Symbol:
Usp49
Name:
ubiquitin specific peptidase 49
RGD ID:
1310513
Description:
Predicted to enable histone binding activity and peptidase activity. Predicted to be involved in mRNA splicing, via spliceosome; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein deubiquitination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC316211; RGD1310513; similar to hypothetical protein MGC20741; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin thioesterase 49
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 9 20,803,177 - 20,867,681 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 9 20,804,921 - 20,863,667 (-) Ensembl GRCr8 mRatBN7.2 9 13,305,640 - 13,366,132 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 9 13,308,178 - 13,366,132 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 9 21,888,201 - 21,945,900 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 9 26,952,281 - 27,010,031 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 9 25,251,607 - 25,309,304 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Dahl_SR_JrHsd 9 24,653,749 - 24,711,497 (-) NCBI Dahl_SR_JrHsd Lyon_Normotensive 9 20,431,716 - 20,489,462 (-) NCBI Lyon_Normotensive Lyon_Hypertensive 9 20,521,453 - 20,579,198 (-) NCBI Lyon_Hypertensive F344_StmMcwi 9 22,473,392 - 22,531,089 (-) NCBI F344_StmMcwi Rnor_6.0 9 15,314,875 - 15,375,365 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 15,317,413 - 15,375,365 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 9 14,239,085 - 14,299,667 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 9 8,774,333 - 8,832,285 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 9 11,060,638 - 11,117,551 (-) NCBI Celera RGSC_v3.1 9 8,778,351 - 8,786,793 (-) NCBI Cytogenetic Map 9 q12 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Usp49 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP49 mRNA] CTD PMID:31150632 Usp49 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 1,2-dimethylhydrazine decreases expression ISO Usp49 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of USP49 mRNA CTD PMID:22206623 Usp49 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2-hydroxypropanoic acid increases expression ISO USP49 (Homo sapiens) 6480464 Lactic Acid results in increased expression of USP49 mRNA CTD PMID:30851411 Usp49 Rat 4,4'-sulfonyldiphenol decreases expression ISO Usp49 (Mus musculus) 6480464 bisphenol S results in decreased expression of USP49 mRNA CTD PMID:39298647 Usp49 Rat 4,4'-sulfonyldiphenol affects methylation ISO Usp49 (Mus musculus) 6480464 bisphenol S affects the methylation of USP49 gene CTD PMID:31683443 Usp49 Rat 4,4'-sulfonyldiphenol decreases methylation ISO Usp49 (Mus musculus) 6480464 bisphenol S results in decreased methylation of USP49 exon CTD PMID:33297965 Usp49 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of USP49 mRNA CTD PMID:24780913|PMID:25825206 Usp49 Rat all-trans-retinoic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Tretinoin results in decreased expression of USP49 mRNA CTD PMID:21934132 Usp49 Rat aristolochic acid A increases expression ISO USP49 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of USP49 mRNA CTD PMID:33212167 Usp49 Rat beta-lapachone decreases expression ISO USP49 (Homo sapiens) 6480464 beta-lapachone results in decreased expression of USP49 mRNA CTD PMID:38218311 Usp49 Rat bis(2-ethylhexyl) phthalate increases expression ISO USP49 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of USP49 mRNA; Diethylhexyl Phthalate results in increased expression more ... CTD PMID:32143396 Usp49 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of USP49 mRNA CTD PMID:25181051 Usp49 Rat bisphenol A decreases expression ISO Usp49 (Mus musculus) 6480464 bisphenol A results in decreased expression of USP49 mRNA CTD PMID:33221593 Usp49 Rat bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of USP49 mRNA CTD PMID:32479839 Usp49 Rat cadmium atom multiple interactions ISO USP49 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:35301059 Usp49 Rat cadmium atom multiple interactions ISO Usp49 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:37236586 Usp49 Rat cadmium dichloride increases expression ISO USP49 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of USP49 mRNA CTD PMID:38568856 Usp49 Rat cadmium dichloride multiple interactions ISO Usp49 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:37236586 Usp49 Rat cadmium dichloride multiple interactions ISO USP49 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:35301059 Usp49 Rat chlorpyrifos decreases expression ISO Usp49 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of USP49 mRNA CTD PMID:37019170 Usp49 Rat copper atom multiple interactions ISO USP49 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of USP49 mRNA CTD PMID:20971185 Usp49 Rat copper(0) multiple interactions ISO USP49 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of USP49 mRNA CTD PMID:20971185 Usp49 Rat Dibutyl phosphate affects expression ISO USP49 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of USP49 mRNA CTD PMID:37042841 Usp49 Rat dorsomorphin multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of USP49 mRNA CTD PMID:29391264 Usp49 Rat entinostat decreases expression ISO USP49 (Homo sapiens) 6480464 entinostat results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat ethyl methanesulfonate increases expression ISO USP49 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of USP49 mRNA CTD PMID:30307764 Usp49 Rat formaldehyde increases expression ISO USP49 (Homo sapiens) 6480464 Formaldehyde results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat hydralazine multiple interactions ISO USP49 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of USP49 mRNA CTD PMID:17183730 Usp49 Rat hydrogen peroxide affects expression ISO USP49 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of USP49 mRNA CTD PMID:21179406 Usp49 Rat methyl methanesulfonate increases expression ISO USP49 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat methylmercury chloride decreases expression ISO USP49 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of USP49 mRNA CTD PMID:28001369 Usp49 Rat N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of USP49 mRNA CTD PMID:28801915 Usp49 Rat okadaic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of USP49 mRNA CTD PMID:38832940 Usp49 Rat ozone multiple interactions ISO Usp49 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... CTD PMID:34911549 Usp49 Rat panobinostat multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat panobinostat decreases expression ISO USP49 (Homo sapiens) 6480464 panobinostat results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat paracetamol affects expression ISO Usp49 (Mus musculus) 6480464 Acetaminophen affects the expression of USP49 mRNA CTD PMID:17562736 Usp49 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat PCB138 multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat pentanal decreases expression ISO USP49 (Homo sapiens) 6480464 pentanal results in decreased expression of USP49 mRNA CTD PMID:26079696 Usp49 Rat phenylmercury acetate decreases expression ISO USP49 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat phenylmercury acetate multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Usp49 Rat pirinixic acid multiple interactions ISO USP49 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Usp49 Rat rac-lactic acid increases expression ISO USP49 (Homo sapiens) 6480464 Lactic Acid results in increased expression of USP49 mRNA CTD PMID:30851411 Usp49 Rat SB 431542 multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat silicon dioxide increases expression ISO USP49 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of USP49 mRNA CTD PMID:23806026 Usp49 Rat Soman increases expression EXP 6480464 Soman results in increased expression of USP49 mRNA CTD PMID:19281266 Usp49 Rat sunitinib decreases expression ISO USP49 (Homo sapiens) 6480464 Sunitinib results in decreased expression of USP49 mRNA CTD PMID:31533062 Usp49 Rat temozolomide decreases expression ISO USP49 (Homo sapiens) 6480464 Temozolomide results in decreased expression of USP49 mRNA CTD PMID:31758290 Usp49 Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of USP49 mRNA CTD PMID:31150632 Usp49 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP49 mRNA] CTD PMID:31150632 Usp49 Rat thimerosal decreases expression ISO USP49 (Homo sapiens) 6480464 Thimerosal results in decreased expression of USP49 mRNA CTD PMID:27188386 Usp49 Rat thiram increases expression ISO USP49 (Homo sapiens) 6480464 Thiram results in increased expression of USP49 mRNA CTD PMID:38568856 Usp49 Rat titanium dioxide increases methylation ISO Usp49 (Mus musculus) 6480464 titanium dioxide results in increased methylation of USP49 gene CTD PMID:35295148 Usp49 Rat titanium dioxide decreases methylation ISO Usp49 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of USP49 promoter CTD PMID:35295148 Usp49 Rat torcetrapib increases expression ISO USP49 (Homo sapiens) 6480464 torcetrapib results in increased expression of USP49 mRNA CTD PMID:23228038 Usp49 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat trichostatin A decreases expression ISO USP49 (Homo sapiens) 6480464 trichostatin A results in decreased expression of USP49 mRNA CTD PMID:24935251|PMID:26272509 Usp49 Rat trichostatin A affects expression ISO USP49 (Homo sapiens) 6480464 trichostatin A affects the expression of USP49 mRNA CTD PMID:28542535 Usp49 Rat trichostatin A multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Usp49 Rat triptonide increases expression ISO Usp49 (Mus musculus) 6480464 triptonide results in increased expression of USP49 mRNA CTD PMID:33045310 Usp49 Rat valproic acid multiple interactions ISO USP49 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of USP49 mRNA; [NOG protein co-treated more ... CTD PMID:17183730|PMID:27188386 Usp49 Rat valproic acid affects expression ISO Usp49 (Mus musculus) 6480464 Valproic Acid affects the expression of USP49 mRNA CTD PMID:17292431 Usp49 Rat valproic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of USP49 mRNA CTD PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:28001369 Usp49 Rat vorinostat decreases expression ISO USP49 (Homo sapiens) 6480464 vorinostat results in decreased expression of USP49 mRNA CTD PMID:26272509|PMID:27188386