Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2) - Rat Genome Database

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Pathways
Gene: Herc2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
RGD ID: 1307989
Description: Predicted to enable SUMO binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in DNA damage response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of Notch signaling pathway; neuron differentiation; and spermatogenesis. Predicted to be located in nucleus. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 38 and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; hect domain and RLD 2; LOC308669; probable E3 ubiquitin-protein ligase HERC2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81116,009,681 - 116,243,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1116,040,736 - 116,243,884 (+)EnsemblGRCr8
mRatBN7.21106,904,789 - 107,110,997 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1106,880,084 - 107,108,134 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1112,296,244 - 112,499,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01120,768,113 - 120,971,079 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01114,017,071 - 114,220,047 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01114,453,033 - 114,653,787 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,453,054 - 114,653,793 (+)Ensemblrn6Rnor6.0
Rnor_5.01115,459,325 - 115,658,977 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41107,440,126 - 107,645,117 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1101,115,534 - 101,316,349 (+)NCBICelera
RGSC_v3.11107,518,956 - 107,722,801 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
membrane  (IBA)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:5565073   PMID:12865426   PMID:19946888   PMID:20304803   PMID:22508508   PMID:22871113   PMID:26692333   PMID:29097665  


Genomics

Comparative Map Data
Herc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81116,009,681 - 116,243,888 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1116,040,736 - 116,243,884 (+)EnsemblGRCr8
mRatBN7.21106,904,789 - 107,110,997 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1106,880,084 - 107,108,134 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1112,296,244 - 112,499,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01120,768,113 - 120,971,079 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01114,017,071 - 114,220,047 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01114,453,033 - 114,653,787 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,453,054 - 114,653,793 (+)Ensemblrn6Rnor6.0
Rnor_5.01115,459,325 - 115,658,977 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41107,440,126 - 107,645,117 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1101,115,534 - 101,316,349 (+)NCBICelera
RGSC_v3.11107,518,956 - 107,722,801 (+)NCBI
Cytogenetic Map1q22NCBI
HERC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381528,111,040 - 28,322,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1528,111,040 - 28,322,179 (-)Ensemblhg38GRCh38
GRCh371528,356,186 - 28,567,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361526,029,781 - 26,240,890 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341526,029,782 - 26,240,845NCBI
Celera156,513,422 - 6,701,708 (-)NCBICelera
Cytogenetic Map15q13.1NCBI
HuRef156,482,549 - 6,693,549 (-)NCBIHuRef
CHM1_11528,305,169 - 28,516,258 (-)NCBICHM1_1
T2T-CHM13v2.01525,853,561 - 26,064,943 (-)NCBIT2T-CHM13v2.0
Herc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39755,699,872 - 55,884,373 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl755,699,944 - 55,881,548 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38756,050,124 - 56,231,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl756,050,196 - 56,231,800 (+)Ensemblmm10GRCm38
MGSCv37763,305,525 - 63,487,170 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36755,918,272 - 56,099,815 (+)NCBIMGSCv36mm8
Celera753,391,067 - 53,570,966 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.42NCBI
Herc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555331,304,675 - 1,489,041 (+)Ensembl
ChiLan1.0NW_0049555331,304,675 - 1,489,041 (+)NCBIChiLan1.0ChiLan1.0
LOC100976978
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11510,603,053 - 10,812,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,590,558 - 1,800,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11525,535,760 - 25,746,444 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1525,536,483 - 25,746,074 (-)EnsemblpanPan2panpan1.1
HERC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,723,113 - 31,966,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,723,500 - 31,966,199 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha334,716,991 - 34,960,078 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0332,370,920 - 32,613,992 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl332,370,916 - 32,613,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,904,221 - 32,147,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0332,153,608 - 32,396,909 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0332,265,346 - 32,508,054 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Herc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,571,057 - 120,758,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647138,419,129 - 38,606,323 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647138,419,147 - 38,606,312 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,438,148 - 56,649,792 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11556,438,117 - 56,649,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21563,528,991 - 63,584,752 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103245991
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,760,172 - 54,007,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,792,593 - 54,007,489 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605436,527,151 - 36,805,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12142,969,120 - 143,150,253 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Herc2
1545 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000019245
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
AF061529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21107,107,638 - 107,107,785 (+)MAPPERmRatBN7.2
Rnor_6.01114,653,288 - 114,653,434NCBIRnor6.0
Rnor_5.01115,658,478 - 115,658,624UniSTSRnor5.0
RGSC_v3.41107,644,622 - 107,644,768UniSTSRGSC3.4
Celera1101,315,854 - 101,316,000UniSTS
Cytogenetic Map1q22UniSTS
AU048235  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81116,150,842 - 116,151,041 (+)Marker Load Pipeline
mRatBN7.21107,015,087 - 107,015,288 (+)MAPPERmRatBN7.2
Rnor_6.01114,563,056 - 114,563,254NCBIRnor6.0
Rnor_5.01115,568,750 - 115,568,948UniSTSRnor5.0
RGSC_v3.41107,551,407 - 107,551,605UniSTSRGSC3.4
Celera1101,224,769 - 101,224,967UniSTS
Cytogenetic Map1q22UniSTS
RH138914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21107,107,762 - 107,108,006 (+)MAPPERmRatBN7.2
Rnor_6.01114,653,412 - 114,653,655NCBIRnor6.0
Rnor_5.01115,658,602 - 115,658,845UniSTSRnor5.0
RGSC_v3.41107,644,746 - 107,644,989UniSTSRGSC3.4
Celera1101,315,978 - 101,316,221UniSTS
RH 3.4 Map1963.61UniSTS
Cytogenetic Map1q22UniSTS
PMC311424P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81116,215,561 - 116,216,473 (+)Marker Load Pipeline
mRatBN7.21107,079,811 - 107,080,723 (+)MAPPERmRatBN7.2
Rnor_6.01114,625,392 - 114,626,301NCBIRnor6.0
Rnor_5.01115,630,582 - 115,631,491UniSTSRnor5.0
RGSC_v3.41107,616,794 - 107,617,705UniSTSRGSC3.4
Celera1101,288,027 - 101,288,938UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019245   ⟹   ENSRNOP00000019245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,040,796 - 116,243,884 (+)Ensembl
mRatBN7.2 Ensembl1106,905,033 - 107,108,134 (+)Ensembl
Rnor_6.0 Ensembl1114,453,275 - 114,653,783 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090796   ⟹   ENSRNOP00000069050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,040,736 - 116,243,884 (+)Ensembl
mRatBN7.2 Ensembl1106,880,084 - 107,108,134 (+)Ensembl
Rnor_6.0 Ensembl1114,453,054 - 114,653,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103366   ⟹   ENSRNOP00000083202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1116,040,736 - 116,243,884 (+)Ensembl
mRatBN7.2 Ensembl1106,880,084 - 107,108,134 (+)Ensembl
RefSeq Acc Id: NM_001107520   ⟹   NP_001100990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,796 - 116,243,884 (+)NCBI
mRatBN7.21106,905,033 - 107,108,134 (+)NCBI
Rnor_6.01114,453,275 - 114,653,783 (+)NCBI
Rnor_5.01115,459,325 - 115,658,977 (+)NCBI
RGSC_v3.41107,440,126 - 107,645,117 (+)RGD
Celera1101,115,534 - 101,316,349 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229300   ⟹   XP_006229362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,543 - 116,243,888 (+)NCBI
mRatBN7.21106,904,789 - 107,110,997 (+)NCBI
Rnor_6.01114,453,033 - 114,653,787 (+)NCBI
Rnor_5.01115,459,325 - 115,658,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229301   ⟹   XP_006229363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,563 - 116,243,888 (+)NCBI
mRatBN7.21106,904,958 - 107,110,997 (+)NCBI
Rnor_6.01114,453,227 - 114,653,787 (+)NCBI
Rnor_5.01115,459,325 - 115,658,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229302   ⟹   XP_006229364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,748 - 116,243,888 (+)NCBI
mRatBN7.21106,904,958 - 107,110,997 (+)NCBI
Rnor_6.01114,453,227 - 114,653,787 (+)NCBI
Rnor_5.01115,459,325 - 115,658,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229304   ⟹   XP_006229366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,543 - 116,243,888 (+)NCBI
mRatBN7.21106,904,789 - 107,110,997 (+)NCBI
Rnor_6.01114,453,033 - 114,653,787 (+)NCBI
Rnor_5.01115,459,325 - 115,658,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112618   ⟹   XP_038968546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,563 - 116,243,888 (+)NCBI
mRatBN7.21106,904,958 - 107,110,997 (+)NCBI
RefSeq Acc Id: XM_039112629   ⟹   XP_038968557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,041,263 - 116,243,888 (+)NCBI
mRatBN7.21106,905,500 - 107,110,997 (+)NCBI
RefSeq Acc Id: XM_063262444   ⟹   XP_063118514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,009,681 - 116,243,888 (+)NCBI
RefSeq Acc Id: XM_063262455   ⟹   XP_063118525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81116,040,543 - 116,216,262 (+)NCBI
RefSeq Acc Id: NP_001100990   ⟸   NM_001107520
- Sequence:
RefSeq Acc Id: XP_006229362   ⟸   XM_006229300
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUC9 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229366   ⟸   XM_006229304
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZVG1 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229364   ⟸   XM_006229302
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUC9 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229363   ⟸   XM_006229301
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUC9 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069050   ⟸   ENSRNOT00000090796
Ensembl Acc Id: ENSRNOP00000019245   ⟸   ENSRNOT00000019245
RefSeq Acc Id: XP_038968546   ⟸   XM_039112618
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUC9 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968557   ⟸   XM_039112629
- Peptide Label: isoform X3
- UniProtKB: D4ACN3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083202   ⟸   ENSRNOT00000103366
RefSeq Acc Id: XP_063118514   ⟸   XM_063262444
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUC9 (UniProtKB/TrEMBL),   D4ACN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118525   ⟸   XM_063262455
- Peptide Label: isoform X4
Protein Domains
Cytochrome b5 heme-binding   DOC   HECT   MIB/HERC2   ZZ-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690095
Promoter ID:EPDNEW_R611
Type:initiation region
Name:Herc2_1
Description:HECT and RLD domain containing E3 ubiquitin protein ligase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01114,453,040 - 114,453,100EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307989 AgrOrtholog
BioCyc Gene G2FUF-59451 BioCyc
Ensembl Genes ENSRNOG00000013718 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019245.8 UniProtKB/TrEMBL
  ENSRNOT00000090796 ENTREZGENE
  ENSRNOT00000090796.3 UniProtKB/TrEMBL
  ENSRNOT00000103366 ENTREZGENE
  ENSRNOT00000103366.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  2.30.30.30 UniProtKB/TrEMBL
  3.10.120.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro APC_su10/DOC_dom UniProtKB/TrEMBL
  Beta-propeller_rpt_TECPR UniProtKB/TrEMBL
  CPH_domain UniProtKB/TrEMBL
  Cyt_B5 UniProtKB/TrEMBL
  Cyt_B5-like_heme/steroid_sf UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HERC2_APC10 UniProtKB/TrEMBL
  Mib_Herc2 UniProtKB/TrEMBL
  Mib_Herc2_sf UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  Reg_csome_cond/b-lactamase_inh UniProtKB/TrEMBL
  Signaling_Regulatory_Domain UniProtKB/TrEMBL
  Transl_SH3-like_sub UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
  ZZ_HERC2 UniProtKB/TrEMBL
KEGG Report rno:308669 UniProtKB/TrEMBL
NCBI Gene 308669 ENTREZGENE
PANTHER BTK-BINDING PROTEIN-RELATED UniProtKB/TrEMBL
  INHIBITOR OF BRUTON TYROSINE KINASE UniProtKB/TrEMBL
Pfam APC10 UniProtKB/TrEMBL
  Cul7 UniProtKB/TrEMBL
  Cyt-b5 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
  PF00569 UniProtKB/TrEMBL
  WD40_RLD UniProtKB/TrEMBL
PhenoGen Herc2 PhenoGen
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE CYTOCHROME_B5_2 UniProtKB/TrEMBL
  DOC UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013718 RatGTEx
SMART APC10 UniProtKB/TrEMBL
  Cyt-b5 UniProtKB/TrEMBL
  HECTc UniProtKB/TrEMBL
  TECPR UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/TrEMBL
Superfamily-SCOP Cyt_B5 UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  SSF159034 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A0G2JUC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVG1 ENTREZGENE, UniProtKB/TrEMBL
  A6KD34_RAT UniProtKB/TrEMBL
  D4ACN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-17 Herc2  HECT and RLD domain containing E3 ubiquitin protein ligase 2  Herc2  hect domain and RLD 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Herc2  hect domain and RLD 2  Herc2  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Herc2  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2   Herc2_predicted  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Herc2_predicted  hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED