Nfatc3 (nuclear factor of activated T-cells 3) - Rat Genome Database

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Gene: Nfatc3 (nuclear factor of activated T-cells 3) Rattus norvegicus
Analyze
Symbol: Nfatc3
Name: nuclear factor of activated T-cells 3
RGD ID: 1308692
Description: Enables transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of transcription by RNA polymerase II; and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human NFATC3 (nuclear factor of activated T cells 3); PARTICIPATES IN endothelin signaling pathway; calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; INTERACTS WITH 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361400; NFAT4; NFATx; nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,870,464 - 50,944,992 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,870,489 - 50,944,992 (+)EnsemblGRCr8
mRatBN7.21933,960,643 - 34,035,150 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,776,399 - 40,850,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,429,711 - 41,504,000 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,728,856 - 43,803,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,039,542 - 38,114,003 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,039,564 - 38,114,003 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,906,285 - 48,980,756 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,907,800 - 35,982,095 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,388,369 - 33,462,475 (+)NCBICelera
RGSC_v3.11935,912,754 - 35,984,893 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BQ 123  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
ethylbenzene  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
harmine  (ISO)
heparin  (EXP)
hydrogen peroxide  (EXP)
ionomycin  (EXP,ISO)
lithium chloride  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
Mitoquinone  (EXP)
N-acetyl-L-cysteine  (ISO)
Nonylphenol  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
platycodin D  (EXP)
rimonabant  (ISO)
SCH 23390  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
transcription regulator complex  (IBA)

References

References - curated
# Reference Title Reference Citation
1. CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation. Chao CN, etal., J Cell Physiol. 2019 Nov;234(11):20128-20138. doi: 10.1002/jcp.28614. Epub 2019 Apr 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4. Goruppi S and Kyriakis JM, J Biol Chem. 2004 May 14;279(20):20950-8. Epub 2004 Mar 11.
4. Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Grebe C, etal., Cardiovasc Res. 2011 Jun 1;90(3):521-8. doi: 10.1093/cvr/cvr023. Epub 2011 Jan 27.
5. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Jayanthi S, etal., Proc Natl Acad Sci U S A 2005 Jan 18;102(3):868-73. Epub 2005 Jan 11.
6. Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. Manukyan I, etal., J Cell Mol Med. 2010 Jun;14(6B):1707-16. doi: 10.1111/j.1582-4934.2009.00804.x. Epub 2009 Jun 16.
7. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:7650004   PMID:9017603   PMID:9768749   PMID:10755616   PMID:11254352   PMID:11439183   PMID:12091710   PMID:12370307   PMID:12671993   PMID:12750314   PMID:14517551   PMID:15173172  
PMID:15322114   PMID:15537643   PMID:15826947   PMID:16260608   PMID:16998587   PMID:17229811   PMID:17403661   PMID:17430895   PMID:17881610   PMID:18398669   PMID:18676376   PMID:18815128  
PMID:18978355   PMID:19179536   PMID:19443652   PMID:19574461   PMID:20177053   PMID:20530871   PMID:21514407   PMID:22977251   PMID:23206701   PMID:23219532   PMID:23255067   PMID:23289723  
PMID:23543060   PMID:23853098   PMID:24291639   PMID:24301466   PMID:24389074   PMID:24392954   PMID:24853029   PMID:25231981   PMID:28402855   PMID:28992110   PMID:30299584   PMID:30318928  
PMID:31091162   PMID:33495839   PMID:34845564   PMID:36373478   PMID:36825443   PMID:38242872  


Genomics

Comparative Map Data
Nfatc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,870,464 - 50,944,992 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,870,489 - 50,944,992 (+)EnsemblGRCr8
mRatBN7.21933,960,643 - 34,035,150 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,776,399 - 40,850,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,429,711 - 41,504,000 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,728,856 - 43,803,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,039,542 - 38,114,003 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,039,564 - 38,114,003 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,906,285 - 48,980,756 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,907,800 - 35,982,095 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,388,369 - 33,462,475 (+)NCBICelera
RGSC_v3.11935,912,754 - 35,984,893 (+)NCBI
Cytogenetic Map19q12NCBI
NFATC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,085,370 - 68,229,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,084,751 - 68,229,259 (+)Ensemblhg38GRCh38
GRCh371668,119,273 - 68,263,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,676,876 - 66,818,338 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1652,627,801 - 52,769,327 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,992,420 - 54,136,266 (+)NCBIHuRef
CHM1_11669,527,224 - 69,671,199 (+)NCBICHM1_1
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBIT2T-CHM13v2.0
Nfatc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,785,450 - 106,857,169 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,785,472 - 106,857,169 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388106,058,818 - 106,130,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,058,840 - 106,130,537 (+)Ensemblmm10GRCm38
MGSCv378108,583,503 - 108,654,437 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368108,949,013 - 109,017,574 (+)NCBIMGSCv36mm8
Celera8110,287,705 - 110,358,321 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.08NCBI
Nfatc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,436,330 - 8,526,680 (-)Ensembl
ChiLan1.0NW_0049554848,433,765 - 8,558,005 (-)NCBIChiLan1.0ChiLan1.0
NFATC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,626,490 - 77,774,335 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,537,771 - 83,685,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,456,144 - 48,603,306 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,850,860 - 67,998,381 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,888,806 - 67,996,274 (+)EnsemblpanPan2panpan1.1
NFATC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,294,656 - 81,434,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,296,214 - 81,434,250 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha581,284,804 - 81,424,209 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0581,729,667 - 81,869,214 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,729,671 - 81,869,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,556,378 - 81,695,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,238,820 - 81,378,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,880,342 - 82,019,645 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfatc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,031,813 - 41,126,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,462,298 - 18,555,220 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,462,424 - 18,557,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,666,549 - 28,806,419 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,836,379 - 25,876,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,193,139 - 59,346,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604721,929,743 - 22,082,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,210,401 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfatc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11725,804,233 - 25,870,045 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nfatc3
327 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1180
Count of miRNA genes:342
Interacting mature miRNAs:453
Transcripts:ENSRNOT00000025402
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
D8Ertd281e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,034,784 - 34,035,033 (+)MAPPERmRatBN7.2
Rnor_6.01938,113,638 - 38,113,886NCBIRnor6.0
Rnor_5.01948,980,391 - 48,980,639UniSTSRnor5.0
RGSC_v3.41935,981,730 - 35,981,978UniSTSRGSC3.4
Celera1933,462,110 - 33,462,358UniSTS
Cytogenetic Map19q12UniSTS
RH144691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,974,679 - 33,974,832 (+)MAPPERmRatBN7.2
Rnor_6.01938,053,553 - 38,053,705NCBIRnor6.0
Rnor_5.01948,920,298 - 48,920,450UniSTSRnor5.0
RGSC_v3.41935,921,624 - 35,921,776UniSTSRGSC3.4
Celera1933,402,194 - 33,402,346UniSTS
RH 3.4 Map19293.7UniSTS
Cytogenetic Map19q12UniSTS
BI280983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,035,090 - 34,035,243 (+)MAPPERmRatBN7.2
Rnor_6.01938,113,944 - 38,114,096NCBIRnor6.0
Rnor_5.01948,980,697 - 48,980,849UniSTSRnor5.0
RGSC_v3.41935,982,036 - 35,982,188UniSTSRGSC3.4
Celera1933,462,416 - 33,462,568UniSTS
RH 3.4 Map19293.9UniSTS
Cytogenetic Map19q12UniSTS
AA850397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,034,746 - 34,034,984 (+)MAPPERmRatBN7.2
Rnor_6.01938,113,600 - 38,113,837NCBIRnor6.0
Rnor_5.01948,980,353 - 48,980,590UniSTSRnor5.0
RGSC_v3.41935,981,692 - 35,981,929UniSTSRGSC3.4
Celera1933,462,072 - 33,462,309UniSTS
RH 3.4 Map19294.8UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000087491   ⟹   ENSRNOP00000068890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,942,758 (+)Ensembl
mRatBN7.2 Ensembl1933,960,852 - 34,033,226 (+)Ensembl
Rnor_6.0 Ensembl1938,039,564 - 38,111,659 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089783   ⟹   ENSRNOP00000069756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,698 - 50,944,992 (+)Ensembl
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)Ensembl
Rnor_6.0 Ensembl1938,039,729 - 38,114,003 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105048   ⟹   ENSRNOP00000090103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,942,713 (+)Ensembl
mRatBN7.2 Ensembl1933,960,852 - 34,033,226 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133806   ⟹   ENSRNOP00000104832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,941,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143669   ⟹   ENSRNOP00000106663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,925,559 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163378   ⟹   ENSRNOP00000112345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,925,216 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168212   ⟹   ENSRNOP00000102155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,870,489 - 50,943,450 (+)Ensembl
RefSeq Acc Id: NM_001108447   ⟹   NP_001101917
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,698 - 50,944,992 (+)NCBI
mRatBN7.21933,960,852 - 34,035,150 (+)NCBI
Rnor_6.01938,039,729 - 38,114,003 (+)NCBI
Rnor_5.01948,906,285 - 48,980,756 (+)NCBI
RGSC_v3.41935,907,800 - 35,982,095 (+)RGD
Celera1933,388,369 - 33,462,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097850   ⟹   XP_038953778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,941,222 (+)NCBI
mRatBN7.21933,960,645 - 34,031,360 (+)NCBI
RefSeq Acc Id: XM_039097855   ⟹   XP_038953783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,921,490 (+)NCBI
mRatBN7.21933,960,646 - 34,011,652 (+)NCBI
RefSeq Acc Id: XM_063278127   ⟹   XP_063134197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,944,987 (+)NCBI
RefSeq Acc Id: XM_063278128   ⟹   XP_063134198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,944,987 (+)NCBI
RefSeq Acc Id: XM_063278129   ⟹   XP_063134199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,944,987 (+)NCBI
RefSeq Acc Id: XM_063278130   ⟹   XP_063134200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,941,222 (+)NCBI
RefSeq Acc Id: XM_063278131   ⟹   XP_063134201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,944,987 (+)NCBI
RefSeq Acc Id: XM_063278132   ⟹   XP_063134202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,944,987 (+)NCBI
RefSeq Acc Id: XM_063278133   ⟹   XP_063134203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,942,104 (+)NCBI
RefSeq Acc Id: XM_063278134   ⟹   XP_063134204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,942,463 (+)NCBI
RefSeq Acc Id: XM_063278135   ⟹   XP_063134205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,464 - 50,942,404 (+)NCBI
RefSeq Acc Id: XM_063278136   ⟹   XP_063134206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,870,489 - 50,944,987 (+)NCBI
RefSeq Acc Id: NP_001101917   ⟸   NM_001108447
- UniProtKB: D3ZU59 (UniProtKB/TrEMBL),   A6IYV7 (UniProtKB/TrEMBL),   A0A8I6AB55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068890   ⟸   ENSRNOT00000087491
Ensembl Acc Id: ENSRNOP00000069756   ⟸   ENSRNOT00000089783
RefSeq Acc Id: XP_038953778   ⟸   XM_039097850
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953783   ⟸   XM_039097855
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000090103   ⟸   ENSRNOT00000105048
RefSeq Acc Id: XP_063134197   ⟸   XM_063278127
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134199   ⟸   XM_063278129
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134201   ⟸   XM_063278131
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134198   ⟸   XM_063278128
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134202   ⟸   XM_063278132
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063134204   ⟸   XM_063278134
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134205   ⟸   XM_063278135
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134203   ⟸   XM_063278133
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134200   ⟸   XM_063278130
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134206   ⟸   XM_063278136
- Peptide Label: isoform X10
Ensembl Acc Id: ENSRNOP00000106663   ⟸   ENSRNOT00000143669
Ensembl Acc Id: ENSRNOP00000102155   ⟸   ENSRNOT00000168212
Ensembl Acc Id: ENSRNOP00000112345   ⟸   ENSRNOT00000163378
Ensembl Acc Id: ENSRNOP00000104832   ⟸   ENSRNOT00000133806
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTY4-F1-model_v2 AlphaFold A0A0G2JTY4 1-1076 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701111
Promoter ID:EPDNEW_R11625
Type:multiple initiation site
Name:Nfatc3_2
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11626  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,039,512 - 38,039,572EPDNEW
RGD ID:13701104
Promoter ID:EPDNEW_R11626
Type:multiple initiation site
Name:Nfatc3_1
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11625  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,039,706 - 38,039,766EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308692 AgrOrtholog
BioCyc Gene G2FUF-5791 BioCyc
Ensembl Genes ENSRNOG00000054264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087491 ENTREZGENE
  ENSRNOT00000087491.2 UniProtKB/Swiss-Prot
  ENSRNOT00000089783 ENTREZGENE
  ENSRNOT00000105048 ENTREZGENE
  ENSRNOT00000133806 ENTREZGENE
  ENSRNOT00000168212 ENTREZGENE
Gene3D-CATH Immunoglobulins UniProtKB/Swiss-Prot
  Rel homology domain (RHD), DNA-binding domain UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  IPT_dom UniProtKB/Swiss-Prot
  NFAT UniProtKB/Swiss-Prot
  p53-like_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 361400 ENTREZGENE
PANTHER NFAT UniProtKB/Swiss-Prot
  NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3 UniProtKB/Swiss-Prot
Pfam RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind UniProtKB/Swiss-Prot
PhenoGen Nfatc3 PhenoGen
PRINTS NUCFACTORATC UniProtKB/Swiss-Prot
PROSITE REL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054264 RatGTEx
SMART IPT UniProtKB/Swiss-Prot
Superfamily-SCOP E set domains UniProtKB/Swiss-Prot
  p53-like transcription factors UniProtKB/Swiss-Prot
UniProt A0A0G2JTY4 ENTREZGENE
  A0A8I6AB55 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8J9_RAT UniProtKB/TrEMBL
  A0ABK0LGV6_RAT UniProtKB/TrEMBL
  A0ABK0LMT3_RAT UniProtKB/TrEMBL
  A0ABK0M4M2_RAT UniProtKB/TrEMBL
  A6IYV6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYV7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU59 ENTREZGENE, UniProtKB/TrEMBL
  NFAC3_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nfatc3  nuclear factor of activated T-cells 3  Nfatc3  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfatc3  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3   Nfatc3_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfatc3_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED