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Gene: Lrrk1 (leucine-rich repeat kinase 1) Rattus norvegicus

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Symbol:

Lrrk1

Name:

leucine-rich repeat kinase 1

RGD ID:

1308000

Description:

Predicted to enable identical protein binding activity and protein kinase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and signal transduction. Predicted to act upstream of or within bone resorption; osteoclast development; and positive regulation of intracellular signal transduction. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine-rich repeat serine/threonine-protein kinase 1; LOC308703

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LRRK1 (leucine rich repeat kinase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lrrk1 (leucine-rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lrrk1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LRRK1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LRRK1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lrrk1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LRRK1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LRRK1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lrrk1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lrrk1 (leucine rich repeat kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LRRC32 (leucine rich repeat containing 32)	HGNC	PhylomeDB
Alliance orthologs ³
Homo sapiens (human):	LRRK1 (leucine rich repeat kinase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lrrk1 (leucine-rich repeat kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lrrk1 (leucine-rich repeat kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lrrk1 (leucine-rich repeat kinase 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lrk-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lrk-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lrrk	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lrrk	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lrrk1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lrrk1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)

Allele / Splice:

Lrrk1^em1Sage

Genetic Models:

LE-Lrrk1^em1SageLrrk2^em1Sage ; LE-Lrrk1^em1Sage-/-Lrrk2^em1Sage-/- ; LE-Lrrk1^em1Sage ; LE-Lrrk1^em1Sage-/-

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	129,254,815 - 129,390,217 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	129,254,515 - 129,389,941 (-)	Ensembl				GRCr8
mRatBN7.2	1	119,844,360 - 119,972,885 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	119,845,146 - 119,979,734 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	127,837,758 - 127,964,722 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	135,009,201 - 135,136,173 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	127,819,030 - 127,946,556 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	127,166,866 - 127,301,053 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	127,166,431 - 127,292,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	128,248,473 - 128,372,456 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	120,695,657 - 120,836,324 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	112,054,004 - 112,179,350 (-)	NCBI		Celera
RGSC_v3.1	1	120,773,221 - 120,921,758 (-)	NCBI
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Desbuquois dysplasia (ISO)

genetic disease (ISO)

osteopetrosis (ISS)

osteosclerotic metaphyseal dysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

butanal (ISO)

C60 fullerene (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

cobalt dichloride (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

fenamidone (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

lead diacetate (ISO)

manganese(II) chloride (EXP)

methapyrilene (ISO)

methidathion (ISO)

methimazole (EXP)

N-methyl-4-phenylpyridinium (EXP)

nickel sulfate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

testosterone (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone resorption (ISO)

negative regulation of peptidyl-tyrosine phosphorylation (ISO)

osteoclast development (ISO)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

positive regulation of intracellular signal transduction (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

regulation of signal transduction (IEA)

signal transduction (IBA)

Cellular Component

cytoplasm (IBA)

cytosol (IEA,ISO)

Molecular Function

ATP binding (IEA)

GTP binding (IEA)

identical protein binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IBA,IEA)

protein serine/threonine kinase activity (IEA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18272292	PMID:19712061	PMID:22899650	PMID:22952686	PMID:23526378

Genomics

Comparative Map Data

Lrrk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	129,254,815 - 129,390,217 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	129,254,515 - 129,389,941 (-)	Ensembl				GRCr8
mRatBN7.2	1	119,844,360 - 119,972,885 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	119,845,146 - 119,979,734 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	127,837,758 - 127,964,722 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	135,009,201 - 135,136,173 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	127,819,030 - 127,946,556 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	127,166,866 - 127,301,053 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	127,166,431 - 127,292,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	128,248,473 - 128,372,456 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	120,695,657 - 120,836,324 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	112,054,004 - 112,179,350 (-)	NCBI		Celera
RGSC_v3.1	1	120,773,221 - 120,921,758 (-)	NCBI
Cytogenetic Map	1	q22	NCBI

LRRK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	100,919,357 - 101,078,257 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	100,919,327 - 101,078,257 (+)	Ensembl			hg38	GRCh38
GRCh37	15	101,459,562 - 101,618,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	99,276,983 - 99,427,840 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	99,380,194 - 99,427,834	NCBI
Celera	15	77,872,799 - 78,023,725 (+)	NCBI		Celera
Cytogenetic Map	15	q26.3	NCBI
HuRef	15	77,581,355 - 77,732,446 (+)	NCBI		HuRef
CHM1_1	15	101,300,443 - 101,451,610 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	98,673,894 - 98,832,884 (+)	NCBI		T2T-CHM13v2.0

Lrrk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	65,908,493 - 66,038,089 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	65,876,660 - 66,038,098 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	66,258,745 - 66,388,341 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	66,226,912 - 66,388,350 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	73,403,631 - 73,533,227 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	55,670,181 - 55,799,947 (-)	NCBI		MGSCv36	mm8
MGSCv36	7	66,137,695 - 66,267,291 (-)	NCBI		MGSCv36	mm8
Celera	7	63,712,568 - 63,843,036 (-)	NCBI		Celera
Celera	7	59,723,311 - 59,724,078 (-)	NCBI		Celera
Cytogenetic Map	7	C	NCBI
cM Map	7	35.57	NCBI

Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	27,865,784 - 27,988,279 (+)	Ensembl
ChiLan1.0	NW_004955416	27,860,934 - 27,988,279 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	90,508,435 - 90,659,979 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	94,208,601 - 94,360,510 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	79,642,908 - 79,793,990 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	98,936,123 - 99,081,168 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	98,931,344 - 99,081,168 (+)	Ensembl			panPan2	panpan1.1

LRRK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	40,003,299 - 40,122,326 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	40,004,557 - 40,122,320 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	42,692,357 - 42,816,723 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	40,394,683 - 40,519,058 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	40,377,843 - 40,513,734 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	39,927,716 - 40,048,483 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	40,164,544 - 40,288,876 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	40,366,423 - 40,490,768 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	143,409,510 - 143,562,544 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	2,771,938 - 2,924,525 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	2,771,939 - 2,922,793 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	139,494,121 - 139,624,604 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	139,494,126 - 139,624,609 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	155,637,573 - 155,853,753 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	19,385,149 - 19,532,440 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	19,386,170 - 19,533,686 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666059	27,010,221 - 27,156,563 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	3,712,049 - 3,848,651 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624768	3,701,187 - 3,848,943 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lrrk1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	133,969,526 - 134,095,574 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lrrk1
714 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	221
Count of miRNA genes:	143
Interacting mature miRNAs:	156
Transcripts:	ENSRNOT00000016959
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	176289080	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
631684	Bp117	Blood pressure QTL 117	8.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	120082258	165082258	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	112521556	157521556	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	128019551	173019551	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
631569	Bp93	Blood pressure QTL 93		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	131244255	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	127329268	206393015	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	112521556	157521556	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	124975316	152612788	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	111949780	160574007	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	97582336	142582336	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	116099376	191260518	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	111404407	142582336	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat
737974	Bp161	Blood pressure QTL 161		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	129182274	174182274	Rat

Markers in Region

D1Mco70

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	119,897,087 - 119,897,283 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	127,219,581 - 127,219,776	NCBI	Rnor6.0
Rnor_5.0	1	128,300,402 - 128,300,597	UniSTS	Rnor5.0
RGSC_v3.4	1	120,747,637 - 120,747,832	UniSTS	RGSC3.4
Celera	1	112,106,555 - 112,106,750	UniSTS
Cytogenetic Map	1	q22	UniSTS

Genetic Models

This gene Lrrk1 is modified in the following models/strains:

LE-Lrrk1^em1SageLrrk2^em1Sage LE-Lrrk1^em1Sage-/-Lrrk2^em1Sage-/- LE-Lrrk1^em1Sage LE-Lrrk1^em1Sage-/-

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010052148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016959 ⟹ ENSRNOP00000016959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	129,254,515 - 129,389,941 (-)	Ensembl
mRatBN7.2 Ensembl	1	119,845,146 - 119,979,734 (-)	Ensembl
Rnor_6.0 Ensembl	1	127,166,431 - 127,292,090 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106564 ⟹ ENSRNOP00000094655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	129,255,601 - 129,381,908 (-)	Ensembl
mRatBN7.2 Ensembl	1	119,845,146 - 119,972,885 (-)	Ensembl

RefSeq Acc Id:

NM_001191624 ⟹ NP_001178553

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,255,601 - 129,383,130 (-)	NCBI
mRatBN7.2	1	119,845,146 - 119,972,885 (-)	NCBI
Rnor_6.0	1	127,167,652 - 127,291,972 (-)	NCBI
Rnor_5.0	1	128,248,473 - 128,372,456 (-)	NCBI
Celera	1	112,054,004 - 112,179,350 (-)	NCBI

Sequence:

show sequence

ATGGCTGCCGTGTCACAGCGACCACCCAGTATGTACTGGTGTGTGGGGACAGAAGGATCAGTTG
TGTGTCCAGGGCCTGCCATGGAGACCCATAATGGTGCCGAAGACATGGGCAGCAAACTGTCTTT
ACCAGGTGGCAACTCCCCAGTGCAGAGCCCCAACATGGAAGAAATCCACACAGCATACAAGCAG
AGAAACCTCTCCCGAGCCCGGGACCTGCTCAGGGAAGTTTGTGAAGAGAGCGAATCCCCACAGG
AAAAGGGCCAGTTGCTGAGCATCTCAGCAGCCCACGGGGATCTAGAGACCGTTCGGTTCCTGCT
CACTGAGAAGCGCGTGGAGCTGCCGATGGAGCCCACCGATGACAACCCAGCTGTGGTGGCAGCG
CATTTTGGACATGCTGAAGTAGTACACGAATTGCTGGAGTCCTTATCAGGTCCCTGTGCCTCGC
AGCGGCTGCTGAACTGGATGCTGGCCCTGGCTTGCCAGCGAGGGCACCTGGAGGTTGTGAAGCT
GCTGGTCCTGACGCACGGGGCTGACCCGGAGAACTACGCCGTCAGGAAGAATGAGTTCCCGGTC
ATTGTGAGGTTGCCCCTCTACGCGGCCATCAAGGCAGGGAATGAAGACATTGCCATATTCCTGC
TTCGGCACGGGGCCTATTTCTGCTCCTACATCCTATTGGATAGCCCTGACCCAAGCAAACATCT
GCTCAGGAAGTATTTCATCGAGGCCAGCGCCCTGCCCAGCAGCTGTCCCGGGAAAACCGCACTT
TGTGTGAAATGGTCCCATCTTAAGTTGCCCTGGGTGGACCTCGACTGGCTCTTAGACATCTCCT
GTCAGATCACAGAGCTTGACCTCTCTGCCAACTGCCTGTCTTCTCTCCCCTCCATCATTCCTTG
GGGACTGATCAATCTGAAGAAGCTGAACCTCTCAAACAACCACCTGGGGGAGCTGCCCTGTGTG
CAATCATCGGACGAAATCATCTGCTCCAGGTTAGTTGAAATCGACATCTCCAGTAACAAACTGT
CCCACCTCCCGCCTGGATTCTTGCACCTCTCAAAACTTGAAAGGCTGACTGCTTCCAAAAACTA
TCTGGAGCGGTTGTTTGAAGAAGAAAATGCCACAAACTGGATCGGCCTGCGGAAGCTGGAGGAA
CTCGACCTAGCTGACAACAGACTGACGGAGCTCCCTGTCCAATTTATGCACTCCTTCAAGTCTC
TCACCAATCTGAATGTCTCCAGGAACAGCCTCAAGAGCTTTCCAGACCCCTGGTCCTGCCCTCT
GAAATGTTGTAAAGCCTCCAAAAATGCTCTGGAATCGCTGCCAGACAAAATGGCCGTCTTCTGG
AAAAACCACCTCAGGGACGTGGATTTCTCCGAGAACTCTCTGAAAGCGGTGCCCCTGGGGGTTT
TCCAACTTGATGCCCTCATGTTCTTGAGGTTACAGGGAAACCTGCTGTTGTCACTGCCACATCA
TGAGAAGTGGACCTGCAGACAACTCAAGACCCTGGACCTCTCCAGAAACCAACTTGGCAAAAAT
GAAGATGGGCTTAAAACAAAGCGGATCTCCCTTTTTACCACCAGAGGGCGCCAGCGTTCTGGAA
CTGAGACAGCGTCCGTGCTAGAATTCCCAGCTTTTCTAAGCGAGTCTTTGGAGGTCCTTTGTCT
GAATGACAACCATCTTGATGCAGTTCCTCCGTCAGTCTGCCTGCTGAAGAACCTCTCAGAGCTC
TACTTGGGCAATAACCCTGGTCTCCGAGAGCTCCCTCCGGAGCTAGGCCAGCTGGGAAACCTCT
GGCAACTGGACATTGAAGATCTGAACATTGGCAACGTGCCTGCAGAGGTCAGGAAAGAAGGCCC
AAAAGCAACGCTGTCTTTCCTGCGTGCTCAGCTGCGCAAAGCAGAGAAGTGTAAACTGATGAAG
ATGATCCTCGTGGGCCCCCCACGCCAGGGCAAGTCCACACTCCTGGAGATCTTACAGACAGGGA
AGGCCCCGCAGCCAGCACACAGCGAAGCCACTGTCAGGACCACCAAGTGGGAGCTCCAGAGACC
AGCAGGCTCCAAAGCCAAGGTTGAGTCTGTGGAGTTCAACGTCTGGGACATCGGGGGCCCTGCC
AGCATGGCCACAGTCAATCAGTGCTTCTTCACAGATAAGGCCCTATATGTGGTGGTCTGGAACC
TGGCCCTGGGGGAAGAAGCTGTGGCCAACCTCCAGTTCTGGCTTCTCAACATTGAGGCCAAGGC
CCCAAACGCCGTTGTGCTGGTGGTTGGGACACATCTGGACCTTATCGAAGCTAAATTCCGAGTA
GAGAGGATCGCAACACTGCGTGCCTACGTGCTGGCCCTCTGCCGCTCACCATCGGGGTCCAGAG
CTACAGGATTCCCAGACATCACTTTCAAACACTTGCACGAGATCTCCTGCAAGAATCTGGAAGG
GCAGGAGGGGCTGAGGCAACTGATCTTCCATGTCACGTGCAACATGAAGGACGTGGGCAGCACT
ATCGGCTGTCAAAAACTCGCTGGCAGGCTGATCCCCAGGAGCTACATAAGCCTACAGGAGGCTG
TGCTGGCTGAACAACAGCGCCGCAGCCTGGAAGATCAAGTACAGTACCTGACGGACAGGCAGCT
GGAGCAGCTGGTGGAGCAGACGCCTGGCAATGACATCAAAGACTATGAGGACCTGCAGTCTGCC
ATCAGCTTCCTCATAGAAACCGGAACCCTGCTGCACTTCCCAGACACGAGCCATGGCCTAAGGA
ATCTCTACTTCCTGGATCCCATCTGGCTCTCTGAATGCCTACAGAGGATCTTTAATATCAAGGG
CTCGCGGTCGGTGGCGAAGAATGGGGTGATCCGAGCAGAGGACCTCAGGATGCTGCTGGTGGGG
ACAGGCTTCACGCAGCAGACGGAGGAGCAATACTTCCAGTTCCTTGCCAAGTTCGAGATTGCCC
TTCCGGTTGCCAATGACAGTTACCTCCTACCACACCTCCTCCCATCCAAACCTGGGCTGGACAC
CCACAGCATGCGGCACCCAATGGCTAACACCATCCAGCGGGTGTTTAAGATGAGCTTCGTGCCT
GTTGGCTTCTGGCAAAGGTTCATAGCACGGATGCTGATCAGCTTGGCTGAGATGGACCTGCAGC
TTTTTGAAAACAAGAAGAATACGAAAAGCAGGAACCGGAAAGTCACCATTTACAGCTTTACAGG
GAACCAGAGAAACCGCTGCAGCACATTCAGAGTCCGAAGGAATCAGACCATCTACTGGCAGGAA
GGGCTGCTGGTCACTTTCGATGGGGGCTACCTCAGTGTGGAATCCTCAGACGTGAACTGGAAAA
AGAAAAAAAGCGGAGGGATTAAAATCGTCTGCCAGTCAGAAATGAGGGACTTCTCAGCAATGGC
TTTTATCACAGACCACGTCAACTCCCTGATCGACCAGTGGTTCCCCGCCCTGACAGCCACAGAA
AGTGACGGGACCCCACTTATGGAGCAGTATGTGCCCTGCCCCGTCTGTGAAGCATCCTGGGCCC
AGCATGCAGATCCAAACGAGAGGTCGGAGAGCGTGCAGTACTTCGATATGGAAGATTGTGTGCT
CACAGCCATTGAAGGGAACTTCATCTCCTGCCCCAGACACCCAGACCTCCCAGTGCCACTTCAG
GAGCTTGTACCAGAGCTGTTTATGACTGACTTCCCAGCCAGGCTTTTCCTGGAGAACAGCAAGC
TGGAGCACACAGAGGGTGAGAACAGCATCCTGGGCCAAGGTGGCAGTGGCACAGTCATCTACCA
GGCCCAGTACCAGGGCCAGCCTGTGGCTGTGAAGAGATTCCACATCAAGAAGTTCAAGAATTCT
GCTAATGCCCCGGCAGACACCATGCTGAGGCACCTGAGAGCCATGGATGCCATGAAGAACTTCT
CGGATTTCCGTCAGGAGGCCAGCATGCTGCATGCCTTGCAGCACCCCTGCATTGTGTCACTCAT
CGGCATCAGCATCCACCCCCTCTGCTTCGCCCTGGAGCTCGCCCCGCTGGGCAGCCTCAACACT
GTGCTGTCTGAGAATGCCAAAGATTCTTCCTTTATGCCCCTGGGACACATGCTCACCCAAAAAA
TAGCCTACCAGATTGCCTCGGGCCTGGCCTACCTGCACAAGAAGAACATCATCTTCTGTGACCT
CAAGTCAGACAACATCCTGGTGTGGTCACTGAGCGTCAAGGAGCTCATCAACATCAAACTGTCA
GACTACGGCATCTCGAGGCAGTCCTTTCACGAGGGGGCCCTGGGTGTGGAGGGCACCCCAGGCT
ACCAGGCTCCAGAGATCAGGCCTCGCATTGTGTATGACGAGAAGGTAGACATGTTCTCCTATGG
CATGGTGCTGTATGAGCTGCTCTCAGGACAGCGTCCTGCGCTGGGCCACCACCAACTTCAGATT
GTCAAGAAGTTGTCCAAGGGCATCCGCCCAGTGCTGGGGCAGCCAGAGGAAGTGCAATTCTATC
GACTGCAGGCGCTCATGATGGAGTGCTGGGACACGAAGCCGGAGAAGCGTCCCCTGGCCCTGTC
TGTGGTGAGCCAGATGAAAGACCCAACCTTCGCCACCTTCATGTACATGCTGCCCTGTGGGAAG
CAGTCGTCCTTCTTCTCATCCCAGAGCCAGGAGTACACTGTGGTGTTCTGGGATGGGAAGGAGG
AGTCAAGGAATTACACGGTGGTCAACACCGAGAAGGGCCTTCTGGAAGTACAGAGGATGACCTG
TCCTGGGATGAAGCTGAGCTGTCAGCTCAAGGTCCAGAGCTCAGTGTGGCTAGCCACCGAGGAC
CAGAAAATCTATATCTACAGCCTTAAGGGTATGTGCCCATTAAGCATGCCCCAGCAGGCCCTGG
ACACGCCGGCTGTTGTCACCTGTTTCTTGGCAGTACCTGTTATTAAAAAGAACTCCTTTCTGGT
GCTGGCTGGCCTGGCTGATGGACTCGTGGCTGTGTTTTCTATGGCACGGGGCACCCCAAAAGAA
AGCTGCTCCTACCTGTGCTCGCACACAGCCAACAGGTCCAAGTTCTGCATCCCAGACGAAGACT
CACGGCAGAACCCCTACCCAGTGAGGGCAATGGAAGTGGTCAACAGCGGGTCTGAGGTCTGGTA
CAGCAATGGGCCAGGCCTCCTCATCATCGACTGTGCCATCCTGGACATCAGCAGGCGGCTGGAG
CCCTATGCAGCCCCATCTGTGGTCACATCACTTGTGTGCAGCTCAGACTGCAGAGGAGAGGAGA
CAGTCTGGTGCCTGGACGACAAGGGCAATTCCTTAGTGATGTACCATTCAGCCACCTACCAGCT
GTGTGCCCGGTACTTCTGCGGGGACCCCAGTCCTCTCAGGGACACGTTTTCTGTACAGCCCTCA
GTCCCAGAAAGCCCAATCCGTCACATAACCACCTCAAAGGAGCCTGAGGAAGAGTGCATCGCCG
ACGTGAGCATCATGTACAGCGAGGAGCTGGGCATGCAGATCCTCACCCACCAGGACTCGCTCAC
TGACTACTGCTCCGTATCCTCGTACTCATCCACACCCCACCCAGACCCCAAGTCCCCCACCAGC
CTGCCCAGCTCCCTCACCAGCTATTCCAGTGTGCCTTTCTCCGCCAATTATGAAGACCCAGACA
GGCTGCAGGAGCCCAGCGTCACCCCTGACAGAACTGAGCATGATCTGAGCCCCATGGATGGGGA
GACGTTCAGCCAACACCTGCAGGCTGTGAAGGTGCTTGCTGTCCAAGACCTCATTTGGGTCCCT
AGACATGGTGGAGATATCATTGTCATCGGCCTGGAGAAGGATTCGGGTGCCCAGCGGGGCAGGG
TCATCGCTGTTTTAAAAGCCAGAGAGCTCAATCCGCATGGGGTCCTGGTGGATGCGGCAGTGGT
GGCAAAGGACACCGTAGTGTGCGGCTTTGCAAACGAAAACACAGAGTGGTGCCTGGCTGTCTGG
AGGGGCTGGGGCGCCAGGGAGTTTGACATCTTCTACCAGTCCTATGAGGAGCTGGGCCGGCTGG
AGGCGTGTCCTCGCAAGAGAAGGTAATGCCTACGGAAGGGCCTCCGCGCGGAGCCAGCAGGTGC
GCGGAGCCAGCAGGTCCGAGCCACTGCCTGACCCCTCAGCTACAGCCCTCCTAGGGCACAGAAG
ACAAACGGGTTCTTTGCTAAGCCTTCTGCTAAGAAGGGCTGAGAAGCTAGGAGCTGCTGGTAGT
TTGGGAGTTCTCAGGTTCTGTGGGGAAAGTTATCAGCCCATGGGAAGCCACAGGGTCTGGTTGA
GAGAGGCCTCCTCTCGCCTCTTCCCTAGGCTTCCAGGAGCCGGGGAGAGTGACCCCATTCCAAA
CCTTTCCAGCATAATGAATGGGCCTGTCCGTTCTTCTACCGCCAGGCCTCCAATGGAATTACAC
TACAGAGTCTTGGTTGAGGAGCAGTTCGGGGTAAGGTGGGAGGAG

hide sequence

RefSeq Acc Id:

XM_039112688 ⟹ XP_038968616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,254,815 - 129,291,014 (-)	NCBI
mRatBN7.2	1	119,844,360 - 119,880,557 (-)	NCBI

RefSeq Acc Id:

XM_063262476 ⟹ XP_063118546

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,254,815 - 129,390,112 (-)	NCBI

RefSeq Acc Id:

XM_063262478 ⟹ XP_063118548

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,254,815 - 129,390,112 (-)	NCBI

RefSeq Acc Id:

XM_063262481 ⟹ XP_063118551

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,254,815 - 129,390,217 (-)	NCBI

RefSeq Acc Id:

XM_063262490 ⟹ XP_063118560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,262,860 - 129,390,124 (-)	NCBI

RefSeq Acc Id:

XM_063262498 ⟹ XP_063118568

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,267,619 - 129,390,120 (-)	NCBI

RefSeq Acc Id:

XR_010052148

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	129,262,885 - 129,390,124 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178553	(Get FASTA)	NCBI Sequence Viewer
	XP_038968616	(Get FASTA)	NCBI Sequence Viewer
	XP_063118546	(Get FASTA)	NCBI Sequence Viewer
	XP_063118548	(Get FASTA)	NCBI Sequence Viewer
	XP_063118551	(Get FASTA)	NCBI Sequence Viewer
	XP_063118560	(Get FASTA)	NCBI Sequence Viewer
	XP_063118568	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016959
	ENSRNOP00000016959.7
	ENSRNOP00000094655
	ENSRNOP00000094655.2

RefSeq Acc Id:

NP_001178553 ⟸ NM_001191624

- UniProtKB:

D3ZRJ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVSQRPPSMYWCVGTEGSVVCPGPAMETHNGAEDMGSKLSLPGGNSPVQSPNMEEIHTAYKQ
RNLSRARDLLREVCEESESPQEKGQLLSISAAHGDLETVRFLLTEKRVELPMEPTDDNPAVVAA
HFGHAEVVHELLESLSGPCASQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPV
IVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASALPSSCPGKTAL
CVKWSHLKLPWVDLDWLLDISCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCV
QSSDEIICSRLVEIDISSNKLSHLPPGFLHLSKLERLTASKNYLERLFEEENATNWIGLRKLEE
LDLADNRLTELPVQFMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKNALESLPDKMAVFW
KNHLRDVDFSENSLKAVPLGVFQLDALMFLRLQGNLLLSLPHHEKWTCRQLKTLDLSRNQLGKN
EDGLKTKRISLFTTRGRQRSGTETASVLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSEL
YLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMK
MILVGPPRQGKSTLLEILQTGKAPQPAHSEATVRTTKWELQRPAGSKAKVESVEFNVWDIGGPA
SMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRV
ERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGST
IGCQKLAGRLIPRSYISLQEAVLAEQQRRSLEDQVQYLTDRQLEQLVEQTPGNDIKDYEDLQSA
ISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVP
VGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVRRNQTIYWQE
GLLVTFDGGYLSVESSDVNWKKKKSGGIKIVCQSEMRDFSAMAFITDHVNSLIDQWFPALTATE
SDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIEGNFISCPRHPDLPVPLQ
ELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNS
ANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNT
VLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSVKELINIKLS
DYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQI
VKKLSKGIRPVLGQPEEVQFYRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGK
QSSFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATED
QKIYIYSLKGMCPLSMPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKE
SCSYLCSHTANRSKFCIPDEDSRQNPYPVRAMEVVNSGSEVWYSNGPGLLIIDCAILDISRRLE
PYAAPSVVTSLVCSSDCRGEETVWCLDDKGNSLVMYHSATYQLCARYFCGDPSPLRDTFSVQPS
VPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSSYSSTPHPDPKSPTS
LPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGETFSQHLQAVKVLAVQDLIWVP
RHGGDIIVIGLEKDSGAQRGRVIAVLKARELNPHGVLVDAAVVAKDTVVCGFANENTEWCLAVW
RGWGAREFDIFYQSYEELGRLEACPRKRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000016959 ⟸ ENSRNOT00000016959

RefSeq Acc Id:	XP_038968616 ⟸ XM_039112688
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000094655 ⟸ ENSRNOT00000106564

RefSeq Acc Id:	XP_063118551 ⟸ XM_063262481
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6B1B9 (UniProtKB/TrEMBL), D3ZRJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063118546 ⟸ XM_063262476
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063118548 ⟸ XM_063262478
- Peptide Label:	isoform X1
- UniProtKB:	D3ZRJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063118560 ⟸ XM_063262490
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063118568 ⟸ XM_063262498
- Peptide Label:	isoform X4

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZRJ7-F1-model_v2	AlphaFold	D3ZRJ7	1-2013	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308000	AgrOrtholog
BioCyc Gene	G2FUF-59010	BioCyc
Ensembl Genes	ENSRNOG00000012730	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016959	ENTREZGENE
	ENSRNOT00000016959.8	UniProtKB/TrEMBL
	ENSRNOT00000106564	ENTREZGENE
	ENSRNOT00000106564.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
	ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	COR	UniProtKB/TrEMBL
	COR-B	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Plant_LRR-RLKs	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	ROC_GTPase	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	308703	ENTREZGENE
PANTHER	LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED	UniProtKB/TrEMBL
	RECEPTOR PROTEIN-TYROSINE KINASE CEPR1	UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/TrEMBL
	COR	UniProtKB/TrEMBL
	COR-B	UniProtKB/TrEMBL
	LRR_1	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
	Roc	UniProtKB/TrEMBL
PhenoGen	Lrrk1	PhenoGen
PROSITE	LRR	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	ROC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012730	RatGTEx
SMART	LRR_BAC	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
	L domain-like	UniProtKB/TrEMBL
	SSF50978	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6B1B9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZRJ7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lrrk1	leucine-rich repeat kinase 1	Lrrk1_predicted	leucine-rich repeat kinase 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Lrrk1_predicted	leucine-rich repeat kinase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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