Tle1 (TLE family member 1, transcriptional corepressor) - Rat Genome Database

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Gene: Tle1 (TLE family member 1, transcriptional corepressor) Rattus norvegicus
Analyze
Symbol: Tle1
Name: TLE family member 1, transcriptional corepressor
RGD ID: 1309237
Description: Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362533; MGC189561; transducin like enhancer of split 1; transducin-like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 1, homolog of Drosophila E(spl); transducin-like enhancer protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8590,898,182 - 90,982,118 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl590,898,182 - 90,980,928 (-)EnsemblGRCr8
mRatBN7.2585,851,827 - 85,934,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl585,851,827 - 85,934,774 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx588,295,406 - 88,378,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0590,124,428 - 90,207,085 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0590,100,107 - 90,182,763 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0588,546,607 - 88,630,277 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl588,546,568 - 88,629,491 (-)Ensemblrn6Rnor6.0
Rnor_5.0592,618,609 - 92,701,908 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4589,682,837 - 89,765,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera584,643,237 - 84,725,613 (-)NCBICelera
RGSC_v3.1589,687,191 - 89,771,601 (-)NCBI
Cytogenetic Map5q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
geraniol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
oxycodone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8687460   PMID:9751710   PMID:10748198   PMID:12359720   PMID:12477932   PMID:15006356   PMID:15528197   PMID:15607978   PMID:16002402   PMID:16081186   PMID:17680780   PMID:22354967  
PMID:22952044   PMID:24596249   PMID:28296634   PMID:37819496  


Genomics

Comparative Map Data
Tle1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8590,898,182 - 90,982,118 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl590,898,182 - 90,980,928 (-)EnsemblGRCr8
mRatBN7.2585,851,827 - 85,934,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl585,851,827 - 85,934,774 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx588,295,406 - 88,378,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0590,124,428 - 90,207,085 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0590,100,107 - 90,182,763 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0588,546,607 - 88,630,277 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl588,546,568 - 88,629,491 (-)Ensemblrn6Rnor6.0
Rnor_5.0592,618,609 - 92,701,908 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4589,682,837 - 89,765,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera584,643,237 - 84,725,613 (-)NCBICelera
RGSC_v3.1589,687,191 - 89,771,601 (-)NCBI
Cytogenetic Map5q31NCBI
TLE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38981,583,683 - 81,689,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl981,582,313 - 81,689,681 (-)Ensemblhg38GRCh38
GRCh37984,198,598 - 84,304,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36983,388,418 - 83,493,416 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34981,428,152 - 81,533,150NCBI
Celera954,775,348 - 54,880,350 (-)NCBICelera
Cytogenetic Map9q21.32NCBI
HuRef954,030,981 - 54,134,939 (-)NCBIHuRef
CHM1_1984,345,031 - 84,450,424 (-)NCBICHM1_1
T2T-CHM13v2.0993,735,751 - 93,841,617 (-)NCBIT2T-CHM13v2.0
Tle1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39472,028,182 - 72,124,575 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl472,036,042 - 72,119,130 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38472,109,945 - 72,200,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl472,117,142 - 72,200,919 (-)Ensemblmm10GRCm38
MGSCv37471,778,176 - 71,861,953 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36471,603,503 - 71,687,218 (-)NCBIMGSCv36mm8
Celera470,703,779 - 70,787,470 (-)NCBICelera
Cytogenetic Map4C2NCBI
cM Map436.06NCBI
Tle1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555301,936,936 - 2,028,803 (+)Ensembl
ChiLan1.0NW_0049555301,936,936 - 2,028,803 (+)NCBIChiLan1.0ChiLan1.0
TLE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,742,706 - 80,849,739 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1980,748,666 - 80,855,682 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0943,150,356 - 43,258,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1980,436,260 - 80,542,033 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl980,436,260 - 80,542,033 (-)EnsemblpanPan2panpan1.1
TLE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,554,718 - 77,639,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,554,717 - 77,639,219 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha178,176,439 - 78,262,403 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0177,890,529 - 77,976,812 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,890,749 - 77,976,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,728,749 - 77,814,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,457,041 - 77,542,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0178,174,199 - 78,260,171 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tle1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947124,495,411 - 124,586,416 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366321,316,812 - 1,408,746 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366321,316,812 - 1,407,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,277,843 - 234,370,593 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11234,278,168 - 234,370,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21261,797,390 - 261,897,695 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11292,455,067 - 92,560,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1292,454,623 - 92,560,207 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603880,851,536 - 80,957,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tle1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248119,287,088 - 9,381,660 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248119,287,088 - 9,382,522 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tle1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1181,195,305 - 81,276,066 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tle1
679 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:46
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000058906
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
D5Rat85  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8590,969,013 - 90,969,256 (+)Marker Load Pipeline
mRatBN7.2585,922,661 - 85,922,904 (+)MAPPERmRatBN7.2
Rnor_6.0588,617,577 - 88,617,819NCBIRnor6.0
Rnor_5.0592,689,230 - 92,689,472UniSTSRnor5.0
RGSC_v3.4589,753,829 - 89,754,072RGDRGSC3.4
RGSC_v3.4589,753,830 - 89,754,072UniSTSRGSC3.4
Celera584,713,703 - 84,713,945UniSTS
RGSC_v3.1589,758,943 - 89,759,185RGD
RH 3.4 Map5665.2RGD
RH 3.4 Map5665.2UniSTS
RH 2.0 Map5526.8RGD
SHRSP x BN Map547.9899RGD
FHH x ACI Map544.62RGD
Cytogenetic Map5q31UniSTS
D5Got125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2585,928,189 - 85,928,350 (+)MAPPERmRatBN7.2
Rnor_6.0588,623,105 - 88,623,265NCBIRnor6.0
Rnor_5.0592,694,758 - 92,694,918UniSTSRnor5.0
RGSC_v3.4589,759,357 - 89,759,518RGDRGSC3.4
RGSC_v3.4589,759,358 - 89,759,518UniSTSRGSC3.4
Celera584,719,231 - 84,719,387UniSTS
RGSC_v3.1589,764,471 - 89,764,631RGD
RH 3.4 Map5666.7UniSTS
RH 3.4 Map5666.7RGD
RH 2.0 Map5524.2RGD
Cytogenetic Map5q31UniSTS
WI-12646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2585,852,249 - 85,852,352 (+)MAPPERmRatBN7.2
Rnor_6.0588,547,030 - 88,547,132NCBIRnor6.0
Rnor_5.0592,619,032 - 92,619,134UniSTSRnor5.0
RGSC_v3.4589,683,260 - 89,683,362UniSTSRGSC3.4
Celera584,643,660 - 84,643,762UniSTS
Cytogenetic Map5q31UniSTS
RH141090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2585,851,977 - 85,852,168 (+)MAPPERmRatBN7.2
Rnor_6.0588,546,758 - 88,546,948NCBIRnor6.0
Rnor_5.0592,618,760 - 92,618,950UniSTSRnor5.0
RGSC_v3.4589,682,988 - 89,683,178UniSTSRGSC3.4
Celera584,643,388 - 84,643,578UniSTS
RH 3.4 Map5658.6UniSTS
Cytogenetic Map5q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 77 59 6 341 177 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001173433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC169119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000058906   ⟹   ENSRNOP00000055692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,576 (-)Ensembl
Rnor_6.0 Ensembl588,546,607 - 88,629,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089560   ⟹   ENSRNOP00000072474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,963,870 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,917,518 (-)Ensembl
Rnor_6.0 Ensembl588,546,568 - 88,612,626 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098507   ⟹   ENSRNOP00000095904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,774 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102954   ⟹   ENSRNOP00000097506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113741   ⟹   ENSRNOP00000083802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116062   ⟹   ENSRNOP00000088662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120232   ⟹   ENSRNOP00000089507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl590,898,182 - 90,980,928 (-)Ensembl
mRatBN7.2 Ensembl585,851,827 - 85,934,576 (-)Ensembl
RefSeq Acc Id: NM_001173433   ⟹   NP_001166904
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,980,928 (-)NCBI
mRatBN7.2585,851,827 - 85,934,576 (-)NCBI
Rnor_6.0588,546,607 - 88,629,491 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Celera584,643,237 - 84,725,613 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238281   ⟹   XP_006238343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,277 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238283   ⟹   XP_006238345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238284   ⟹   XP_006238346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,277 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238286   ⟹   XP_006238348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238287   ⟹   XP_006238349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,275 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238288   ⟹   XP_006238350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238289   ⟹   XP_006238351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,978,737 (-)NCBI
mRatBN7.2585,851,827 - 85,932,385 (-)NCBI
Rnor_6.0588,546,607 - 88,627,250 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238293   ⟹   XP_006238355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Rnor_5.0592,618,609 - 92,701,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763786   ⟹   XP_008762008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,628,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763792   ⟹   XP_008762014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,963,721 (-)NCBI
mRatBN7.2585,851,827 - 85,917,376 (-)NCBI
Rnor_6.0588,546,607 - 88,612,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593476   ⟹   XP_017448965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593478   ⟹   XP_017448967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
Rnor_6.0588,546,607 - 88,630,276 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110257   ⟹   XP_038966185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8590,898,182 - 90,982,118 (-)NCBI
mRatBN7.2585,851,827 - 85,934,806 (-)NCBI
RefSeq Acc Id: NP_001166904   ⟸   NM_001173433
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238355   ⟸   XM_006238293
- Peptide Label: isoform X13
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238350   ⟸   XM_006238288
- Peptide Label: isoform X8
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238346   ⟸   XM_006238284
- Peptide Label: isoform X4
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238349   ⟸   XM_006238287
- Peptide Label: isoform X7
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238345   ⟸   XM_006238283
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AT29 (UniProtKB/TrEMBL),   D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238348   ⟸   XM_006238286
- Peptide Label: isoform X6
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238343   ⟸   XM_006238281
- Peptide Label: isoform X1
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238351   ⟸   XM_006238289
- Peptide Label: isoform X9
- UniProtKB: A0A0G2K324 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762008   ⟸   XM_008763786
- Peptide Label: isoform X2
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762014   ⟸   XM_008763792
- Peptide Label: isoform X11
- UniProtKB: A0A0G2K324 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448967   ⟸   XM_017593478
- Peptide Label: isoform X12
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448965   ⟸   XM_017593476
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A8I5 (UniProtKB/TrEMBL),   D3ZCM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072474   ⟸   ENSRNOT00000089560
Ensembl Acc Id: ENSRNOP00000055692   ⟸   ENSRNOT00000058906
RefSeq Acc Id: XP_038966185   ⟸   XM_039110257
- Peptide Label: isoform X10
- UniProtKB: D3ZCM7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095904   ⟸   ENSRNOT00000098507
Ensembl Acc Id: ENSRNOP00000088662   ⟸   ENSRNOT00000116062
Ensembl Acc Id: ENSRNOP00000097506   ⟸   ENSRNOT00000102954
Ensembl Acc Id: ENSRNOP00000083802   ⟸   ENSRNOT00000113741
Ensembl Acc Id: ENSRNOP00000089507   ⟸   ENSRNOT00000120232
Protein Domains
Groucho/TLE N-terminal Q-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCM7-F1-model_v2 AlphaFold D3ZCM7 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309237 AgrOrtholog
BioCyc Gene G2FUF-40983 BioCyc
Ensembl Genes ENSRNOG00000005882 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058906 ENTREZGENE
  ENSRNOT00000058906.5 UniProtKB/TrEMBL
  ENSRNOT00000089560 ENTREZGENE
  ENSRNOT00000089560.3 UniProtKB/TrEMBL
  ENSRNOT00000098507 ENTREZGENE
  ENSRNOT00000098507.2 UniProtKB/TrEMBL
  ENSRNOT00000102954 ENTREZGENE
  ENSRNOT00000102954.2 UniProtKB/TrEMBL
  ENSRNOT00000113741.2 UniProtKB/TrEMBL
  ENSRNOT00000116062 ENTREZGENE
  ENSRNOT00000116062.2 UniProtKB/TrEMBL
  ENSRNOT00000120232.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Groucho/TLE_N UniProtKB/TrEMBL
  Groucho_enhance UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 362533 ENTREZGENE
PANTHER PTHR10814 UniProtKB/TrEMBL
  TRANSDUCIN-LIKE ENHANCER PROTEIN 1 UniProtKB/TrEMBL
Pfam TLE_N UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Tle1 PhenoGen
PRINTS GROUCHOFAMLY UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005882 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K324 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWP5_RAT UniProtKB/TrEMBL
  A0A8I6A8I5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKS1_RAT UniProtKB/TrEMBL
  A0A8I6AT29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI60_RAT UniProtKB/TrEMBL
  B5DFM6_RAT UniProtKB/TrEMBL
  D3ZCM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Tle1  TLE family member 1, transcriptional corepressor  Tle1  transducin like enhancer of split 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Tle1  transducin like enhancer of split 1  Tle1  transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Tle1  transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)  Tle1  transducin-like enhancer of split 1, homolog of Drosophila E(spl)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tle1  transducin-like enhancer of split 1, homolog of Drosophila E(spl)   Tle1_predicted  transducin-like enhancer of split 1, homolog of Drosophila E(spl) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tle1_predicted  transducin-like enhancer of split 1, homolog of Drosophila E(spl) (predicted)      Symbol and Name status set to approved 70820 APPROVED