Ist1 (IST1 factor associated with ESCRT-III) - Rat Genome Database

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Gene: Ist1 (IST1 factor associated with ESCRT-III) Rattus norvegicus
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Symbol: Ist1
Name: IST1 factor associated with ESCRT-III
RGD ID: 1307799
Description: Predicted to enable MIT domain binding activity and identical protein binding activity. Predicted to be involved in several processes, including establishment of protein localization; midbody abscission; and positive regulation of proteolysis. Predicted to act upstream of or within positive regulation of collateral sprouting. Predicted to be located in several cellular components, including Flemming body; endoplasmic reticulum-Golgi intermediate compartment; and extracellular exosome. Orthologous to human IST1 (IST1 factor associated with ESCRT-III); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: charged multivesicular body protein 8; CHMP8; increased sodium tolerance 1; increased sodium tolerance 1 homolog; increased sodium tolerance 1 homolog (yeast); IST1 homolog; IST1, ESCRT-III associated factor; LOC307833; MAPK activating protein PM28; MGC109331; RGD1307799; similar to RIKEN cDNA 2400003C14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,558,353 - 54,580,551 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,558,353 - 54,580,491 (-)EnsemblGRCr8
mRatBN7.21937,648,840 - 37,671,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,648,095 - 37,670,956 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,461,787 - 44,483,896 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,115,119 - 45,137,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,424,730 - 47,446,839 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,968,692 - 41,990,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,968,705 - 41,990,843 (+)Ensemblrn6Rnor6.0
Rnor_5.01952,793,716 - 52,815,862 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,554,205 - 39,576,343 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,052,746 - 37,074,884 (-)NCBICelera
RGSC_v3.11939,559,093 - 39,581,181 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10942595   PMID:12477932   PMID:19056867   PMID:19129479   PMID:19129480   PMID:19199708   PMID:19525971   PMID:20458337   PMID:20719964   PMID:20849418   PMID:21557262   PMID:22619377  
PMID:23015756   PMID:23376485   PMID:23533145   PMID:25468996   PMID:28242692  


Genomics

Comparative Map Data
Ist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,558,353 - 54,580,551 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,558,353 - 54,580,491 (-)EnsemblGRCr8
mRatBN7.21937,648,840 - 37,671,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,648,095 - 37,670,956 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,461,787 - 44,483,896 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,115,119 - 45,137,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,424,730 - 47,446,839 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,968,692 - 41,990,843 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,968,705 - 41,990,843 (+)Ensemblrn6Rnor6.0
Rnor_5.01952,793,716 - 52,815,862 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,554,205 - 39,576,343 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,052,746 - 37,074,884 (-)NCBICelera
RGSC_v3.11939,559,093 - 39,581,181 (-)NCBI
Cytogenetic Map19q12NCBI
IST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,894,408 - 71,931,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,845,996 - 71,931,199 (+)Ensemblhg38GRCh38
GRCh371671,928,311 - 71,965,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,486,947 - 70,520,407 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1656,243,371 - 56,276,822 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,696,177 - 57,731,724 (+)NCBIHuRef
CHM1_11673,341,627 - 73,377,874 (+)NCBICHM1_1
T2T-CHM13v2.01677,711,542 - 77,748,323 (+)NCBIT2T-CHM13v2.0
Ist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,397,953 - 110,419,929 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,397,957 - 110,419,892 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,671,321 - 109,693,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,671,325 - 109,693,260 (-)Ensemblmm10GRCm38
MGSCv378112,195,221 - 112,217,194 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,560,458 - 112,582,393 (-)NCBIMGSCv36mm8
Celera8113,896,960 - 113,918,958 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.18NCBI
Ist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,589,311 - 4,630,203 (+)Ensembl
ChiLan1.0NW_0049554844,589,311 - 4,630,464 (+)NCBIChiLan1.0ChiLan1.0
IST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,231,091 - 82,313,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,158,887 - 88,202,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,082,530 - 53,115,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,733,868 - 71,765,969 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,733,302 - 71,765,969 (+)EnsemblpanPan2panpan1.1
IST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,660,033 - 77,693,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,660,081 - 77,692,396 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha577,621,109 - 77,655,606 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0578,099,321 - 78,133,852 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,098,618 - 78,133,639 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,919,418 - 77,953,932 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,742,127 - 77,776,623 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,241,426 - 78,275,957 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101977053
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,680,804 - 37,699,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,890,013 - 21,908,245 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,890,011 - 21,908,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,836,752 - 14,911,311 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1614,868,859 - 14,910,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,465,663 - 14,489,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,030,916 - 55,063,824 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,050,795 - 55,064,549 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604717,832,602 - 17,864,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ist1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11729,394,469 - 29,416,467 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ist1
167 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:374
Count of miRNA genes:194
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000020365
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020365   ⟹   ENSRNOP00000020365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1954,558,353 - 54,580,491 (-)Ensembl
mRatBN7.2 Ensembl1937,648,095 - 37,670,956 (-)Ensembl
Rnor_6.0 Ensembl1941,968,705 - 41,990,843 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107910   ⟹   ENSRNOP00000088873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1954,558,353 - 54,580,491 (-)Ensembl
mRatBN7.2 Ensembl1937,648,095 - 37,670,956 (-)Ensembl
RefSeq Acc Id: NM_001017454   ⟹   NP_001017454
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,558,353 - 54,580,491 (-)NCBI
mRatBN7.21937,648,840 - 37,670,978 (-)NCBI
Rnor_6.01941,968,705 - 41,990,843 (+)NCBI
Rnor_5.01952,793,716 - 52,815,862 (+)NCBI
RGSC_v3.41939,554,205 - 39,576,343 (-)RGD
Celera1937,052,746 - 37,074,884 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278049   ⟹   XP_063134119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,561,785 - 54,580,551 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001017454 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH92631 (Get FASTA)   NCBI Sequence Viewer  
  EDL92508 (Get FASTA)   NCBI Sequence Viewer  
  EDL92509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020365
GenBank Protein Q568Z6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017454   ⟸   NM_001017454
- UniProtKB: Q568Z6 (UniProtKB/Swiss-Prot),   A6IZ30 (UniProtKB/TrEMBL),   A0A8L2QA75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020365   ⟸   ENSRNOT00000020365
Ensembl Acc Id: ENSRNOP00000088873   ⟸   ENSRNOT00000107910
RefSeq Acc Id: XP_063134119   ⟸   XM_063278049
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QA75 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q568Z6-F1-model_v2 AlphaFold Q568Z6 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701134
Promoter ID:EPDNEW_R11658
Type:initiation region
Name:Ist1_1
Description:IST1, ESCRT-III associated factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01941,968,705 - 41,968,765EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307799 AgrOrtholog
BioCyc Gene G2FUF-5727 BioCyc
Ensembl Genes ENSRNOG00000015144 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020365 ENTREZGENE
Gene3D-CATH 1.20.1260.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314864 IMAGE-MGC_LOAD
InterPro Ist1 UniProtKB/Swiss-Prot
  IST1-like UniProtKB/Swiss-Prot
KEGG Report rno:307833 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109331 IMAGE-MGC_LOAD
NCBI Gene 307833 ENTREZGENE
PANTHER IST1 HOMOLOG UniProtKB/Swiss-Prot
  PTHR12161 UniProtKB/Swiss-Prot
Pfam Ist1 UniProtKB/Swiss-Prot
PhenoGen Ist1 PhenoGen
RatGTEx ENSRNOG00000015144 RatGTEx
UniProt A0A8I6AJP9_RAT UniProtKB/TrEMBL
  A0A8L2QA75 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ30 ENTREZGENE, UniProtKB/TrEMBL
  IST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Ist1  IST1 factor associated with ESCRT-III  Ist1  IST1, ESCRT-III associated factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Ist1  IST1, ESCRT-III associated factor  Ist1  increased sodium tolerance 1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-31 Ist1  increased sodium tolerance 1 homolog (yeast)  RGD1307799  similar to RIKEN cDNA 2400003C14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307799  similar to RIKEN cDNA 2400003C14  RGD1307799_predicted  similar to RIKEN cDNA 2400003C14 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307799_predicted  similar to RIKEN cDNA 2400003C14 (predicted)  LOC307833_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307833_predicted  similar to RIKEN cDNA 2400003C14 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL