Rapgef6 (Rap guanine nucleotide exchange factor 6) - Rat Genome Database

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Pathways
Gene: Rapgef6 (Rap guanine nucleotide exchange factor 6) Rattus norvegicus
Analyze
Symbol: Rapgef6
Name: Rap guanine nucleotide exchange factor 6
RGD ID: 1307645
Description: Predicted to enable several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Predicted to be involved in Ras protein signal transduction and positive regulation of microvillus assembly. Predicted to be located in cytosol. Predicted to be active in apical plasma membrane and endocytic vesicle. Orthologous to human RAPGEF6 (Rap guanine nucleotide exchange factor 6); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303141; Rap guanine nucleotide exchange factor (GEF) 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,156,573 - 39,324,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,156,620 - 39,324,946 (+)EnsemblGRCr8
mRatBN7.21038,655,854 - 38,824,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,655,867 - 38,823,211 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,341,598 - 43,507,466 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,831,675 - 42,997,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,335,387 - 38,501,259 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,875,322 - 40,039,929 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,875,371 - 40,039,929 (+)Ensemblrn6Rnor6.0
Rnor_5.01039,648,090 - 39,812,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,935,952 - 40,101,623 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,996,384 - 38,160,561 (+)NCBICelera
RGSC_v3.11039,949,735 - 40,131,150 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
endocytic vesicle  (IBA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11524421   PMID:12477932   PMID:22797597   PMID:23885123  


Genomics

Comparative Map Data
Rapgef6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,156,573 - 39,324,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,156,620 - 39,324,946 (+)EnsemblGRCr8
mRatBN7.21038,655,854 - 38,824,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,655,867 - 38,823,211 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,341,598 - 43,507,466 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,831,675 - 42,997,544 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,335,387 - 38,501,259 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,875,322 - 40,039,929 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,875,371 - 40,039,929 (+)Ensemblrn6Rnor6.0
Rnor_5.01039,648,090 - 39,812,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,935,952 - 40,101,623 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,996,384 - 38,160,561 (+)NCBICelera
RGSC_v3.11039,949,735 - 40,131,150 (+)NCBI
Cytogenetic Map10q22NCBI
RAPGEF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385131,423,921 - 131,635,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5131,423,921 - 131,635,234 (-)Ensemblhg38GRCh38
GRCh375130,759,614 - 130,970,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365130,789,500 - 130,998,828 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345130,789,502 - 130,998,828NCBI
Celera5126,889,939 - 127,101,211 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5125,950,778 - 126,162,839 (-)NCBIHuRef
CHM1_15130,192,482 - 130,403,787 (-)NCBICHM1_1
T2T-CHM13v2.05131,943,517 - 132,155,185 (-)NCBIT2T-CHM13v2.0
Rapgef6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,413,630 - 54,590,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,413,673 - 54,590,111 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381154,522,809 - 54,699,286 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,522,847 - 54,699,285 (+)Ensemblmm10GRCm38
MGSCv371154,336,349 - 54,512,787 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,366,270 - 54,542,708 (+)NCBIMGSCv36mm8
Celera1159,110,416 - 59,286,532 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Rapgef6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,902,530 - 3,109,273 (-)Ensembl
ChiLan1.0NW_0049554082,902,530 - 3,109,273 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24126,748,041 - 126,963,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15124,887,606 - 125,099,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05126,852,474 - 127,064,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,018,249 - 133,228,855 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,018,249 - 133,228,851 (-)EnsemblpanPan2panpan1.1
RAPGEF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11119,775,874 - 19,973,784 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1118,572,675 - 18,769,686 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01120,553,837 - 20,751,119 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1120,555,931 - 20,751,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,281,977 - 19,478,740 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,128,865 - 19,326,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01119,727,794 - 19,938,614 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rapgef6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,431,902 - 116,642,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,434,577 - 3,647,456 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,434,409 - 3,647,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2133,708,266 - 133,951,433 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12133,708,265 - 133,951,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,027,117 - 139,199,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,266,842 - 34,474,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,266,368 - 34,474,432 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603443,492,385 - 43,699,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,402,318 - 40,609,234 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473340,403,340 - 40,609,104 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rapgef6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1936,974,253 - 37,137,180 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rapgef6
1303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:168
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000013481
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AI233944  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,689,905 - 38,691,001 (+)MAPPERmRatBN7.2
Rnor_6.01039,907,471 - 39,908,566NCBIRnor6.0
Rnor_5.01039,680,219 - 39,681,314UniSTSRnor5.0
RGSC_v3.41039,969,239 - 39,970,334UniSTSRGSC3.4
Celera1038,029,543 - 38,030,638UniSTS
RH 3.4 Map10405.3UniSTS
Cytogenetic Map10q22UniSTS
AI172313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,650,382 - 38,650,563 (+)MAPPERmRatBN7.2
Rnor_6.01039,869,747 - 39,869,927NCBIRnor6.0
Rnor_5.01039,642,495 - 39,642,675UniSTSRnor5.0
RGSC_v3.41039,930,440 - 39,930,620UniSTSRGSC3.4
Celera1037,990,872 - 37,991,052UniSTS
RH 3.4 Map10405.1UniSTS
Cytogenetic Map10q22UniSTS
BQ210088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,567,020 - 38,567,220 (+)MAPPERmRatBN7.2
Rnor_6.01039,785,979 - 39,786,178NCBIRnor6.0
Rnor_5.01039,559,043 - 39,559,242UniSTSRnor5.0
RGSC_v3.41039,847,269 - 39,847,468UniSTSRGSC3.4
Celera1037,907,534 - 37,907,733UniSTS
RH 3.4 Map10403.8UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_594661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_594662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC105830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013481   ⟹   ENSRNOP00000013481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,655,895 - 38,822,079 (+)Ensembl
Rnor_6.0 Ensembl1039,875,371 - 40,039,929 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099767   ⟹   ENSRNOP00000090336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,156,620 - 39,324,946 (+)Ensembl
mRatBN7.2 Ensembl1038,655,867 - 38,823,211 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102938   ⟹   ENSRNOP00000078181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,156,623 - 39,314,130 (+)Ensembl
mRatBN7.2 Ensembl1038,655,867 - 38,820,302 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109018   ⟹   ENSRNOP00000081855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,724,023 - 38,822,079 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109709   ⟹   ENSRNOP00000096908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,156,620 - 39,322,786 (+)Ensembl
mRatBN7.2 Ensembl1038,655,895 - 38,822,079 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110844   ⟹   ENSRNOP00000090946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,156,620 - 39,324,946 (+)Ensembl
mRatBN7.2 Ensembl1038,655,867 - 38,823,211 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113485   ⟹   ENSRNOP00000094611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,178,274 - 39,324,946 (+)Ensembl
mRatBN7.2 Ensembl1038,655,889 - 38,822,079 (+)Ensembl
RefSeq Acc Id: NM_001107003   ⟹   NP_001100473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,623 - 39,322,799 (+)NCBI
mRatBN7.21038,655,895 - 38,822,079 (+)NCBI
Rnor_6.01039,875,371 - 40,039,929 (+)NCBI
Rnor_5.01039,648,090 - 39,812,677 (+)NCBI
RGSC_v3.41039,935,952 - 40,101,623 (+)RGD
Celera1037,996,384 - 38,160,561 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246277   ⟹   XP_006246339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
mRatBN7.21038,655,859 - 38,824,227 (+)NCBI
Rnor_6.01039,875,323 - 40,039,668 (+)NCBI
Rnor_5.01039,648,090 - 39,812,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246278   ⟹   XP_006246340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
mRatBN7.21038,655,859 - 38,824,227 (+)NCBI
Rnor_6.01039,875,323 - 40,039,668 (+)NCBI
Rnor_5.01039,648,090 - 39,812,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246279   ⟹   XP_006246341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
mRatBN7.21038,656,056 - 38,824,227 (+)NCBI
Rnor_6.01039,875,323 - 40,039,668 (+)NCBI
Rnor_5.01039,648,090 - 39,812,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246280   ⟹   XP_006246342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
mRatBN7.21038,656,056 - 38,821,065 (+)NCBI
Rnor_6.01039,875,323 - 40,039,668 (+)NCBI
Rnor_5.01039,648,090 - 39,812,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597259   ⟹   XP_017452748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
mRatBN7.21038,655,858 - 38,824,227 (+)NCBI
Rnor_6.01039,875,322 - 40,039,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597260   ⟹   XP_017452749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,178,236 - 39,324,947 (+)NCBI
mRatBN7.21038,677,510 - 38,824,227 (+)NCBI
Rnor_6.01039,896,754 - 40,039,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597261   ⟹   XP_017452750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,217,339 - 39,324,947 (+)NCBI
mRatBN7.21038,718,260 - 38,824,227 (+)NCBI
Rnor_6.01039,941,922 - 40,039,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597262   ⟹   XP_017452751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,217,298 - 39,324,947 (+)NCBI
mRatBN7.21038,716,570 - 38,824,227 (+)NCBI
Rnor_6.01039,934,785 - 40,039,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085933   ⟹   XP_038941861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,217,340 - 39,324,947 (+)NCBI
mRatBN7.21038,724,932 - 38,824,227 (+)NCBI
RefSeq Acc Id: XM_039085934   ⟹   XP_038941862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,314,131 (+)NCBI
mRatBN7.21038,655,854 - 38,813,410 (+)NCBI
RefSeq Acc Id: XM_039085935   ⟹   XP_038941863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,314,131 (+)NCBI
mRatBN7.21038,656,056 - 38,813,174 (+)NCBI
RefSeq Acc Id: XM_063268981   ⟹   XP_063125051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,324,947 (+)NCBI
RefSeq Acc Id: XR_001840077
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,156,573 - 39,316,261 (+)NCBI
mRatBN7.21038,655,854 - 38,815,536 (+)NCBI
Rnor_6.01039,875,322 - 40,033,323 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001100473   ⟸   NM_001107003
- UniProtKB: A6HEI1 (UniProtKB/TrEMBL),   A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246341   ⟸   XM_006246279
- Peptide Label: isoform X5
- UniProtKB: A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246340   ⟸   XM_006246278
- Peptide Label: isoform X3
- UniProtKB: D3ZTL8 (UniProtKB/TrEMBL),   A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246339   ⟸   XM_006246277
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLT7 (UniProtKB/TrEMBL),   A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246342   ⟸   XM_006246280
- Peptide Label: isoform X6
- UniProtKB: A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452748   ⟸   XM_017597259
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YCN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452749   ⟸   XM_017597260
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AM01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452751   ⟸   XM_017597262
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZU25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452750   ⟸   XM_017597261
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZU25 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013481   ⟸   ENSRNOT00000013481
RefSeq Acc Id: XP_038941862   ⟸   XM_039085934
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038941863   ⟸   XM_039085935
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038941861   ⟸   XM_039085933
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZU25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078181   ⟸   ENSRNOT00000102938
Ensembl Acc Id: ENSRNOP00000090946   ⟸   ENSRNOT00000110844
Ensembl Acc Id: ENSRNOP00000081855   ⟸   ENSRNOT00000109018
Ensembl Acc Id: ENSRNOP00000096908   ⟸   ENSRNOT00000109709
Ensembl Acc Id: ENSRNOP00000090336   ⟸   ENSRNOT00000099767
Ensembl Acc Id: ENSRNOP00000094611   ⟸   ENSRNOT00000113485
RefSeq Acc Id: XP_063125051   ⟸   XM_063268981
- Peptide Label: isoform X7
- UniProtKB: A0A8I5YCN5 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTL8-F1-model_v2 AlphaFold D3ZTL8 1-1606 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697188
Promoter ID:EPDNEW_R7713
Type:initiation region
Name:Rapgef6_1
Description:Rap guanine nucleotide exchange factor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01039,875,371 - 39,875,431EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307645 AgrOrtholog
BioCyc Gene G2FUF-25105 BioCyc
Ensembl Genes ENSRNOG00000009995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099767 ENTREZGENE
  ENSRNOT00000099767.2 UniProtKB/TrEMBL
  ENSRNOT00000102938 ENTREZGENE
  ENSRNOT00000102938.2 UniProtKB/TrEMBL
  ENSRNOT00000109709 ENTREZGENE
  ENSRNOT00000109709.2 UniProtKB/TrEMBL
  ENSRNOT00000110844 ENTREZGENE
  ENSRNOT00000110844.2 UniProtKB/TrEMBL
  ENSRNOT00000113485 ENTREZGENE
  ENSRNOT00000113485.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro cNMP-bd UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Ras-assoc UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:303141 UniProtKB/TrEMBL
NCBI Gene 303141 ENTREZGENE
PANTHER CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PhenoGen Rapgef6 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PS50200 UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009995 RatGTEx
SMART cNMP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP cNMP_binding UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  Ras_GEF UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5YCN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZU25 ENTREZGENE
  A0A8I6ADK8_RAT UniProtKB/TrEMBL
  A0A8I6AM01 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIT4_RAT UniProtKB/TrEMBL
  A0A8I6GLT7 ENTREZGENE, UniProtKB/TrEMBL
  A6HEI1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTL8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef6  Rap guanine nucleotide exchange factor 6  Rapgef6  Rap guanine nucleotide exchange factor (GEF) 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rapgef6  Rap guanine nucleotide exchange factor (GEF) 6   Rapgef6_predicted  Rap guanine nucleotide exchange factor (GEF) 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rapgef6_predicted  Rap guanine nucleotide exchange factor (GEF) 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED