Bag3 (BAG cochaperone 3) - Rat Genome Database

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Gene: Bag3 (BAG cochaperone 3) Rattus norvegicus
Analyze
Symbol: Bag3
Name: BAG cochaperone 3
RGD ID: 1307794
Description: Predicted to enable adenyl-nucleotide exchange factor activity; protein-folding chaperone binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including autophagosome assembly; chaperone-mediated autophagy; and negative regulation of protein targeting to mitochondrion. Located in stress fiber. Used to study glioblastoma. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2JJ; autosomal dominant distal hereditary motor neuronopathy 15; dilated cardiomyopathy 1HH; and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BAG family molecular chaperone regulator 3; Bcl2-associated athanogene 3; LOC293524
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,533,460 - 192,557,281 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,475,828 - 192,557,280 (+)EnsemblGRCr8
mRatBN7.21183,103,038 - 183,126,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,453,498 - 191,477,319 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,639,582 - 198,663,403 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,309,832 - 191,333,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,941,258 - 199,965,191 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,989,244 - 207,013,177 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,781,147 - 187,804,835 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,749,355 - 180,773,125 (+)NCBICelera
RGSC_v3.11187,931,027 - 187,954,715 (+)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
ABT-737  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
amiodarone  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen chloride  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
lactulose  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melibiose  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
morphine  (EXP)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naled  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrethrins  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
staurosporine  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
Triptolide  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein folding chaperone complex  (IEA,ISO)
stress fiber  (IDA)
Z disc  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a synaptosome-associated form of BAG3 protein. Bruno AP, etal., Cell Cycle. 2008 Oct;7(19):3104-5. Epub 2008 Oct 12.
2. Transient expression of Bis protein in midline radial glia in developing rat brainstem and spinal cord. Choi JS, etal., Cell Tissue Res. 2009 Jul;337(1):27-36. Epub 2009 May 5.
3. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Festa M, etal., Am J Pathol. 2011 Jun;178(6):2504-12. Epub 2011 May 10.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure. Lee MY, etal., Exp Mol Med. 2002 May 31;34(2):167-71.
7. Reactive astrocytes express bis, a bcl-2-binding protein, after transient forebrain ischemia. Lee MY, etal., Exp Neurol. 2002 Jun;175(2):338-46.
8. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. Liao Q, etal., FEBS Lett. 2001 Aug 17;503(2-3):151-7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
Additional References at PubMed
PMID:10597216   PMID:11527400   PMID:12477932   PMID:16936253   PMID:18006506   PMID:19085932   PMID:20060297   PMID:20599823   PMID:20884878   PMID:20962586   PMID:22366786   PMID:24318877  
PMID:24675892   PMID:25212465   PMID:25468996   PMID:25904010   PMID:26159920   PMID:27381181   PMID:27383426   PMID:27756573   PMID:28144784   PMID:28755400   PMID:28941726   PMID:29484366  
PMID:30326144   PMID:30631036   PMID:30744518   PMID:30932190   PMID:31114002   PMID:31209204   PMID:33578031   PMID:33989081   PMID:34162039   PMID:34379447   PMID:35253089   PMID:35352799  
PMID:37899687   PMID:38488519  


Genomics

Comparative Map Data
Bag3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,533,460 - 192,557,281 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,475,828 - 192,557,280 (+)EnsemblGRCr8
mRatBN7.21183,103,038 - 183,126,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,453,498 - 191,477,319 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,639,582 - 198,663,403 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,309,832 - 191,333,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,941,258 - 199,965,191 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,989,244 - 207,013,177 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,781,147 - 187,804,835 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,749,355 - 180,773,125 (+)NCBICelera
RGSC_v3.11187,931,027 - 187,954,715 (+)NCBI
Cytogenetic Map1q37NCBI
BAG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,651,380 - 119,677,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,650,879 - 119,677,913 (+)Ensemblhg38GRCh38
GRCh3710121,410,892 - 121,437,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,400,872 - 121,427,321 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410121,400,871 - 121,427,317NCBI
Celera10115,141,910 - 115,168,393 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10115,040,288 - 115,066,931 (+)NCBIHuRef
CHM1_110121,695,782 - 121,722,250 (+)NCBICHM1_1
T2T-CHM13v2.010120,548,963 - 120,575,488 (+)NCBIT2T-CHM13v2.0
Bag3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397128,125,307 - 128,148,705 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7128,125,340 - 128,148,705 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387128,523,583 - 128,546,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,523,616 - 128,546,981 (+)Ensemblmm10GRCm38
MGSCv377135,667,097 - 135,690,495 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367128,314,764 - 128,355,703 (+)NCBIMGSCv36mm8
Celera7128,367,952 - 128,391,279 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.26NCBI
Bag3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955551446,605 - 469,207 (+)Ensembl
ChiLan1.0NW_004955551446,322 - 468,329 (+)NCBIChiLan1.0ChiLan1.0
BAG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,509,777 - 131,536,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,515,147 - 131,541,828 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010116,221,747 - 116,248,692 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,654,366 - 119,665,964 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,643,963 - 119,665,964 (+)EnsemblpanPan2panpan1.1
BAG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,792,612 - 29,815,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,792,777 - 29,815,138 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2829,934,645 - 29,957,491 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02830,323,229 - 30,346,844 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2830,322,795 - 30,346,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,876,932 - 29,899,733 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,897,755 - 29,920,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02830,092,215 - 30,115,061 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bag3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,553,837 - 16,575,442 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,985,761 - 9,007,502 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,985,871 - 9,007,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,466,905 - 129,533,993 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114129,510,240 - 129,533,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214141,034,569 - 141,058,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,439,954 - 112,465,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,439,782 - 112,466,086 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604873,714,873 - 73,741,128 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,171,402 - 27,195,004 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473727,171,402 - 27,195,008 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bag3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1273,395,151 - 73,419,277 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bag3
219 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:74
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000027616
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
AW532391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,102,664 - 183,102,854 (+)MAPPERmRatBN7.2
Rnor_6.01199,940,885 - 199,941,074NCBIRnor6.0
Rnor_5.01206,988,871 - 206,989,060UniSTSRnor5.0
RGSC_v3.41187,780,774 - 187,780,963UniSTSRGSC3.4
Celera1180,748,982 - 180,749,171UniSTS
RH 3.4 Map11384.7UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027616   ⟹   ENSRNOP00000027616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,532,966 - 192,556,954 (+)Ensembl
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)Ensembl
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141431   ⟹   ENSRNOP00000103287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,475,828 - 192,557,280 (+)Ensembl
RefSeq Acc Id: NM_001011936   ⟹   NP_001011936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,533,460 - 192,557,281 (+)NCBI
mRatBN7.21183,103,038 - 183,126,862 (+)NCBI
Rnor_6.01199,941,258 - 199,965,191 (+)NCBI
Rnor_5.01206,989,244 - 207,013,177 (+)NCBI
RGSC_v3.41187,781,147 - 187,804,835 (+)RGD
Celera1180,749,355 - 180,773,125 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011936 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85857 (Get FASTA)   NCBI Sequence Viewer  
  ABG23394 (Get FASTA)   NCBI Sequence Viewer  
  EDM17171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027616
  ENSRNOP00000027616.4
  ENSRNOP00000103287.1
RefSeq Acc Id: NP_001011936   ⟸   NM_001011936
- UniProtKB: Q5U2U8 (UniProtKB/TrEMBL),   A6IA08 (UniProtKB/TrEMBL),   Q156J1 (UniProtKB/TrEMBL),   F7EZX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027616   ⟸   ENSRNOT00000027616
Ensembl Acc Id: ENSRNOP00000103287   ⟸   ENSRNOT00000141431
Protein Domains
BAG   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2U8-F1-model_v2 AlphaFold Q5U2U8 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690460
Promoter ID:EPDNEW_R985
Type:initiation region
Name:Bag3_1
Description:Bcl2-associated athanogene 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R986  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,941,085 - 199,941,145EPDNEW
RGD ID:13690461
Promoter ID:EPDNEW_R986
Type:multiple initiation site
Name:Bag3_2
Description:Bcl2-associated athanogene 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R985  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,941,276 - 199,941,336EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307794 AgrOrtholog
BioCyc Gene G2FUF-57292 BioCyc
Ensembl Genes ENSRNOG00000020298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027616 ENTREZGENE
  ENSRNOT00000027616.8 UniProtKB/TrEMBL
  ENSRNOT00000141431.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.120 UniProtKB/TrEMBL
  2.20.70.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190249 IMAGE-MGC_LOAD
InterPro Apoptosis_reg_Bcl-2_prot_BAG UniProtKB/TrEMBL
  BAG_chaperone_regulator UniProtKB/TrEMBL
  BAG_dom_sf UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:293524 UniProtKB/TrEMBL
MGC_CLONE MGC:94584 IMAGE-MGC_LOAD
NCBI Gene 293524 ENTREZGENE
PANTHER BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3 UniProtKB/TrEMBL
  PTHR12329 UniProtKB/TrEMBL
Pfam BAG UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Bag3 PhenoGen
PROSITE BAG UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020298 RatGTEx
SMART BAG UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF63491 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0ABK0LS17_RAT UniProtKB/TrEMBL
  A6IA08 ENTREZGENE, UniProtKB/TrEMBL
  F7EZX8 ENTREZGENE, UniProtKB/TrEMBL
  Q156J1 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2U8 ENTREZGENE
UniProt Secondary Q5U2U8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Bag3  BAG cochaperone 3  Bag3  Bcl2-associated athanogene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Bag3  Bcl2-associated athanogene 3  Bag3_predicted  Bcl2-associated athanogene 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Bag3_predicted  Bcl2-associated athanogene 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED