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Gene: Tmem168 (transmembrane protein 168) Rattus norvegicus

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Symbol:

Tmem168

Name:

transmembrane protein 168

RGD ID:

1307778

Description:

Predicted to enable sodium channel regulator activity. Predicted to act upstream of or within regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear membrane and transport vesicle. Orthologous to human TMEM168 (transmembrane protein 168); INTERACTS WITH acetamide; bisphenol A; 1,2-dimethylhydrazine (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC312135; RGD1307778; similar to RIKEN cDNA 8430437G11

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM168 (transmembrane protein 168)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Tmem168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem168 (transmembrane protein 168)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tmem168 (transmembrane protein 168)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM168 (transmembrane protein 168)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem168a (transmembrane protein 168a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tmem168b (transmembrane protein 168b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem168	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	42,796,714 - 42,824,854 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	42,796,720 - 42,824,854 (-)	Ensembl				GRCr8
mRatBN7.2	4	41,830,623 - 41,858,763 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	41,830,624 - 41,858,776 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	46,807,390 - 46,834,480 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	42,728,393 - 42,755,484 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	41,137,097 - 41,164,187 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	44,536,706 - 44,563,796 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	41,966,424 - 41,993,514 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	42,529,847 - 42,556,937 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	42,351,592 - 42,378,682 (-)	NCBI		F344_StmMcwi
Rnor_6.0	4	40,006,362 - 40,041,129 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	40,007,844 - 40,036,563 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	39,840,355 - 39,868,490 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	39,012,323 - 39,039,671 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	37,179,920 - 37,207,841 (-)	NCBI		Celera
RGSC_v3.1	4	39,130,864 - 39,158,211 (-)	NCBI
Cytogenetic Map	4	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

choline (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

L-methionine (ISO)

leflunomide (ISO)

methylmercury chloride (ISO)

paclitaxel (ISO)

paracetamol (ISO)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of ubiquitin-dependent protein catabolic process (ISO)

regulation of voltage-gated sodium channel activity (ISO)

Cellular Component

nuclear membrane (IEA,ISO,ISS)

transport vesicle (ISO)

Molecular Function

sodium channel regulator activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data

Tmem168
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	42,796,714 - 42,824,854 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	42,796,720 - 42,824,854 (-)	Ensembl				GRCr8
mRatBN7.2	4	41,830,623 - 41,858,763 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	41,830,624 - 41,858,776 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	46,807,390 - 46,834,480 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	42,728,393 - 42,755,484 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	41,137,097 - 41,164,187 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	44,536,706 - 44,563,796 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	41,966,424 - 41,993,514 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	42,529,847 - 42,556,937 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	42,351,592 - 42,378,682 (-)	NCBI		F344_StmMcwi
Rnor_6.0	4	40,006,362 - 40,041,129 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	40,007,844 - 40,036,563 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	39,840,355 - 39,868,490 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	39,012,323 - 39,039,671 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	37,179,920 - 37,207,841 (-)	NCBI		Celera
RGSC_v3.1	4	39,130,864 - 39,158,211 (-)	NCBI
Cytogenetic Map	4	q21	NCBI

TMEM168
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	112,762,377 - 112,790,393 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	112,762,377 - 112,790,715 (-)	Ensembl			hg38	GRCh38
GRCh37	7	112,402,432 - 112,430,448 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	112,193,023 - 112,217,714 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	107,217,551 - 107,242,217 (-)	NCBI		Celera
Cytogenetic Map	7	q31.1	NCBI
HuRef	7	106,773,091 - 106,797,770 (-)	NCBI		HuRef
CHM1_1	7	112,339,671 - 112,364,332 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	114,080,668 - 114,108,691 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	111,774,269 - 111,798,936 (-)	NCBI

Tmem168
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	13,580,688 - 13,608,097 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	13,580,686 - 13,608,099 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	13,580,689 - 13,608,098 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	13,580,687 - 13,608,100 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	13,530,689 - 13,558,063 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	13,530,687 - 13,558,063 (-)	NCBI		MGSCv36	mm8
Celera	6	13,672,708 - 13,700,081 (-)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	5.68	NCBI

Tmem168
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	19,001,816 - 19,032,432 (-)	Ensembl
ChiLan1.0	NW_004955432	19,002,083 - 19,032,432 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM168
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	149,596,308 - 149,620,903 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	1,606,567 - 1,632,890 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	104,729,362 - 104,756,299 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	117,433,384 - 117,457,999 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	117,433,384 - 117,458,000 (-)	Ensembl			panPan2	panpan1.1

TMEM168
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	52,312,109 - 52,340,151 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	52,314,856 - 52,338,214 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	51,771,324 - 51,801,797 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	52,341,015 - 52,371,609 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	52,341,352 - 52,374,455 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	52,381,313 - 52,411,795 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	52,055,666 - 52,086,114 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	52,438,340 - 52,468,897 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem168
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	40,990,152 - 41,018,604 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936589	5,671,185 - 5,701,173 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936589	5,671,182 - 5,699,714 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM168
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	32,927,748 - 32,957,960 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	32,928,104 - 32,960,884 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	35,535,714 - 35,603,519 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM168
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	81,567,647 - 81,594,451 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666042	22,209,045 - 22,235,420 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem168
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624827	6,526,073 - 6,557,851 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624827	6,522,145 - 6,557,543 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem168
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	124,491,271 - 124,516,904 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem168
121 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	13080146	58080146	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	15644309	60644309	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
8655949	Rf62	Renal function QTL 62	22		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	4	35396600	45429897	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	40490442	75726188	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	18900697	63900697	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	40471453	75939996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
2290374	Gluco32	Glucose level QTL 32	6.27		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	38144194	45429897	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	22288453	63245191	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	18900697	63900697	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	18913151	63913151	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	27862204	62997402	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
11530004	Niddm71	Non-insulin dependent diabetes mellitus QTL 71		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	33538816	53719714	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	22288453	45429897	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat

Markers in Region

RH128793

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	41,830,580 - 41,830,762 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	40,006,320 - 40,006,501	NCBI	Rnor6.0
Rnor_5.0	4	39,840,509 - 39,840,690	UniSTS	Rnor5.0
RGSC_v3.4	4	39,012,281 - 39,012,462	UniSTS	RGSC3.4
Celera	4	37,179,878 - 37,180,059	UniSTS
Cytogenetic Map	4	q21	UniSTS

RH129582

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	41,830,657 - 41,830,875 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	40,006,397 - 40,006,614	NCBI	Rnor6.0
Rnor_5.0	4	39,840,586 - 39,840,803	UniSTS	Rnor5.0
RGSC_v3.4	4	39,012,358 - 39,012,575	UniSTS	RGSC3.4
Celera	4	37,179,955 - 37,180,172	UniSTS
RH 3.4 Map	4	241.4	UniSTS
Cytogenetic Map	4	q21	UniSTS

RH142359

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	41,830,740 - 41,830,908 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	40,006,480 - 40,006,647	NCBI	Rnor6.0
Rnor_5.0	4	39,840,669 - 39,840,836	UniSTS	Rnor5.0
RGSC_v3.4	4	39,012,441 - 39,012,608	UniSTS	RGSC3.4
Celera	4	37,180,038 - 37,180,205	UniSTS
RH 3.4 Map	4	238.8	UniSTS
Cytogenetic Map	4	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000084531 ⟹ ENSRNOP00000069933

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	42,796,720 - 42,824,854 (-)	Ensembl
mRatBN7.2 Ensembl	4	41,830,624 - 41,858,776 (-)	Ensembl
Rnor_6.0 Ensembl	4	40,007,844 - 40,036,563 (-)	Ensembl

RefSeq Acc Id:

NM_001014054 ⟹ NP_001014076

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	42,796,714 - 42,824,854 (-)	NCBI
mRatBN7.2	4	41,830,623 - 41,858,763 (-)	NCBI
Dahl_SR_JrHsd	4	44,536,706 - 44,563,796 (-)	NCBI
Lyon_Normotensive	4	41,966,424 - 41,993,514 (-)	NCBI
Lyon_Hypertensive	4	42,529,847 - 42,556,937 (-)	NCBI
F344_StmMcwi	4	42,351,592 - 42,378,682 (-)	NCBI
Rnor_6.0	4	40,006,362 - 40,041,107 (-)	NCBI
Rnor_5.0	4	39,840,355 - 39,868,490 (-)	NCBI
RGSC_v3.4	4	39,012,323 - 39,039,671 (-)	RGD
Celera	4	37,179,920 - 37,207,841 (-)	RGD

Sequence:

show sequence

GCCAGCAGTCAGTGGCGGAAATATGGCGGCAGTGTCCGTATTAGAGAAAGTTTCTATCGAGGCC
CTGTGGTGCTAGTGCGGGAGGCCTCAGGCTCAGGTCCCCACACCACCTCCAGGTTCTGACTTGG
AGGCTTCGCGCCCTTTTGTTTTGTAAGCTTCGCAACGGACGGAGAGAGGCTCGGTGGCGACCAC
TGATTCAGGTCACTATAAAGAAAACTTCTGAGAAAATGTTGGAATAGGCGTTACCAACACATTG
GATGCATTGAATGAAATACAGAAAGTTAGTTTTTGTGACGTGTGGGAAGCCCCCCGAGCGCCAG
AGTACATGTGTAAATCACTGCGTTACTGCTTTAGTCATTGTCTCTACCTAGCAATGACGAGGCT
GGAAGAAGTCAACAGAGAAGTGAACATGCATTCCTCCGTGCGCTATCTCGGCTATCTAGCCAGG
TTCAACTTACTGGTGGCCATTTGTTTAGGCCTTTATGTGAGATGGGAGAAAACAGCAAATTCTT
TAATTTTGGTGATTTTTATTCTCGGCCTCTTTGTCCTTGGGATCGCCAGCATTCTCTACTATTA
CTTTTCAATGGAAGCGGCAAGTTTAAGTCTCTCCAATCTCTGGTTTGGATTTCTGCTTGGCCTC
CTGTGTTTTCTTGATAATTCATCCTTTAAAAGTGACGTGAAAGAAGAAACAACCAAATACTTGC
TTCTGACGTCTATAGTATTGAGGATACTGTGTGCGTTGGTGGAGAGACTTTCTGGTTATGTCCG
ACATCGGCCTACTTTACTAACCACAGTAGAGTTTCTGGAACTTGTTGGGTTTGCCATCGCCAGC
ACAACCATGTTGGTGGAGAGATCTCTGAGTGTGATCTTGCTTGTCATGGCTTTGGCCATGCTCA
TCATCGACCTGAGAATGAAGTCCTTTCTAGCTATTCCAAACTTAATCATTTTTTCAGTATTGCT
ATTTTTCTCCTCATTGGAAACTCCCCAAAATCCAATTGCTTTCGCATGTTTTTTTATTTGCCTG
ATAACTGATCCTTTTCTTGACATTTATTTTAGTGGACTCTCAGTAACCGAAAGGTGGAAGCCCT
TTCTGTACCGTGGCAGAATTTGCAGGAGACTTTCGGTGGTTTTCACAGGAATGATCGAGCTTAC
ATTCTTCACTCTTTCAGCATTTAAACTTAGAGACACTCATCTCTGGTATTTCGTGATACCAGGC
TTTTCCATTTTTGGAATTTTCTGGATGATTTGCCATATTATTTTTCTTTTAACTCTTTGGGGAT
TTCACACCAAATTAAATGACTGCCATAAAGTGTATATCAACCACAGGGCAGATAACAACAGCCT
TGACAGAATCATGGCATCCAAAGGGATGCGGCATTTTTGCTTAATTTCAGAACAGTTAGTTTTT
TTTAGTCTTCTTGCAACAGCAATTTTGGGAGCCGTCTCCTGGCAGCCCACAAATGGAATCTTCT
TGAGCATGTTTCTTATTGTTTTGCCACTGGAGTCCATGGCTCATGGGCTCTTCCATGAATTAGG
TAACTGCTTAGGAGGAACGTCTGTTGGATATGCTATTGTGATCCCTACCAACTTCTGCAGTCCT
GATGGCCAGCCAACACTGCTTCCTCCAGAACATGTTCAGGAGTTAAATTTGAGGTCTACTGGCA
TGCTCAATGCCATCCAAAGATTTTTTGCATATCATATGATTGAGACCTATGGATGTGACTATTC
CACAAGTGGACTGTCTTTTGATACTCTACATTCCAAACTGAAAGCTTTCCTTGAACTCCGGACG
GTGGATGGACCTAGACATGATACATATGTTTTATATTATAGTGGACACACCCATGGCTCAGGAG
AGTGGGCTCTAGCAGGTGGAGACATACTTCGCCTTGATACACTTTTAGAATGGTGGAGAGAAAA
GAATGGTTCCTTCTGTTCCCGGCTTATCATCATATTAGACAGCGAGAATTCAACCCCCTGGGTG
AAAGAAGTGAGAAAGATTAATGACCAGTATGTTGCAGTTCAGGGGGCTGAGCTGGCGAAGACAG
TGGATATTGAAGAAGCCGACCCACCACAGCTGGGCGACTTTACTAGAGACTGGGTCGAGTACAA
CTGCAACTCCACAAACAACATCTGCTGGACTGAGAAGGGGCGCACAGTGAAGGCTATGTATGGT
GTGTCAAAGCGTTGGAGTGACTACACTCTACACTTGCCGACAGGAAGTGATGTGGCCAAGCACT
GGATGCTACACTTTCCTCGTATTACATATCCATTAGTGCATTTGGCAAACTGGTTATGTGGCCT
GAACCTCTTTTGGATGTGCAAAGCCTGTTTTAGGTGCTTGAAAAGATTAAAAATGAGTTGGTTT
CTTCCTACAGTGCTGGACACAGGACAAGGCTTTAAACTTGTCAAGTCTTAATTTGGACATCAAG
GAAGGATAGTATGAGAGTTCATGTTACCATTTATCAGTAACTTGCCATTTTTTGTATGCTGTAT
TTTTATTTGTGGGAAGTATTTTGCTACATTTGTAGCTGCTCTCACTTTGTCTTTTCTTAAGTAA
TTATGGGATGTGTAAGATATTGGGAATATGCATGATTTTATACTAAAAGTATACAGAGGGTCAT
AAATATGCTGAATGTAAATGTGTAAGAGATGTTAAAAGTAACAGTGCACTTTCAGATAACTTTC
CATTTGTCTCCAATGAAAAGAAAGTTGTCTGTGCTCTGAAGTGGCCAATTGACAATTTCTAATG
CCTTATTTTCTAGGCATACATTAGAGAATGTAGACCAGACAAGTGTGTTTTAAGAGAACTACCA
ATTTACTTCATAGAAGATTCTTCCATGTGTGTGATTCATGTAGGTTTGACCCCAAGACTGTTTG
CAGAAGTATAAACTCTTGGAGCAGGAAGAGACCTGCTCATAATGACTGCAGAATGCCCTTTCTC
CATCACACCCAAAAGTCTTGGCTATGACCTTTACCAGTACAGCAGAGAAGCCACAACTGCCTTT
GAGATGAAAGCATTATTAATGTAGGTTACAATAAGAGCTTAGAGGCAACAAAGCCTTCCTTCAT
GATTAGTGAGGGACTTTGAAAATACTGGTAATTTGAAGAGTCCTTCTCAGGGTAATTTAGTTTT
CTTAATGAGTAATATTTCCAGCTACAGATTCCTTTCAAGTAAATTGCCATTCTTTTCAAAAAGT
ACACTTAGAAAATAAATGTAGCAGTTTCTCATTGACCAATTCACCCTGTCTTAAGTATTCTGAG
AAGTAGTGCTCTGCCATGAAAATTACTTTTCAGATCCTATTGTAATAACTCTTTTCTGCTGAAG
GTCAAAGGATGGGAACAGATCATTTTGTTGTTGTTGTTGTTATATACCTGTATTGTATTATGTA
AAAAAGTATTCATTTTGGCAATTTTAGGTAAGCATAATGGTGAGGTTGTAATTTTTAAACTTTA
ATTCAGTGTTTTGTTGGAGTAAAGTAGGCACTGATCAGGATATTTCCTTAAGAGGTAATTCTCT
TCCTGTTCCCTTCCAATAATCCTTACATTTTTAGATTTTCATCTTGGCAAGAGGGAGGTATAAT
TAAATTGGAGATTAGACTTTGCTAACATGGTGACTTCTCACCATTGAAGCCATTTTTCCAGGCC
CAGAGAGAGAAGGTAACGCATCTACCATTTCTACCGATGACTTGAAAACTGACGTTTTCTTTAG
AAAGAAGTCACTCCGTCAGGGAACATGTATACCGCTATCTATGCAGCATTGCAGCAGCCTATTC
CTATGTTTTGAATACTGTACTCTTAATACTTTGAATAATATTTTGTTAAAGATCAATTTTTCAT
TGAATGTGAAATGAAGAGTTCCTGAATATTTTACTGTATTAAAAGTGGAAGTTATACAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014076	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87124	(Get FASTA)	NCBI Sequence Viewer
	EDM15086	(Get FASTA)	NCBI Sequence Viewer
	EDM15087	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069933
	ENSRNOP00000069933.2
GenBank Protein	Q5PQM0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014076 ⟸ NM_001014054

- UniProtKB:

Q5PQM0 (UniProtKB/Swiss-Prot), A6IDZ9 (UniProtKB/TrEMBL), A0A096MIS5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARFNLLVAICLGLYVRWEKTANSLI
LVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKSDVKEETTKYLLL
TSIVLRILCALVERLSGYVRHRPTLLTTVEFLELVGFAIASTTMLVERSLSVILLVMALAMLII
DLRMKSFLAIPNLIIFSVLLFFSSLETPQNPIAFACFFICLITDPFLDIYFSGLSVTERWKPFL
YRGRICRRLSVVFTGMIELTFFTLSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFH
TKLNDCHKVYINHRADNNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLS
MFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGML
NAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGPRHDTYVLYYSGHTHGSGEW
ALAGGDILRLDTLLEWWREKNGSFCSRLIIILDSENSTPWVKEVRKINDQYVAVQGAELAKTVD
IEEADPPQLGDFTRDWVEYNCNSTNNICWTEKGRTVKAMYGVSKRWSDYTLHLPTGSDVAKHWM
LHFPRITYPLVHLANWLCGLNLFWMCKACFRCLKRLKMSWFLPTVLDTGQGFKLVKS

hide sequence

Ensembl Acc Id:

ENSRNOP00000069933 ⟸ ENSRNOT00000084531

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQM0-F1-model_v2	AlphaFold	Q5PQM0	1-697	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307778	AgrOrtholog
BioCyc Gene	G2FUF-45612	BioCyc
Ensembl Genes	ENSRNOG00000057290	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000084531	ENTREZGENE
	ENSRNOT00000084531.2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7108688	IMAGE-MGC_LOAD
InterPro	TMEM168	UniProtKB/Swiss-Prot
KEGG Report	rno:312135	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94827	IMAGE-MGC_LOAD
NCBI Gene	312135	ENTREZGENE
PANTHER	PTHR14437	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 168	UniProtKB/Swiss-Prot
PhenoGen	Tmem168	PhenoGen
RatGTEx	ENSRNOG00000057290	RatGTEx
UniProt	A0A096MIS5	ENTREZGENE, UniProtKB/TrEMBL
	A6IDZ9	ENTREZGENE, UniProtKB/TrEMBL
	Q5PQM0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Tmem168	transmembrane protein 168	RGD1307778	similar to RIKEN cDNA 8430437G11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1307778	similar to RIKEN cDNA 8430437G11	RGD1307778_predicted	similar to RIKEN cDNA 8430437G11 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307778_predicted	similar to RIKEN cDNA 8430437G11 (predicted)	LOC312135_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC312135_predicted	similar to RIKEN cDNA 8430437G11 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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