Pds5b (PDS5 cohesin associated factor B) - Rat Genome Database

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Gene: Pds5b (PDS5 cohesin associated factor B) Rattus norvegicus
Analyze
Symbol: Pds5b
Name: PDS5 cohesin associated factor B
RGD ID: 1310838
Description: Predicted to enable DNA binding activity and cohesin unloader activity. Involved in negative regulation of cell population proliferation. Located in nucleus. Orthologous to human PDS5B (PDS5 cohesin associated factor B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aconitine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: androgen-induced proliferation inhibitor; androgen-induced prostate proliferative shutoff associated protein; androgen-induced prostate proliferative shutoff-associated protein AS3; androgen-induced shutoff 3; Aprin; AS3; CG008; FLJ23236; KIAA0979; LOC304218; PDS5, regulator of cohesion maintenance, homolog B; PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); sister chromatid cohesion protein PDS5 homolog B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8125,038,114 - 5,181,208 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl125,038,160 - 5,181,208 (+)EnsemblGRCr8
mRatBN7.212202,481 - 345,596 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12255,313 - 345,596 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx12821,620 - 911,824 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,343,867 - 1,434,071 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012243,664 - 333,913 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd125,722,167 - 5,812,304 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive126,181,401 - 6,271,509 (+)NCBILyon_Normotensive
Lyon_Hypertensive128,421,154 - 8,511,290 (-)NCBILyon_Hypertensive
F344_StmMcwi1215,596,988 - 15,687,128 (+)NCBIF344_StmMcwi
Rnor_6.012659,995 - 794,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12660,011 - 794,042 (+)Ensemblrn6Rnor6.0
Rnor_5.012644,249 - 777,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4124,038,430 - 4,128,352 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,961,611 - 2,051,657 (+)NCBICelera
RGSC_v3.1124,038,429 - 4,128,343 (-)NCBI
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate. Maffini MV, etal., Endocrinology. 2002 Jul;143(7):2708-14.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10963680   PMID:15855230   PMID:16682347   PMID:19412548  


Genomics

Comparative Map Data
Pds5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8125,038,114 - 5,181,208 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl125,038,160 - 5,181,208 (+)EnsemblGRCr8
mRatBN7.212202,481 - 345,596 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12255,313 - 345,596 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx12821,620 - 911,824 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,343,867 - 1,434,071 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012243,664 - 333,913 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd125,722,167 - 5,812,304 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive126,181,401 - 6,271,509 (+)NCBILyon_Normotensive
Lyon_Hypertensive128,421,154 - 8,511,290 (-)NCBILyon_Hypertensive
F344_StmMcwi1215,596,988 - 15,687,128 (+)NCBIF344_StmMcwi
Rnor_6.012659,995 - 794,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12660,011 - 794,042 (+)Ensemblrn6Rnor6.0
Rnor_5.012644,249 - 777,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4124,038,430 - 4,128,352 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,961,611 - 2,051,657 (+)NCBICelera
RGSC_v3.1124,038,429 - 4,128,343 (-)NCBI
Cytogenetic Map12p12NCBI
PDS5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381332,586,452 - 32,778,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1332,586,315 - 32,778,022 (+)Ensemblhg38GRCh38
GRCh371333,160,589 - 33,352,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,058,624 - 32,250,157 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1314,227,385 - 14,418,972 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1313,971,711 - 14,163,184 (+)NCBIHuRef
CHM1_11333,128,125 - 33,319,684 (+)NCBICHM1_1
T2T-CHM13v2.01331,803,785 - 31,995,311 (+)NCBIT2T-CHM13v2.0
Pds5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,597,178 - 150,734,174 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,597,204 - 150,734,155 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385150,673,713 - 150,810,669 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,673,739 - 150,810,690 (+)Ensemblmm10GRCm38
MGSCv375151,476,402 - 151,613,244 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365150,984,792 - 151,077,265 (+)NCBIMGSCv36mm8
Celera5148,678,294 - 148,814,947 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.61NCBI
Pds5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543113,078,726 - 13,197,482 (-)Ensembl
ChiLan1.0NW_00495543113,083,229 - 13,268,680 (-)NCBIChiLan1.0ChiLan1.0
PDS5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21432,150,787 - 32,340,037 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11323,257,110 - 23,446,338 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01313,843,910 - 14,033,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,337,765 - 32,462,333 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,337,765 - 32,462,333 (+)EnsemblpanPan2panpan1.1
PDS5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,407,533 - 7,587,177 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,410,481 - 7,586,563 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha257,437,222 - 7,617,068 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0257,503,195 - 7,683,352 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,505,704 - 7,683,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,402,088 - 7,583,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,401,438 - 7,581,519 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,458,932 - 7,638,962 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pds5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945168,574,878 - 168,766,999 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647227,258,090 - 27,378,084 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647227,258,084 - 27,377,278 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDS5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,014,755 - 9,223,031 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1119,014,694 - 9,223,035 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,020,332 - 9,044,202 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDS5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,330,817 - 11,511,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,389,199 - 11,508,441 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605732,839,271 - 33,022,073 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pds5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247765,013,796 - 5,244,957 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247765,013,796 - 5,225,743 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pds5b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v116230,314 - 361,958 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pds5b
1363 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3028
Count of miRNA genes:317
Interacting mature miRNAs:410
Transcripts:ENSRNOT00000001464, ENSRNOT00000040830, ENSRNOT00000050733, ENSRNOT00000064951, ENSRNOT00000074682
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat

Markers in Region
RH131564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212345,190 - 345,400 (+)MAPPERmRatBN7.2
Rnor_6.012793,637 - 793,846NCBIRnor6.0
Rnor_5.012777,396 - 777,605UniSTSRnor5.0
RGSC_v3.4124,038,626 - 4,038,835UniSTSRGSC3.4
Celera122,051,252 - 2,051,461UniSTS
Cytogenetic Map12p12UniSTS
RH140226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212343,139 - 343,333 (+)MAPPERmRatBN7.2
Rnor_6.012791,586 - 791,779NCBIRnor6.0
Rnor_5.012775,345 - 775,538UniSTSRnor5.0
RGSC_v3.4124,040,693 - 4,040,886UniSTSRGSC3.4
Celera122,049,201 - 2,049,394UniSTS
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001101805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001102383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY388627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY820183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY831451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY831452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY836673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001464   ⟹   ENSRNOP00000001464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,090,942 - 5,181,208 (+)Ensembl
mRatBN7.2 Ensembl12255,323 - 345,596 (+)Ensembl
Rnor_6.0 Ensembl12703,281 - 794,042 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000040830   ⟹   ENSRNOP00000041874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,045,272 - 5,179,212 (+)Ensembl
mRatBN7.2 Ensembl12255,313 - 334,077 (+)Ensembl
Rnor_6.0 Ensembl12660,011 - 783,122 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050733   ⟹   ENSRNOP00000040297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,038,160 - 5,178,477 (+)Ensembl
mRatBN7.2 Ensembl12255,323 - 345,596 (+)Ensembl
Rnor_6.0 Ensembl12703,290 - 791,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064951   ⟹   ENSRNOP00000063199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,038,160 - 5,177,096 (+)Ensembl
mRatBN7.2 Ensembl12255,313 - 341,484 (+)Ensembl
Rnor_6.0 Ensembl12703,290 - 791,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107387   ⟹   ENSRNOP00000083511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl12255,323 - 345,596 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112327   ⟹   ENSRNOP00000092974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,045,213 - 5,181,205 (+)Ensembl
mRatBN7.2 Ensembl12255,323 - 345,596 (+)Ensembl
RefSeq Acc Id: NM_001101805   ⟹   NP_001095275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,942 - 5,181,208 (+)NCBI
mRatBN7.212255,323 - 345,596 (+)NCBI
Dahl_SR_JrHsd125,722,167 - 5,812,304 (+)NCBI
Lyon_Normotensive126,181,401 - 6,271,509 (+)NCBI
Lyon_Hypertensive128,421,154 - 8,511,290 (-)NCBI
F344_StmMcwi1215,596,988 - 15,687,128 (+)NCBI
Rnor_6.012703,281 - 794,042 (+)NCBI
Rnor_5.012644,249 - 777,801 (+)NCBI
RGSC_v3.4124,038,430 - 4,128,352 (-)RGD
Celera121,961,611 - 2,051,657 (+)RGD
Sequence:
RefSeq Acc Id: NM_001102383   ⟹   NP_001095853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,942 - 5,181,208 (+)NCBI
mRatBN7.212255,323 - 345,596 (+)NCBI
Dahl_SR_JrHsd125,722,167 - 5,812,304 (+)NCBI
Lyon_Normotensive126,181,401 - 6,271,509 (+)NCBI
Lyon_Hypertensive128,421,154 - 8,511,290 (-)NCBI
F344_StmMcwi1215,596,988 - 15,687,128 (+)NCBI
Rnor_6.012703,281 - 794,042 (+)NCBI
Rnor_5.012644,249 - 777,801 (+)NCBI
RGSC_v3.4124,038,430 - 4,128,352 (-)RGD
Celera121,961,611 - 2,051,657 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089319   ⟹   XP_038945247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,181,173 (+)NCBI
mRatBN7.212255,313 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089320   ⟹   XP_038945248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,181,173 (+)NCBI
mRatBN7.212255,313 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089321   ⟹   XP_038945249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,181,173 (+)NCBI
mRatBN7.212255,313 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089322   ⟹   XP_038945250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,045,225 - 5,181,173 (+)NCBI
mRatBN7.212209,608 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089323   ⟹   XP_038945251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,038,114 - 5,181,173 (+)NCBI
mRatBN7.212202,481 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089324   ⟹   XP_038945252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,038,121 - 5,181,173 (+)NCBI
mRatBN7.212202,502 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089325   ⟹   XP_038945253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,181,173 (+)NCBI
mRatBN7.212255,313 - 345,561 (+)NCBI
RefSeq Acc Id: XM_039089328   ⟹   XP_038945256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,181,173 (+)NCBI
mRatBN7.212255,313 - 345,561 (+)NCBI
RefSeq Acc Id: XM_063271248   ⟹   XP_063127318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,038,230 - 5,181,173 (+)NCBI
RefSeq Acc Id: XR_010056381
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,090,932 - 5,167,058 (+)NCBI
RefSeq Acc Id: NP_001095275   ⟸   NM_001101805
- Peptide Label: isoform 2
- UniProtKB: D3ZU56 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001095853   ⟸   NM_001102383
- Peptide Label: isoform 1
- UniProtKB: D3ZXE2 (UniProtKB/TrEMBL),   F1M797 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001464   ⟸   ENSRNOT00000001464
Ensembl Acc Id: ENSRNOP00000041874   ⟸   ENSRNOT00000040830
Ensembl Acc Id: ENSRNOP00000063199   ⟸   ENSRNOT00000064951
Ensembl Acc Id: ENSRNOP00000040297   ⟸   ENSRNOT00000050733
RefSeq Acc Id: XP_038945251   ⟸   XM_039089323
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GK18 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945252   ⟸   XM_039089324
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GK18 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945250   ⟸   XM_039089322
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GK18 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945247   ⟸   XM_039089319
- Peptide Label: isoform X1
- UniProtKB: Q6TRW4 (UniProtKB/Swiss-Prot),   Q5PY35 (UniProtKB/Swiss-Prot),   Q5G6V8 (UniProtKB/Swiss-Prot),   Q5G6V7 (UniProtKB/Swiss-Prot),   Q5G5U1 (UniProtKB/Swiss-Prot),   Q5PY36 (UniProtKB/Swiss-Prot),   D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945253   ⟸   XM_039089325
- Peptide Label: isoform X5
- UniProtKB: D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945248   ⟸   XM_039089320
- Peptide Label: isoform X2
- UniProtKB: D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945249   ⟸   XM_039089321
- Peptide Label: isoform X3
- UniProtKB: D3ZXE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945256   ⟸   XM_039089328
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GAU9 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083511   ⟸   ENSRNOT00000107387
Ensembl Acc Id: ENSRNOP00000092974   ⟸   ENSRNOT00000112327
RefSeq Acc Id: XP_063127318   ⟸   XM_063271248
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GK18 (UniProtKB/TrEMBL),   D3ZXE2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TRW4-F1-model_v2 AlphaFold Q6TRW4 1-1447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698385
Promoter ID:EPDNEW_R8884
Type:initiation region
Name:Pds5b_1
Description:PDS5 cohesin associated factor B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.012659,993 - 660,053EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310838 AgrOrtholog
BioCyc Gene G2FUF-20522 BioCyc
Ensembl Genes ENSRNOG00000001098 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001464 ENTREZGENE
  ENSRNOT00000040830 ENTREZGENE
  ENSRNOT00000050733 ENTREZGENE
  ENSRNOT00000112327 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Pds5 UniProtKB/Swiss-Prot
NCBI Gene 304218 ENTREZGENE
PANTHER PTHR12663 UniProtKB/Swiss-Prot
  SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B UniProtKB/Swiss-Prot
Pfam PDS5 UniProtKB/Swiss-Prot
PhenoGen Pds5b PhenoGen
RatGTEx ENSRNOG00000001098 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I6GAU9 ENTREZGENE
  A0A8I6GK18 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMU3_RAT UniProtKB/TrEMBL
  D3ZU56 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXE2 ENTREZGENE, UniProtKB/TrEMBL
  F1M797 ENTREZGENE, UniProtKB/TrEMBL
  PDS5B_RAT UniProtKB/Swiss-Prot
  Q5G5U1 ENTREZGENE
  Q5G6V7 ENTREZGENE
  Q5G6V8 ENTREZGENE
  Q5PY35 ENTREZGENE
  Q5PY36 ENTREZGENE
  Q6TRW4 ENTREZGENE
UniProt Secondary Q5G5U1 UniProtKB/Swiss-Prot
  Q5G6V7 UniProtKB/Swiss-Prot
  Q5G6V8 UniProtKB/Swiss-Prot
  Q5PY35 UniProtKB/Swiss-Prot
  Q5PY36 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-01 Pds5b  PDS5 cohesin associated factor B  Pds5b  PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Pds5b  PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)  RGD1624199  androgen-induced proliferation inhibitor  Data merged from RGD:1624199 1643240 APPROVED
2008-01-30 Pds5b  PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)  Aprin_predicted  androgen-induced proliferation inhibitor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 Aprin_predicted  androgen-induced proliferation inhibitor (predicted)  Aprin  androgen-induced proliferation inhibitor  Symbol and Name status set to approved 1299863 APPROVED
2005-12-06 Aprin  androgen-induced proliferation inhibitor  Aprin_predicted  androgen-induced proliferation inhibitor (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Aprin_predicted  androgen-induced proliferation inhibitor (predicted)      Symbol and Name status set to approved 70820 APPROVED