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Gene: Cdt1 (chromatin licensing and DNA replication factor 1) Rattus norvegicus

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Symbol:

Cdt1

Name:

chromatin licensing and DNA replication factor 1

RGD ID:

1309211

Description:

Predicted to enable DNA binding activity; DNA polymerase binding activity; and chromatin binding activity. Predicted to be involved in several processes, including DNA replication checkpoint signaling; attachment of mitotic spindle microtubules to kinetochore; and regulation of DNA-templated DNA replication. Predicted to act upstream of or within regulation of nuclear cell cycle DNA replication. Predicted to be located in kinetochore. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA replication factor Cdt1; LOC292071; retroviral integration site 2; Ris2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	67,529,249 - 67,534,195 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	67,529,201 - 67,534,194 (+)	Ensembl				GRCr8
mRatBN7.2	19	50,620,713 - 50,625,659 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	50,620,713 - 50,625,659 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,415,480 - 57,420,429 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,095,635 - 58,100,581 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	60,314,104 - 60,319,053 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	55,381,565 - 55,386,511 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	55,381,565 - 55,386,511 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	66,090,081 - 66,095,027 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	52,848,559 - 52,853,880 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	49,860,119 - 49,865,065 (+)	NCBI		Celera
RGSC_v3.1	19	52,852,915 - 52,858,234 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenine phosphoribosyltransferase deficiency (ISO)

Desbuquois dysplasia (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Meier-Gorlin syndrome (ISO)

Meier-Gorlin syndrome 4 (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-diaminotoluene (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP,ISO)

androstane-3,17-dione (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

bromobenzene (EXP)

C60 fullerene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

deguelin (ISO)

diazinon (EXP)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

glycidol (EXP)

GSK-J4 (ISO)

Lasiocarpine (ISO)

lidocaine (EXP)

menadione (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

nickel sulfate (ISO)

nitrofen (EXP)

nocodazole (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pevonedistat (ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phytoestrogen (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

simvastatin (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tebufenpyrad (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

troglitazone (ISO)

valproic acid (ISO)

vancomycin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (IEA,ISO)

DNA replication (IEA)

DNA replication checkpoint signaling (IBA,IEA,ISO)

DNA replication preinitiation complex assembly (IEA)

mitotic cell cycle (IBA)

mitotic DNA replication initiation (IEA,ISO)

mitotic pre-replicative complex assembly (IEA,ISO)

negative regulation of cell cycle (IEA,ISO)

negative regulation of DNA-templated DNA replication (IEA,ISO)

positive regulation of DNA replication (IEA,ISO)

regulation of DNA-templated DNA replication initiation (IBA,IEA,ISO)

regulation of nuclear cell cycle DNA replication (ISO)

response to sorbitol (IEA,ISO)

Cellular Component

kinetochore (IEA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

chromatin binding (IEA,ISO)

DNA binding (IBA,IEA,ISO)

DNA polymerase binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11125146	PMID:11850834	PMID:12192004	PMID:14672932	PMID:14993212	PMID:21856198	PMID:22581055	PMID:24217620	PMID:26842564

Genomics

Comparative Map Data

Cdt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	67,529,249 - 67,534,195 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	67,529,201 - 67,534,194 (+)	Ensembl				GRCr8
mRatBN7.2	19	50,620,713 - 50,625,659 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	50,620,713 - 50,625,659 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	57,415,480 - 57,420,429 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,095,635 - 58,100,581 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	60,314,104 - 60,319,053 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	55,381,565 - 55,386,511 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	55,381,565 - 55,386,511 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	66,090,081 - 66,095,027 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	52,848,559 - 52,853,880 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	49,860,119 - 49,865,065 (+)	NCBI		Celera
RGSC_v3.1	19	52,852,915 - 52,858,234 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

CDT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	88,803,789 - 88,809,258 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	88,803,789 - 88,809,258 (+)	Ensembl			hg38	GRCh38
GRCh37	16	88,870,197 - 88,875,666 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	87,397,687 - 87,403,167 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	16	73,938,823 - 73,944,303 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	74,567,412 - 74,572,892 (+)	NCBI		HuRef
CHM1_1	16	90,281,453 - 90,286,933 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	94,874,309 - 94,879,778 (+)	NCBI		T2T-CHM13v2.0

Cdt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	123,294,754 - 123,299,869 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	123,294,754 - 123,300,293 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	122,568,015 - 122,573,130 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	122,568,015 - 122,573,554 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	125,091,915 - 125,097,030 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	125,454,105 - 125,459,220 (+)	NCBI		MGSCv36	mm8
Celera	8	126,797,613 - 126,802,728 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	71.91	NCBI

Cdt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,683,408 - 2,687,102 (+)	Ensembl
ChiLan1.0	NW_004955541	2,683,030 - 2,687,883 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	98,576,543 - 98,582,287 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	104,488,752 - 104,494,459 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	69,516,728 - 69,522,419 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	89,173,312 - 89,178,809 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	89,174,071 - 89,177,823 (+)	Ensembl			panPan2	panpan1.1

CDT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	64,566,035 - 64,570,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	64,566,043 - 64,570,748 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	64,577,507 - 64,581,789 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	64,786,263 - 64,790,545 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	64,786,266 - 64,790,971 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	64,812,442 - 64,816,851 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	64,643,948 - 64,648,365 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	65,049,993 - 65,054,410 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cdt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,163,147 - 25,172,972 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	917,435 - 920,981 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	916,695 - 925,411 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	893,381 - 897,934 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	893,377 - 897,706 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	1,083,762 - 1,089,922 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	74,190,409 - 74,196,589 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	74,190,947 - 74,195,972 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	1,482,389 - 1,488,114 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	809,252 - 812,993 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	808,463 - 813,464 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cdt1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	42,198,039 - 42,202,842 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	56
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000018923
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	61249161	74246245	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC134009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018923 ⟹ ENSRNOP00000018923

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	67,529,201 - 67,534,194 (+)	Ensembl
mRatBN7.2 Ensembl	19	50,620,713 - 50,625,659 (+)	Ensembl
Rnor_6.0 Ensembl	19	55,381,565 - 55,386,511 (+)	Ensembl

RefSeq Acc Id:

NM_001106192 ⟹ NP_001099662

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	67,529,249 - 67,534,195 (+)	NCBI
mRatBN7.2	19	50,620,713 - 50,625,659 (+)	NCBI
Rnor_6.0	19	55,381,565 - 55,386,511 (+)	NCBI
Rnor_5.0	19	66,090,081 - 66,095,027 (+)	NCBI
RGSC_v3.4	19	52,848,559 - 52,853,880 (+)	RGD
Celera	19	49,860,119 - 49,865,065 (+)	RGD

Sequence:

show sequence

GAAAATTGCGCGAAATCCGCGGGAAGTAGCTTTTTGGCGCCATGGCGCAGAGTCGTGTTACCGA
TTTCTATGCGTGCCGTCGTCCGGGCCTTGCGATTCCGCGAGCCAAGTCGACCTGTCTCACCCCG
AGCCCTGGTGGGCTCGTGGCTCCTGAGTTCACCCGGAGCAGCAGCCGCAAGCGCGTCCGGCCCC
ACGCCGAACCCGGGAGCGACCAGCCCGCGCCGCCCGCGCGCCGGAGGCTACGGCTACCTGGATT
GGATTCTTGTCCCAGTTTCCCAGCTGACCCCAGCTCTCCAGCTGACCCCAGCTCCCCAGCTGAC
CCCAGCTCCTCCGTTTGCCCATCCCCCGTCTGCCCATCCCCCGTCAAGAGAACAAAGAGTACTA
CAGTTTCTAGAGGTCCACAGCAGAGCAAGGTCCCCTCCCAGGACTCCATCTCCGAGCTCCAGTC
CTGCCTGAGGCAGGCACGTAAGTTGGGAGCCCAGGCAAGGGCCCTGAGAGCGAGAGTCCAAGAG
AATGTTGTGGAGCCTTCTACCCCAGATACCAAGGAGCCCACAGAACAACCATGTGTCGACAAAG
CTCCTGCCTACCAGCGCTTCCATGCCCTGGCCCAGCCTGGCCTCCCCGGCCTTGTCCTACCATA
CAAGTATCAGGTGCTGGCCGAGATGTTCCGCAGCATGGACACCATCGTGAGCATGCTTCACAAC
CGCTCTGAGACCGTCACCTTTGCTAAAGTCAAGCAAGGGGTTCAGGAGATGATACGCAAGCGCT
TTGAAGAGCGCAATATGGGCCAGATCAAAACCGTGTACCCCGAGTCGTATTCCTTCCGCCAGGA
GTGCAACGTCCCCACTTTCAAGGACAGCATCAAGAGATCTGATTACCAGCTCACCATCGAGCCC
TTGCTGGGCCAGGAGGCTGGTGGTGCCACCCAGCTCACAGCCACGGGTCTCCTGCAGCGCCGGC
AAGTCTTCCGGCAGAACCTGGTGGAACGTGTTAAGGAGCATCACAAGGTTTTCCTGGCGTCCTT
AAACCCCCCCATGACGGTGCCCGAAGACCAGCTGACACGCTGGCACCCGCGTTTCAATGTGGAT
GAGGTGCCTGATATTGAGCCGGCCGAACTGCCCCAGCCTCCCGTGACAGAGAAGCTCACTACTG
CCCAGGAAGTGTTGGCCCGTGCCCGGAACTTGATGACGCCCAAGATGGAGAAGGCGTTGAGTAA
CCTGGCCCTGCGCTCAGCTGAGCCTGGTAGCCCTGGGACCTCTAGTCCAGCCCTCCCAGCCACT
CCACCAGCCACCCCGCCCGCTGCCTCTCCTAGTGCCCTGAAGGGTGTGTCACAAGCACTGCTGG
AGCGGATAAGAGCCAAGGAGGTCCAGAAGCAGTTGGCACGGATGACAAGGTGCCCTGAGAAGGA
GCTTCGGCTGCAGCGGTTAGAACGTTTGCCAGAGCTGGCCCGTGTGCTGCGCGGTGTCTTCGTG
TCTGAGCGGAAGCCGGCGCTCACCATGGAAGTGGTCTGTGCAAGGATGGTAGACAGTTCCCGAG
CCGCCCTGAGCCCAGGGGAGATGGAGAAACACCTGTTGCTCCTGGCCGAGTTGCTGCCAGACTG
GCTCAGCCTGCACCGCGTTCGCACCGATACCTACGTCAAGCTGGACAAAGCCGCTGACCTGGCT
GGCCTCACCGCGAAGCTGGCCCGCCAGGTCCACGCCGAGGGGCTGTGACTTTGAATTCCTTGCC
TGATGGCCTGTTTTCTTTCATCGGTAGACAACGCACTTAAGCTTCCCTGTCTGCATCACGGGTC
CAAGGAGGGCCTGTCGCCCAGTATGGGCGGCTACGGTGCCCATGGATCTCAAAGTGCTGTTGTT
GCAGGGGTTCCTGGGGCCTTGGGGTACCCCAGACTCAGCTATAGGGGACGTAGACTCTGGAGAG
TAGGGAATGTTGAATGCCCTTTCCACAAACTGCTCAAGTACTCATCAAGGGCCAGGTGGAAGGT
GAGGCCAGCATAGCCTCGGCTCTCCGGGCTTGGGAAAGCTGCGAGAGCTCGGAGCCTTAAGAGT
TGCACAGAACTTGGACCTCTGGCCTGATTTCGCAGGACGGTGGTGATCTGAGAGTGAAGTTGGA
CCTTCTGTAAACATGTGGAGTTTGGTTTCTTTTTAAACCTTCTATACTTACACGGCCCTGCATG
TGACTGCTAGTTTTGGCTTTTTAATAAAGTCATGTAAGATTTAAATAAAATACTACTGAGATT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099662	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL92755	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018923
	ENSRNOP00000018923.4

RefSeq Acc Id:

NP_001099662 ⟸ NM_001106192

- UniProtKB:

D3ZKD4 (UniProtKB/TrEMBL), A6IZS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQSRVTDFYACRRPGLAIPRAKSTCLTPSPGGLVAPEFTRSSSRKRVRPHAEPGSDQPAPPAR
RRLRLPGLDSCPSFPADPSSPADPSSPADPSSSVCPSPVCPSPVKRTKSTTVSRGPQQSKVPSQ
DSISELQSCLRQARKLGAQARALRARVQENVVEPSTPDTKEPTEQPCVDKAPAYQRFHALAQPG
LPGLVLPYKYQVLAEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMIRKRFEERNMGQIKTVYP
ESYSFRQECNVPTFKDSIKRSDYQLTIEPLLGQEAGGATQLTATGLLQRRQVFRQNLVERVKEH
HKVFLASLNPPMTVPEDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARARNLMTP
KMEKALSNLALRSAEPGSPGTSSPALPATPPATPPAASPSALKGVSQALLERIRAKEVQKQLAR
MTRCPEKELRLQRLERLPELARVLRGVFVSERKPALTMEVVCARMVDSSRAALSPGEMEKHLLL
LAELLPDWLSLHRVRTDTYVKLDKAADLAGLTAKLARQVHAEGL

hide sequence

Ensembl Acc Id:

ENSRNOP00000018923 ⟸ ENSRNOT00000018923

Protein Domains

CDT1 Geminin-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKD4-F1-model_v2	AlphaFold	D3ZKD4	1-556	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701211

Promoter ID:

EPDNEW_R11734

Type:

single initiation site

Name:

Cdt1_1

Description:

chromatin licensing and DNA replication factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	55,381,593 - 55,381,653	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309211	AgrOrtholog
BioCyc Gene	G2FUF-5382	BioCyc
Ensembl Genes	ENSRNOG00000013970	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018923	ENTREZGENE
	ENSRNOT00000018923.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.1420	UniProtKB/TrEMBL
InterPro	Cdt1	UniProtKB/TrEMBL
	Cdt1_C	UniProtKB/TrEMBL
	Cdt1_C_WH_dom_sf	UniProtKB/TrEMBL
	DNA_replication_fac_CDT1-like	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:292071	UniProtKB/TrEMBL
NCBI Gene	292071	ENTREZGENE
PANTHER	DNA REPLICATION FACTOR CDT1	UniProtKB/TrEMBL
	PTHR28637	UniProtKB/TrEMBL
Pfam	CDT1	UniProtKB/TrEMBL
	CDT1_C	UniProtKB/TrEMBL
PhenoGen	Cdt1	PhenoGen
RatGTEx	ENSRNOG00000013970	RatGTEx
SMART	CDT1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A6IZS7	ENTREZGENE, UniProtKB/TrEMBL
	D3ZKD4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Cdt1	chromatin licensing and DNA replication factor 1	Ris2_predicted	retroviral integration site 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Ris2_predicted	retroviral integration site 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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