Angptl6 (angiopoietin-like 6) - Rat Genome Database

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Gene: Angptl6 (angiopoietin-like 6) Rattus norvegicus
Analyze
Symbol: Angptl6
Name: angiopoietin-like 6
RGD ID: 1311141
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in blood coagulation. Predicted to be located in secretory granule. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human ANGPTL6 (angiopoietin like 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiopoietin-related protein 6; LOC298698
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,689,804 - 27,696,172 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,689,806 - 27,696,111 (-)EnsemblGRCr8
mRatBN7.2819,413,617 - 19,419,925 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,413,619 - 19,419,925 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,432,985 - 23,439,290 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,730,832 - 21,737,137 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,643,302 - 19,649,607 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,895,523 - 21,902,002 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,895,524 - 21,901,829 (-)Ensemblrn6Rnor6.0
Rnor_5.0821,951,838 - 21,958,144 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,899,121 - 19,905,696 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,808,621 - 20,814,926 (-)NCBICelera
RGSC_v3.1819,899,197 - 19,904,566 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Oike Y, etal., Blood. 2004 May 15;103(10):3760-5. Epub 2004 Feb 5.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.
Additional References at PubMed
PMID:12477932   PMID:12871997   PMID:23533145  


Genomics

Comparative Map Data
Angptl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,689,804 - 27,696,172 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl827,689,806 - 27,696,111 (-)EnsemblGRCr8
mRatBN7.2819,413,617 - 19,419,925 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,413,619 - 19,419,925 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,432,985 - 23,439,290 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,730,832 - 21,737,137 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,643,302 - 19,649,607 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,895,523 - 21,902,002 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,895,524 - 21,901,829 (-)Ensemblrn6Rnor6.0
Rnor_5.0821,951,838 - 21,958,144 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,899,121 - 19,905,696 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,808,621 - 20,814,926 (-)NCBICelera
RGSC_v3.1819,899,197 - 19,904,566 (-)NCBI
Cytogenetic Map8q13NCBI
ANGPTL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,092,338 - 10,106,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,092,337 - 10,106,612 (-)Ensemblhg38GRCh38
GRCh371910,203,014 - 10,216,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,064,013 - 10,074,425 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341910,064,012 - 10,074,425NCBI
Celera1910,098,503 - 10,108,914 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,783,670 - 9,794,081 (-)NCBIHuRef
CHM1_11910,203,288 - 10,213,699 (-)NCBICHM1_1
T2T-CHM13v2.01910,218,556 - 10,232,399 (-)NCBIT2T-CHM13v2.0
Angptl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,785,104 - 20,791,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,785,104 - 20,791,023 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38920,873,808 - 20,879,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,873,808 - 20,879,727 (-)Ensemblmm10GRCm38
MGSCv37920,678,253 - 20,684,154 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,624,211 - 20,630,112 (-)NCBIMGSCv36mm8
Celera918,142,507 - 18,148,408 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Angptl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,437,239 - 1,441,236 (-)Ensembl
ChiLan1.0NW_0049554951,437,024 - 1,446,328 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,007,695 - 15,015,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,007,988 - 14,015,407 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,641,164 - 9,651,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,300,184 - 10,303,937 (-)NCBIPanPan1.1PanPan1.1panPan2
ANGPTL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,953,029 - 50,961,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,953,498 - 50,961,576 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2050,822,536 - 50,831,158 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,474,790 - 51,483,407 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,475,288 - 51,483,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,682,677 - 50,691,304 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,109,694 - 51,118,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,350,586 - 51,359,216 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Angptl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,854,975 - 209,863,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659487,983 - 499,448 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659491,330 - 499,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,947,071 - 68,958,766 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1268,947,067 - 68,958,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,275,242 - 69,286,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPTL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,162,219 - 9,175,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,894,920 - 10,899,106 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,290,511 - 2,296,341 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,291,682 - 2,301,165 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Angptl6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,141,956 - 17,147,953 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Angptl6
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000027963
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH130656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,413,815 - 19,414,003 (+)MAPPERmRatBN7.2
Rnor_6.0821,895,721 - 21,895,908NCBIRnor6.0
Rnor_5.0821,952,036 - 21,952,223UniSTSRnor5.0
RGSC_v3.4819,899,318 - 19,899,505UniSTSRGSC3.4
Celera820,808,818 - 20,809,005UniSTS
RH 3.4 Map8179.6UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 47 157 91 90 59 82 59 6 312 160 9 137 70 86 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027963   ⟹   ENSRNOP00000027963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl827,689,806 - 27,696,111 (-)Ensembl
mRatBN7.2 Ensembl819,413,619 - 19,419,925 (-)Ensembl
Rnor_6.0 Ensembl821,895,524 - 21,901,829 (-)Ensembl
RefSeq Acc Id: NM_001106702   ⟹   NP_001100172
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,689,806 - 27,696,111 (-)NCBI
mRatBN7.2819,413,619 - 19,419,925 (-)NCBI
Rnor_6.0821,895,524 - 21,901,829 (-)NCBI
Rnor_5.0821,951,838 - 21,958,144 (-)NCBI
RGSC_v3.4819,899,121 - 19,905,696 (-)RGD
Celera820,808,621 - 20,814,926 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080978   ⟹   XP_038936906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,689,804 - 27,694,455 (-)NCBI
mRatBN7.2819,413,617 - 19,418,246 (-)NCBI
RefSeq Acc Id: XM_063265038   ⟹   XP_063121108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,689,804 - 27,696,172 (-)NCBI
RefSeq Acc Id: XM_063265039   ⟹   XP_063121109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,689,804 - 27,692,243 (-)NCBI
RefSeq Acc Id: NP_001100172   ⟸   NM_001106702
- Peptide Label: precursor
- UniProtKB: A6JNL9 (UniProtKB/TrEMBL),   B2RYM1 (UniProtKB/TrEMBL),   F1LME9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027963   ⟸   ENSRNOT00000027963
RefSeq Acc Id: XP_038936906   ⟸   XM_039080978
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121108   ⟸   XM_063265038
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121109   ⟸   XM_063265039
- Peptide Label: isoform X3
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYM1-F1-model_v2 AlphaFold B2RYM1 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695765
Promoter ID:EPDNEW_R6290
Type:single initiation site
Name:Angptl6_1
Description:angiopoietin-like 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0821,901,845 - 21,901,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311141 AgrOrtholog
BioCyc Gene G2FUF-31456 BioCyc
Ensembl Genes ENSRNOG00000020603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027963 ENTREZGENE
  ENSRNOT00000027963.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8373153 IMAGE-MGC_LOAD
InterPro FIB_ANG-like UniProtKB/TrEMBL
  Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/TrEMBL
KEGG Report rno:298698 UniProtKB/TrEMBL
MGC_CLONE MGC:188711 IMAGE-MGC_LOAD
NCBI Gene 298698 ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/TrEMBL
  FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PhenoGen Angptl6 PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020603 RatGTEx
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/TrEMBL
UniProt A6JNL9 ENTREZGENE, UniProtKB/TrEMBL
  B2RYM1 ENTREZGENE, UniProtKB/TrEMBL
  F1LME9 ENTREZGENE
UniProt Secondary F1LME9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Angptl6  angiopoietin-like 6   Angptl6_predicted  angiopoietin-like 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Angptl6_predicted  angiopoietin-like 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED