Fbxw12 (F-box and WD repeat domain containing 12) - Rat Genome Database

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Gene: Fbxw12 (F-box and WD repeat domain containing 12) Rattus norvegicus
Analyze
Symbol: Fbxw12
Name: F-box and WD repeat domain containing 12
RGD ID: 1307859
Description: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12); INTERACTS WITH vinclozolin; aldehydo-D-glucose (ortholog); arsane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box and WD-40 domain protein 12; F-box/WD repeat-containing protein 12; LOC301015; RGD1307859; similar to RIKEN cDNA E330009P21 gene
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,660,777 - 118,680,565 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,660,605 - 118,680,572 (-)EnsemblGRCr8
mRatBN7.28109,782,315 - 109,802,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)EnsemblmRatBN7.2
Rnor_6.08117,871,409 - 117,890,944 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)Ensemblrn6Rnor6.0
Rnor_5.08117,223,248 - 117,243,442 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,152,906 - 114,173,805 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,072,457 - 109,091,905 (-)NCBICelera
RGSC_v3.18114,174,950 - 114,193,260 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19028597  


Genomics

Comparative Map Data
Fbxw12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,660,777 - 118,680,565 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8118,660,605 - 118,680,572 (-)EnsemblGRCr8
mRatBN7.28109,782,315 - 109,802,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)EnsemblmRatBN7.2
Rnor_6.08117,871,409 - 117,890,944 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)Ensemblrn6Rnor6.0
Rnor_5.08117,223,248 - 117,243,442 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48114,152,906 - 114,173,805 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,072,457 - 109,091,905 (-)NCBICelera
RGSC_v3.18114,174,950 - 114,193,260 (-)NCBI
Cytogenetic Map8q32NCBI
FBXW12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,372,219 - 48,394,725 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,372,219 - 48,401,259 (+)Ensemblhg38GRCh38
GRCh37348,413,709 - 48,436,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,388,713 - 48,411,194 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34348,388,712 - 48,411,194NCBI
Celera348,364,476 - 48,386,962 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,468,007 - 48,490,493 (+)NCBIHuRef
CHM1_1348,365,990 - 48,388,474 (+)NCBICHM1_1
T2T-CHM13v2.0348,400,304 - 48,422,793 (+)NCBIT2T-CHM13v2.0
Fbxw13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,008,295 - 109,025,043 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,008,295 - 109,025,043 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389109,179,227 - 109,195,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,179,227 - 109,195,975 (-)Ensemblmm10GRCm38
MGSCv379109,081,741 - 109,098,489 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369109,036,633 - 109,053,381 (-)NCBIMGSCv36mm8
Celera9108,737,972 - 108,754,720 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
FBXW12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,342,011 - 48,371,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,346,966 - 48,383,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,290,904 - 48,318,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,375,181 - 49,399,598 (+)NCBIPanPan1.1PanPan1.1panPan2
FBXW12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,696,434 - 40,711,177 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,696,502 - 40,710,720 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2040,610,074 - 40,686,892 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02041,177,976 - 41,255,021 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,181,959 - 41,196,209 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,418,762 - 40,495,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,819,973 - 40,896,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,100,712 - 41,177,532 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxw12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,396,384 - 63,415,071 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936529156,881 - 175,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,771,420 - 9,795,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,772,202 - 9,794,123 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041157,298,216 - 157,320,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxw12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18100,401,706 - 100,421,514 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbxw12
216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:105
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000028113
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 2 13 38 32 30 2 30 63 7 10 21 39 2

Sequence


Ensembl Acc Id: ENSRNOT00000028113   ⟹   ENSRNOP00000028113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8118,660,605 - 118,680,572 (-)Ensembl
mRatBN7.2 Ensembl8109,786,815 - 109,801,813 (-)Ensembl
Rnor_6.0 Ensembl8117,871,442 - 117,890,930 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078885   ⟹   ENSRNOP00000072825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8117,871,445 - 117,887,894 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079879   ⟹   ENSRNOP00000071073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8117,871,445 - 117,890,930 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086509   ⟹   ENSRNOP00000073995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,786,821 - 109,801,813 (-)Ensembl
Rnor_6.0 Ensembl8117,871,445 - 117,890,930 (-)Ensembl
RefSeq Acc Id: XM_039082627   ⟹   XP_038938555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,660,777 - 118,680,565 (-)NCBI
mRatBN7.28109,782,315 - 109,802,086 (-)NCBI
RefSeq Acc Id: XM_063266472   ⟹   XP_063122542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,665,305 - 118,670,696 (-)NCBI
RefSeq Acc Id: XM_063266473   ⟹   XP_063122543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,664,348 - 118,680,565 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038938555 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122542 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122543 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028113
  ENSRNOP00000028113.8
Ensembl Acc Id: ENSRNOP00000028113   ⟸   ENSRNOT00000028113
Ensembl Acc Id: ENSRNOP00000071073   ⟸   ENSRNOT00000079879
Ensembl Acc Id: ENSRNOP00000073995   ⟸   ENSRNOT00000086509
Ensembl Acc Id: ENSRNOP00000072825   ⟸   ENSRNOT00000078885
RefSeq Acc Id: XP_038938555   ⟸   XM_039082627
- Peptide Label: isoform X2
- UniProtKB: A6I3B7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122543   ⟸   XM_063266473
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K6Z0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122542   ⟸   XM_063266472
- Peptide Label: isoform X1
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A956-F1-model_v2 AlphaFold D4A956 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307859 AgrOrtholog
BioCyc Gene G2FUF-29089 BioCyc
Ensembl Genes ENSRNOG00000020720 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028113 ENTREZGENE
  ENSRNOT00000028113.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  F-box_SCF_Substrate_Recog UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 301015 ENTREZGENE
PANTHER EXPRESSED SEQUENCE C85627-RELATED UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxw12 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020720 RatGTEx
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K6Z0 ENTREZGENE
  A6I3B7 ENTREZGENE, UniProtKB/TrEMBL
  D4A956_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fbxw12  F-box and WD repeat domain containing 12  Fbxw12  F-box and WD-40 domain protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fbxw12  F-box and WD-40 domain protein 12  RGD1307859_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307859_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)  LOC301015_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301015_predicted  similar to RIKEN cDNA E330009P21 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL