Washc1 (WASH complex subunit 1) - Rat Genome Database

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Gene: Washc1 (WASH complex subunit 1) Rattus norvegicus
Analyze
Symbol: Washc1
Name: WASH complex subunit 1
RGD ID: 1310196
Description: Predicted to enable phosphatidylinositol 3-kinase inhibitor activity; tubulin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; endosomal transport; and meiotic nuclear division. Predicted to act upstream of or within several processes, including low-density lipoprotein particle clearance; positive regulation of cholesterol import; and positive regulation of protein localization to cell surface. Predicted to be located in several cellular components, including autophagosome; centrosome; and lamellipodium. Predicted to be part of BLOC-1 complex; WASH complex; and exocyst. Predicted to be active in early endosome and recycling endosome. Orthologous to several human genes including WASHC1 (WASH complex subunit 1); PARTICIPATES IN retromer-mediated pathway; INTERACTS WITH bisphenol A; (+)-catechin (ortholog); (1->4)-beta-D-glucan (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102553152; LOC367328; LOC689385; open reading frame 19; ORF19; similar to CXYorf1-related protein; uncharacterized LOC102553152; WAS protein family homolog; WAS protein family homolog 1; WAS protein family homolog 2; Wash; Wash1; Wash2
RGD Orthologs
Human
Mouse
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,169,730 - 113,179,829 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9113,168,259 - 113,179,835 (+)EnsemblGRCr8
mRatBN7.29105,722,779 - 105,830,836 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,722,899 - 105,733,009 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9114,131,463 - 114,141,570 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,241,477 - 119,251,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,597,316 - 117,607,423 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,918,914 - 113,936,861 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,918,858 - 113,936,860 (+)Ensemblrn6Rnor6.0
Rnor_5.09113,443,351 - 113,459,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49104,885,755 - 104,896,516 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9103,300,490 - 103,302,995 (-)NCBICelera
RGSC_v3.19105,095,204 - 105,105,650 (+)NCBI
Cytogenetic Map9q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autophagosome  (IEA,ISO)
BLOC-1 complex  (IEA,ISO)
centrosome  (IEA,ISO)
cytosol  (IEA)
early endosome  (IBA,IEA,ISO,ISS)
early endosome membrane  (IEA)
endosome  (IEA,ISO)
exocyst  (ISO)
filopodium  (ISO)
lamellipodium  (ISO)
late endosome  (IEA,ISO)
recycling endosome  (IBA,IEA,ISO,ISS)
recycling endosome membrane  (IEA)
WASH complex  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Retromer and sorting nexins in endosomal sorting. Gallon M and Cullen PJ, Biochem Soc Trans. 2015 Feb;43(1):33-47. doi: 10.1042/BST20140290.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:19922874   PMID:19922875   PMID:20308062   PMID:22114305   PMID:23275443   PMID:23452853   PMID:23974797   PMID:24344185   PMID:24886983   PMID:24998208   PMID:26965651  
PMID:27390154   PMID:27927957  


Genomics

Comparative Map Data
Washc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,169,730 - 113,179,829 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9113,168,259 - 113,179,835 (+)EnsemblGRCr8
mRatBN7.29105,722,779 - 105,830,836 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,722,899 - 105,733,009 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9114,131,463 - 114,141,570 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,241,477 - 119,251,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,597,316 - 117,607,423 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,918,914 - 113,936,861 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,918,858 - 113,936,860 (+)Ensemblrn6Rnor6.0
Rnor_5.09113,443,351 - 113,459,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49104,885,755 - 104,896,516 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9103,300,490 - 103,302,995 (-)NCBICelera
RGSC_v3.19105,095,204 - 105,105,650 (+)NCBI
Cytogenetic Map9q37NCBI
WASHC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38914,513 - 30,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl914,475 - 73,865 (-)Ensemblhg38GRCh38
GRCh37914,513 - 29,739 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y57,764,816 - 57,767,433 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map9p24.3NCBI
CHM1_1914,312 - 29,934 (-)NCBICHM1_1
T2T-CHM13v2.098,314 - 23,877 (-)NCBIT2T-CHM13v2.0
Washc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,418,524 - 66,427,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,418,540 - 66,427,498 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381766,111,529 - 66,120,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1766,111,545 - 66,120,503 (+)Ensemblmm10GRCm38
MGSCv371766,460,886 - 66,469,843 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361766,011,089 - 66,020,046 (+)NCBIMGSCv36mm8
Celera1770,419,820 - 70,428,779 (+)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1735.26NCBI
WASHC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,102,694 - 42,118,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,099,886 - 42,116,339 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha274,564,689 - 4,581,124 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02742,461,263 - 42,477,702 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,461,240 - 42,477,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,402,542 - 42,419,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,372,199 - 42,388,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,924,862 - 3,941,306 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Washc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,955,066 - 108,974,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936606206,388 - 223,194 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936606209,289 - 228,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASHC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,394,875 - 67,412,431 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1567,395,737 - 67,412,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,630,618 - 69,644,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WASHC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,075 - 27,633 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,116 - 22,842 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660638,319,471 - 8,337,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Washc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828249,994 - 269,347 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Washc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14154,688,397 - 154,691,430 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Washc1
4 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat

Markers in Region
RH142616  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29106,024,663 - 106,024,787 (-)MAPPERmRatBN7.2
mRatBN7.29105,732,839 - 105,732,963 (+)MAPPERmRatBN7.2
Rnor_6.09113,936,723 - 113,936,846NCBIRnor6.0
Rnor_5.09113,459,134 - 113,459,257UniSTSRnor5.0
RGSC_v3.49104,896,378 - 104,896,501UniSTSRGSC3.4
RGSC_v3.49105,207,457 - 105,207,580UniSTSRGSC3.4
Celera9103,107,044 - 103,107,167UniSTS
Cytogenetic Map9q37UniSTS
BE116357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29106,024,759 - 106,024,997 (-)MAPPERmRatBN7.2
mRatBN7.29105,732,629 - 105,732,867 (+)MAPPERmRatBN7.2
Rnor_6.09113,936,513 - 113,936,750NCBIRnor6.0
Rnor_5.09113,458,924 - 113,459,161UniSTSRnor5.0
Celera9103,300,601 - 103,300,838UniSTS
Celera9103,106,834 - 103,107,071UniSTS
Cytogenetic Map9q37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 81 204 91 90 59 159 59 6 479 282 21 183 107 113 31 31 31

Sequence


Ensembl Acc Id: ENSRNOT00000091398   ⟹   ENSRNOP00000073916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9113,175,915 - 113,179,835 (+)Ensembl
mRatBN7.2 Ensembl9105,729,064 - 105,733,009 (+)Ensembl
Rnor_6.0 Ensembl9113,918,858 - 113,936,860 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099987   ⟹   ENSRNOP00000080241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9113,169,730 - 113,179,828 (+)Ensembl
mRatBN7.2 Ensembl9105,722,899 - 105,733,009 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104558   ⟹   ENSRNOP00000095443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9113,168,259 - 113,179,835 (+)Ensembl
mRatBN7.2 Ensembl9105,722,921 - 105,732,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112451   ⟹   ENSRNOP00000088619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9113,169,730 - 113,179,828 (+)Ensembl
mRatBN7.2 Ensembl9105,722,899 - 105,733,009 (+)Ensembl
RefSeq Acc Id: NM_001127390   ⟹   NP_001120862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89113,169,730 - 113,179,829 (+)NCBI
mRatBN7.29105,722,879 - 105,732,978 (+)NCBI
Rnor_6.09113,918,914 - 113,936,861 (+)NCBI
Rnor_5.09113,443,351 - 113,459,272 (+)NCBI
RGSC_v3.49104,885,755 - 104,896,516 (+)RGD
Celera9103,300,490 - 103,302,995 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010054622
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89113,171,953 - 113,179,361 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001120862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88270 (Get FASTA)   NCBI Sequence Viewer  
  AAI01889 (Get FASTA)   NCBI Sequence Viewer  
  AAI66761 (Get FASTA)   NCBI Sequence Viewer  
  B2RYF7 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080241
RefSeq Acc Id: NP_001120862   ⟸   NM_001127390
- UniProtKB: B2RYF7 (UniProtKB/Swiss-Prot),   A0A8I6G6B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073916   ⟸   ENSRNOT00000091398
Ensembl Acc Id: ENSRNOP00000080241   ⟸   ENSRNOT00000099987
Ensembl Acc Id: ENSRNOP00000088619   ⟸   ENSRNOT00000112451
Ensembl Acc Id: ENSRNOP00000095443   ⟸   ENSRNOT00000104558
Protein Domains
WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYF7-F1-model_v2 AlphaFold B2RYF7 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310196 AgrOrtholog
BioCyc Gene G2FUF-26472 BioCyc
Ensembl Genes ENSRNOG00000053306 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000099987 ENTREZGENE
IMAGE_CLONE IMAGE:7379544 IMAGE-MGC_LOAD
  IMAGE:7930838 IMAGE-MGC_LOAD
  IMAGE:7930951 IMAGE-MGC_LOAD
InterPro WASH1 UniProtKB/Swiss-Prot
  WASH1_WAHD UniProtKB/Swiss-Prot
  WH2_dom UniProtKB/Swiss-Prot
KEGG Report rno:367328 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109109 IMAGE-MGC_LOAD
  MGC:124793 IMAGE-MGC_LOAD
  MGC:188513 IMAGE-MGC_LOAD
NCBI Gene 367328 ENTREZGENE
PANTHER PTHR23331 UniProtKB/Swiss-Prot
  WAS PROTEIN FAMILY HOMOLOG 2-RELATED UniProtKB/Swiss-Prot
Pfam WASH_WAHD UniProtKB/Swiss-Prot
PhenoGen Washc1 PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053306 RatGTEx
UniProt A0A0G2K6R7_RAT UniProtKB/TrEMBL
  A0A8I6A877_RAT UniProtKB/TrEMBL
  A0A8I6ANH7_RAT UniProtKB/TrEMBL
  A0A8I6G6B9 ENTREZGENE, UniProtKB/TrEMBL
  B2RYF7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Washc1  WASH complex subunit 1  LOC102553152  uncharacterized LOC102553152  Data merged from RGD:7749899 737654 PROVISIONAL
2016-10-28 Washc1  WASH complex subunit 1  Wash1  WAS protein family homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Wash1  WAS protein family homolog 1  LOC689385  similar to CXYorf1-related protein  Data merged from RGD:1593479 737654 PROVISIONAL
2015-03-16 Wash1  WAS protein family homolog 1  Wash  WAS protein family homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102553152  uncharacterized LOC102553152      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Wash  WAS protein family homolog  LOC684479  similar to CXYorf1-related protein  Data merged from RGD:1590288 1643240 APPROVED
2013-02-11 Wash  WAS protein family homolog  Wash2  WAS protein family homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Wash2  WAS protein family homolog 2   ORF19  open reading frame 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689385  similar to CXYorf1-related protein  LOC687200  similar to CXYorf1-related protein  Data merged from RGD:1587776 1643240 APPROVED
2006-11-20 LOC689385  similar to CXYorf1-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684479  similar to CXYorf1-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687200  similar to CXYorf1-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 ORF19  open reading frame 19  ORF19_predicted  open reading frame 19 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 ORF19_predicted  open reading frame 19 (predicted)      Symbol and Name status set to approved 70820 APPROVED