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Gene: Crebl2 (cAMP responsive element binding protein-like 2) Rattus norvegicus

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Symbol:

Crebl2

Name:

cAMP responsive element binding protein-like 2

RGD ID:

1309502

Description:

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in several processes, including positive regulation of D-glucose import; positive regulation of metabolic process; and protein stabilization. Predicted to be active in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cAMP-responsive element-binding protein-like 2; LOC362453; MGC109304

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	169,404,630 - 169,430,618 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	169,376,495 - 169,430,611 (+)	Ensembl				GRCr8
mRatBN7.2	4	167,673,359 - 167,699,299 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	167,673,315 - 167,699,292 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	173,966,821 - 173,992,692 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	169,749,912 - 169,775,777 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	168,373,843 - 168,399,670 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	168,599,387 - 168,625,239 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	168,599,331 - 168,619,764 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	232,874,601 - 232,900,502 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	171,744,836 - 171,771,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	156,270,048 - 156,295,864 (+)	NCBI		Celera
RGSC_v3.1	4	171,989,771 - 172,016,132 (+)	NCBI
Cytogenetic Map	4	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-diaminotoluene (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

indometacin (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mitoxantrone (ISO)

N-methyl-4-phenylpyridinium (EXP)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

DNA-templated transcription (IEA)

positive regulation of D-glucose import across plasma membrane (ISO,ISS)

positive regulation of DNA-templated transcription (ISO,ISS)

positive regulation of fat cell differentiation (ISO,ISS)

positive regulation of lipid biosynthetic process (ISO,ISS)

positive regulation of peptidyl-serine phosphorylation (ISO,ISS)

protein stabilization (ISO,ISS)

regulation of DNA-templated transcription (IBA,IEA)

Cellular Component

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:21728997

Genomics

Comparative Map Data

Crebl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	169,404,630 - 169,430,618 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	169,376,495 - 169,430,611 (+)	Ensembl				GRCr8
mRatBN7.2	4	167,673,359 - 167,699,299 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	167,673,315 - 167,699,292 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	173,966,821 - 173,992,692 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	169,749,912 - 169,775,777 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	168,373,843 - 168,399,670 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	168,599,387 - 168,625,239 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	168,599,331 - 168,619,764 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	232,874,601 - 232,900,502 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	171,744,836 - 171,771,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	156,270,048 - 156,295,864 (+)	NCBI		Celera
RGSC_v3.1	4	171,989,771 - 172,016,132 (+)	NCBI
Cytogenetic Map	4	q43	NCBI

CREBL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	12,611,876 - 12,645,108 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	12,611,827 - 12,645,108 (+)	Ensembl			hg38	GRCh38
GRCh37	12	12,764,810 - 12,798,042 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	12,656,098 - 12,689,308 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	12,656,097 - 12,689,308	NCBI
Celera	12	17,908,970 - 17,942,189 (+)	NCBI		Celera
Cytogenetic Map	12	p13.1	NCBI
HuRef	12	12,529,511 - 12,563,345 (+)	NCBI		HuRef
CHM1_1	12	12,729,857 - 12,763,067 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	12,481,031 - 12,514,259 (+)	NCBI		T2T-CHM13v2.0

Crebl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	134,807,090 - 134,835,894 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	134,807,117 - 134,835,894 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	134,830,127 - 134,880,580 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	134,830,154 - 134,858,931 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	134,780,217 - 134,807,901 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	134,795,892 - 134,823,576 (+)	NCBI		MGSCv36	mm8
Celera	6	137,786,985 - 137,814,582 (+)	NCBI		Celera
Cytogenetic Map	6	G1	NCBI
cM Map	6	65.77	NCBI

Crebl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	9,513,625 - 9,535,817 (+)	Ensembl
ChiLan1.0	NW_004955413	9,513,625 - 9,535,817 (+)	NCBI	ChiLan1.0	ChiLan1.0

CREBL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	18,076,295 - 18,109,159 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	18,073,054 - 18,105,918 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	12,632,763 - 12,665,646 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	13,010,802 - 13,043,708 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

CREBL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	33,684,376 - 33,711,625 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	33,687,491 - 33,711,512 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	12,733,992 - 12,761,343 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	33,991,666 - 34,018,945 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	33,991,679 - 34,018,669 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	33,884,586 - 33,911,795 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	33,833,953 - 33,861,265 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	12,468,125 - 12,495,502 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Crebl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	94,915,874 - 94,936,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936587	4,643,123 - 4,663,964 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936587	4,645,507 - 4,663,920 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREBL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	59,805,600 - 59,831,183 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	59,804,348 - 59,831,197 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CREBL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	12,510,529 - 12,541,026 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	12,510,540 - 12,537,901 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666069	22,778,192 - 22,808,330 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crebl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624752	25,280,957 - 25,301,562 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Crebl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	14,583,845 - 14,607,574 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Crebl2
76 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	28
Count of miRNA genes:	24
Interacting mature miRNAs:	27
Transcripts:	ENSRNOT00000009324
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	160623982	184426481	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat

Markers in Region

D4Uia5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	169,427,244 - 169,427,688 (+)	Marker Load Pipeline
mRatBN7.2	4	167,695,918 - 167,696,362 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	168,621,862 - 168,622,309	NCBI	Rnor6.0
Rnor_5.0	4	232,897,125 - 232,897,572	UniSTS	Rnor5.0
RGSC_v3.4	4	171,767,821 - 171,768,268	UniSTS	RGSC3.4
Celera	4	156,292,507 - 156,292,934	UniSTS
Cytogenetic Map	4	q43	UniSTS

RH127311

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	167,698,854 - 167,699,060 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	168,624,802 - 168,625,007	NCBI	Rnor6.0
Rnor_5.0	4	232,900,065 - 232,900,270	UniSTS	Rnor5.0
RGSC_v3.4	4	171,770,761 - 171,770,966	UniSTS	RGSC3.4
Celera	4	156,295,427 - 156,295,632	UniSTS
RH 3.4 Map	4	1025.6	UniSTS
Cytogenetic Map	4	q43	UniSTS

BARC145

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	167,694,247 - 167,695,912 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	168,620,192 - 168,621,855	NCBI	Rnor6.0
Rnor_5.0	4	232,895,455 - 232,897,118	UniSTS	Rnor5.0
RGSC_v3.4	4	171,766,151 - 171,767,814	UniSTS	RGSC3.4
Celera	4	156,290,838 - 156,292,500	UniSTS
Cytogenetic Map	4	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001015027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009324 ⟹ ENSRNOP00000009324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	167,689,049 - 167,692,600 (+)	Ensembl
Rnor_6.0 Ensembl	4	168,615,890 - 168,619,269 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086719 ⟹ ENSRNOP00000070776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	168,599,331 - 168,619,764 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097223 ⟹ ENSRNOP00000090607

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	169,377,485 - 169,430,611 (+)	Ensembl
mRatBN7.2 Ensembl	4	167,689,274 - 167,699,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103810 ⟹ ENSRNOP00000097590

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	169,404,860 - 169,430,611 (+)	Ensembl
mRatBN7.2 Ensembl	4	167,673,315 - 167,699,292 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119142 ⟹ ENSRNOP00000094879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	169,404,707 - 169,430,611 (+)	Ensembl
mRatBN7.2 Ensembl	4	167,673,315 - 167,699,292 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132816 ⟹ ENSRNOP00000111626

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	169,376,495 - 169,430,611 (+)	Ensembl

RefSeq Acc Id:

NM_001015027 ⟹ NP_001015027

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,404,763 - 169,430,618 (+)	NCBI
mRatBN7.2	4	167,673,434 - 167,699,292 (+)	NCBI
Rnor_6.0	4	168,599,387 - 168,625,239 (+)	NCBI
Rnor_5.0	4	232,874,601 - 232,900,502 (+)	NCBI
RGSC_v3.4	4	171,744,836 - 171,771,198 (+)	RGD
Celera	4	156,270,048 - 156,295,864 (+)	RGD

Sequence:

show sequence

GGCTTCAGGGAAGCGAACTGTTAGGCGAAGGAGGAGGCAGTCAGAGCCATATCCCCTTCTTCCC
CGGGGCGGGGGCCGGGCCTGGCCCGCTGAGGAGGGGGAGGGCCGGGAGGGCGTCGGGCCGGGCC
GGCCTGTCTGCGGAGATGGATGACAGCAAGGTGGTCGGAGGCAAAGTGAAGAAGCCTGGTAAGC
GAGGGCGGAAGCCAGCCAAAATTGACTTGAAAGCAAAACTTGAGCGAAGCCGGCAGAGTGCAAG
AGAGTGCCGGGCCAGGAAAAAGCTGAGATACCAGTACTTGGAGGAGTTGGTGTCCAGTCGGGAA
AGAGCTATATGTGCACTCCGAGAGGAACTGGAAATGTACAAGCAGTGGTGCATGGCAATGGACC
AAGGGAAAATCCCTTCTGAAATAAGGGCCCTACTCACTGGCGAGGAGCAGAACAAGTCTCAGCA
GAACTCAAGCAGGCATCCCAAAGCTGGAAAGACAGACGCTAACACCAATTCGTTGGTGGGGAAT
TGAACCCGTGGCTTCAGACATGCTGGGGTGAAGATGGTATAAAATGCAGTCAGTGATCAAAGGT
TGGATAATGTCTACGGAGGACGAATGGGCAGGACTGTGCTTCTTTGCTCTATTTTCCGCTTACT
GCTCAGTAAGCATCTCTGTAAACCCAAAGTTTCTACCAAAATGTGTGACGATATGTCACGAAGG
TCCTTGTGCAACACTTAGGTTTGCCAACCTTCAGACCTGCTCGATGTTGCTCTCCATGCCGGGT
AACAAGTCATGATGCCCGAGATCGTGGGAGTGGAGGCAGTGGATGGACGCGCACGTTTGCACCT
TAGCCCTATGGCTTTCATGGTTAATTCCTATGTGTCCTGTGTAATTGATAGGTGTGTGTGTGTT
GTTTAGTTGTCTTTTCTTTTCATGTTTTTAGTCACCCTACACAAAGACACCAGGTCGGCTGTTT
GTCCCTGTGGTTCTCGGCCTTTATGGACCCAATACCAACTCCTTTGTATTTACCTGAGTGAAGT
GTGGGTACCTGTGAGCCATTCCAGCATAAGCTGTATGTAGTGACAGATATATACACCTCCGTTT
TTGTAACCCATAGCGATATGCCTGGTTTAAAGAGTGTGCGTAACAAAACCAACCCAACAAGGAA
GCCCTCGACAGCCTCTTGTTGCTGTTTCCTCTGACTGTATTTATGAAAGCTGGCTAGGGCCAAA
TCCATGCTTGGAGAATAATTAGCCACATTTTATTTTTAAGTGAAAAGTAACCTTTCAGTGGCAT
TCAGTACCTTAACCTGCAGTATGTGTGTGACATGGTCCTGCTGTGTGTCTCCATGCACACACAT
TTGCTTGTGCACTCCACTGAGGCGTGGGATTCCCCTGAAGAATACAGAATGAACGTAGCTGCTG
AGACTGAGTATCTGCCTTTCCGTGTGGAGCACAGGTCACCCTGCTGGTGACGTCATGGCGGTTG
CTGTTGACAGAATACTCAGTTCTTCCCTGACGTGAGTGTCCTTTGAATGTGTTCTGAGCCAGAG
AGAAGCCCACTGTGTGTTTGCACCTGCTTTAGCCTGTGCCCCACTGCGGTGGGGCATCCTGAGC
TGCACCCTGCACTGCAGCCTGGGCCTGGTGGGCATGTAGAGTGGCATGTGGCTCTGAATGGTTC
CCATCACAGCTGCCTTTACATGACATGGAGTGGTGTGGAGGGGCAGAGTCATAGTAGGATAGGT
TCAGAGACAAGGAGCTTCTACTTCACTCGCTTCTCTCACTAGTTCAGTCAGATGTGTTCTCTGT
TGCTGCTAATTACAAGTGTTCCTCCCTCTGCTGAAGCAGGAATTTGACTTCAGGAAAAGAAGTA
TTTGCTACAGACTGGCAGTTGAAGAGGAAGTTATCATAGCCATTAGGCATGTCCAACCTTTTGA
CGTTGTGACTTGAAGCCTGAGAATTGAATGTTTTTAGTGAGTTTACAGTTTTGTGCTGGGCCAC
ATTCCTAGCTACTCTGAGGCATGGGCAGCCTGCAAGCTGTGGTTCAGACTTGCCTGGAAGGTGT
CTGTGAGGTGGACATGAGATGGACTGTGTAGCTTGTGATCTTGTGACAGGCATTAGAACAGATG
CCTCCTCCCGTTAGCTGGAGATCCCTTGAGTGCAGGCTGCAACCTCAGTCCTCCATGGTAGGTG
AGTGACCACCGACCGAGCGCTTGCACAGCTTGCTGGGTCTCTGTGTTATAGGAAAATGGGCATT
AGGGTATTTAATGTCTTCTTAGGACCATAAATGGAGACAAGGATTTTTGACACAGGCCCTTCAG
AATTTAAGTGTTTTAAATGTAGTGTTCTGACTGTAATGGGTGTGCTCCTGCCTACTCAGTCATA
GACCTTACTTTGCAGAACAGCCCAGGACCTTATGTTGCTTTGTTTGTTACCTTTTGTTTCTCCA
GAAAAAAAAAAAAATGTTTTCAAAGCAGACATTCCAGGCTGAATGTGGCTCGTCAGTGGAATGT
GTGCCTTGTGCTCAAAGGTTCTGCAGGGTGTGTGTACTTGTAGTAGCCAGGCCATTCCCAGGCT
GTAGTTATAACTGCAGGGTCATCCCCCGGTAGAAGAGATGTGCTTTGGAGTGAATGTGGCTGCA
CTTTGAGTTTACTCTCGGGCCTGTATCTCTTTAGTGTTCTGGAGGTATCAAACCAAGACAATGG
CCCTCAGCATCTGACGGGGACAGGCTAACTGCGCTGGGTTCTATGCTGGCCCTTCTCCCTCATC
TGTGATCCAATCACTGTTCTGATCCCAACAGCTGCAGCGTCTCCTTTTCCGCTTCCATCCAGTG
GGGCTCTGCGGGCTAACCGCAGTTCTTCCCAGAGGAGAGCAAGCTGAGAGAGGACAGAGCCCAA
GGCTCCATCTAGGGCAGGAAGAGGCCACGTGCTTCCTCAGCAGAGCCCGCTCCCTTTTCTCTTT
ACCTCAGAAGTTAAGGAGATTCGCTCGTTCACACCAGTCCGGCTCTGCCACTTGAGTGTCCACT
CCCACACACTGGAGCAACTGGTGCAACATGGAGCTGATCTGGTCAGGTCAACCTCTAGGCTATG
TGAAGTTCTGAGTGTGCTTTCTGTCCTCATCTAACATAGTCCTGTGACGCCCAAATCAGCCCTG
AGTGCAGCAGCCCCTGCCACTGCCTGCCCTGTGCACAGCCCAGCGTCTCCAGCTGTGACGTCAT
CATCTTGGGCCGCATGGGTCCGCTTTGGCTGGTGGTAGAGAACAGATTTAAGCTGGGCTTCACT
TTTAGTTAAAGGCGAGTAAAATCAACAAAAACAAATACTATATTTCACAGAAATCAGCTGCATG
TTTTTACAAATATTAAAATACATATTTTGTTTTTTAAGAGATAAGAGATGATTAAACCACATGG
TATTTGGGGGCAAATGAAGGATTTTTTTCCTTAGAAGAGCATTGTACAATTATATTTTTATGGA
AAATAAAGTATCTTCACCAAAATCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039107908 ⟹ XP_038963836

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,404,630 - 169,430,618 (+)	NCBI
mRatBN7.2	4	167,673,359 - 167,699,299 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001015027	(Get FASTA)	NCBI Sequence Viewer
	XP_038963836	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91323	(Get FASTA)	NCBI Sequence Viewer
	EDM01648	(Get FASTA)	NCBI Sequence Viewer
	EDM01649	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000094879.1
	ENSRNOP00000097590
GenBank Protein	Q5BJU6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001015027 ⟸ NM_001015027
- UniProtKB:	Q5BJU6 (UniProtKB/Swiss-Prot), A6IME0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICA LREELEMYKQWCMAMDQGKIPSEIRALLTGEEQNKSQQNSSRHPKAGKTDANTNSLVGN hide sequence

Ensembl Acc Id:

ENSRNOP00000009324 ⟸ ENSRNOT00000009324

Ensembl Acc Id:

ENSRNOP00000070776 ⟸ ENSRNOT00000086719

RefSeq Acc Id:	XP_038963836 ⟸ XM_039107908
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ANJ8 (UniProtKB/TrEMBL), A6IMD9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000097590 ⟸ ENSRNOT00000103810

Ensembl Acc Id:

ENSRNOP00000090607 ⟸ ENSRNOT00000097223

Ensembl Acc Id:

ENSRNOP00000094879 ⟸ ENSRNOT00000119142

Ensembl Acc Id:

ENSRNOP00000111626 ⟸ ENSRNOT00000132816

Protein Domains

bZIP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5BJU6-F1-model_v2	AlphaFold	Q5BJU6	1-123	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693462

Promoter ID:

EPDNEW_R3977

Type:

multiple initiation site

Name:

Crebl2_1

Description:

cAMP responsive element binding protein-like 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	168,599,355 - 168,599,415	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309502	AgrOrtholog
BioCyc Gene	G2FUF-42647	BioCyc
Ensembl Genes	ENSRNOG00000007115	Ensembl
	ENSRNOG00000067300	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000103810	ENTREZGENE
	ENSRNOT00000119142.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7313598	IMAGE-MGC_LOAD
InterPro	bZIP	UniProtKB/Swiss-Prot
	bZIP_sf	UniProtKB/Swiss-Prot
	CREBL2/REPTOR-BP	UniProtKB/Swiss-Prot
KEGG Report	rno:362453	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109304	IMAGE-MGC_LOAD
NCBI Gene	362453	ENTREZGENE
PANTHER	CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2	UniProtKB/Swiss-Prot
	PTHR21051	UniProtKB/Swiss-Prot
Pfam	bZIP_2	UniProtKB/Swiss-Prot
PhenoGen	Crebl2	PhenoGen
RatGTEx	ENSRNOG00000007115	RatGTEx
	ENSRNOG00000067300	RatGTEx
Superfamily-SCOP	SSF57959	UniProtKB/Swiss-Prot
UniProt	A0A8I6AC58_RAT	UniProtKB/TrEMBL
	A0A8I6ANJ8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0M1H6_RAT	UniProtKB/TrEMBL
	A6IMD9	ENTREZGENE, UniProtKB/TrEMBL
	A6IME0	ENTREZGENE, UniProtKB/TrEMBL
	CRBL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Crebl2	cAMP responsive element binding protein-like 2	Crebl2_predicted	cAMP responsive element binding protein-like 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Crebl2_predicted	cAMP responsive element binding protein-like 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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