Parp4 (poly (ADP-ribose) polymerase family, member 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Parp4 (poly (ADP-ribose) polymerase family, member 4) Rattus norvegicus
Analyze
Symbol: Parp4 (Ensembl: Mphosph8)
Name: poly (ADP-ribose) polymerase family, member 4 (Ensembl:M-phase phosphoprotein 8)
RGD ID: 1310524
Description: Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+); ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase)-like 1; Adprtl1; LOC361046; poly (ADP-ribose) polymerase)-like 1; poly [ADP-ribose] polymerase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,806,203 - 34,908,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,816,701 - 34,944,433 (+)EnsemblGRCr8
mRatBN7.21530,690,503 - 30,792,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,686,613 - 30,828,810 (+)EnsemblmRatBN7.2
Rnor_6.01536,809,362 - 36,911,167 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01540,662,704 - 40,763,497 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41535,564,314 - 35,659,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1530,402,728 - 30,506,603 (+)NCBICelera
RGSC_v3.11535,562,158 - 35,675,067 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Raval-Fernandes S, etal., Cancer Res. 2005 Oct 1;65(19):8846-52. doi: 10.1158/0008-5472.CAN-05-0770.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10477748   PMID:12123754   PMID:12140175   PMID:12477932   PMID:15169895   PMID:19056867   PMID:19946888   PMID:25043379  


Genomics

Comparative Map Data
Parp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,806,203 - 34,908,492 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,816,701 - 34,944,433 (+)EnsemblGRCr8
mRatBN7.21530,690,503 - 30,792,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,686,613 - 30,828,810 (+)EnsemblmRatBN7.2
Rnor_6.01536,809,362 - 36,911,167 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01540,662,704 - 40,763,497 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41535,564,314 - 35,659,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1530,402,728 - 30,506,603 (+)NCBICelera
RGSC_v3.11535,562,158 - 35,675,067 (+)NCBI
Cytogenetic Map15p12NCBI
PARP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381324,420,931 - 24,512,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1324,420,931 - 24,512,925 (-)Ensemblhg38GRCh38
GRCh371324,995,069 - 25,086,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361323,893,069 - 23,984,948 (-)NCBIBuild 36Build 36hg18NCBI36
Celera136,058,392 - 6,150,239 (-)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef135,807,328 - 5,899,247 (-)NCBIHuRef
CHM1_11324,963,059 - 25,055,268 (-)NCBICHM1_1
T2T-CHM13v2.01323,628,369 - 23,720,247 (-)NCBIT2T-CHM13v2.0
Parp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,812,982 - 56,897,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,813,076 - 56,897,251 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381456,575,619 - 56,659,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,575,619 - 56,659,794 (+)Ensemblmm10GRCm38
MGSCv371457,194,456 - 57,278,635 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361455,526,056 - 55,613,904 (+)NCBIMGSCv36mm8
Celera1454,373,436 - 54,457,522 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.31NCBI
Parp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542520,957,032 - 21,047,971 (+)NCBIChiLan1.0ChiLan1.0
PARP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21424,038,802 - 24,133,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11315,147,700 - 15,242,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,734,322 - 5,827,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11324,029,216 - 24,121,668 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1324,029,405 - 24,113,075 (-)EnsemblpanPan2panpan1.1
PARP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12518,447,413 - 18,544,990 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2518,447,413 - 18,544,777 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2518,476,239 - 18,566,533 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02518,584,762 - 18,682,254 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,585,841 - 18,682,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12518,450,479 - 18,540,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02518,462,666 - 18,552,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02518,519,499 - 18,609,531 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Parp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945120,501,413 - 120,590,813 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367202,048,455 - 2,119,662 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367202,049,045 - 2,138,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11359,476 - 442,436 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.111359,503 - 432,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21187,072,353 - 87,132,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.134,374,610 - 4,468,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl34,374,824 - 4,468,505 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605739,976,661 - 40,073,664 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477618,048,642 - 18,159,198 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477618,049,512 - 18,159,149 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Parp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11268,188,401 - 68,264,162 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Parp4
488 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
AU048445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21530,721,996 - 30,722,195 (+)MAPPERmRatBN7.2
Rnor_6.01536,840,055 - 36,840,259NCBIRnor6.0
Rnor_5.01540,693,430 - 40,693,634UniSTSRnor5.0
RGSC_v3.41535,586,482 - 35,586,680UniSTSRGSC3.4
Celera1530,434,401 - 30,434,599UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 50 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028145   ⟹   ENSRNOP00000028145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,800,531 - 30,828,375 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076030   ⟹   ENSRNOP00000068433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,701,067 - 30,792,865 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076667   ⟹   ENSRNOP00000068234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,704,519 - 30,752,886 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078051   ⟹   ENSRNOP00000075447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,686,613 - 30,828,810 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090573   ⟹   ENSRNOP00000073383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,686,613 - 30,828,810 (+)Ensembl
RefSeq Acc Id: NM_001427093   ⟹   NP_001414022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,806,203 - 34,908,492 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414022 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86332 (Get FASTA)   NCBI Sequence Viewer  
  EDM14329 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068433
  ENSRNOP00000068433.2
  ENSRNOP00000073383.2
  ENSRNOP00000075447.3
Ensembl Acc Id: ENSRNOP00000028145   ⟸   ENSRNOT00000028145
Ensembl Acc Id: ENSRNOP00000068234   ⟸   ENSRNOT00000076667
Ensembl Acc Id: ENSRNOP00000068433   ⟸   ENSRNOT00000076030
Ensembl Acc Id: ENSRNOP00000073383   ⟸   ENSRNOT00000090573
Ensembl Acc Id: ENSRNOP00000075447   ⟸   ENSRNOT00000078051
RefSeq Acc Id: NP_001414022   ⟸   NM_001427093
- UniProtKB: A0A096MK99 (UniProtKB/TrEMBL)
Protein Domains
BRCT   Chromo   PARP alpha-helical   PARP catalytic   VIT   VWFA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310524 AgrOrtholog
BioCyc Gene G2FUF-13628 BioCyc
Ensembl Genes ENSRNOG00000061152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076030 ENTREZGENE
  ENSRNOT00000076030.4 UniProtKB/TrEMBL
  ENSRNOT00000078051.3 UniProtKB/TrEMBL
  ENSRNOT00000090573.3 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  2.40.50.40 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/TrEMBL
  Chromo_domain UniProtKB/TrEMBL
  Chromodomain_CS UniProtKB/TrEMBL
  PARP4 UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom_sf UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene 361046 ENTREZGENE
PANTHER PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4 UniProtKB/TrEMBL
  PTHR46530 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  BRCT UniProtKB/TrEMBL
  Chromo UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA_3 UniProtKB/TrEMBL
PhenoGen Parp4 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  BRCT UniProtKB/TrEMBL
  CHROMO_1 UniProtKB/TrEMBL
  CHROMO_2 UniProtKB/TrEMBL
  PARP_ALPHA_HD UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061152 RatGTEx
SMART ANK UniProtKB/TrEMBL
  BRCT UniProtKB/TrEMBL
  CHROMO UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  SSF47587 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF54160 UniProtKB/TrEMBL
UniProt A0A096MK99 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAM1_RAT UniProtKB/TrEMBL
  Q5U213_RAT UniProtKB/TrEMBL
  Q7TP67_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2K5D3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Parp4  poly (ADP-ribose) polymerase family, member 4  Adprtl1  ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Adprtl1  ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1  Adprtl1_predicted  ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Adprtl1_predicted  ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED