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Gene: Foxl2 (forkhead box L2) Rattus norvegicus

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Symbol:

Foxl2

Name:

forkhead box L2

RGD ID:

1310041

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2); INTERACTS WITH 4-vinylcyclohexene dioxide; all-trans-retinoic acid; Butylparaben.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

forkhead box protein L2; LOC367152

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOXL2 (forkhead box L2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Foxl2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Foxl2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FOXL2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOXL2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Foxl2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOXL2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOXL2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Foxl2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Foxl2 (forkhead box L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FOXL2 (forkhead box L2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Foxl2 (forkhead box L2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	slp1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	HCM1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	foxl2b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	foxl2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	foxl2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	foxl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pes-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	pes-1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	108,392,466 - 108,395,553 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	108,382,872 - 108,396,835 (+)	Ensembl				GRCr8
mRatBN7.2	8	99,512,971 - 99,514,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	99,513,303 - 99,514,427 (+)	Ensembl				mRatBN7.2
Dahl_SR_JrHsd	8	109,297,115 - 109,300,206 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	111,401,900 - 111,404,991 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	109,891,130 - 109,894,221 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	101,300,553 - 101,303,644 (+)	NCBI		F344_StmMcwi
Rnor_6.0	8	107,194,492 - 107,197,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	107,194,551 - 107,195,675 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	106,618,909 - 106,622,004 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	103,804,019 - 103,805,239 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	98,919,088 - 98,922,240 (+)	NCBI		Celera
RGSC_v3.1	8	103,818,892 - 103,825,932 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

blepharophimosis (ISO)

Blepharophimosis Syndrome Type 1 (ISO)

Blepharophimosis Syndrome Type 2 (ISO)

blepharophimosis, ptosis, and epicanthus inversus syndrome (ISO,ISS)

Colorectal Neoplasms (ISO)

Duane retraction syndrome (ISO)

genetic disease (ISO)

granulosa cell tumor (ISS)

hereditary breast ovarian cancer syndrome (ISO)

Keloid (ISO)

laryngeal squamous cell carcinoma (ISO)

lung non-small cell carcinoma (ISO)

primary ovarian insufficiency 16 (ISO)

primary ovarian insufficiency 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-vinylcyclohexene dioxide (EXP)

5-fluorouracil (ISO)

all-trans-retinoic acid (EXP,ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol AF (ISO)

Butylparaben (EXP)

cadmium atom (ISO)

chlordecone (ISO)

DDE (ISO)

dexamethasone (EXP,ISO)

dimethylselenide (ISO)

dorsomorphin (ISO)

entinostat (ISO)

folic acid (ISO)

hexadecanoic acid (ISO)

hydroxyl (ISO)

iron dichloride (ISO)

ketoconazole (ISO)

mercury dibromide (ISO)

mestranol (ISO)

methylparaben (EXP)

mifepristone (ISO)

mono(2-ethylhexyl) phthalate (EXP,ISO)

oxybenzone (EXP)

paracetamol (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propylparaben (EXP)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

testosterone (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic DNA fragmentation (ISO)

cell differentiation (IEA)

DNA-templated transcription (IEA)

embryonic eye morphogenesis (ISO)

extraocular skeletal muscle development (ISO)

female gonad development (ISO)

female somatic sex determination (ISO)

granulosa cell differentiation (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of gene expression (IMP)

negative regulation of transcription by RNA polymerase II (ISO)

ovarian follicle development (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of follicle-stimulating hormone secretion (ISO)

positive regulation of luteinizing hormone secretion (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (IEA)

response to human chorionic gonadotropin (IEP)

single fertilization (ISO)

uterus development (ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (IEA,ISO)

Molecular Function

cysteine-type endopeptidase regulator activity involved in apoptotic process (ISO)

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (IEA,ISO)

nuclear estrogen receptor binding (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (ISO)

ubiquitin conjugating enzyme binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes.	Agca C, etal., Mol Reprod Dev. 2013 Feb;80(2):102-17. doi: 10.1002/mrd.22141.
2.	Parabens inhibit the early phase of folliculogenesis and steroidogenesis in the ovaries of neonatal rats.	Ahn HJ, etal., Mol Reprod Dev. 2012 Sep;79(9):626-36. doi: 10.1002/mrd.22070. Epub 2012 Jul 26.
3.	The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome.	Crisponi L, etal., Nat Genet. 2001 Feb;27(2):159-66.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	FOXL2 expression might be a novel prognostic biomarker in patients with laryngeal squamous cell carcinoma.	Ge J, etal., J Int Med Res. 2020 Apr;48(4):300060520919252. doi: 10.1177/0300060520919252.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model.	Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
8.	Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells.	McTavish KJ, etal., Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64. doi: 10.1016/j.mce.2013.03.021. Epub 2013 Apr 6.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures.	Santamaría CG, etal., Toxicol Lett. 2019 Mar 15;303:48-54. doi: 10.1016/j.toxlet.2018.12.016. Epub 2018 Dec 30.
15.	Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer.	Zhao Y, etal., Oncol Lett. 2013 Apr;5(4):1211-1218. doi: 10.3892/ol.2013.1161. Epub 2013 Jan 29.

Additional References at PubMed

PMID:12161610	PMID:12471206	PMID:12630957	PMID:12943993	PMID:14736745	PMID:15056605	PMID:15944199	PMID:16153597	PMID:16720712	PMID:19264703	PMID:19744555	PMID:19797124
PMID:20005806	PMID:21757499	PMID:21991325	PMID:24739304

Genomics

Comparative Map Data

Foxl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	108,392,466 - 108,395,553 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	108,382,872 - 108,396,835 (+)	Ensembl				GRCr8
mRatBN7.2	8	99,512,971 - 99,514,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	99,513,303 - 99,514,427 (+)	Ensembl				mRatBN7.2
Dahl_SR_JrHsd	8	109,297,115 - 109,300,206 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	111,401,900 - 111,404,991 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	109,891,130 - 109,894,221 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	101,300,553 - 101,303,644 (+)	NCBI		F344_StmMcwi
Rnor_6.0	8	107,194,492 - 107,197,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	107,194,551 - 107,195,675 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	106,618,909 - 106,622,004 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	103,804,019 - 103,805,239 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	98,919,088 - 98,922,240 (+)	NCBI		Celera
RGSC_v3.1	8	103,818,892 - 103,825,932 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

FOXL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	138,944,224 - 138,947,137 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	138,944,224 - 138,947,137 (-)	Ensembl			hg38	GRCh38
GRCh37	3	138,663,066 - 138,665,979 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	140,145,756 - 140,148,491 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	140,145,765 - 140,148,499	NCBI
Celera	3	137,089,495 - 137,092,452 (-)	NCBI		Celera
Cytogenetic Map	3	q22.3	NCBI
HuRef	3	136,038,560 - 136,041,476 (-)	NCBI		HuRef
CHM1_1	3	138,627,041 - 138,629,957 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	141,685,214 - 141,688,129 (-)	NCBI		T2T-CHM13v2.0

Foxl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	98,837,495 - 98,840,601 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	98,837,341 - 98,840,596 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	98,955,607 - 98,958,126 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	98,955,288 - 98,958,543 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	98,856,026 - 98,858,545 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	98,765,013 - 98,766,140 (+)	NCBI		MGSCv36	mm8
Celera	9	98,493,332 - 98,496,090 (+)	NCBI		Celera
Cytogenetic Map	9	E3.3	NCBI
cM Map	9	51.41	NCBI

Foxl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955501	83,965 - 84,476 (+)	NCBI	ChiLan1.0	ChiLan1.0

FOXL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	136,854,028 - 136,857,037 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	136,849,646 - 136,861,671 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	135,968,040 - 135,980,063 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	143,568,268 - 143,577,397 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

FOXL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	35,145,856 - 35,147,185 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	35,138,304 - 35,139,560 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	35,688,052 - 35,689,311 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	23	35,368,849 - 35,370,105 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	35,433,498 - 35,434,751 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	35,684,283 - 35,685,539 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Foxl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	74,396,620 - 74,398,797 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936540	1,136,468 - 1,137,574 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936540	1,136,403 - 1,137,984 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOXL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	79,708,693 - 79,709,825 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	79,708,693 - 79,709,825 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	87,350,661 - 87,351,794 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOXL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	51,595,806 - 51,598,124 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	51,596,218 - 51,597,348 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	24,582,612 - 24,585,160 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Foxl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	15,490,664 - 15,491,800 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	15,489,261 - 15,492,645 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Foxl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	90,298,833 - 90,301,567 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Foxl2
23 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	73
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000023091
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

D8Got153

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	108,390,483 - 108,390,863 (+)	Marker Load Pipeline
mRatBN7.2	8	99,511,100 - 99,511,480 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,192,349 - 107,192,728	NCBI	Rnor6.0
Rnor_5.0	8	106,616,935 - 106,617,314	UniSTS	Rnor5.0
RGSC_v3.4	8	103,801,863 - 103,802,243	RGD	RGSC3.4
RGSC_v3.4	8	103,801,864 - 103,802,243	UniSTS	RGSC3.4
Celera	8	98,916,945 - 98,917,324	UniSTS
RGSC_v3.1	8	103,821,319 - 103,821,698	RGD
RH 3.4 Map	8	1052.29	UniSTS
RH 3.4 Map	8	1052.29	RGD
RH 2.0 Map	8	847.2	RGD
Cytogenetic Map	8	q31	UniSTS

UniSTS:463208

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	99,515,689 - 99,516,112 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,196,938 - 107,197,360	NCBI	Rnor6.0
Rnor_5.0	8	106,621,524 - 106,621,946	UniSTS	Rnor5.0
RGSC_v3.4	8	103,806,453 - 103,806,875	UniSTS	RGSC3.4
Celera	8	98,921,534 - 98,921,956	UniSTS
Cytogenetic Map	8	q31	UniSTS

BB557226

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	108,395,040 - 108,395,134 (+)	Marker Load Pipeline
mRatBN7.2	8	99,515,656 - 99,515,751 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,196,905 - 107,196,999	NCBI	Rnor6.0
Rnor_5.0	8	106,621,491 - 106,621,585	UniSTS	Rnor5.0
RGSC_v3.4	8	103,806,420 - 103,806,514	UniSTS	RGSC3.4
Celera	8	98,921,501 - 98,921,595	UniSTS
Cytogenetic Map	8	q31	UniSTS

AU045128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	99,515,425 - 99,515,686 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,196,674 - 107,196,934	NCBI	Rnor6.0
Rnor_5.0	8	106,621,260 - 106,621,520	UniSTS	Rnor5.0
RGSC_v3.4	8	103,806,189 - 103,806,449	UniSTS	RGSC3.4
Celera	8	98,921,270 - 98,921,530	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH143792

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	99,515,839 - 99,515,987 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,197,088 - 107,197,235	NCBI	Rnor6.0
Rnor_5.0	8	106,621,674 - 106,621,821	UniSTS	Rnor5.0
RGSC_v3.4	8	103,806,603 - 103,806,750	UniSTS	RGSC3.4
Celera	8	98,921,684 - 98,921,831	UniSTS
RH 3.4 Map	8	1039.39	UniSTS
Cytogenetic Map	8	q31	UniSTS

Foxl2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	99,513,302 - 99,513,672 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	107,194,551 - 107,194,920	NCBI	Rnor6.0
Rnor_5.0	8	106,619,137 - 106,619,506	UniSTS	Rnor5.0
RGSC_v3.4	8	103,804,066 - 103,804,435	UniSTS	RGSC3.4
Celera	8	98,919,147 - 98,919,516	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
1	2	15	103	20	19	8	2	8	36	19	101	6	73	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003754448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023091 ⟹ ENSRNOP00000023091

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	99,513,303 - 99,514,427 (+)	Ensembl
Rnor_6.0 Ensembl	8	107,194,551 - 107,195,675 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139163 ⟹ ENSRNOP00000111718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	108,382,872 - 108,396,835 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166035 ⟹ ENSRNOP00000109978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	108,382,872 - 108,395,432 (+)	Ensembl

RefSeq Acc Id:

NM_001427191 ⟹ NP_001414120

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	108,392,466 - 108,395,553 (+)	NCBI
Dahl_SR_JrHsd	8	109,297,115 - 109,300,206 (+)	NCBI
Lyon_Normotensive	8	111,401,900 - 111,404,991 (+)	NCBI
Lyon_Hypertensive	8	109,891,130 - 109,894,221 (+)	NCBI
F344_StmMcwi	8	101,300,553 - 101,303,644 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414120	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000109978
	ENSRNOP00000109978.1
	ENSRNOP00000111718.1

Ensembl Acc Id:

ENSRNOP00000023091 ⟸ ENSRNOT00000023091

RefSeq Acc Id:	NP_001414120 ⟸ NM_001427191
- UniProtKB:	D4A0S1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109978 ⟸ ENSRNOT00000166035

Ensembl Acc Id:

ENSRNOP00000111718 ⟸ ENSRNOT00000139163

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A0S1-F1-model_v2	AlphaFold	D4A0S1	1-374	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310041	AgrOrtholog
BioCyc Gene	G2FUF-29408	BioCyc
Ensembl Genes	ENSRNOG00000017190	Ensembl
	ENSRNOG00000072374	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000139163.1	UniProtKB/TrEMBL
	ENSRNOT00000166035	ENTREZGENE
	ENSRNOT00000166035.1	UniProtKB/TrEMBL
NCBI Gene	367152	ENTREZGENE
PhenoGen	Foxl2	PhenoGen
RatGTEx	ENSRNOG00000017190	RatGTEx
	ENSRNOG00000072374	RatGTEx
UniProt	A0ABK0LZJ6_RAT	UniProtKB/TrEMBL
	D4A0S1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Foxl2	forkhead box L2	Foxl2_predicted	forkhead box L2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Foxl2_predicted	forkhead box L2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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