING-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311551 AgrOrtholog
BioCyc Gene G2FUF-6467 BioCyc
Ensembl Genes ENSRNOG00000055446 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082066 ENTREZGENE
  ENSRNOT00000082066.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro AMFR_Ube2g2-bd UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 361367 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE AMFR UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE RNF8 UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
  G2BR UniProtKB/TrEMBL
  TPR_SYVN1_N UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PhenoGen Amfr PhenoGen
PROSITE CUE UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055446 RatGTEx
SMART CUE UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0G2K437_RAT UniProtKB/TrEMBL
  A6JY80 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Amfr  autocrine motility factor receptor  Amfr  autocrine motility factor receptor, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Amfr  autocrine motility factor receptor, E3 ubiquitin protein ligase  Amfr  autocrine motility factor receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Amfr  autocrine motility factor receptor   Amfr_predicted  autocrine motility factor receptor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Amfr_predicted  autocrine motility factor receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED