Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ube2l3 | Rat | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | EXP | | 6480464 | o,p'-DDT results in increased expression of UBE2L3 mRNA | CTD | PMID:24096037 | Ube2l3 | Rat | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | o,p'-DDT results in increased expression of UBE2L3 mRNA | CTD | PMID:24096037 | Ube2l3 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2L3 mRNA | CTD | PMID:17942748 | Ube2l3 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of UBE2L3 mRNA | CTD | PMID:17555576|PMID:17942748|PMID:24096037 | Ube2l3 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of UBE2L3 mRNA | CTD | PMID:24096037 | Ube2l3 | Rat | 1H-pyrazole | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | pyrazole results in increased expression of UBE2L3 mRNA | CTD | PMID:17945193 | Ube2l3 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Ube2l3 (Mus musculus) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether affects the expression of UBE2L3 mRNA | CTD | PMID:30294300 | Ube2l3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2L3 mRNA; AHR protein affects more ... | CTD | PMID:17942748|PMID:26318284|PMID:28621812 | Ube2l3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of UBE2L3 mRNA | CTD | PMID:33387578 | Ube2l3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UBE2L3 mRNA; Tetrachlorodibenzodioxin results in increased expression of UBE2L3 more ... | CTD | PMID:19770486|PMID:26318284|PMID:28621812 | Ube2l3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UBE2L3 mRNA | CTD | PMID:29274324 | Ube2l3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of UBE2L3 mRNA | CTD | PMID:21570461 | Ube2l3 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of and affects the more ... | CTD | PMID:38598786 | Ube2l3 | Rat | 2-bromohexadecanoic acid | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Ube2l3 | Rat | 7,12-dimethyltetraphene | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of UBE2L3 protein | CTD | PMID:38307155 | Ube2l3 | Rat | actinomycin D | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; Dactinomycin inhibits the more ... | CTD | PMID:26318284 | Ube2l3 | Rat | actinomycin D | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of UBE2L3 protein | CTD | PMID:38460933 | Ube2l3 | Rat | aflatoxin B1 | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of UBE2L3 mRNA | CTD | PMID:19770486 | Ube2l3 | Rat | benzo[a]pyrene | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of UBE2L3 mRNA | CTD | PMID:34332006 | Ube2l3 | Rat | benzo[e]pyrene | decreases methylation | ISO | UBE2L3 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of UBE2L3 intron | CTD | PMID:30157460 | Ube2l3 | Rat | beta-naphthoflavone | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | beta-Naphthoflavone results in increased expression of UBE2L3 mRNA | CTD | PMID:26318284 | Ube2l3 | Rat | beta-naphthoflavone | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; Dactinomycin inhibits more ... | CTD | PMID:26318284 | Ube2l3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of UBE2L3 mRNA | CTD | PMID:30816183|PMID:41034487 | Ube2l3 | Rat | bisphenol A | decreases methylation | ISO | UBE2L3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of UBE2L3 gene | CTD | PMID:31601247 | Ube2l3 | Rat | bisphenol A | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of UBE2L3 mRNA | CTD | PMID:33221593 | Ube2l3 | Rat | bisphenol AF | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of UBE2L3 protein | CTD | PMID:34186270 | Ube2l3 | Rat | butane-2,3-dione | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Diacetyl results in increased expression of UBE2L3 protein | CTD | PMID:34031698 | Ube2l3 | Rat | cadmium atom | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Ube2l3 | Rat | cadmium dichloride | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... | CTD | PMID:38195004 | Ube2l3 | Rat | carbon nanotube | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of UBE2L3 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25620056 | Ube2l3 | Rat | carbon nanotube | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of UBE2L3 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Ube2l3 | Rat | CGP 52608 | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to UBE2L3 gene] | CTD | PMID:28238834 | Ube2l3 | Rat | copper atom | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | MT1 affects the reaction [Copper results in increased expression of UBE2L3 mRNA]; MT2 affects the more ... | CTD | PMID:16629173 | Ube2l3 | Rat | copper(0) | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | MT1 affects the reaction [Copper results in increased expression of UBE2L3 mRNA]; MT2 affects the more ... | CTD | PMID:16629173 | Ube2l3 | Rat | copper(II) sulfate | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of UBE2L3 mRNA | CTD | PMID:20599845 | Ube2l3 | Rat | CU-O LINKAGE | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of UBE2L3 protein | CTD | PMID:25470785 | Ube2l3 | Rat | cyclosporin A | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of UBE2L3 mRNA | CTD | PMID:19770486 | Ube2l3 | Rat | diazinon | decreases methylation | ISO | UBE2L3 (Homo sapiens) | 6480464 | Diazinon results in decreased methylation of UBE2L3 gene | CTD | PMID:22964155 | Ube2l3 | Rat | Dibutyl phosphate | affects expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of UBE2L3 mRNA | CTD | PMID:37042841 | Ube2l3 | Rat | dibutyl phthalate | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of UBE2L3 mRNA | CTD | PMID:17361019|PMID:21266533 | Ube2l3 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of UBE2L3 mRNA | CTD | PMID:21551480 | Ube2l3 | Rat | dopamine | increases expression | EXP | | 6480464 | Dopamine results in increased expression of UBE2L3 mRNA | CTD | PMID:21983523 | Ube2l3 | Rat | dorsomorphin | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ube2l3 | Rat | doxorubicin | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of UBE2L3 mRNA | CTD | PMID:29803840 | Ube2l3 | Rat | elemental selenium | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Selenium results in increased expression of UBE2L3 mRNA | CTD | PMID:19244175 | Ube2l3 | Rat | enzyme inhibitor | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Ube2l3 | Rat | ethanol | affects expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Ethanol affects the expression of UBE2L3 mRNA | CTD | PMID:30319688 | Ube2l3 | Rat | fenoldopam | increases expression | EXP | | 6480464 | Fenoldopam results in increased expression of UBE2L3 mRNA | CTD | PMID:21983523 | Ube2l3 | Rat | fenthion | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Fenthion results in decreased expression of UBE2L3 mRNA | CTD | PMID:34813904 | Ube2l3 | Rat | ferroheme b | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Heme metabolite results in increased expression of UBE2L3 mRNA | CTD | PMID:19191707 | Ube2l3 | Rat | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of UBE2L3 mRNA | CTD | PMID:24136188 | Ube2l3 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of UBE2L3 mRNA | CTD | PMID:24136188 | Ube2l3 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of UBE2L3 mRNA | CTD | PMID:24793618 | Ube2l3 | Rat | formaldehyde | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of UBE2L3 mRNA | CTD | PMID:23649840 | Ube2l3 | Rat | furfural | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ... | CTD | PMID:38598786 | Ube2l3 | Rat | heme b | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Heme metabolite results in increased expression of UBE2L3 mRNA | CTD | PMID:19191707 | Ube2l3 | Rat | ivermectin | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of UBE2L3 protein | CTD | PMID:32959892 | Ube2l3 | Rat | lead(0) | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Lead results in decreased expression of UBE2L3 mRNA | CTD | PMID:19921347 | Ube2l3 | Rat | mercury atom | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of UBE2L3 mRNA | CTD | PMID:25056781 | Ube2l3 | Rat | mercury(0) | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of UBE2L3 mRNA | CTD | PMID:25056781 | Ube2l3 | Rat | methapyrilene | decreases methylation | ISO | UBE2L3 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of UBE2L3 intron | CTD | PMID:30157460 | Ube2l3 | Rat | methidathion | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | methidathion results in decreased expression of UBE2L3 mRNA | CTD | PMID:34813904 | Ube2l3 | Rat | methylmercury chloride | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of UBE2L3 mRNA | CTD | PMID:28001369 | Ube2l3 | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with CGA protein] results in increased expression of UBE2L3 protein | CTD | PMID:20463053 | Ube2l3 | Rat | Monobutylphthalate | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | monobutyl phthalate results in decreased expression of UBE2L3 protein | CTD | PMID:26903627 | Ube2l3 | Rat | N-methyl-4-phenylpyridinium | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of UBE2L3 protein | CTD | PMID:26558463 | Ube2l3 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of UBE2L3 mRNA | CTD | PMID:24136188 | Ube2l3 | Rat | nitrates | multiple interactions | ISO | Ube2l3 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of UBE2L3 more ... | CTD | PMID:35964746 | Ube2l3 | Rat | nitric oxide | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Nitric Oxide deficiency results in decreased expression of UBE2L3 mRNA | CTD | PMID:15878706 | Ube2l3 | Rat | Nutlin-3 | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of UBE2L3 protein | CTD | PMID:38460933 | Ube2l3 | Rat | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of UBE2L3 mRNA | CTD | PMID:22124623 | Ube2l3 | Rat | ozone | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of UBE2L3 mRNA | CTD | PMID:35430440 | Ube2l3 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of UBE2L3 mRNA | CTD | PMID:33387578 | Ube2l3 | Rat | parathion | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Parathion results in decreased expression of UBE2L3 mRNA | CTD | PMID:34813904 | Ube2l3 | Rat | phlorizin | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Phlorhizin results in decreased expression of UBE2L3 mRNA | CTD | PMID:22538082 | Ube2l3 | Rat | piroxicam | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Piroxicam results in increased expression of UBE2L3 mRNA | CTD | PMID:21858171 | Ube2l3 | Rat | quercetin | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Quercetin results in increased expression of UBE2L3 mRNA | CTD | PMID:21632981 | Ube2l3 | Rat | resveratrol | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | resveratrol results in increased expression of UBE2L3 protein | CTD | PMID:18089832 | Ube2l3 | Rat | resveratrol | decreases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | resveratrol results in decreased expression of UBE2L3 protein | CTD | PMID:25505154 | Ube2l3 | Rat | SB 431542 | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ube2l3 | Rat | selenium atom | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Selenium results in increased expression of UBE2L3 mRNA | CTD | PMID:19244175 | Ube2l3 | Rat | silicon dioxide | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of UBE2L3 mRNA | CTD | PMID:25351596 | Ube2l3 | Rat | sodium arsenate | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of UBE2L3 mRNA | CTD | PMID:30953684 | Ube2l3 | Rat | sodium arsenite | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of UBE2L3 protein | CTD | PMID:20050688 | Ube2l3 | Rat | sodium arsenite | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of UBE2L3 mRNA | CTD | PMID:34032870 | Ube2l3 | Rat | sodium chloride | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of more ... | CTD | PMID:38598786 | Ube2l3 | Rat | tamoxifen | affects expression | ISO | Ube2l3 (Mus musculus) | 6480464 | Tamoxifen affects the expression of UBE2L3 mRNA | CTD | PMID:17555576 | Ube2l3 | Rat | temozolomide | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of UBE2L3 mRNA | CTD | PMID:31758290 | Ube2l3 | Rat | thimerosal | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of UBE2L3 mRNA | CTD | PMID:27188386 | Ube2l3 | Rat | titanium dioxide | decreases methylation | ISO | Ube2l3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of UBE2L3 gene | CTD | PMID:35295148 | Ube2l3 | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of UBE2L3 gene | CTD | PMID:27618143 | Ube2l3 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of UBE2L3 mRNA | CTD | PMID:33387578 | Ube2l3 | Rat | trimellitic anhydride | increases expression | ISO | Ube2l3 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of UBE2L3 mRNA | CTD | PMID:19042947 | Ube2l3 | Rat | valproic acid | decreases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of UBE2L3 mRNA | CTD | PMID:23179753|PMID:26272509 | Ube2l3 | Rat | valproic acid | multiple interactions | ISO | UBE2L3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Ube2l3 | Rat | vitamin E | increases expression | ISO | UBE2L3 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of UBE2L3 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||





















