Eif1b (eukaryotic translation initiation factor 1B) - Rat Genome Database

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Gene: Eif1b (eukaryotic translation initiation factor 1B) Rattus norvegicus
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Symbol: Eif1b (Ensembl: Eif1-ps8)
Name: eukaryotic translation initiation factor 1B (Ensembl:eukaryotic translation initiation factor 1, pseudogene 8)
RGD ID: 1309241
Description: Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to act upstream of or within positive regulation of mRNA cis splicing, via spliceosome and random inactivation of X chromosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. Orthologous to human EIF1B (eukaryotic translation initiation factor 1B); PARTICIPATES IN RNA transport pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301068; RGD1309241; similar to translation factor sui1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88129,080,497 - 129,083,772 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8129,078,293 - 129,083,772 (+)EnsemblGRCr8
GRCr8 Ensembl525,895,968 - 25,896,654 (-)EnsemblGRCr8
mRatBN7.28120,203,561 - 120,206,176 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl521,098,535 - 21,099,211 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl8120,203,451 - 120,206,176 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8125,780,434 - 125,783,050 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,979,447 - 123,982,063 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,821,683 - 121,824,295 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08129,158,112 - 129,160,726 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8129,158,103 - 129,160,757 (+)Ensemblrn6Rnor6.0
Rnor_5.08128,356,696 - 128,359,310 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48125,499,378 - 125,501,992 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8119,345,651 - 119,348,265 (+)NCBICelera
RGSC_v3.18125,519,015 - 125,521,753 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22681889   PMID:25943107  


Genomics

Comparative Map Data
Eif1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88129,080,497 - 129,083,772 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8129,078,293 - 129,083,772 (+)EnsemblGRCr8
GRCr8 Ensembl525,895,968 - 25,896,654 (-)EnsemblGRCr8
mRatBN7.28120,203,561 - 120,206,176 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl521,098,535 - 21,099,211 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl8120,203,451 - 120,206,176 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8125,780,434 - 125,783,050 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,979,447 - 123,982,063 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,821,683 - 121,824,295 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08129,158,112 - 129,160,726 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8129,158,103 - 129,160,757 (+)Ensemblrn6Rnor6.0
Rnor_5.08128,356,696 - 128,359,310 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48125,499,378 - 125,501,992 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8119,345,651 - 119,348,265 (+)NCBICelera
RGSC_v3.18125,519,015 - 125,521,753 (+)NCBI
Cytogenetic Map8q32NCBI
EIF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38340,309,707 - 40,312,424 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl340,309,707 - 40,312,424 (+)Ensemblhg38GRCh38
GRCh37340,351,198 - 40,353,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36340,326,177 - 40,328,919 (+)NCBIBuild 36Build 36hg18NCBI36
Celera340,293,858 - 40,296,600 (+)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef340,395,243 - 40,397,984 (+)NCBIHuRef
CHM1_1340,301,070 - 40,303,813 (+)NCBICHM1_1
T2T-CHM13v2.0340,324,755 - 40,327,472 (+)NCBIT2T-CHM13v2.0
Eif1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,321,672 - 120,324,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9120,321,298 - 120,324,396 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389120,492,606 - 120,495,327 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,492,232 - 120,495,330 (+)Ensemblmm10GRCm38
MGSCv379120,401,724 - 120,404,445 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369120,341,339 - 120,344,025 (+)NCBIMGSCv36mm8
Celera9120,962,066 - 120,964,791 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.67NCBI
Eif1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542029,514,067 - 29,515,363 (-)Ensembl
ChiLan1.0NW_00495542029,514,067 - 29,515,362 (-)NCBIChiLan1.0ChiLan1.0
EIF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2240,268,513 - 40,271,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1340,273,274 - 40,276,215 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0340,213,113 - 40,215,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1340,484,768 - 40,487,517 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl340,484,768 - 40,487,517 (+)EnsemblpanPan2panpan1.1
EIF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1239,798,141 - 9,800,976 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl239,798,232 - 9,800,700 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha239,830,732 - 9,834,558 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02310,083,552 - 10,087,361 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2310,084,513 - 10,087,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,893,821 - 9,897,619 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02310,031,452 - 10,035,258 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02310,019,063 - 10,022,873 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eif1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118196,151,887 - 196,154,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647329,290,460 - 29,292,968 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647329,290,460 - 29,292,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,574,910 - 24,577,616 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11324,575,183 - 24,577,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,926,936 - 26,932,666 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1221,806,431 - 1,809,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl221,806,396 - 1,809,466 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041165,394,513 - 165,397,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473078,361,181 - 78,363,333 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Eif1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18111,706,228 - 111,708,925 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000025615
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
RH131770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,205,808 - 120,206,001 (+)MAPPERmRatBN7.2
Rnor_6.08129,160,359 - 129,160,551NCBIRnor6.0
Rnor_5.08128,358,943 - 128,359,135UniSTSRnor5.0
RGSC_v3.48125,501,625 - 125,501,817UniSTSRGSC3.4
Celera8119,347,898 - 119,348,090UniSTS
RH 3.4 Map81284.6UniSTS
Cytogenetic Map8q32UniSTS
AA849630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28120,205,977 - 120,206,172 (+)MAPPERmRatBN7.2
Rnor_6.08129,160,528 - 129,160,722NCBIRnor6.0
Rnor_5.08128,359,112 - 128,359,306UniSTSRnor5.0
RGSC_v3.48125,501,794 - 125,501,988UniSTSRGSC3.4
Celera8119,348,067 - 119,348,261UniSTS
RH 3.4 Map81317.6UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025615   ⟹   ENSRNOP00000025615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8129,078,384 - 129,083,458 (+)Ensembl
mRatBN7.2 Ensembl8120,203,451 - 120,205,694 (+)Ensembl
Rnor_6.0 Ensembl8129,158,103 - 129,160,757 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000049520   ⟹   ENSRNOP00000090078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl525,895,968 - 25,896,654 (-)Ensembl
mRatBN7.2 Ensembl521,098,535 - 21,099,211 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109763   ⟹   ENSRNOP00000078643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8129,078,293 - 129,083,772 (+)Ensembl
mRatBN7.2 Ensembl8120,204,439 - 120,206,176 (+)Ensembl
RefSeq Acc Id: NM_001106867   ⟹   NP_001100337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,081,158 - 129,083,772 (+)NCBI
mRatBN7.28120,203,561 - 120,206,176 (+)NCBI
Rnor_6.08129,158,112 - 129,160,726 (+)NCBI
Rnor_5.08128,356,696 - 128,359,310 (+)NCBI
RGSC_v3.48125,499,378 - 125,501,992 (+)RGD
Celera8119,345,651 - 119,348,265 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265305   ⟹   XP_063121375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88129,080,497 - 129,083,764 (+)NCBI
RefSeq Acc Id: NP_001100337   ⟸   NM_001106867
- UniProtKB: B5DFN1 (UniProtKB/TrEMBL),   A0A8I6AB39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025615   ⟸   ENSRNOT00000025615
Ensembl Acc Id: ENSRNOP00000078643   ⟸   ENSRNOT00000109763
RefSeq Acc Id: XP_063121375   ⟸   XM_063265305
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000090078   ⟸   ENSRNOT00000049520
Protein Domains
SUI1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFN1-F1-model_v2 AlphaFold B5DFN1 1-113 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696385
Promoter ID:EPDNEW_R6908
Type:multiple initiation site
Name:Eif1b_1
Description:eukaryotic translation initiation factor 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08129,158,109 - 129,158,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309241 AgrOrtholog
BioCyc Gene G2FUF-28737 BioCyc
Ensembl Genes ENSRNOG00000018848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000033979 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025615 ENTREZGENE
  ENSRNOT00000025615.9 UniProtKB/TrEMBL
  ENSRNOT00000049520.5 UniProtKB/TrEMBL
  ENSRNOT00000109763.2 UniProtKB/TrEMBL
Gene3D-CATH SUI1-like domain UniProtKB/TrEMBL
InterPro SUI1_dom_sf UniProtKB/TrEMBL
  SUI1_euk UniProtKB/TrEMBL
  TIF_SUI1 UniProtKB/TrEMBL
KEGG Report rno:301068 UniProtKB/TrEMBL
NCBI Gene 301068 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1 UniProtKB/TrEMBL
Pfam SUI1 UniProtKB/TrEMBL
PhenoGen Eif1b PhenoGen
PIRSF SUI1_euk UniProtKB/TrEMBL
PROSITE SUI1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018848 RatGTEx
  ENSRNOG00000033979 RatGTEx
Superfamily-SCOP TIF_SUI1 UniProtKB/TrEMBL
UniProt A0A8I5ZL75_RAT UniProtKB/TrEMBL
  A0A8I6AB39 ENTREZGENE, UniProtKB/TrEMBL
  B5DFN1 ENTREZGENE, UniProtKB/TrEMBL
  F7F4Q4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Eif1b  eukaryotic translation initiation factor 1B   Eif1b_predicted  eukaryotic translation initiation factor 1B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Eif1b_predicted  eukaryotic translation initiation factor 1B (predicted)  RGD1309241_predicted  similar to translation factor sui1 homolog (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309241_predicted  similar to translation factor sui1 homolog (predicted)  LOC301068_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301068_predicted  similar to translation factor sui1 homolog (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL