ANGPTL6 (angiopoietin like 6) - Rat Genome Database

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Gene: ANGPTL6 (angiopoietin like 6) Canis lupus familiaris
Analyze
Symbol: ANGPTL6
Name: angiopoietin like 6
RGD ID: 12347688
Description: ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); gestational diabetes (ortholog); FOUND IN secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiopoietin-related protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,953,029 - 50,961,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,953,498 - 50,961,576 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,822,536 - 50,831,158 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,474,790 - 51,483,407 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,475,288 - 51,483,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,682,677 - 50,691,304 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,109,694 - 51,118,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,350,586 - 51,359,216 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ANGPTL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,953,029 - 50,961,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,953,498 - 50,961,576 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,822,536 - 50,831,158 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,474,790 - 51,483,407 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,475,288 - 51,483,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,682,677 - 50,691,304 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,109,694 - 51,118,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,350,586 - 51,359,216 (+)NCBIUU_Cfam_GSD_1.0
ANGPTL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,092,338 - 10,106,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,092,338 - 10,102,678 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,203,014 - 10,216,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,064,013 - 10,074,425 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,064,012 - 10,074,425NCBI
Celera1910,098,503 - 10,108,914 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,783,670 - 9,794,081 (-)NCBIHuRef
CHM1_11910,203,288 - 10,213,699 (-)NCBICHM1_1
T2T-CHM13v2.01910,218,556 - 10,232,399 (-)NCBIT2T-CHM13v2.0
Angptl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,785,104 - 20,791,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,785,104 - 20,791,023 (-)EnsemblGRCm39 Ensembl
GRCm38920,873,808 - 20,879,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,873,808 - 20,879,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,678,253 - 20,684,154 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,624,211 - 20,630,112 (-)NCBIMGSCv36mm8
Celera918,142,507 - 18,148,408 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Angptl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,689,804 - 27,696,172 (-)NCBIGRCr8
mRatBN7.2819,413,617 - 19,419,925 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,413,619 - 19,419,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,432,985 - 23,439,290 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,730,832 - 21,737,137 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,643,302 - 19,649,607 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,895,523 - 21,902,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,895,524 - 21,901,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,951,838 - 21,958,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,899,121 - 19,905,696 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,899,197 - 19,904,566 (-)NCBI
Celera820,808,621 - 20,814,926 (-)NCBICelera
Cytogenetic Map8q13NCBI
Angptl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,437,239 - 1,441,236 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,437,024 - 1,446,328 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,007,695 - 15,015,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,007,988 - 14,015,407 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,641,164 - 9,651,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,300,184 - 10,303,937 (-)NCBIpanpan1.1PanPan1.1panPan2
Angptl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,854,975 - 209,863,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659487,983 - 499,448 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659491,330 - 499,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,947,071 - 68,958,766 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,947,067 - 68,958,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,275,242 - 69,286,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPTL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,162,219 - 9,175,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,894,920 - 10,899,106 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,290,511 - 2,296,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,291,682 - 2,301,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANGPTL6
91 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 13 6 2 6 12 7 2
Low 5 5 9 4 6 6 1 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028437   ⟹   ENSCAFP00000026447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2050,953,498 - 50,961,576 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033265   ⟹   ENSCAFP00845026043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2051,475,288 - 51,483,383 (+)Ensembl
RefSeq Acc Id: XM_022407069   ⟹   XP_022262777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12050,953,029 - 50,961,598 (+)NCBI
Dog10K_Boxer_Tasha2050,822,536 - 50,831,158 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038428676   ⟹   XP_038284604
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02051,474,790 - 51,483,407 (+)NCBI
RefSeq Acc Id: XM_038428677   ⟹   XP_038284605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02051,474,790 - 51,483,407 (+)NCBI
RefSeq Acc Id: XM_038504320   ⟹   XP_038360248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12050,682,677 - 50,691,304 (+)NCBI
RefSeq Acc Id: XM_038504321   ⟹   XP_038360249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12050,682,677 - 50,691,304 (+)NCBI
RefSeq Acc Id: XM_038567352   ⟹   XP_038423280
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02051,350,586 - 51,359,216 (+)NCBI
RefSeq Acc Id: XM_038567353   ⟹   XP_038423281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02051,350,586 - 51,359,216 (+)NCBI
RefSeq Acc Id: XM_038631500   ⟹   XP_038487428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02051,109,694 - 51,118,314 (+)NCBI
RefSeq Acc Id: XM_038631501   ⟹   XP_038487429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02051,109,694 - 51,118,314 (+)NCBI
RefSeq Acc Id: XM_848939   ⟹   XP_854032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12050,953,029 - 50,961,598 (+)NCBI
Dog10K_Boxer_Tasha2050,822,536 - 50,831,158 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_854032   ⟸   XM_848939
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022262777   ⟸   XM_022407069
- Peptide Label: isoform X2
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026447   ⟸   ENSCAFT00000028437
RefSeq Acc Id: XP_038360248   ⟸   XM_038504320
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038360249   ⟸   XM_038504321
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038487428   ⟸   XM_038631500
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038487429   ⟸   XM_038631501
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038284604   ⟸   XM_038428676
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038284605   ⟸   XM_038428677
- Peptide Label: isoform X2
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423280   ⟸   XM_038567352
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423281   ⟸   XM_038567353
- Peptide Label: isoform X2
- UniProtKB: A0A8P0NIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026043   ⟸   ENSCAFT00845033265
Protein Domains
Fibrinogen C-terminal

Promoters
RGD ID:13687045
Promoter ID:EPDNEW_C5115
Type:single initiation site
Name:ANGPTL6_1
Description:angiopoietin like 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12050,953,585 - 50,953,645EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017920 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845018834 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028437.6 UniProtKB/TrEMBL
  ENSCAFT00845033265.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/TrEMBL
NCBI Gene ANGPTL6 ENTREZGENE
PANTHER ANGIOPOIETIN-RELATED PROTEIN 6 UniProtKB/TrEMBL
  FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_1 UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/TrEMBL
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/TrEMBL
UniProt A0A8I3S3N3_CANLF UniProtKB/TrEMBL
  A0A8P0NIZ7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37862 ENTREZGENE