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Gene: Xcr1 (X-C motif chemokine receptor 1) Rattus norvegicus

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Symbol:

Xcr1

Name:

X-C motif chemokine receptor 1

RGD ID:

1311480

Description:

Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis; release of sequestered calcium ion into cytosol; and response to cytokine. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human XCR1 (X-C motif chemokine receptor 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

chemokine (C motif) receptor 1; chemokine XC receptor 1; LOC301086

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	XCR1 (X-C motif chemokine receptor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Xcr1 (chemokine (C motif) receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	XCR1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	XCR1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Xcr1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	XCR1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	XCR1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Xcr1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Xcr1 (X-C motif chemokine receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MYL11 (myosin light chain 11)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	XCR1 (X-C motif chemokine receptor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	XCR1 (X-C motif chemokine receptor 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Xcr1 (chemokine (C motif) receptor 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	xcr1b.1 (chemokine (C motif) receptor 1b, duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	xcr1a.1 (chemokine (C motif) receptor 1a, duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	xcr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	132,357,020 - 132,393,596 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	132,357,020 - 132,385,862 (-)	Ensembl				GRCr8
mRatBN7.2	8	123,479,454 - 123,516,168 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	123,479,590 - 123,487,226 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	129,071,800 - 129,079,436 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	127,270,777 - 127,278,413 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	125,099,978 - 125,107,614 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,911,474 - 132,919,110 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,911,486 - 132,919,110 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	132,062,477 - 132,091,285 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	128,612,753 - 128,620,389 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	122,587,775 - 122,595,411 (-)	NCBI		Celera
RGSC_v3.1	8	128,635,635 - 128,636,605 (-)	NCBI
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-nitropyrene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

aldehydo-D-glucose (ISO)

amphetamine (EXP)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

dorsomorphin (ISO)

flavonoids (ISO)

fructose (ISO)

glucose (ISO)

glyphosate (ISO)

iron(2+) sulfate (anhydrous) (ISO)

lipopolysaccharide (ISO)

neoechinulin A (ISO)

ozone (ISO)

paracetamol (ISO)

PCB138 (ISO)

pioglitazone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sterigmatocystin (ISO)

tert-butyl hydroperoxide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

TMC-120A (ISO)

triptonide (ISO)

valproic acid (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IBA)

cell chemotaxis (IBA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

immune response (IBA)

positive regulation of cytosolic calcium ion concentration (IBA)

release of sequestered calcium ion into cytosol (ISO)

response to cytokine (ISO)

signal transduction (IEA)

Cellular Component

external side of plasma membrane (IBA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

C-C chemokine binding (IBA)

C-C chemokine receptor activity (IBA)

chemokine receptor activity (IEA)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

cytokine mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10518929	PMID:24155383	PMID:31649144

Genomics

Comparative Map Data

Xcr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	132,357,020 - 132,393,596 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	132,357,020 - 132,385,862 (-)	Ensembl				GRCr8
mRatBN7.2	8	123,479,454 - 123,516,168 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	123,479,590 - 123,487,226 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	129,071,800 - 129,079,436 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	127,270,777 - 127,278,413 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	125,099,978 - 125,107,614 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,911,474 - 132,919,110 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,911,486 - 132,919,110 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	132,062,477 - 132,091,285 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	128,612,753 - 128,620,389 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	122,587,775 - 122,595,411 (-)	NCBI		Celera
RGSC_v3.1	8	128,635,635 - 128,636,605 (-)	NCBI
Cytogenetic Map	8	q32	NCBI

XCR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	46,017,007 - 46,085,844 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	46,016,990 - 46,085,825 (-)	Ensembl			hg38	GRCh38
GRCh37	3	46,058,499 - 46,127,336 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	46,037,295 - 46,043,983 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	46,037,441 - 46,038,443	NCBI
Celera	3	45,999,653 - 46,006,341 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	46,106,108 - 46,112,796 (-)	NCBI		HuRef
CHM1_1	3	46,011,957 - 46,018,641 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	46,032,885 - 46,101,714 (-)	NCBI		T2T-CHM13v2.0

Xcr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	123,681,380 - 123,691,094 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	123,681,380 - 123,691,094 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	123,852,315 - 123,862,029 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	123,852,315 - 123,862,029 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	123,761,436 - 123,771,246 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	123,701,016 - 123,710,826 (-)	NCBI		MGSCv36	mm8
Celera	9	124,300,685 - 124,310,371 (-)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	74.71	NCBI

XCR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	45,979,946 - 45,986,410 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	45,984,868 - 45,991,177 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	45,922,985 - 45,934,332 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	47,032,887 - 47,039,877 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,033,084 - 47,034,085 (-)	Ensembl			panPan2	panpan1.1

XCR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	42,505,534 - 42,516,524 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	42,511,431 - 42,512,423 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	42,421,402 - 42,432,159 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	42,988,286 - 42,999,051 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	42,988,356 - 42,998,804 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	42,229,406 - 42,240,162 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	42,636,610 - 42,647,379 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	42,911,915 - 42,922,678 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Xcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	200,544,294 - 200,545,341 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	93,433 - 94,434 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	93,433 - 94,480 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XCR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	29,150,379 - 29,159,637 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	29,150,376 - 29,233,802 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	32,246,790 - 32,330,226 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XCR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	7,495,008 - 7,503,202 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	7,496,260 - 7,497,261 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	159,658,784 - 159,667,802 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xcr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	74,915,383 - 74,919,308 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	74,913,815 - 74,921,198 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Xcr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	114,959,459 - 114,967,098 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	691
Count of miRNA genes:	280
Interacting mature miRNAs:	338
Transcripts:	ENSRNOT00000008747
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	9	27	77	73	73	42	68	42	6	234	124	11	55	47	72	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008747 ⟹ ENSRNOP00000008747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	132,357,020 - 132,364,656 (-)	Ensembl
mRatBN7.2 Ensembl	8	123,479,590 - 123,487,226 (-)	Ensembl
Rnor_6.0 Ensembl	8	132,911,486 - 132,919,110 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122011 ⟹ ENSRNOP00000103086

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	132,359,005 - 132,385,862 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122533 ⟹ ENSRNOP00000103296

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	132,359,166 - 132,385,862 (-)	Ensembl

RefSeq Acc Id:

NM_001106871 ⟹ NP_001100341

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,357,020 - 132,364,656 (-)	NCBI
mRatBN7.2	8	123,479,590 - 123,487,226 (-)	NCBI
Rnor_6.0	8	132,911,474 - 132,919,110 (-)	NCBI
Rnor_5.0	8	132,062,477 - 132,091,285 (-)	NCBI
RGSC_v3.4	8	128,612,753 - 128,620,389 (-)	RGD
Celera	8	122,587,775 - 122,595,411 (-)	RGD

Sequence:

show sequence

TGTTGCCTATATGAAGCTCTAGCACTAGAAGGGGAGAACAAAGGAAGCACAAAACATACAGACT
TGAAAACGTGACATGGACTCAGACTCAGATGCTCTCAGTATACCTGCCTCCTGGGTCCAGATGG
AGTCCTCTACAGTCTTTGATTATGATAAATCGAATCTTCTATGTGACAACAATGTCATCTTCTT
TTCCATCATCTTCACCATTGTCCTGTACTCTCTGGTATTTCTCCTCAGCCTGGTGGGTAACAGC
CTGGTTTTGTGGGTCTTGGTGAAGTATGAGAATCTAGAGTCACTCACCAATGTCTTCATCCTCA
ACCTGTGTCTCTCAGACCTCATGTTCTCCTGCCTACTGCCCGTGTTGATCTCAGCACAATGGGG
GTGGTTTCTAGGCGACTTCTTCTGCAAGTTCATCAACATGATCTTCTGCATCAGCCTCTACAGC
AGCATCTTCTTCCTTACCATCATGACAATCCACCGATACATGTCTGTAGTGAGCCCCATCTCCT
CTCTGGGCATCTATACCCTCCGCTGCCGCATGCTGGTGACCACATCTGTGTGGGCAGCCAGTAT
CCTGTTCTCCATCCCTGATACTGTCTTCCACAAAGTGATTTCCTTAAAATGTGACTTTTCTGAA
CGTCATGGGTTGTTGGCATCAGTCTACCAGCACAACATCCTCTTCCTCCTCTCCATGGGGATAA
TCTTGTTCTGCTATGTACAGATTCTCAGGACCTTGTTTCGCTCAAGGTCCAGACAGAGACACCG
AACGGTCAGGCTCATCTTCACCATCGTGGTAGCATACTTCCTCAGCTGGGCTCCTTACAACCTC
GTTCTCTTCCTGAAAACTGAAGTCATCCAGCTGAGCTGTGAGGGAAGACAGCAGCTGGACTTTG
CTATGATCATCTGTCGCAATTTGGCCTTCTCCCACTGCTGCTTCAATCCAGTGCTTTATGTCTT
TGTTGGGGTCAAGTTCCGCAGACACCTAAAACGTCTCCTCCAGCAGGTCTGGCTGTGCCCAAAG
ACATCCAATCCTGTTCCATTCTCCTACTCCCCTGGTACCTTTACATATGAGGGCCCCTCCTTCT
ACTGAGAGGAGAGGATGGGAACATGGAGATGACTAGGTGAGCTGAAGGAAGACAAGAAGAAGTG
GATCAGGAAGGAAAATATAACAGTGGAGATACCAGCATTGACTACAGAGGTGTGGAGGAAAGAC
ATGATAGCTCTGGGAAAGTGGCTTCCAGCTGGGCAATTCAAAGCAACACTTCCTGATGAAGCAA
CACTTCATCATTCATTCTTTTACTCAGACATAGATTGCTTATCAGTGATTGGTCAAAAGATCCT
AAATGGAAGGATTTCTGGACTTGAAGTTAATAGTATGTGCTAACTTTGAAGTCAGGTTTCTGGC
ACATAGGGTTGTCACAAACTATTTTTTTTCCACCTTGGTGATGGCTGACTCTGTGGTTCTTAGC
AGCTACTGAAGAAAACGGTCTCTTCATGACAAGAATAATCACATCTTCAAATAAGTACAGTCAC
AATGAAGTCTAGACCATAAAATCCCACTAAAATGAAGATAGTACTGTATTCTGGCAACAGCTGC
TAACACATAAACTGGCTTTTAAACATTTATCTCATAACTGAAGGAATGGATGCAAAATGTGTTA
CTGTCTACACTAAGTAATTATTTGGACAATACAAAGAAGAATAAGATATTGTTGCTAACTTCCA
GTTGACACCAATCCATCCAAGAAGATCCAGATAAAAAAGTCTACTTAACAGAGGCATTCAAGTT
GAATATTTCTCTGTCATTTCATCTCTTCCAAATTGAGAAAGATGATTTCCTCCATCTGGATAAT
AGTACCAGCTTCCCCCTTTTAACCAAGTACTGCATTCCCTTTCCCTAAGTTCACAGAGCCAGGT
TCTGTGGATTCTGCGTTTCCAGGATCTCTCCAGCTTATTCTCACGATCACATACCGGTGACTCC
ACCTCTACTATGCTCTCTATTCCATAGTGTCTTCCTTTTGCTTCTTTTTTTCCTCTGTTCCTTC
TCCAGGAAGCTGCACGCCTGAGATTTTTCTTTTATTTACAGCTTCTCTGTCTGGAGTTTTTCTT
TAAAGCTTTAATAAAATTGTCCTCAAGCTTCCTTCTGAGTTACTTCTTAAATTCTTTTATTAAT
GAAACTAATAACCCAAAAAGAGGACCCAGATTTCCCTGGTAATATAAGGTGACTCCATCAGGAT
GCTCCAGAATTTCAGGTAACATTATTACCTTTGGGAAGTTTAGACTGTTATGTCTGCATCCAGG
GCCAGAGACAGAACTCAAATCCTGTTCTTTCAACCAAAAATAAATAAAAACATATAACAGTAGA
GTTTGAAGAATTAATGAAAAAGTTAAAAGCCATAAAACAGCTATGGTTTACCCAGAAGAAGTAA
CTTTCAAGTGGATAGAGAGATGGCTCAGCAGTTAAGAGCACTGCTATTCCTCCAGAGGGCCTAA
GTTCAGTTCCCTAAGCCCACATGGTAGCTCACAACCATTTTTAACTCCAGTTCCAGGGGAATCC
ATTGCCCTCTTCTGGCCTCCTTTCCTTTGTAAACAAAGATGAACATTTCATATATCTGACAATG
TGTTGGTTAGAAATGCCTCAGGAACCTTCTACTTCATCCTACTTTATATCCTGTCCATTAGCCA
GGTGAACTTGGAATTCCTTTATGTCTCCAAGACTCAATCTCATCTTTGAAGAGCAGAAATCTCT
ATAGCACAGAGCTGTGTTGAGTTTTAAACATGATGCTCTATAGGTTTTTGGTTTTGGTTAGGGT
GTGACATACTAGGTTTTAAATATATACAACCATCTACTGCACAATATTTTGGTCAAAGTTGGAT
CACATATGACTGTGGTCCCTTAAGACTAAATCATCTAGTGATGTCATAGTCATCTTAATTTGTC
TAACTATACCCCAGATGAATTGTCTATGAAATTCTCAAAAATGCATCATTACCCTTAAATAACT
CATGATTGTTGGAGGTCCGTCTTCCTCTTTTCTGTAAACTTATTTGGGGTCTAGGTTTCAACAA
GGGTATTTGAAATCTTTCTTATAGGAACAGGACTGAGGATGAGGGTTCAGAGACAAGAGTCATG
TGACTAATCTTGGTAAATCAGACTCTGGAGACCAGCATCAGGGTGTAGATCTGGGTTTATTGCC
CAGCACATTAGCTTATAGAGAGTGTTTGAGCAATCCCAAGCCTCTAAATCTTTGGTCAGTCATA
GCTCACCACATCTCAGCTCCAATAAAAGCTGAGATTGAGGAGGTAACTCAGAGAGGGGTTGGGG
AAGCATCATCACCTATTGGGACGTCCGTGAACACTCAGAAACAACCGCACTGTCCTGGCCTTAG
TTCCTTTTTGCTTTCTCACTGGTGTTCTGGAGCCATCTTAGATCTAATGCTATGTACGGTAGAT
GAGGACTCTTCAAGTTGTCACAGGAGCCTGTGGCGCTGTGTGCTCTCCATCCCGCATTTTTTCT
TCACAAGGTTGTCTTCCACATCCCCCACACTCTCATCCTTAAACACCCCAAAGCTGTTCAGACT
GTGGTAAGAGCAAGTTTTTCTTAGTTCACTATATTGATAAATCTTCATTTCTGATGTCACTTCC
TCCCACTTCTCCCCTTTTTTGTTTTCCTTTGTTAACAGAAAAGGGAATCATTTCTGTTCACGAG
GTTCCTTTTTATCCCCATCTACAAACTGCCAACTCCATCAAGTTAATGTTGTCTCATATACCTC
TAGTATAAAAAATGAAATTAACTAAAAAGATTTATTTTTCCTTCCTGTATGAATATATCCTGAA
AACCTGGAATGCTGAAGTCTGGCAGATGCCACTATTTTGCAAAAGTACACAGGCATTTCTAGCT
AAAATGGCAAAAAGTAAGGCAGAGTGAGAGGCCAGCCAGAGCTAAGGAGCAGAACCTAATCACG
GGCTGACATTCCTACGTACTGTCCCATTTCTTTAGCATGTTCATCGATACTGGAGTCGGAATGC
AGTGTTCTCTTTCATCTAGCTTTAGGGTGCTTTGCAACTCAGCAACAAGGAAACACAGGGCTGA
GGAAGCTAAACATGATAAGTAGTTCATTAGCACATATTTTCAAACACTGATTTTTAATTCTTTG
TTAAGGAGGGGAATCAAAAACTGAGAACTTAGGTCCAGCAATACACACTTAAGTTCAGTTTTTT
AGTTAGATAAATAAAA

hide sequence

RefSeq Acc Id:

XM_039081319 ⟹ XP_038937247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,359,117 - 132,393,596 (-)	NCBI
mRatBN7.2	8	123,479,454 - 123,516,168 (-)	NCBI

RefSeq Acc Id:

XM_039081320 ⟹ XP_038937248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,359,117 - 132,361,153 (-)	NCBI
mRatBN7.2	8	123,479,454 - 123,483,723 (-)	NCBI

RefSeq Acc Id:

XM_063265313 ⟹ XP_063121383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,359,117 - 132,393,596 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100341	(Get FASTA)	NCBI Sequence Viewer
	XP_038937247	(Get FASTA)	NCBI Sequence Viewer
	XP_038937248	(Get FASTA)	NCBI Sequence Viewer
	XP_063121383	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76749	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008747
	ENSRNOP00000008747.5
	ENSRNOP00000103086
	ENSRNOP00000103086.1
	ENSRNOP00000103296
	ENSRNOP00000103296.1

RefSeq Acc Id:	NP_001100341 ⟸ NM_001106871
- UniProtKB:	D3ZGG9 (UniProtKB/TrEMBL), A6I4C8 (UniProtKB/TrEMBL), A0A4D6YKT9 (UniProtKB/TrEMBL), A0A4D6YN16 (UniProtKB/TrEMBL), A0A4D6YRC8 (UniProtKB/TrEMBL), A0A4D6YRD9 (UniProtKB/TrEMBL), A0A4D6YTG8 (UniProtKB/TrEMBL), A0A4D6YWI1 (UniProtKB/TrEMBL), A0A4D6YWI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDSDSDALSIPASWVQMESSTVFDYDKSNLLCDNNVIFFSIIFTIVLYSLVFLLSLVGNSLVLW VLVKYENLESLTNVFILNLCLSDLMFSCLLPVLISAQWGWFLGDFFCKFINMIFCISLYSSIFF LTIMTIHRYMSVVSPISSLGIYTLRCRMLVTTSVWAASILFSIPDTVFHKVISLKCDFSERHGL LASVYQHNILFLLSMGIILFCYVQILRTLFRSRSRQRHRTVRLIFTIVVAYFLSWAPYNLVLFL KTEVIQLSCEGRQQLDFAMIICRNLAFSHCCFNPVLYVFVGVKFRRHLKRLLQQVWLCPKTSNP VPFSYSPGTFTYEGPSFY hide sequence

Ensembl Acc Id:

ENSRNOP00000008747 ⟸ ENSRNOT00000008747

RefSeq Acc Id:	XP_038937247 ⟸ XM_039081319
- Peptide Label:	isoform X2
- UniProtKB:	A0A4D6YWI5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038937248 ⟸ XM_039081320
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063121383 ⟸ XM_063265313
- Peptide Label:	isoform X1
- UniProtKB:	A0A4D6YKT9 (UniProtKB/TrEMBL), A0A4D6YN16 (UniProtKB/TrEMBL), A0A4D6YRC8 (UniProtKB/TrEMBL), A0A4D6YRD9 (UniProtKB/TrEMBL), A0A4D6YTG8 (UniProtKB/TrEMBL), A0A4D6YWI1 (UniProtKB/TrEMBL), A0A4D6YWI5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103086 ⟸ ENSRNOT00000122011

Ensembl Acc Id:

ENSRNOP00000103296 ⟸ ENSRNOT00000122533

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZGG9-F1-model_v2	AlphaFold	D3ZGG9	1-338	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696414

Promoter ID:

EPDNEW_R6939

Type:

multiple initiation site

Name:

Xcr1_1

Description:

X-C motif chemokine receptor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	132,919,121 - 132,919,181	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311480	AgrOrtholog
BioCyc Gene	G2FUF-28603	BioCyc
Ensembl Genes	ENSRNOG00000006620	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008747	ENTREZGENE
	ENSRNOT00000008747.8	UniProtKB/TrEMBL
	ENSRNOT00000122011	ENTREZGENE
	ENSRNOT00000122011.1	UniProtKB/TrEMBL
	ENSRNOT00000122533	ENTREZGENE
	ENSRNOT00000122533.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR1	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
	XCR1_lymph_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:301086	UniProtKB/TrEMBL
NCBI Gene	301086	ENTREZGENE
PANTHER	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
	CHEMOKINE XC RECEPTOR 1	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Xcr1	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	LYMPHOTACTNR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006620	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A4D6YKT9	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YKV7_RAT	UniProtKB/TrEMBL
	A0A4D6YMZ8_RAT	UniProtKB/TrEMBL
	A0A4D6YN16	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YNW0_RAT	UniProtKB/TrEMBL
	A0A4D6YNX2_RAT	UniProtKB/TrEMBL
	A0A4D6YRB6_RAT	UniProtKB/TrEMBL
	A0A4D6YRC8	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YRD9	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YTF9_RAT	UniProtKB/TrEMBL
	A0A4D6YTG8	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YVV8_RAT	UniProtKB/TrEMBL
	A0A4D6YVW0_RAT	UniProtKB/TrEMBL
	A0A4D6YVZ1_RAT	UniProtKB/TrEMBL
	A0A4D6YWB6_RAT	UniProtKB/TrEMBL
	A0A4D6YWC4_RAT	UniProtKB/TrEMBL
	A0A4D6YWI1	ENTREZGENE, UniProtKB/TrEMBL
	A0A4D6YWI5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LF54_RAT	UniProtKB/TrEMBL
	A0ABK0LNQ7_RAT	UniProtKB/TrEMBL
	A6I4C8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZGG9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-22	Xcr1	X-C motif chemokine receptor 1	Xcr1	chemokine (C motif) receptor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Xcr1	chemokine (C motif) receptor 1	Xcr1_predicted	chemokine (C motif) receptor 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Xcr1_predicted	chemokine (C motif) receptor 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)