Lars2 (leucyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Gene: Lars2 (leucyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Lars2
Name: leucyl-tRNA synthetase 2, mitochondrial
RGD ID: 1308429
Description: Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; valine, leucine and isoleucine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2; leucyl-tRNA synthetase, mitochondrial; LOC363172; probable leucine--tRNA ligase, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,887,728 - 131,983,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8131,887,753 - 131,983,866 (+)EnsemblGRCr8
mRatBN7.28123,010,271 - 123,106,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,010,293 - 123,106,395 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,599,822 - 128,694,986 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,798,766 - 126,893,950 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,628,137 - 124,723,305 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,441,277 - 132,537,176 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)Ensemblrn6Rnor6.0
Rnor_5.08131,593,987 - 131,689,876 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,136,948 - 128,232,441 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,121,425 - 122,216,021 (+)NCBICelera
RGSC_v3.18128,156,801 - 128,252,130 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10684970   PMID:14651853   PMID:18614015   PMID:26537577   PMID:34800366  


Genomics

Comparative Map Data
Lars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,887,728 - 131,983,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8131,887,753 - 131,983,866 (+)EnsemblGRCr8
mRatBN7.28123,010,271 - 123,106,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,010,293 - 123,106,395 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,599,822 - 128,694,986 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,798,766 - 126,893,950 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,628,137 - 124,723,305 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,441,277 - 132,537,176 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)Ensemblrn6Rnor6.0
Rnor_5.08131,593,987 - 131,689,876 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,136,948 - 128,232,441 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,121,425 - 122,216,021 (+)NCBICelera
RGSC_v3.18128,156,801 - 128,252,130 (+)NCBI
Cytogenetic Map8q32NCBI
LARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,388,576 - 45,549,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,388,527 - 45,554,726 (+)Ensemblhg38GRCh38
GRCh37345,430,068 - 45,590,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,405,079 - 45,565,332 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34345,405,078 - 45,565,332NCBI
Celera345,368,449 - 45,528,754 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,473,932 - 45,634,902 (+)NCBIHuRef
CHM1_1345,380,072 - 45,540,452 (+)NCBICHM1_1
T2T-CHM13v2.0345,404,942 - 45,565,766 (+)NCBIT2T-CHM13v2.0
Lars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,196,001 - 123,291,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,195,992 - 123,291,731 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389123,366,927 - 123,462,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,366,927 - 123,462,666 (+)Ensemblmm10GRCm38
MGSCv379123,276,058 - 123,371,782 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369123,215,638 - 123,311,362 (+)NCBIMGSCv36mm8
Celera9123,819,514 - 123,915,073 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.92NCBI
Lars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,343,649 - 26,441,736 (-)Ensembl
ChiLan1.0NW_00495542026,342,129 - 26,446,959 (-)NCBIChiLan1.0ChiLan1.0
LARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,353,155 - 45,513,037 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,357,921 - 45,517,809 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,296,129 - 45,455,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1346,405,636 - 46,564,994 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,405,636 - 46,564,994 (+)EnsemblpanPan2panpan1.1
LARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,891,823 - 43,080,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,892,801 - 43,081,197 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2042,808,439 - 42,996,879 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02043,376,360 - 43,565,565 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,376,366 - 43,565,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,616,558 - 42,805,467 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02043,024,169 - 43,213,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02043,299,029 - 43,487,924 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118198,001,624 - 198,139,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936695350,975 - 492,011 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936695353,965 - 492,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,524,796 - 28,692,327 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11328,524,778 - 28,692,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,530,356 - 31,641,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,861,105 - 7,021,325 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,861,006 - 7,020,009 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041160,147,025 - 160,307,861 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,228,316 - 75,335,052 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473075,228,638 - 75,335,045 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lars2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18114,486,218 - 114,579,468 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:140
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000068233
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat

Markers in Region
D8Rat192  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,047,278 - 123,047,447 (+)MAPPERmRatBN7.2
Rnor_6.08132,478,292 - 132,478,460NCBIRnor6.0
Rnor_5.08131,630,992 - 131,631,160UniSTSRnor5.0
RGSC_v3.48128,174,399 - 128,174,568RGDRGSC3.4
RGSC_v3.48128,174,400 - 128,174,568UniSTSRGSC3.4
Celera8122,157,980 - 122,158,148UniSTS
RGSC_v3.18128,194,136 - 128,194,305RGD
Cytogenetic Map8q32UniSTS
BE110407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,105,908 - 123,106,025 (+)MAPPERmRatBN7.2
Rnor_6.08132,536,684 - 132,536,800NCBIRnor6.0
Rnor_5.08131,689,384 - 131,689,500UniSTSRnor5.0
RGSC_v3.48128,232,792 - 128,232,908UniSTSRGSC3.4
Celera8122,216,372 - 122,216,488UniSTS
RH 3.4 Map81277.79UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000068233   ⟹   ENSRNOP00000058878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,010,301 - 123,105,558 (+)Ensembl
Rnor_6.0 Ensembl8132,441,314 - 132,536,333 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087488   ⟹   ENSRNOP00000074967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,887,753 - 131,983,857 (+)Ensembl
mRatBN7.2 Ensembl8123,010,293 - 123,105,695 (+)Ensembl
Rnor_6.0 Ensembl8132,441,285 - 132,536,369 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096718   ⟹   ENSRNOP00000078962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,932,398 - 131,983,866 (+)Ensembl
mRatBN7.2 Ensembl8123,054,924 - 123,105,558 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101297   ⟹   ENSRNOP00000082486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8131,887,753 - 131,983,866 (+)Ensembl
mRatBN7.2 Ensembl8123,010,302 - 123,106,395 (+)Ensembl
RefSeq Acc Id: NM_001413842   ⟹   NP_001400771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,887,756 - 131,983,866 (+)NCBI
mRatBN7.28123,010,302 - 123,106,395 (+)NCBI
RefSeq Acc Id: XM_008766727   ⟹   XP_008764949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,887,732 - 131,983,866 (+)NCBI
mRatBN7.28123,010,271 - 123,105,558 (+)NCBI
Rnor_6.08132,441,277 - 132,536,333 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265860   ⟹   XP_063121930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,887,728 - 131,973,038 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001400771 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764949 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121930 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074967
  ENSRNOP00000074967.2
  ENSRNOP00000078962.1
  ENSRNOP00000082486
  ENSRNOP00000082486.1
RefSeq Acc Id: XP_008764949   ⟸   XM_008766727
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9E5 (UniProtKB/TrEMBL),   A0A8I6G2M3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074967   ⟸   ENSRNOT00000087488
Ensembl Acc Id: ENSRNOP00000058878   ⟸   ENSRNOT00000068233
Ensembl Acc Id: ENSRNOP00000078962   ⟸   ENSRNOT00000096718
Ensembl Acc Id: ENSRNOP00000082486   ⟸   ENSRNOT00000101297
RefSeq Acc Id: NP_001400771   ⟸   NM_001413842
- UniProtKB: A0A8I5ZU78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121930   ⟸   XM_063265860
- Peptide Label: isoform X2
Protein Domains
Aminoacyl-tRNA synthetase class Ia   Leucyl-tRNA synthetase editing   Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9E5-F1-model_v2 AlphaFold A0A0G2K9E5 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696408
Promoter ID:EPDNEW_R6933
Type:multiple initiation site
Name:Lars2_1
Description:leucyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,441,315 - 132,441,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308429 AgrOrtholog
BioCyc Gene G2FUF-28615 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000004760 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087488 ENTREZGENE
  ENSRNOT00000087488.3 UniProtKB/TrEMBL
  ENSRNOT00000096718.2 UniProtKB/TrEMBL
  ENSRNOT00000101297 ENTREZGENE
  ENSRNOT00000101297.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  Isoleucyl-tRNA Synthetase, Domain 1 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ia UniProtKB/TrEMBL
  Leu-tRNA-synth_Ia_bac/mito UniProtKB/TrEMBL
  Leu_tRNA-synth_edit UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNAsynth_1a_anticodon-bd UniProtKB/TrEMBL
  V/L/I-tRNA-synth_anticodon-bd UniProtKB/TrEMBL
  Val/Leu/Ile-tRNA-synth_Ia_edit UniProtKB/TrEMBL
NCBI Gene 363172 ENTREZGENE
PANTHER LEUCINE--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR43740 UniProtKB/TrEMBL
Pfam Anticodon_1 UniProtKB/TrEMBL
  tRNA-synt_1 UniProtKB/TrEMBL
  tRNA-synt_1_2 UniProtKB/TrEMBL
PhenoGen Lars2 PhenoGen
PRINTS TRNASYNTHLEU UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004760 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  tRNAsyn_1a_bind UniProtKB/TrEMBL
  ValRS_IleRS_edit UniProtKB/TrEMBL
UniProt A0A0G2K9E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZU78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2M3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-27 Lars2  leucyl-tRNA synthetase 2, mitochondrial  Lars2  leucyl-tRNA synthetase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-23 Lars2  leucyl-tRNA synthetase 2  Lars2  leucyl-tRNA synthetase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Lars2  leucyl-tRNA synthetase 2, mitochondrial  Lars2  leucyl-tRNA synthetase, mitochondrial   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lars2  leucyl-tRNA synthetase, mitochondrial   Lars2_predicted  leucyl-tRNA synthetase, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lars2_predicted  leucyl-tRNA synthetase, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED