PARP4 (poly(ADP-ribose) polymerase family member 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PARP4 (poly(ADP-ribose) polymerase family member 4) Canis lupus familiaris
Analyze
Symbol: PARP4
Name: poly(ADP-ribose) polymerase family member 4
RGD ID: 12070064
Description: ENCODES a protein that exhibits enzyme binding (ortholog); NAD+-protein ADP-ribosyltransferase activity (ortholog); INVOLVED IN inflammatory response (ortholog); protein modification process (ortholog); telomere maintenance via telomerase (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Colonic Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); spindle microtubule (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: poly [ADP-ribose] polymerase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12518,447,413 - 18,544,990 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2518,447,413 - 18,544,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2518,476,239 - 18,566,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02518,584,762 - 18,682,254 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,585,841 - 18,682,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12518,450,479 - 18,540,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02518,462,666 - 18,552,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02518,519,499 - 18,609,531 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PARP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12518,447,413 - 18,544,990 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2518,447,413 - 18,544,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2518,476,239 - 18,566,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02518,584,762 - 18,682,254 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,585,841 - 18,682,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12518,450,479 - 18,540,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02518,462,666 - 18,552,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02518,519,499 - 18,609,531 (-)NCBIUU_Cfam_GSD_1.0
PARP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381324,420,931 - 24,512,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1324,420,931 - 24,512,778 (-)EnsemblGRCh38hg38GRCh38
GRCh371324,995,069 - 25,086,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361323,893,069 - 23,984,948 (-)NCBINCBI36Build 36hg18NCBI36
Celera136,058,392 - 6,150,239 (-)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef135,807,328 - 5,899,247 (-)NCBIHuRef
CHM1_11324,963,059 - 25,055,268 (-)NCBICHM1_1
T2T-CHM13v2.01323,628,369 - 23,720,247 (-)NCBIT2T-CHM13v2.0
Parp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,812,982 - 56,897,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,813,076 - 56,897,251 (+)EnsemblGRCm39 Ensembl
GRCm381456,575,619 - 56,659,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,575,619 - 56,659,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv371457,194,456 - 57,278,635 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361455,526,056 - 55,613,904 (+)NCBIMGSCv36mm8
Celera1454,373,436 - 54,457,522 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.31NCBI
Parp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,806,203 - 34,908,492 (+)NCBIGRCr8
mRatBN7.21530,690,503 - 30,792,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,686,613 - 30,828,810 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01536,809,362 - 36,911,167 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01540,662,704 - 40,763,497 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41535,564,314 - 35,659,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11535,562,158 - 35,675,067 (+)NCBI
Celera1530,402,728 - 30,506,603 (+)NCBICelera
Cytogenetic Map15p12NCBI
Parp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542520,957,032 - 21,047,971 (+)NCBIChiLan1.0ChiLan1.0
PARP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21424,038,802 - 24,133,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11315,147,700 - 15,242,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,734,322 - 5,827,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11324,029,216 - 24,121,668 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1324,029,405 - 24,113,075 (-)Ensemblpanpan1.1panPan2
Parp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945120,501,413 - 120,590,813 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367202,048,455 - 2,119,662 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367202,049,045 - 2,138,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11359,476 - 442,436 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111359,503 - 432,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21187,072,353 - 87,132,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.134,374,610 - 4,468,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl34,374,824 - 4,468,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605739,976,661 - 40,073,664 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477618,048,642 - 18,159,198 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477618,049,512 - 18,159,149 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PARP4
836 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 6 12 8 10 6
Low 5 6 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011825   ⟹   ENSCAFP00000010963
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2518,447,413 - 18,544,777 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042594   ⟹   ENSCAFP00845033394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2518,585,841 - 18,682,365 (-)Ensembl
RefSeq Acc Id: NM_001145980   ⟹   NP_001139452
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12518,447,413 - 18,538,508 (-)NCBI
Dog10K_Boxer_Tasha2518,476,239 - 18,566,533 (-)NCBI
ROS_Cfam_1.02518,584,762 - 18,675,867 (-)NCBI
UMICH_Zoey_3.12518,450,479 - 18,540,786 (-)NCBI
UNSW_CanFamBas_1.02518,462,666 - 18,552,839 (-)NCBI
UU_Cfam_GSD_1.02518,519,499 - 18,609,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038434543   ⟹   XP_038290471
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02518,584,762 - 18,682,254 (-)NCBI
RefSeq Acc Id: XM_038434544   ⟹   XP_038290472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02518,586,056 - 18,682,230 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001139452   ⟸   NM_001145980
- UniProtKB: A0A8I3PH61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010963   ⟸   ENSCAFT00000011825
RefSeq Acc Id: XP_038290471   ⟸   XM_038434543
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P5J2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038290472   ⟸   XM_038434544
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P5J2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033394   ⟸   ENSCAFT00845042594
Protein Domains
BRCT   PARP alpha-helical   PARP catalytic   VIT   VWFA

Promoters
RGD ID:13687745
Promoter ID:EPDNEW_C5813
Type:initiation region
Name:PARP4_2
Description:poly(ADP-ribose) polymerase family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C5812  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12518,544,975 - 18,545,035EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007375 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022657 UniProtKB/TrEMBL
  ENSCAFG00845024103 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011825.7 UniProtKB/TrEMBL
  ENSCAFT00000099405.1 UniProtKB/TrEMBL
  ENSCAFT00030041660.1 UniProtKB/TrEMBL
  ENSCAFT00845042594 ENTREZGENE
  ENSCAFT00845042594.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.142.10 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  PARP4 UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom_sf UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene PARP4 ENTREZGENE
PANTHER PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4 UniProtKB/TrEMBL
  PTHR46530 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA_3 UniProtKB/TrEMBL
PROSITE BRCT UniProtKB/TrEMBL
  PARP_ALPHA_HD UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART BRCT UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  SSF47587 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt A0A8C0P5J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PH61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLJ0_CANLF UniProtKB/TrEMBL
  A0A8P0SCN0_CANLF UniProtKB/TrEMBL