Tlk1 (tousled-like kinase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tlk1 (tousled-like kinase 1) Rattus norvegicus
Analyze
Symbol: Tlk1
Name: tousled-like kinase 1
RGD ID: 1310370
Description: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromosome segregation; intracellular protein transport; and regulation of chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TLK1 (tousled like kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690017; LOC311118; serine/threonine-protein kinase tousled-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8375,928,303 - 76,035,246 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl375,928,303 - 76,035,059 (-)EnsemblGRCr8
mRatBN7.2355,520,559 - 55,627,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl355,503,358 - 55,691,968 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx358,917,777 - 59,024,581 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0367,501,356 - 67,608,146 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,264,020 - 65,370,844 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,012,738 - 57,376,336 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,013,025 - 57,119,001 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl357,318,795 - 57,389,901 (-)Ensemblrn6Rnor6.0
Rnor_5.0363,798,702 - 63,897,975 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4352,941,668 - 53,033,853 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,071,408 - 55,162,356 (-)NCBICelera
RGSC_v3.1352,838,037 - 52,946,531 (-)NCBI
Cytogenetic Map3q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4-Chloro-ortho-phenylenediamine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
monocrotaline  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10523312   PMID:10588641   PMID:12660173  


Genomics

Comparative Map Data
Tlk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8375,928,303 - 76,035,246 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl375,928,303 - 76,035,059 (-)EnsemblGRCr8
mRatBN7.2355,520,559 - 55,627,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl355,503,358 - 55,691,968 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx358,917,777 - 59,024,581 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0367,501,356 - 67,608,146 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,264,020 - 65,370,844 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,012,738 - 57,376,336 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,013,025 - 57,119,001 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl357,318,795 - 57,389,901 (-)Ensemblrn6Rnor6.0
Rnor_5.0363,798,702 - 63,897,975 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4352,941,668 - 53,033,853 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,071,408 - 55,162,356 (-)NCBICelera
RGSC_v3.1352,838,037 - 52,946,531 (-)NCBI
Cytogenetic Map3q22NCBI
TLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382170,990,823 - 171,231,293 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2170,990,823 - 171,231,314 (-)Ensemblhg38GRCh38
GRCh372171,847,333 - 172,087,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362171,556,814 - 171,725,206 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342171,674,076 - 171,842,467NCBI
Celera2165,463,993 - 165,633,992 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2163,735,825 - 163,862,446 (-)NCBIHuRef
CHM1_12171,853,562 - 172,094,367 (-)NCBICHM1_1
T2T-CHM13v2.02171,467,942 - 171,708,444 (-)NCBIT2T-CHM13v2.0
Tlk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39270,542,751 - 70,656,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl270,542,751 - 70,656,072 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38270,712,407 - 70,825,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl270,712,407 - 70,825,728 (-)Ensemblmm10GRCm38
MGSCv37270,550,464 - 70,663,537 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36270,513,246 - 70,626,319 (-)NCBIMGSCv36mm8
Celera272,378,426 - 72,452,886 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map241.9NCBI
Tlk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554493,747,504 - 3,840,468 (+)Ensembl
ChiLan1.0NW_0049554493,694,624 - 3,840,468 (+)NCBIChiLan1.0ChiLan1.0
TLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21373,663,124 - 73,833,947 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B73,678,097 - 73,849,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B58,277,362 - 58,445,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B175,732,125 - 175,903,322 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B175,735,054 - 175,903,322 (-)EnsemblpanPan2panpan1.1
TLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13615,524,350 - 15,675,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3615,526,564 - 15,675,678 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3615,535,299 - 15,686,057 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03615,647,895 - 15,798,892 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3615,648,757 - 15,799,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13615,736,600 - 15,883,859 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03615,724,513 - 15,884,153 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03615,836,292 - 15,986,945 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tlk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303132,762,004 - 132,898,538 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,317,534 - 1,404,705 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365091,315,802 - 1,403,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1577,170,086 - 77,329,402 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11577,169,661 - 77,329,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21586,557,730 - 86,717,578 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11056,521,983 - 56,688,458 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1056,523,879 - 56,592,671 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040142,857,744 - 143,024,242 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247878,489,175 - 8,651,614 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247878,489,175 - 8,651,626 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tlk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1547,992,381 - 48,112,393 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tlk1
958 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:178
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000064203
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH142342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2355,522,063 - 55,522,213 (+)MAPPERmRatBN7.2
Rnor_6.0357,319,625 - 57,319,774NCBIRnor6.0
Rnor_6.0357,013,851 - 57,014,000NCBIRnor6.0
Rnor_5.0363,800,197 - 63,800,346UniSTSRnor5.0
RGSC_v3.4352,942,494 - 52,942,643UniSTSRGSC3.4
Celera355,072,234 - 55,072,383UniSTS
Cytogenetic Map3q21UniSTS
Tlk1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2355,521,412 - 55,522,416 (+)MAPPERmRatBN7.2
Rnor_6.0357,318,974 - 57,319,977NCBIRnor6.0
Rnor_6.0357,013,200 - 57,014,203NCBIRnor6.0
Rnor_5.0363,799,546 - 63,800,549UniSTSRnor5.0
RGSC_v3.4352,941,843 - 52,942,846UniSTSRGSC3.4
Celera355,071,583 - 55,072,586UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 165 91 90 59 92 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064203   ⟹   ENSRNOP00000063398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,936,898 - 76,019,837 (-)Ensembl
mRatBN7.2 Ensembl355,521,238 - 55,612,242 (-)Ensembl
Rnor_6.0 Ensembl357,013,025 - 57,104,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076281   ⟹   ENSRNOP00000068174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,928,303 - 76,035,059 (-)Ensembl
mRatBN7.2 Ensembl355,520,392 - 55,691,968 (-)Ensembl
Rnor_6.0 Ensembl357,318,795 - 57,389,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076554   ⟹   ENSRNOP00000068430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl355,521,238 - 55,592,642 (-)Ensembl
Rnor_6.0 Ensembl357,318,797 - 57,389,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083171   ⟹   ENSRNOP00000074825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl355,520,392 - 55,627,785 (-)Ensembl
Rnor_6.0 Ensembl357,014,054 - 57,119,001 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096336   ⟹   ENSRNOP00000089283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl355,520,392 - 55,593,791 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109940   ⟹   ENSRNOP00000088461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl355,503,358 - 55,627,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110107   ⟹   ENSRNOP00000096029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl375,928,303 - 76,035,059 (-)Ensembl
mRatBN7.2 Ensembl355,520,392 - 55,627,785 (-)Ensembl
RefSeq Acc Id: NM_001395018   ⟹   NP_001381947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,303 - 76,035,059 (-)NCBI
mRatBN7.2355,520,559 - 55,627,327 (-)NCBI
RefSeq Acc Id: NM_001395019   ⟹   NP_001381948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,303 - 76,034,635 (-)NCBI
mRatBN7.2355,520,559 - 55,626,903 (-)NCBI
RefSeq Acc Id: XM_008761897   ⟹   XP_008760119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,980 - 76,010,648 (-)NCBI
mRatBN7.2355,520,559 - 55,602,914 (-)NCBI
Rnor_6.0357,012,738 - 57,095,981 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761899   ⟹   XP_008760121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,980 - 76,001,258 (-)NCBI
mRatBN7.2355,520,559 - 55,592,854 (-)NCBI
Rnor_6.0357,012,738 - 57,084,582 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104855   ⟹   XP_038960783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,980 - 76,034,845 (-)NCBI
mRatBN7.2355,520,559 - 55,627,125 (-)NCBI
RefSeq Acc Id: XM_039104856   ⟹   XP_038960784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,980 - 75,966,742 (-)NCBI
mRatBN7.2355,520,559 - 55,558,981 (-)NCBI
RefSeq Acc Id: XM_063283624   ⟹   XP_063139694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,928,980 - 76,000,035 (-)NCBI
RefSeq Acc Id: XR_005501858
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8375,939,983 - 76,035,246 (-)NCBI
mRatBN7.2355,533,482 - 55,627,580 (-)NCBI
RefSeq Acc Id: XP_008760119   ⟸   XM_008761897
- Peptide Label: isoform X1
- UniProtKB: A0A096MJL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760121   ⟸   XM_008761899
- Peptide Label: isoform X1
- UniProtKB: A0A096MJL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074825   ⟸   ENSRNOT00000083171
Ensembl Acc Id: ENSRNOP00000063398   ⟸   ENSRNOT00000064203
RefSeq Acc Id: XP_038960783   ⟸   XM_039104855
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960784   ⟸   XM_039104856
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000068174   ⟸   ENSRNOT00000076281
Ensembl Acc Id: ENSRNOP00000068430   ⟸   ENSRNOT00000076554
Ensembl Acc Id: ENSRNOP00000088461   ⟸   ENSRNOT00000109940
Ensembl Acc Id: ENSRNOP00000096029   ⟸   ENSRNOT00000110107
Ensembl Acc Id: ENSRNOP00000089283   ⟸   ENSRNOT00000096336
RefSeq Acc Id: NP_001381947   ⟸   NM_001395018
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K920 (UniProtKB/TrEMBL),   A0A8I6AQ02 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381948   ⟸   NM_001395019
- Peptide Label: isoform 2
- UniProtKB: A0A096MJL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139694   ⟸   XM_063283624
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K920-F1-model_v2 AlphaFold A0A0G2K920 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692131
Promoter ID:EPDNEW_R2654
Type:initiation region
Name:Tlk1_1
Description:tousled-like kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0357,119,034 - 57,119,094EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310370 AgrOrtholog
BioCyc Gene G2FUF-49482 BioCyc
Ensembl Genes ENSRNOG00000009300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000060572 Ensembl
Ensembl Transcript ENSRNOT00000064203 ENTREZGENE
  ENSRNOT00000064203.4 UniProtKB/TrEMBL
  ENSRNOT00000076281 ENTREZGENE
  ENSRNOT00000076281.4 UniProtKB/TrEMBL
  ENSRNOT00000110107.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 311118 ENTREZGENE
PANTHER MIXED LINEAGE PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TOUSLED-LIKE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Tlk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009300 RatGTEx
  ENSRNOG00000060572 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A096MJL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K920 ENTREZGENE
  A0A8I6AQ02 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXW7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tlk1  tousled-like kinase 1  LOC103690017  serine/threonine-protein kinase tousled-like 1  Data merged from RGD:9355222 737654 PROVISIONAL
2014-08-25 LOC103690017  serine/threonine-protein kinase tousled-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Tlk1  tousled-like kinase 1   Tlk1_predicted  tousled-like kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tlk1_predicted  tousled-like kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED