Map10 (microtubule-associated protein 10) - Rat Genome Database

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Gene: Map10 (microtubule-associated protein 10) Rattus norvegicus
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Symbol: Map10
Name: microtubule-associated protein 10
RGD ID: 1308644
Description: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Predicted to be located in spindle pole. Predicted to be active in microtubule cytoskeleton and midbody. Orthologous to human MAP10 (microtubule associated protein 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307948; microtubule regulator of 120 KDa; RGD1308644; similar to Hypothetical protein KIAA1383; uncharacterized protein KIAA1383 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,539,482 - 70,542,274 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,534,286 - 70,543,410 (+)EnsemblGRCr8
mRatBN7.21953,642,156 - 53,644,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,642,156 - 53,644,948 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1960,431,099 - 60,433,891 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,287,362 - 61,290,154 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,363,317 - 63,366,109 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1964,390,890 - 64,393,682 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1962,604,784 - 62,607,576 (+)NCBILyon_Normotensive
Lyon_Hypertensive1964,548,725 - 64,551,517 (+)NCBILyon_Hypertensive
F344_StmMcwi1962,236,965 - 62,239,757 (+)NCBIF344_StmMcwi
Rnor_6.01958,505,811 - 58,508,603 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,505,811 - 58,508,603 (+)Ensemblrn6Rnor6.0
Rnor_5.01969,203,363 - 69,206,155 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,879,310 - 55,882,308 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,003,421 - 53,006,213 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IBA,IEA,ISO,ISS)
cytoplasmic microtubule  (IBA,ISO,ISS)
cytoskeleton  (IEA)
midbody  (IBA,IEA,ISO,ISS)
mitotic spindle midzone  (IBA,ISO,ISS)
mitotic spindle pole  (IBA,ISO,ISS)
spindle pole  (IEA)

Molecular Function
microtubule binding  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23264731  


Genomics

Comparative Map Data
Map10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,539,482 - 70,542,274 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,534,286 - 70,543,410 (+)EnsemblGRCr8
mRatBN7.21953,642,156 - 53,644,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,642,156 - 53,644,948 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1960,431,099 - 60,433,891 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,287,362 - 61,290,154 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,363,317 - 63,366,109 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1964,390,890 - 64,393,682 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1962,604,784 - 62,607,576 (+)NCBILyon_Normotensive
Lyon_Hypertensive1964,548,725 - 64,551,517 (+)NCBILyon_Hypertensive
F344_StmMcwi1962,236,965 - 62,239,757 (+)NCBIF344_StmMcwi
Rnor_6.01958,505,811 - 58,508,603 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,505,811 - 58,508,603 (+)Ensemblrn6Rnor6.0
Rnor_5.01969,203,363 - 69,206,155 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,879,310 - 55,882,308 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,003,421 - 53,006,213 (+)NCBICelera
Cytogenetic Map19q12NCBI
MAP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,805,416 - 232,809,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,805,416 - 232,809,929 (+)Ensemblhg38GRCh38
GRCh371232,941,162 - 232,945,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,007,261 - 231,012,715 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1206,211,063 - 206,216,517 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1203,430,361 - 203,435,815 (+)NCBIHuRef
CHM1_11234,214,285 - 234,219,739 (+)NCBICHM1_1
T2T-CHM13v2.01232,191,843 - 232,196,356 (+)NCBIT2T-CHM13v2.0
Map10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398126,396,557 - 126,400,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8126,396,557 - 126,400,098 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388125,669,818 - 125,673,365 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,669,818 - 125,673,359 (+)Ensemblmm10GRCm38
MGSCv378128,193,718 - 128,197,265 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368128,555,956 - 128,559,446 (+)NCBIMGSCv36mm8
Celera8129,983,066 - 129,986,613 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.65NCBI
Map10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554926,401,173 - 6,404,068 (-)NCBIChiLan1.0ChiLan1.0
MAP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,299,030 - 16,403,401 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,505,372 - 16,599,855 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01208,352,323 - 208,357,555 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,370,599 - 213,374,422 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,371,044 - 213,374,187 (+)EnsemblpanPan2panpan1.1
MAP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.146,867,323 - 6,870,177 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl46,867,326 - 6,870,063 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha46,854,273 - 6,858,279 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.046,888,191 - 6,892,173 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl46,889,414 - 6,892,158 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.146,897,856 - 6,901,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.047,018,473 - 7,022,475 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.047,242,533 - 7,246,539 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,465,719 - 42,468,911 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648418,630,595 - 18,634,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1457,964,197 - 57,972,352 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11457,967,663 - 57,978,573 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21462,012,112 - 62,094,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12570,022,711 - 70,026,303 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2570,023,344 - 70,026,067 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605571,973,917 - 71,978,670 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477517,171,998 - 17,175,494 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Map10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11745,186,635 - 45,189,507 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:107
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000031717
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 150 243 91 90 65 104 59 22 449 296 11 222 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031717   ⟹   ENSRNOP00000036118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,534,286 - 70,543,410 (+)Ensembl
mRatBN7.2 Ensembl1953,642,156 - 53,644,948 (+)Ensembl
Rnor_6.0 Ensembl1958,505,811 - 58,508,603 (+)Ensembl
RefSeq Acc Id: NM_001277391   ⟹   NP_001264320
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,539,482 - 70,542,274 (+)NCBI
mRatBN7.21953,642,156 - 53,644,948 (+)NCBI
Dahl_SR_JrHsd1964,390,890 - 64,393,682 (+)NCBI
Lyon_Normotensive1962,604,784 - 62,607,576 (+)NCBI
Lyon_Hypertensive1964,548,725 - 64,551,517 (+)NCBI
F344_StmMcwi1962,236,965 - 62,239,757 (+)NCBI
Rnor_6.01958,505,811 - 58,508,603 (+)NCBI
Rnor_5.01969,203,363 - 69,206,155 (+)NCBI
Celera1953,003,421 - 53,006,213 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001264320 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZAP3 (Get FASTA)   NCBI Sequence Viewer  
  EDL96759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036118
  ENSRNOP00000036118.3
RefSeq Acc Id: NP_001264320   ⟸   NM_001277391
- UniProtKB: D3ZAP3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036118   ⟸   ENSRNOT00000031717

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAP3-F1-model_v2 AlphaFold D3ZAP3 1-888 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701249
Promoter ID:EPDNEW_R11772
Type:single initiation site
Name:Map10_1
Description:microtubule-associated protein 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01958,505,802 - 58,505,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308644 AgrOrtholog
BioCyc Gene G2FUF-5204 BioCyc
Ensembl Genes ENSRNOG00000028652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031717 ENTREZGENE
  ENSRNOT00000031717.5 UniProtKB/Swiss-Prot
InterPro MAP10 UniProtKB/Swiss-Prot
  MAP10_C-term UniProtKB/Swiss-Prot
KEGG Report rno:307948 UniProtKB/Swiss-Prot
NCBI Gene 307948 ENTREZGENE
PANTHER MICROTUBULE-ASSOCIATED PROTEIN 10 UniProtKB/Swiss-Prot
  PTHR21831 UniProtKB/Swiss-Prot
Pfam HPHLAWLY UniProtKB/Swiss-Prot
  MAP10_N UniProtKB/Swiss-Prot
PhenoGen Map10 PhenoGen
RatGTEx ENSRNOG00000028652 RatGTEx
UniProt D3ZAP3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-01 Map10  microtubule-associated protein 10  RGD1308644  similar to Hypothetical protein KIAA1383  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308644  similar to Hypothetical protein KIAA1383   RGD1308644_predicted  similar to Hypothetical protein KIAA1383 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308644_predicted  similar to Hypothetical protein KIAA1383 (predicted)  LOC307948_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307948_predicted  similar to Hypothetical protein KIAA1383 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL