Rapgef6 (Rap guanine nucleotide exchange factor 6) - Rat Genome Database

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Gene: Rapgef6 (Rap guanine nucleotide exchange factor 6) Chinchilla lanigera
Analyze
Symbol: Rapgef6
Name: Rap guanine nucleotide exchange factor 6
RGD ID: 9009025
Description: ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); phosphatidic acid binding (ortholog); INVOLVED IN establishment of endothelial intestinal barrier (ortholog); microvillus assembly (ortholog); protein localization to plasma membrane (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Immunodeficiency 93 (ortholog); FOUND IN apical plasma membrane (ortholog); centrosome (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rap guanine nucleotide exchange factor (GEF) 6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,902,530 - 3,109,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,902,530 - 3,109,273 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rapgef6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,902,530 - 3,109,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,902,530 - 3,109,273 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385131,423,921 - 131,635,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5131,423,921 - 131,635,231 (-)EnsemblGRCh38hg38GRCh38
GRCh375130,759,614 - 130,970,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365130,789,500 - 130,998,828 (-)NCBINCBI36Build 36hg18NCBI36
Build 345130,789,502 - 130,998,828NCBI
Celera5126,889,939 - 127,101,211 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5125,950,778 - 126,162,839 (-)NCBIHuRef
CHM1_15130,192,482 - 130,403,787 (-)NCBICHM1_1
T2T-CHM13v2.05131,943,517 - 132,155,185 (-)NCBIT2T-CHM13v2.0
Rapgef6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,413,630 - 54,590,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,413,673 - 54,590,111 (+)EnsemblGRCm39 Ensembl
GRCm381154,522,809 - 54,699,286 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,522,847 - 54,699,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,336,349 - 54,512,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,366,270 - 54,542,708 (+)NCBIMGSCv36mm8
Celera1159,110,416 - 59,286,532 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Rapgef6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,156,573 - 39,324,947 (+)NCBIGRCr8
mRatBN7.21038,655,854 - 38,824,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,655,867 - 38,823,211 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,341,598 - 43,507,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,831,675 - 42,997,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,335,387 - 38,501,259 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,875,322 - 40,039,929 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,875,371 - 40,039,929 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,648,090 - 39,812,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,935,952 - 40,101,623 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,949,735 - 40,131,150 (+)NCBI
Celera1037,996,384 - 38,160,561 (+)NCBICelera
Cytogenetic Map10q22NCBI
RAPGEF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24126,748,041 - 126,963,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15124,887,606 - 125,099,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05126,852,474 - 127,064,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,018,249 - 133,228,855 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,018,249 - 133,228,851 (-)Ensemblpanpan1.1panPan2
RAPGEF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11119,775,874 - 19,973,784 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1118,572,675 - 18,769,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01120,553,837 - 20,751,119 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1120,555,931 - 20,751,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,281,977 - 19,478,740 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,128,865 - 19,326,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01119,727,794 - 19,938,614 (-)NCBIUU_Cfam_GSD_1.0
Rapgef6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,431,902 - 116,642,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,434,577 - 3,647,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,434,409 - 3,647,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2133,708,266 - 133,951,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12133,708,265 - 133,951,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,027,117 - 139,199,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,266,842 - 34,474,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,266,368 - 34,474,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603443,492,385 - 43,699,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,402,318 - 40,609,234 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,403,340 - 40,609,104 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021844   ⟹   ENSCLAP00000021641
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554082,902,530 - 3,109,273 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021845   ⟹   ENSCLAP00000021642
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554082,902,593 - 3,109,273 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021846   ⟹   ENSCLAP00000021643
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554082,914,917 - 2,985,532 (-)Ensembl
RefSeq Acc Id: XM_005376072   ⟹   XP_005376129
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554082,902,530 - 3,109,273 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376129 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021641
  ENSCLAP00000021641.1
  ENSCLAP00000021642.1
  ENSCLAP00000021643.1
Reference Protein Sequences
RefSeq Acc Id: XP_005376129   ⟸   XM_005376072
- UniProtKB: A0A8C2YT92 (UniProtKB/TrEMBL),   A0A8C2YT93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021641   ⟸   ENSCLAT00000021844
RefSeq Acc Id: ENSCLAP00000021643   ⟸   ENSCLAT00000021846
RefSeq Acc Id: ENSCLAP00000021642   ⟸   ENSCLAT00000021845
Protein Domains
Cyclic nucleotide-binding   N-terminal Ras-GEF   PDZ   Ras-associating   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014812 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021844 ENTREZGENE
  ENSCLAT00000021844.1 UniProtKB/TrEMBL
  ENSCLAT00000021845.1 UniProtKB/TrEMBL
  ENSCLAT00000021846.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene Rapgef6 ENTREZGENE
PANTHER CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PS50200 UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
UniProt A0A8C2VWH5_CHILA UniProtKB/TrEMBL
  A0A8C2YT92 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YT93 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Rapgef6  Rap guanine nucleotide exchange factor 6    Rap guanine nucleotide exchange factor (GEF) 6  Symbol and/or name change 5135510 APPROVED