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Gene: Bkgd (beta-keto-L-gulonate decarboxylase) Rattus norvegicus

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Symbol:

Bkgd (Ensembl: C8h11orf54)

Name:

beta-keto-L-gulonate decarboxylase (Ensembl:similar to human chromosome 11 open reading frame 54)

RGD ID:

1309534

Description:

Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in DNA damage response and regulation of DNA repair. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human BKGD (beta-keto-L-gulonate decarboxylase); INTERACTS WITH 17beta-estradiol (ortholog); 2-hydroxypropanoic acid (ortholog); 3-isobutyl-1-methyl-7H-xanthine (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

C8h11orf54; ester hydrolase C11orf54 homolog; LOC363016; RGD1309534; similar to human chromosome 11 open reading frame 54; similar to RIKEN cDNA 4931406C07

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BKGD (beta-keto-L-gulonate decarboxylase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	4931406C07Rik (RIKEN cDNA 4931406C07 gene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bkgd (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BKGD (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C21H11orf54 (chromosome 21 C11orf54 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bkgd (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C9H11orf54 (chromosome 9 C11orf54 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BKGD (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bkgd (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Bkgd (beta-keto-L-gulonate decarboxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	4931406C07Rik (RIKEN cDNA 4931406C07 gene)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BKGD (beta-keto-L-gulonate decarboxylase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:85789	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C24B5.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32335	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9119	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9119	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c11orf54	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,405,240 - 20,427,811 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	20,405,241 - 20,427,811 (-)	Ensembl				GRCr8
mRatBN7.2	8	12,123,839 - 12,146,412 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	12,123,823 - 12,146,473 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	16,105,416 - 16,128,149 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,403,166 - 14,425,899 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,386,795 - 12,409,368 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	20,411,194 - 20,433,767 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	22,586,851 - 22,609,426 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	21,158,737 - 21,181,312 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	12,489,870 - 12,512,445 (-)	NCBI		F344_StmMcwi
Rnor_6.0	8	13,838,549 - 13,861,120 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,838,572 - 13,861,212 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,778,079 - 13,800,657 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	12,084,956 - 12,106,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,591,560 - 13,614,122 (-)	NCBI		Celera
RGSC_v3.1	8	12,084,956 - 12,106,942 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

arsenous acid (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

buspirone (EXP)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

flutamide (EXP)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glafenine (EXP)

glycidyl methacrylate (ISO)

glyphosate (EXP)

gold atom (ISO)

gold(0) (ISO)

hydrogen peroxide (ISO)

imidacloprid (EXP)

indometacin (ISO)

ivermectin (ISO)

L-ascorbic acid (ISO)

leflunomide (EXP)

levofloxacin (EXP)

methyl methanesulfonate (ISO)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorononanoic acid (ISO)

phenformin (EXP)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP)

sodium dichromate (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thiabendazole (EXP)

thioacetamide (EXP)

triphenyl phosphate (EXP)

trovafloxacin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IEA,ISO,ISS)

regulation of DNA repair (IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO,ISS)

nucleus (IBA,IEA,ISO)

Molecular Function

carboxy-lyase activity (IEA)

dehydro-L-gulonate decarboxylase activity (IEA)

hydrolase activity (IEA)

hydrolase activity, acting on ester bonds (IBA,IEA,ISO,ISS)

lyase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:16522806	PMID:19056867	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Bkgd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,405,240 - 20,427,811 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	20,405,241 - 20,427,811 (-)	Ensembl				GRCr8
mRatBN7.2	8	12,123,839 - 12,146,412 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	12,123,823 - 12,146,473 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	16,105,416 - 16,128,149 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,403,166 - 14,425,899 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,386,795 - 12,409,368 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	20,411,194 - 20,433,767 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	22,586,851 - 22,609,426 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	21,158,737 - 21,181,312 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	12,489,870 - 12,512,445 (-)	NCBI		F344_StmMcwi
Rnor_6.0	8	13,838,549 - 13,861,120 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,838,572 - 13,861,212 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,778,079 - 13,800,657 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	12,084,956 - 12,106,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,591,560 - 13,614,122 (-)	NCBI		Celera
RGSC_v3.1	8	12,084,956 - 12,106,942 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

BKGD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	93,741,672 - 93,764,749 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	93,741,570 - 93,767,202 (+)	Ensembl			hg38	GRCh38
GRCh37	11	93,474,838 - 93,497,915 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,114,441 - 93,135,895 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	11	90,766,246 - 90,787,706 (+)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	89,552,027 - 89,573,474 (+)	NCBI		HuRef
CHM1_1	11	93,357,812 - 93,379,251 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	93,658,054 - 93,681,124 (+)	NCBI		T2T-CHM13v2.0

4931406C07Rik
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	15,194,633 - 15,217,836 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	15,194,633 - 15,217,744 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	15,283,337 - 15,306,448 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	15,283,337 - 15,306,448 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	15,087,783 - 15,106,000 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	15,033,732 - 15,051,949 (-)	NCBI		MGSCv36	mm8
Celera	9	12,562,605 - 12,580,874 (-)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI
cM Map	9	4.76	NCBI

Bkgd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	780,167 - 789,294 (-)	Ensembl
ChiLan1.0	NW_004955414	780,009 - 809,016 (-)	NCBI	ChiLan1.0	ChiLan1.0

BKGD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	94,601,352 - 94,623,197 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	95,695,275 - 95,717,119 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	88,763,232 - 88,785,075 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	92,250,482 - 92,272,026 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	92,250,482 - 92,272,026 (+)	Ensembl			panPan2	panpan1.1

C21H11orf54
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,993,272 - 7,013,053 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,993,856 - 7,009,268 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	7,008,685 - 7,028,015 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	7,173,928 - 7,193,277 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	7,173,933 - 7,193,558 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	6,960,106 - 6,979,446 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	7,024,513 - 7,043,848 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	7,073,365 - 7,092,705 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bkgd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	78,846,944 - 78,862,659 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	1,026,714 - 1,043,103 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	1,028,866 - 1,044,421 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C9H11orf54
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,170,413 - 26,187,619 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	26,167,341 - 26,187,627 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	29,769,206 - 29,821,157 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BKGD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	84,993,668 - 85,014,743 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	84,999,541 - 85,013,322 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	40,786,224 - 40,807,523 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bkgd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	38,411,829 - 38,422,981 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624735	38,407,335 - 38,427,688 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bkgd
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	11,079,660 - 11,098,331 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bkgd
290 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	583
Count of miRNA genes:	268
Interacting mature miRNAs:	340
Transcripts:	ENSRNOT00000014496
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

D8Rat225

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	20,408,765 - 20,409,004 (+)	Marker Load Pipeline
mRatBN7.2	8	12,127,364 - 12,127,603 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,842,075 - 13,842,313	NCBI	Rnor6.0
Rnor_5.0	8	13,781,605 - 13,781,843	UniSTS	Rnor5.0
RGSC_v3.4	8	12,088,482 - 12,088,720	UniSTS	RGSC3.4
RGSC_v3.4	8	12,088,481 - 12,088,720	RGD	RGSC3.4
Celera	8	13,595,086 - 13,595,324	UniSTS
RGSC_v3.1	8	12,088,482 - 12,088,720	RGD
RH 3.4 Map	8	113.4	UniSTS
RH 3.4 Map	8	113.4	RGD
SHRSP x BN Map	8	10.83	RGD
SHRSP x BN Map	8	10.83	UniSTS
Cytogenetic Map	8	q12	UniSTS

RH139254

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	12,131,859 - 12,131,985 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,846,568 - 13,846,693	NCBI	Rnor6.0
Rnor_5.0	8	13,786,098 - 13,786,223	UniSTS	Rnor5.0
RGSC_v3.4	8	12,092,975 - 12,093,100	UniSTS	RGSC3.4
Celera	8	13,599,570 - 13,599,695	UniSTS
RH 3.4 Map	8	111.1	UniSTS
Cytogenetic Map	8	q12	UniSTS

RH128142

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	12,124,084 - 12,124,275 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,838,795 - 13,838,985	NCBI	Rnor6.0
Rnor_5.0	8	13,778,325 - 13,778,515	UniSTS	Rnor5.0
RGSC_v3.4	8	12,085,202 - 12,085,392	UniSTS	RGSC3.4
Celera	8	13,591,806 - 13,591,996	UniSTS
RH 3.4 Map	8	116.7	UniSTS
Cytogenetic Map	8	q12	UniSTS

AA892561

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	20,421,187 - 20,421,731 (+)	Marker Load Pipeline
mRatBN7.2	8	12,139,788 - 12,140,332 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,854,497 - 13,855,040	NCBI	Rnor6.0
Rnor_5.0	8	13,794,029 - 13,794,572	UniSTS	Rnor5.0
RGSC_v3.4	8	12,100,319 - 12,100,862	UniSTS	RGSC3.4
Celera	8	13,607,499 - 13,608,042	UniSTS
RH 3.4 Map	8	107.4	UniSTS
Cytogenetic Map	8	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	49	113	91	90	59	25	59	6	218	97	11	93	45	60	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014496 ⟹ ENSRNOP00000014496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,405,241 - 20,427,811 (-)	Ensembl
mRatBN7.2 Ensembl	8	12,123,823 - 12,146,473 (-)	Ensembl
Rnor_6.0 Ensembl	8	13,838,572 - 13,861,212 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117122 ⟹ ENSRNOP00000077800

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,405,241 - 20,422,512 (-)	Ensembl
mRatBN7.2 Ensembl	8	12,123,840 - 12,143,521 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167667 ⟹ ENSRNOP00000101634

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,405,241 - 20,425,200 (-)	Ensembl

RefSeq Acc Id:

NM_001014206 ⟹ NP_001014228

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,405,240 - 20,427,811 (-)	NCBI
mRatBN7.2	8	12,123,839 - 12,146,412 (-)	NCBI
Dahl_SR_JrHsd	8	20,411,194 - 20,433,767 (-)	NCBI
Lyon_Normotensive	8	22,586,851 - 22,609,426 (-)	NCBI
Lyon_Hypertensive	8	21,158,737 - 21,181,312 (-)	NCBI
F344_StmMcwi	8	12,489,870 - 12,512,445 (-)	NCBI
Rnor_6.0	8	13,838,549 - 13,861,120 (-)	NCBI
Rnor_5.0	8	13,778,079 - 13,800,657 (-)	NCBI
RGSC_v3.4	8	12,084,956 - 12,106,942 (-)	RGD
Celera	8	13,591,560 - 13,614,122 (-)	RGD

Sequence:

show sequence

AGCAAGGCATTCCTCCAAGACACTGCGGGTCAGAGCAGGGACTGTTCACGCTGGTGCCCTGTGA
ACTCTGGTGGAGGTCAGCCAACAGCTGCTGTGTCTGAGTTGCTGAGAGGAGAGAGAATGGCTTG
CACTGAGTTTTCTTTCCACGTGCCAAGTCTGGAGGAGCTCGCAGAAGTTTTGCAGAAGGGGCTA
AAGGACAACTTTGCTCATGTCCAGGTCTCTGTGGTCGACTGCCCAGATTTAACAAAGGAGCCAT
TTACCTTTCCCGTAAAAGGCATCTGTGGGCAAACTAGAATTGCAGAAGTCGGAGGTGTGCCTTA
CTTACTGCCTCTTGTAAACAAAAAAAAGGTTTATGACCTGAATGAAATTGCCAAAGAAATAAAG
CTGCCGGGAGCGTTTATCCTTGGAGCGGGGGCAGGTCCCTTTCAAACGCTTGGGTTCAATTCTG
AGTTCATGCCAATAGTTCAAACAGCAAGTGAACACCACCAACCTGTGAATGGAAGTTACTTTGC
CCGTGCAAACCCTGCAGATGGAAAGTGCCTGCTGGAGAAATACAGCCAAAAGTATCCTGACTTC
GGATGTGCATTACTGGCTAACCTTTTTGCCAGTGAGGGCCAACCTGGCAAGGTCATTGAAGTGC
AAGCCAAGAAAAGAACGGGAGAACATAACTTTGTGAGCTGCATGAGGCAGACTCTGGAGAAGCA
CTATGGTGACAAGCCCGTGGGCATGGGAGGCACCTTCCTTGTGCAGAAGGGGAAAGTGAAAGCC
CACATCATGCCAGCAGAGTTTTCTTCCTGTTCACTGAACTCAGACGAAGCTGTCAATCAATGGC
TAAACTTCTATGAGATGAAGGCGCCTTTGGTTTGTCTGCCAGTTTTTGTTTCCAAAGACCCGGG
GCTTGATTTACGACTGGAGCATACACATTTCTTCAGTCATCATGGAGAAGGTGGGCACTACCAC
TACGATACCACCCCAGACACAGTGGAGTATCTCGGCTACTTCTCGCCTGCACAGTTCCTCTACC
GAATTGACCAGCCCAAGGAGACCCATGCCTTTGGGAGGGATTAAAGCAGCTGCTGCTTGATTAG
GGGAAAAATGGTTAGCTAAGGTTATATTGCTAACCCAGCAATTGACAGTAATTAAAAAATATAG
TAGGACCAAAGAGAGAGAGAGAGAGACCGCAGCCAACAACAGTCATTTCACTACATTAGCACTG
TTTTTATGGCATCCATGTGGATAAGGGACACTCGTGTTATTTAGCATCTTTATGTGAAGGAGTC
TTGGGAACAAAGATAACTAATTGAGATGCTCACTTTACTCAACCAATTTTCTGTCTTTATAGCC
CAGAAGTCCACCTTCCTTCTCTTCACACCTCAGGTATGGGCATGGACAGGGACCTTTCATTATC
CCTGCTATCGAGTAACATTTGGGTCACATTGCTGAATTTTTCAAGTTCATCTCACAAGGCTAAG
GGGTCATTACTGAGTGTTAGACACAGCAGTGTGGAGTCGTTGCACTGGGTTTTAAAAGCCCACT
CTGGAAATCAGTGTACTCTGTTCTCAGCACTTGGGGGGCTACCCACACTCAGAAGTCTGCAGCT
GCCATCCACAGTTGGTAGTGACACTGATTAGCCAGGCTGTCCCTGAATTAGGTTGATAGCCAAC
AGTTTGTACCTTAGTAATGCAAGATAAGAAAAGAAACAGCAACAAAACACAACACTGAACCCCG
CCACTCTCCATTGTGAGAAACTACTCTTACTGTGTGGTGTCTTAAAGAGACGCCTTTGTGCCCT
TTCTTTGGCTACATAGACTGCTGAGACAATGACCACAAGACACTGGAATTACCTCAGGAATTTC
ATGCCAGGAGAAGGAAAAGGCTAAAGCCTGGTGCCAGCTTGAGGAGGAACGTGGCTCCCAGAAA
GAGATGTTGCATAGTCCTCAGGACAAATGGTGGTGGGCACAGCTTGACCTTAGTTAGGCATACC
TTGTGCCTCCTATTGAAACCCAGACCTCACGCCAGAACCCAGCATGGATTTTGCAGGATGGTGG
AGGGAAGGTTGGGAATCCAGAGACCTGTTTGTTACTCTTTCCAAAGTGATTCCACTAAAGAAAT
CTTTTTGCGCTTTTCCAAAGATATTACACTATTATTGAGTGTTGATGGTTAGTGTGTGGTGATG
ATGGTTAGAAAACTCCTCTCTGTTCTGTATTATAGAACCTGTGATGATCATTAGCCAGAAATCA
ACTTCCTAACCTTGCTAATGGTGATAAGATGTGGGTCTAGGACCTCTTTAGAACTAAACCCTCA
ACGTTTTCCGATTCTTTACTTTGTAATGCACATGTCTTGTATTATTTTTAATAATAGTGTTATT
TTTAATTAAACATGATTTTTGAGGTGAAACTGAATAAAATCATTTAATACTAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAA

hide sequence

RefSeq Acc Id:

XM_063265683 ⟹ XP_063121753

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,405,240 - 20,424,983 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014228	(Get FASTA)	NCBI Sequence Viewer
	XP_063121753	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85915	(Get FASTA)	NCBI Sequence Viewer
	EDL78448	(Get FASTA)	NCBI Sequence Viewer
	EDL78449	(Get FASTA)	NCBI Sequence Viewer
	EDL78450	(Get FASTA)	NCBI Sequence Viewer
	EDL78451	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014496
GenBank Protein	Q5U2Q3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014228 ⟸ NM_001014206

- UniProtKB:

Q5U2Q3 (UniProtKB/Swiss-Prot), A6JNB6 (UniProtKB/TrEMBL), A0A8I5ZKD7 (UniProtKB/TrEMBL), A6JNB5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MACTEFSFHVPSLEELAEVLQKGLKDNFAHVQVSVVDCPDLTKEPFTFPVKGICGQTRIAEVGG
VPYLLPLVNKKKVYDLNEIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPIVQTASEHHQPVNGS
YFARANPADGKCLLEKYSQKYPDFGCALLANLFASEGQPGKVIEVQAKKRTGEHNFVSCMRQTL
EKHYGDKPVGMGGTFLVQKGKVKAHIMPAEFSSCSLNSDEAVNQWLNFYEMKAPLVCLPVFVSK
DPGLDLRLEHTHFFSHHGEGGHYHYDTTPDTVEYLGYFSPAQFLYRIDQPKETHAFGRD

hide sequence

Ensembl Acc Id:

ENSRNOP00000014496 ⟸ ENSRNOT00000014496

Ensembl Acc Id:

ENSRNOP00000077800 ⟸ ENSRNOT00000117122

RefSeq Acc Id:	XP_063121753 ⟸ XM_063265683
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000101634 ⟸ ENSRNOT00000167667

Protein Domains

DUF1907

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2Q3-F1-model_v2	AlphaFold	Q5U2Q3	1-315	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695753

Promoter ID:

EPDNEW_R6276

Type:

initiation region

Name:

RGD1309534_1

Description:

similar to RIKEN cDNA 4931406C07

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	13,861,180 - 13,861,240	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309534	AgrOrtholog
BioCyc Gene	G2FUF-31665	BioCyc
Ensembl Genes	ENSRNOG00000010887	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000014496	ENTREZGENE
IMAGE_CLONE	IMAGE:7107444	IMAGE-MGC_LOAD
InterPro	DUF1907	UniProtKB/Swiss-Prot
KEGG Report	rno:363016	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94800	IMAGE-MGC_LOAD
NCBI Gene	363016	ENTREZGENE
PANTHER	ESTER HYDROLASE C11ORF54	UniProtKB/Swiss-Prot
	PTHR13204	UniProtKB/Swiss-Prot
Pfam	DUF1907	UniProtKB/Swiss-Prot
PhenoGen	Bkgd	PhenoGen
RatGTEx	ENSRNOG00000010887	RatGTEx
SMART	DUF1907	UniProtKB/Swiss-Prot
Superfamily-SCOP	AF0104/ALDC/Ptd012-like	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZKD7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q735_RAT	UniProtKB/TrEMBL
	A0ABK0LK50_RAT	UniProtKB/TrEMBL
	A6JNB5	ENTREZGENE, UniProtKB/TrEMBL
	A6JNB6	ENTREZGENE, UniProtKB/TrEMBL
	CK054_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Bkgd	beta-keto-L-gulonate decarboxylase	C8h11orf54	similar to human chromosome 11 open reading frame 54	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2022-06-23	C8h11orf54	similar to human chromosome 11 open reading frame 54	RGD1309534	similar to RIKEN cDNA 4931406C07	Name and Symbol changed	629549	APPROVED
2005-12-06	RGD1309534	similar to RIKEN cDNA 4931406C07	RGD1309534_predicted	similar to RIKEN cDNA 4931406C07 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309534_predicted	similar to RIKEN cDNA 4931406C07 (predicted)	LOC363016_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC363016_predicted	similar to RIKEN cDNA 4931406C07 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD