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Gene: Afg2a (AAA ATPase AFG2A) Rattus norvegicus

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Symbol:

Afg2a

Name:

AAA ATPase AFG2A (Ensembl:AFG2 AAA ATPase homolog A)

RGD ID:

1310478

Description:

Predicted to enable ATP hydrolysis activity and preribosome binding activity. Predicted to be involved in brain development and ribosomal large subunit biogenesis. Predicted to be located in cytosol and spindle. Predicted to be active in cytoplasm. Orthologous to human AFG2A (AFG2 AAA ATPase homolog A); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AFG2 AAA ATPase homolog A; ATPase family gene 2 protein homolog A; ATPase family protein 2 homolog; LOC361935; ribosome biogenesis protein SPATA5; Spata5; spermatogenesis associated 5; spermatogenesis-associated protein 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AFG2A (AAA ATPase AFG2A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Afg2a (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Afg2a (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AFG2A (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Afg2a (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AFG2A (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Afg2a (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Afg2a (AAA ATPase AFG2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AFG2A (AAA ATPase AFG2A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Afg2a (AFG2 AAA ATPase homolog A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	spata5 (spermatogenesis associated 5)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AFG2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5776	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG5776	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cdc-48.3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cdc-48.3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	spata5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	122,234,738 - 122,425,808 (+)	Ensembl				GRCr8
mRatBN7.2	2	120,306,417 - 120,497,707 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	126,869,277 - 127,060,635 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,981,783 - 125,173,154 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	119,610,740 - 119,802,117 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	124,149,872 - 124,341,138 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,131 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	143,758,068 - 143,950,578 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	123,962,875 - 124,154,127 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	115,253,057 - 115,441,808 (+)	NCBI		Celera
RGSC_v3.1	2	123,913,002 - 124,104,391 (+)	NCBI
Cytogenetic Map	2	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities (ISO)

Neurodevelopmental Disorders (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bortezomib (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

dioxygen (ISO)

enzyme inhibitor (ISO)

fipronil (EXP)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidyl methacrylate (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

leflunomide (ISO)

methotrexate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

propiconazole (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

T-2 toxin (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP,ISO)

Triptolide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (IEA,ISO)

DNA replication (IEA,ISO)

regulation of ribosome biogenesis (IEA,ISO)

ribosomal large subunit biogenesis (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA,ISO)

mitochondrion (ISO)

nucleus (IEA,ISO)

spindle (IEA,ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA,IEA)

nucleotide binding (IEA)

preribosome binding (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:26299366	PMID:29343804

Genomics

Comparative Map Data

Afg2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	122,234,738 - 122,425,808 (+)	Ensembl				GRCr8
mRatBN7.2	2	120,306,417 - 120,497,707 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	126,869,277 - 127,060,635 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,981,783 - 125,173,154 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	119,610,740 - 119,802,117 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	124,149,872 - 124,341,138 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,131 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	143,758,068 - 143,950,578 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	123,962,875 - 124,154,127 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	115,253,057 - 115,441,808 (+)	NCBI		Celera
RGSC_v3.1	2	123,913,002 - 124,104,391 (+)	NCBI
Cytogenetic Map	2	q25	NCBI

AFG2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	122,923,078 - 123,319,433 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	122,923,070 - 123,319,433 (+)	Ensembl			hg38	GRCh38
GRCh37	4	123,844,233 - 124,240,588 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	124,063,675 - 124,460,055 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	124,201,833 - 124,593,407	NCBI
Celera	4	121,227,068 - 121,623,149 (+)	NCBI		Celera
Cytogenetic Map	4	q28.1	NCBI
HuRef	4	119,570,673 - 119,967,245 (+)	NCBI		HuRef
CHM1_1	4	123,820,765 - 124,217,279 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	126,227,197 - 126,623,517 (+)	NCBI		T2T-CHM13v2.0

Afg2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	37,474,052 - 37,633,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	37,474,045 - 37,633,245 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	37,419,903 - 37,579,096 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	37,419,896 - 37,579,096 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	37,319,202 - 37,478,017 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	37,611,847 - 37,770,640 (+)	NCBI		MGSCv36	mm8
Celera	3	37,295,123 - 37,453,242 (+)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	18.46	NCBI

Afg2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	17,524,583 - 17,823,108 (-)	Ensembl
ChiLan1.0	NW_004955428	17,525,388 - 17,823,478 (-)	NCBI	ChiLan1.0	ChiLan1.0

AFG2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	120,699,939 - 121,092,742 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	120,965,751 - 121,358,911 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	115,101,064 - 115,489,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	126,245,508 - 126,632,165 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	126,256,152 - 126,631,500 (+)	Ensembl			panPan2	panpan1.1

AFG2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	17,020,337 - 17,371,396 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	16,994,661 - 17,463,151 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	17,233,899 - 17,584,562 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	17,132,668 - 17,484,528 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	17,164,097 - 17,578,900 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	17,090,290 - 17,440,587 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	17,368,198 - 17,719,114 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	17,839,642 - 18,190,985 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Afg2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	64,912,369 - 65,214,617 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936662	1,958,268 - 2,208,207 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936662	1,886,176 - 1,929,097 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936662	1,957,364 - 2,207,410 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AFG2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	100,917,319 - 101,241,099 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	100,918,331 - 101,241,099 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	108,342,977 - 108,446,111 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AFG2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	70,188,246 - 70,585,022 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	49,158,187 - 49,516,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Afg2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624777	3,342,271 - 3,639,118 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624777	3,342,437 - 3,710,544 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Afg2a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	116,408,920 - 116,613,198 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Afg2a
940 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	19
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000023584
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	105628029	150628029	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	82947902	127947902	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	84056790	132859658	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
2317886	Alcrsp23	Alcohol response QTL 23	2.4	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	95142371	140142371	Rat
2317058	Aia13	Adjuvant induced arthritis QTL 13	2.9		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	78269809	123269809	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	120039407	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	100807373	145807373	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	106869825	151869825	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	120039407	151869825	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	93602631	145807373	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	82214549	127214549	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
7488933	Bp368	Blood pressure QTL 368		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	104957381	149957381	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	120339555	165339555	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	114032149	150226270	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	114440891	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	116804572	161804572	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat

Markers in Region

D2Rat218

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	122,274,224 - 122,274,338 (+)	Marker Load Pipeline
mRatBN7.2	2	120,346,103 - 120,346,217 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,189,562 - 124,189,675	NCBI	Rnor6.0
Rnor_5.0	2	143,797,758 - 143,797,871	UniSTS	Rnor5.0
RGSC_v3.4	2	124,002,565 - 124,002,678	UniSTS	RGSC3.4
RGSC_v3.4	2	124,002,564 - 124,002,678	RGD	RGSC3.4
Celera	2	115,292,631 - 115,292,744	UniSTS
RGSC_v3.1	2	123,952,334 - 123,952,447	RGD
RH 3.4 Map	2	673.2	UniSTS
RH 3.4 Map	2	673.2	RGD
SHRSP x BN Map	2	44.6298	RGD
SHRSP x BN Map	2	44.6298	UniSTS
Cytogenetic Map	2	q25	UniSTS

D3Got115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,490,082 - 120,490,284 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,333,512 - 124,333,713	NCBI	Rnor6.0
Rnor_5.0	2	143,942,966 - 143,943,167	UniSTS	Rnor5.0
RGSC_v3.4	2	124,146,514 - 124,146,716	RGD	RGSC3.4
RGSC_v3.4	2	124,146,515 - 124,146,716	UniSTS	RGSC3.4
Celera	2	115,434,266 - 115,434,467	UniSTS
RGSC_v3.1	2	124,096,779 - 124,096,980	RGD
RH 3.4 Map	2	676.7	UniSTS
RH 3.4 Map	2	676.7	RGD
RH 2.0 Map	2	593.2	RGD
Cytogenetic Map	2	q25	UniSTS

BF404163

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,391,886 - 120,391,985 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,235,343 - 124,235,441	NCBI	Rnor6.0
Rnor_5.0	2	143,844,225 - 143,844,323	UniSTS	Rnor5.0
RGSC_v3.4	2	124,048,346 - 124,048,444	UniSTS	RGSC3.4
Celera	2	115,337,372 - 115,337,470	UniSTS
RH 3.4 Map	2	674.2	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH136733

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	122,350,335 - 122,350,454 (+)	Marker Load Pipeline
mRatBN7.2	2	120,422,221 - 120,422,340 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,265,670 - 124,265,788	NCBI	Rnor6.0
Rnor_5.0	2	143,874,760 - 143,874,878	UniSTS	Rnor5.0
RGSC_v3.4	2	124,078,673 - 124,078,791	UniSTS	RGSC3.4
Celera	2	115,368,070 - 115,368,188	UniSTS
RH 3.4 Map	2	675.2	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH126301

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,310,928 - 120,311,132 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,154,389 - 124,154,592	NCBI	Rnor6.0
Rnor_5.0	2	143,762,585 - 143,762,788	UniSTS	Rnor5.0
RGSC_v3.4	2	123,967,392 - 123,967,595	UniSTS	RGSC3.4
Celera	2	115,257,578 - 115,257,781	UniSTS
Cytogenetic Map	2	q25	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023584 ⟹ ENSRNOP00000023584

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	122,234,877 - 122,425,805 (+)	Ensembl
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,697 (+)	Ensembl
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,124 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078650 ⟹ ENSRNOP00000071455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	122,238,372 - 122,425,808 (+)	Ensembl
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl
Rnor_6.0 Ensembl	2	124,150,224 - 124,341,131 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119204 ⟹ ENSRNOP00000086493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	122,234,738 - 122,425,808 (+)	Ensembl
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,702 (+)	Ensembl

RefSeq Acc Id:

NM_001415082 ⟹ NP_001402011

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,883 - 122,425,808 (+)	NCBI
mRatBN7.2	2	120,306,760 - 120,497,707 (+)	NCBI

RefSeq Acc Id:

XM_008760933 ⟹ XP_008759155

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI
mRatBN7.2	2	120,306,437 - 120,497,707 (+)	NCBI
Rnor_6.0	2	124,150,209 - 124,341,137 (+)	NCBI

Sequence:

show sequence

GTTTTATCCCCGTGCCGCGCACGTTGAGCCGGCTTTGGGCTGCTTTTCTCCGACAGCCTGCGGT
CATGTCTTCCAAGAAGAACAGAAAGCGACAGAAAGAGGGCGCGGAGGGGACCTCGCCCTCGCTC
TCTGCGGCTTCGTCTCGCTCGGGGACCTCGACTCCTCTCGCTCAGCCGAACGTGGCGGCGCCGG
GGATGTTGGTGGTGACCAACTTTCTTGAGAAAGATGGCAAAGTTCCTAAGACATTCCAGAATTC
CCTAGTTCATCTTGGACTTAACACTATGAAGTCTGCAAACATATGTATAGGTCGACCAGTGCTC
CTTACCAGTTTGGATGGAAAGCAGGAGGTTTATACAGCCTGGCCAGTTGCAGGATTTCCTGGAG
GCAAGGTTGGTCTAAGTGAAATGGCACAGAAGAATGTGGGTGTGAAAGCTGGTGAGACCATCCG
GGTCCAACCTCTTTTGGGTGCTGTACTTCAGGCCCAGGAAATGGACTTGGCACTGAGTGACAAA
GATAAGGAAATTAATGAAGAAGAACTGACTGGTTGTATTCTGAGAAAACTAGATGGCAAGATTG
TTTTACCAGGCAACTTTCTGTACTGTACATTCTATGGACGACTCTGCAAGTTACAAGTGTTGCA
AGTAAAAGGGACAGATGGCACAACATTGGGAAAGCCTCAGAGCTCCTCTGGCACTGATGTCCAT
GGAATGGCCTCTGAGCAGTCTAGCATGGAAAGCAGTGATGTGGATATTTCATTCCAGCTAAGCC
AGTTAGATCTGAAAGAACCTCAGAGCCCAGCATCACAGAGTACTCCCTGTAAACCCATCAATGA
CAGAACTATGAATAAAGCTGGTGAAGTTTTGTTGGATGTTACACAGAGCCCTAGGGATGGAAGT
GGACTTGGACTAGAGGAAATCACAGGGCTTAAGTGTAGTTTTGATTCATCCAAAGAAGGAAATA
CACAACCTATCAGTGAAGAGAAACTACTAAAATCTACTAGTGCAGGTGCAAAGAACAATACTGA
TACTTTTTATTTTATTTCTTCAACAACAAGAATCAATCTTCGAAAAATTTGTACAAATTCAAAA
GAACAAGACAGTCAGTTCAAAGTAACTTATGACATGATTGGAGGCTTAAACAGTCAGCTGAAAG
CAATAAGAGAAATAATTGAACTGCCTCTCAAGCAGCCTGAACTTTTCAAGAGTTACGGAATTCC
AGCACCTAGAGGGTTATTACTCTATGGTCCTCCAGGTACCGGAAAGACAATGATTGCTAGGGCT
GTTGCTAATGAAGTTGGAGCTTATGTTTCTGTAATTAATGGTCCTGAAATTATAAGCAAATTCT
ATGGTGAGACTGAAGCAAGGTTACGCCAGATATTTGCTGAAGCCACTCTACGGCATCCATCGAT
TATTTTTATTGATGAGCTGGATGCACTTTGCCCTAAAAGAGAAGGAGCTCAAAGTGAAGTGGAA
AAGAGAGTTGTAGCTTCGCTCTTAACATTGATGGATGGCATTGGCTCAGAAGGAAGTGAAGGAC
GGGTATTAGTCCTTGGGGCCACAAATCGCCCTCAAGCGCTAGATGCTGCACTCAGAAGACCTGG
GCGATTTGATAAAGAGATTGAGATTGGCATTCCTAATGCCCAAGACCGGCTTGATATTCTCCAG
AAACTACTCCGAAGGGTGCCACACTTACTCACCAAAGCTGAGCTTCTGAGATTGGCAAATAATG
CCCATGGTTATGTTGGCGCAGACTTGAAAGCCTTGTGTAATGAAGCAGGTCTGTATGCCTTGCG
AAGAGTCCTGAGGAAACAGCCTAATCTCCCTGATAGCAAGGTGGCTGGCATGGTGAAGATTACC
CTAAATGATTTCTTACAGGGGATGAATGATATCAGGCCTAGTGCTATGAGAGAGGTAGCAATTG
ATGTCCCAAATGTATCCTGGTCAGATATTGGAGGACTGGAAAATATCAAACTGAAATTGAAACA
GGCTGTGGAATGGCCCTTGAAACATCCTAAGTCTTTCAGCAGAATGGGTATTCAGCCACCTAAA
GGAGTTCTCTTGTATGGGCCTCCTGGATGCTCAAAAACAATGATAGCAAAGGCTTTGGCCAATG
AAAGTGGGTTGAACTTTCTAGCTATAAAGGGGCCTGAATTAATGAATAAGTATGTTGGTGAATC
TGAAAGAGCAGTTAGAGAGGTATTCCGTAAAGCAAGAGCAGTGGCACCTTCCATTATCTTTTTT
GATGAACTTGATGCCTTGGCTGTTGAAAGGGGCAGTTCTTCAGGTGCCGGGAATGTTGCAGATC
GTGTTTTGGCTCAGCTGTTAACGGAAATGGATGGAATTGAACAGCTAAAAAATGTGACAGTTTT
GGCAGCTACTAATCGCCCAGATAGAATAGACAAGGCTCTGATGAGGCCTGGAAGAATTGACAGG
ATCATTTATGTGCCCTTACCGGATGCAGCAACAAGAAGGGAAATACTGAACTTGCAGTTCCACT
CAATGCCAATCAGTAACGAGGTTGACCTGGATGAACTGGTCCTCCAAACTGACACCTACTCAGG
AGCAGAGATCATAGCAGTCTGCAAGGAGGCCGCTCTCCTAGCTCTGGAAGAAAACATTAAAGCT
GACTGCATTATGAAGAGGCATTTCACTCAAGCCTTGAGCATTGTGACACCCAGAATCCCGGAGT
CACTGAGGCGCTTTTATGAAGATTACCAAGAGAAGAGTGGGTTACACATGGTCTAAGAAATACC
TATGTGCATATATTTTCTAGAAAAAAGTTTGTATTCAAATTTTGTCTTGAGAGTGTTTACGGTT
TCTTAATAGGTAAATGTTTGAAATCCTCACTGGAGTTGAAGAGCCAAATGTTTTGAGTCATTCT
AGTACAATAAACATTTCTCCGGGCATGTGTTCAAACCA

hide sequence

RefSeq Acc Id:

XM_008760934 ⟹ XP_008759156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,619 - 122,425,687 (+)	NCBI
mRatBN7.2	2	120,306,417 - 120,497,488 (+)	NCBI
Rnor_6.0	2	124,149,877 - 124,340,866 (+)	NCBI

Sequence:

show sequence

TTGAGCTGGAATTTCCATTTGACAGTTTAGTGGAGCTGACTGACCTCCACGGGTCTGGGACAGA
GAGGAGAAACTTTTCGACTTTTTTTTTTTTTTGTTGCTGTTGTTACTTTAATCCGACCCATATT
TGCTTCGAGAGTAGGCAAAGCAGCGGAACAGCCGAAGTTCACTTTCCAAGGGCTCATAACGTAA
ACGGCGGTTCCTATGCCTAGGCGGTCTTTCTTTACGCAACGGTGTTTTGCGAGACCCTCGCTAA
TCACCTCAGCCTCGCCGGCTGCGCTGTACGTGGGGCATTACGGCGGTGCGCCGAGCCGCTGACC
TCTGACCCGGAAGTTTTATCCCCGTGCCGCGCACGTTGAGCCGGCTTTGGGCTGCTTTTCTCCG
ACAGCCTGCGGTCATGTCTTCCAAGAAGAACAGAAAGCGACAGAAAGAGGGCGCGGAGGGGACC
TCGCCCTCGCTCTCTGCGGCTTCGTCTCGCTCGGGGACCTCGACTCCTCTCGCTCAGCCGAACG
TGGCGGCGCCGGGGATGTTGGTGGTGACCAACTTTCTTGAGAAAGTAGATGGCAAAGTTCCTAA
GACATTCCAGAATTCCCTAGTTCATCTTGGACTTAACACTATGAAGTCTGCAAACATATGTATA
GGTCGACCAGTGCTCCTTACCAGTTTGGATGGAAAGCAGGAGGTTTATACAGCCTGGCCAGTTG
CAGGATTTCCTGGAGGCAAGGTTGGTCTAAGTGAAATGGCACAGAAGAATGTGGGTGTGAAAGC
TGGTGAGACCATCCGGGTCCAACCTCTTTTGGGTGCTGTACTTCAGGCCCAGGAAATGGACTTG
GCACTGAGTGACAAAGATAAGGAAATTAATGAAGAAGAACTGACTGGTTGTATTCTGAGAAAAC
TAGATGGCAAGATTGTTTTACCAGGCAACTTTCTGTACTGTACATTCTATGGACGACTCTGCAA
GTTACAAGTGTTGCAAGTAAAAGGGACAGATGGCACAACATTGGGAAAGCCTCAGAGCTCCTCT
GGCACTGATGTCCATGGAATGGCCTCTGAGCAGTCTAGCATGGAAAGCAGTGATGTGGATATTT
CATTCCAGCTAAGCCAGTTAGATCTGAAAGAACCTCAGAGCCCAGCATCACAGAGTACTCCCTG
TAAACCCATCAATGACAGAACTATGAATAAAGCTGGTGAAGTTTTGTTGGATGTTACACAGAGC
CCTAGGGATGGAAGTGGACTTGGACTAGAGGAAATCACAGGGCTTAAGTGTAGTTTTGATTCAT
CCAAAGAAGGAAATACACAACCTATCAGTGAAGAGAAACTACTAAAATCTACTAGTGCAGGTGC
AAAGAACAATACTGATACTTTTTATTTTATTTCTTCAACAACAAGAATCAATCTTCGAAAAATT
TGTACAAATTCAAAAGAACAAGACAGTCAGTTCAAAGTAACTTATGACATGATTGGAGGCTTAA
ACAGTCAGCTGAAAGCAATAAGAGAAATAATTGAACTGCCTCTCAAGCAGCCTGAACTTTTCAA
GAGTTACGGAATTCCAGCACCTAGAGGGTTATTACTCTATGGTCCTCCAGGTACCGGAAAGACA
ATGATTGCTAGGGCTGTTGCTAATGAAGTTGGAGCTTATGTTTCTGTAATTAATGGTCCTGAAA
TTATAAGCAAATTCTATGGTGAGACTGAAGCAAGGTTACGCCAGATATTTGCTGAAGCCACTCT
ACGGCATCCATCGATTATTTTTATTGATGAGCTGGATGCACTTTGCCCTAAAAGAGAAGGAGCT
CAAAGTGAAGTGGAAAAGAGAGTTGTAGCTTCGCTCTTAACATTGATGGATGGCATTGGCTCAG
AAGGAAGTGAAGGACGGGTATTAGTCCTTGGGGCCACAAATCGCCCTCAAGCGCTAGATGCTGC
ACTCAGAAGACCTGGGCGATTTGATAAAGAGATTGAGATTGGCATTCCTAATGCCCAAGACCGG
CTTGATATTCTCCAGAAACTACTCCGAAGGGTGCCACACTTACTCACCAAAGCTGAGCTTCTGA
GATTGGCAAATAATGCCCATGGTTATGTTGGCGCAGACTTGAAAGCCTTGTGTAATGAAGCAGG
TCTGTATGCCTTGCGAAGAGTCCTGAGGAAACAGCCTAATCTCCCTGATAGCAAGGTGGCTGGC
ATGGTGAAGATTACCCTAAATGATTTCTTACAGGGGATGAATGATATCAGGCCTAGTGCTATGA
GAGAGGTAGCAATTGATGTCCCAAATGTATCCTGGTCAGATATTGGAGGACTGGAAAATATCAA
ACTGAAATTGAAACAGGCTGTGGAATGGCCCTTGAAACATCCTAAGTCTTTCAGCAGAATGGGT
ATTCAGCCACCTAAAGGAGTTCTCTTGTATGGGCCTCCTGGATGCTCAAAAACAATGATAGCAA
AGGCTTTGGCCAATGAAAGTGGGTTGAACTTTCTAGCTATAAAGGGGCCTGAATTAATGAATAA
GTATGTTGGTGAATCTGAAAGAGCAGTTAGAGAGGTATTCCGTAAAGCAAGAGCAGTGGCACCT
TCCATTATCTTTTTTGATGAACTTGATGCCTTGGCTGTTGAAAGGGGCAGTTCTTCAGGTGCCG
GGAATGTTGCAGATCGTGTTTTGGCTCAGCTGTTAACGGAAATGGATGGAATTGAACAGCTAAA
AAATGTGACAGTTTTGGCAGCTACTAATCGCCCAGATAGAATAGACAAGGCTCTGATGAGGCCT
GGAAGAATTGACAGGATCATTTATGTGCCCTTACCGGATGCAGCAACAAGAAGGGAAATACTGA
ACTTGCAGTTCCACTCAATGCCAATCAGTAACGAGGTTGACCTGGATGAACTGGTCCTCCAAAC
TGACACCTACTCAGGAGCAGAGAGTGACAACAGTGCTACAGTTTGAAGGCCAAAATTAGATCAT
AGCAGTCTGCAAGGAGGCCGCTCTCCTAGCTCTGGAAGAAAACATTAAAGCTGACTGCATTATG
AAGAGGCATTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001402011	(Get FASTA)	NCBI Sequence Viewer
	XP_008759155	(Get FASTA)	NCBI Sequence Viewer
	XP_008759156	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01312	(Get FASTA)	NCBI Sequence Viewer
	EDM01313	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023584
	ENSRNOP00000023584.6
	ENSRNOP00000071455
	ENSRNOP00000071455.2
	ENSRNOP00000086493
	ENSRNOP00000086493.2

RefSeq Acc Id:	XP_008759156 ⟸ XM_008760934
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K0I1 (UniProtKB/TrEMBL), A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKNRKRQKEGAEGTSPSLSAASSRSGTSTPLAQPNVAAPGMLVVTNFLEKVDGKVPKTFQN SLVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVKAGETI RVQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVL QVKGTDGTTLGKPQSSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPIN DRTMNKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKNNT DTFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGI PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPS IIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRP GRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLYAL RRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLK QAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGE SERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTV LAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYS GAESDNSATV hide sequence

RefSeq Acc Id:	XP_008759155 ⟸ XM_008760933
- Peptide Label:	isoform X1
- UniProtKB:	A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKNRKRQKEGAEGTSPSLSAASSRSGTSTPLAQPNVAAPGMLVVTNFLEKDGKVPKTFQNS LVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVKAGETIR VQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQ VKGTDGTTLGKPQSSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPIND RTMNKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKNNTD TFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIP APRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSI IFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPG RFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLYALR RVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQ AVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES ERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVL AATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSG AEIIAVCKEAALLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHMV hide sequence

Ensembl Acc Id:

ENSRNOP00000023584 ⟸ ENSRNOT00000023584

Ensembl Acc Id:

ENSRNOP00000071455 ⟸ ENSRNOT00000078650

Ensembl Acc Id:

ENSRNOP00000086493 ⟸ ENSRNOT00000119204

RefSeq Acc Id:	NP_001402011 ⟸ NM_001415082
- UniProtKB:	A0A8I6A2A6 (UniProtKB/TrEMBL), A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K0I1-F1-model_v2	AlphaFold	A0A0G2K0I1	1-842	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691301

Promoter ID:

EPDNEW_R1823

Type:

initiation region

Name:

Spata5_1

Description:

spermatogenesis associated 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	124,150,250 - 124,150,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310478	AgrOrtholog
BioCyc Gene	G2FUF-53303	BioCyc
Ensembl Genes	ENSRNOG00000017462	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023584	ENTREZGENE
	ENSRNOT00000023584.8	UniProtKB/TrEMBL
	ENSRNOT00000078650	ENTREZGENE
	ENSRNOT00000078650.3	UniProtKB/TrEMBL
	ENSRNOT00000119204	ENTREZGENE
	ENSRNOT00000119204.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	2.40.40.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA_ATPase_domain	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	Asp_de-COase-like_fold	UniProtKB/TrEMBL
	ATPase_AAA+_core	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	361935	ENTREZGENE
PANTHER	AAA-FAMILY ATPASE	UniProtKB/TrEMBL
	ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
PhenoGen	Afg2a	PhenoGen
PROSITE	AAA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017462	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	Asp_decarb_fold	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2K0I1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A2A6	ENTREZGENE, UniProtKB/TrEMBL
	A6II14	ENTREZGENE, UniProtKB/TrEMBL
	D4A6T1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Afg2a	AAA ATPase AFG2A	Afg2a	AFG2 AAA ATPase homolog A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2023-04-17	Afg2a	AFG2 AAA ATPase homolog A	Spata5	spermatogenesis associated 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Spata5	spermatogenesis associated 5	Spata5_predicted	spermatogenesis associated 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Spata5_predicted	spermatogenesis associated 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)