USP49 (ubiquitin specific peptidase 49) - Rat Genome Database

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Gene: USP49 (ubiquitin specific peptidase 49) Pan paniscus
Analyze
Symbol: USP49
Name: ubiquitin specific peptidase 49
RGD ID: 11730469
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); infantile Refsum disease (ortholog); Zellweger syndrome (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase 49
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,282,907 - 56,389,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,678,680 - 42,781,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
USP49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,282,907 - 56,389,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,678,680 - 42,781,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)Ensemblpanpan1.1panPan2
USP49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,789,896 - 41,895,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,789,896 - 41,895,375 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,757,634 - 41,863,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,873,361 - 41,971,077 (-)NCBINCBI36Build 36hg18NCBI36
Celera643,318,714 - 43,416,439 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,484,106 - 41,581,878 (-)NCBIHuRef
CHM1_1641,768,743 - 41,866,405 (-)NCBICHM1_1
T2T-CHM13v2.0641,618,461 - 41,723,935 (-)NCBIT2T-CHM13v2.0
Usp49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,941,615 - 47,997,664 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,941,615 - 47,997,663 (+)EnsemblGRCm39 Ensembl
GRCm381747,630,690 - 47,686,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,767,639 - 47,821,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,093,881 - 47,147,258 (+)NCBIMGSCv36mm8
Celera1751,067,647 - 51,120,972 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.72NCBI
Usp49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,803,177 - 20,867,681 (-)NCBIGRCr8
mRatBN7.2913,305,640 - 13,366,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,308,178 - 13,366,132 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,888,201 - 21,945,900 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,952,281 - 27,010,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,251,607 - 25,309,304 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,314,875 - 15,375,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,239,085 - 14,299,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,774,333 - 8,832,285 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,778,351 - 8,786,793 (-)NCBI
Celera911,060,638 - 11,117,551 (-)NCBICelera
Cytogenetic Map9q12NCBI
Usp49
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,191,236 - 8,198,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,187,118 - 8,237,910 (-)NCBIChiLan1.0ChiLan1.0
USP49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,474,873 - 10,556,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,479,733 - 10,577,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,504,358 - 10,589,769 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,955,129 - 11,041,174 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,955,164 - 11,051,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,485,701 - 10,567,699 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,569,381 - 10,654,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,663,097 - 10,748,867 (-)NCBIUU_Cfam_GSD_1.0
Usp49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,957,669 - 46,049,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,991,688 - 18,000,794 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,946,875 - 18,002,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,981,383 - 37,052,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,978,291 - 37,054,027 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,393,547 - 42,458,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP49
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,265,322 - 30,373,547 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,356,698 - 30,366,940 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,783,918 - 41,895,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp49
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,266,561 - 17,274,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,226,723 - 17,281,206 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008958800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008958801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008958803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008958804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008958805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014345361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034962080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055113595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063604889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000020071   ⟹   ENSPPAP00000004348
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000020075   ⟹   ENSPPAP00000004350
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl642,685,376 - 42,695,707 (-)Ensembl
RefSeq Acc Id: XM_008958800   ⟹   XP_008957048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,386,540 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,256,177 (-)NCBI
Mhudiblu_PPA_v0641,375,083 - 41,478,710 (-)NCBI
PanPan1.1642,678,680 - 42,781,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008958805   ⟹   XP_008957053
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,386,540 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,256,177 (-)NCBI
Mhudiblu_PPA_v0641,381,735 - 41,478,710 (-)NCBI
PanPan1.1642,685,376 - 42,781,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014345361   ⟹   XP_014200847
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,386,977 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBI
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBI
PanPan1.1642,678,680 - 42,781,748 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055113592   ⟹   XP_054969567
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,323,035 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,182,363 (-)NCBI
RefSeq Acc Id: XM_055113593   ⟹   XP_054969568
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,334,474 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,204,429 (-)NCBI
RefSeq Acc Id: XM_055113594   ⟹   XP_054969569
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,389,693 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBI
RefSeq Acc Id: XM_055113595   ⟹   XP_054969570
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,323,035 (-)NCBI
NHGRI_mPanPan1652,152,885 - 52,182,363 (-)NCBI
RefSeq Acc Id: XM_063604889   ⟹   XP_063460959
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2556,282,907 - 56,334,474 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_014200847   ⟸   XM_014345361
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZNI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008957048   ⟸   XM_008958800
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZNI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008957053   ⟸   XM_008958805
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000004348   ⟸   ENSPPAT00000020071
RefSeq Acc Id: ENSPPAP00000004350   ⟸   ENSPPAT00000020075
RefSeq Acc Id: XP_054969569   ⟸   XM_055113594
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054969568   ⟸   XM_055113593
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZNI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969570   ⟸   XM_055113595
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054969567   ⟸   XM_055113592
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZNI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063460959   ⟸   XM_063604889
- Peptide Label: isoform X2
Protein Domains
UBP-type   USP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000018338 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000020071.1 UniProtKB/TrEMBL
  ENSPPAT00000020075.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_UBP UniProtKB/TrEMBL
KEGG Report pps:100971570 UniProtKB/TrEMBL
NCBI Gene USP49 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 49 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  zf-UBP UniProtKB/TrEMBL
PROSITE USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
  ZF_UBP UniProtKB/TrEMBL
SMART ZnF_UBP UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A2R8ZH96_PANPA UniProtKB/TrEMBL
  A0A2R8ZNI6 ENTREZGENE, UniProtKB/TrEMBL