Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Zfp521 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZFP521 mRNA | CTD | PMID:22206623 | Zfp521 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP521 mRNA | CTD | PMID:32109520 | Zfp521 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZFP521 mRNA | CTD | PMID:33387578 | Zfp521 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ZFP521 mRNA | CTD | PMID:32109520 | Zfp521 | Rat | 3-methylcholanthrene | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Methylcholanthrene results in decreased expression of ZFP521 mRNA | CTD | PMID:20713471 | Zfp521 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Fenretinide results in increased expression of ZNF521 mRNA | CTD | PMID:28973697 | Zfp521 | Rat | 7,12-dimethyltetraphene | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | 9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of ZFP521 mRNA | CTD | PMID:32553695 | Zfp521 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of ZFP521 mRNA | CTD | PMID:28959563 | Zfp521 | Rat | aflatoxin B1 | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ZNF521 mRNA | CTD | PMID:22100608|PMID:32234424 | Zfp521 | Rat | aflatoxin B1 | increases methylation | ISO | ZNF521 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ZNF521 exon; Aflatoxin B1 results in increased methylation more ... | CTD | PMID:30157460 | Zfp521 | Rat | aldehydo-D-glucose | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in decreased expression of ZFP521 mRNA | CTD | PMID:33448797 | Zfp521 | Rat | aldehydo-D-glucose | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in increased expression of ZFP521 mRNA | CTD | PMID:16805838 | Zfp521 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] | CTD | PMID:33448797 | Zfp521 | Rat | all-trans-retinoic acid | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ZNF521 mRNA | CTD | PMID:21934132 | Zfp521 | Rat | all-trans-retinoic acid | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of ZNF521 mRNA | CTD | PMID:23724009 | Zfp521 | Rat | antirheumatic drug | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ZNF521 mRNA | CTD | PMID:24449571 | Zfp521 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of ZFP521 gene | CTD | PMID:35440735 | Zfp521 | Rat | benzo[a]pyrene | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of ZFP521 mRNA | CTD | PMID:21569818 | Zfp521 | Rat | benzo[a]pyrene | increases methylation | ISO | ZNF521 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ZNF521 5' UTR | CTD | PMID:27901495 | Zfp521 | Rat | benzo[a]pyrene | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ZNF521 mRNA | CTD | PMID:22316170|PMID:32234424 | Zfp521 | Rat | benzo[a]pyrene diol epoxide I | affects expression | ISO | ZNF521 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ZNF521 mRNA | CTD | PMID:20382639 | Zfp521 | Rat | bisphenol A | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ZNF521 mRNA | CTD | PMID:25047013 | Zfp521 | Rat | bisphenol A | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ZFP521 mRNA | CTD | PMID:32156529 | Zfp521 | Rat | bisphenol A | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ZNF521 mRNA | CTD | PMID:29275510 | Zfp521 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of ZFP521 gene | CTD | PMID:28505145 | Zfp521 | Rat | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of ZFP521 gene | CTD | PMID:28505145 | Zfp521 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ZFP521 gene | CTD | PMID:28505145 | Zfp521 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ZNF521 mRNA | CTD | PMID:25181051 | Zfp521 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of ZNF521 promoter | CTD | PMID:22457795 | Zfp521 | Rat | chloroprene | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of ZFP521 mRNA | CTD | PMID:23125180 | Zfp521 | Rat | clothianidin | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | clothianidin results in decreased expression of ZNF521 mRNA | CTD | PMID:31626844 | Zfp521 | Rat | cobalt dichloride | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of ZNF521 mRNA | CTD | PMID:19320972 | Zfp521 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of ZFP521 mRNA | CTD | PMID:26577399 | Zfp521 | Rat | D-glucose | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in increased expression of ZFP521 mRNA | CTD | PMID:16805838 | Zfp521 | Rat | D-glucose | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in decreased expression of ZFP521 mRNA | CTD | PMID:33448797 | Zfp521 | Rat | D-glucose | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] | CTD | PMID:33448797 | Zfp521 | Rat | dexamethasone | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of ZNF521 mRNA | CTD | PMID:25047013 | Zfp521 | Rat | dibenz[a,h]anthracene | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | 1,2,5,6-dibenzanthracene results in increased expression of ZFP521 mRNA | CTD | PMID:26377693 | Zfp521 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of ZNF521 mRNA | CTD | PMID:25152437 | Zfp521 | Rat | dorsomorphin | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Zfp521 | Rat | doxorubicin | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ZNF521 mRNA | CTD | PMID:29803840 | Zfp521 | Rat | entinostat | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | entinostat results in decreased expression of ZNF521 mRNA | CTD | PMID:26272509 | Zfp521 | Rat | entinostat | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Zfp521 | Rat | epoxiconazole | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of ZFP521 mRNA | CTD | PMID:35436446 | Zfp521 | Rat | ethanol | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Ethanol results in decreased expression of ZNF521 protein | CTD | PMID:20621659 | Zfp521 | Rat | ethanol | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Ethanol results in increased expression of ZFP521 mRNA | CTD | PMID:30319688 | Zfp521 | Rat | folic acid | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZFP521 mRNA | CTD | PMID:22206623 | Zfp521 | Rat | folic acid | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of ZFP521 mRNA | CTD | PMID:25629700 | Zfp521 | Rat | fucoxanthin | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] | CTD | PMID:33448797 | Zfp521 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of ZFP521 mRNA | CTD | PMID:27387713 | Zfp521 | Rat | gemcitabine | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Gemcitabine results in decreased expression of ZNF521 mRNA | CTD | PMID:17039268 | Zfp521 | Rat | genistein | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of ZFP521 gene | CTD | PMID:28505145 | Zfp521 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ZFP521 mRNA | CTD | PMID:33387578 | Zfp521 | Rat | glucose | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in increased expression of ZFP521 mRNA | CTD | PMID:16805838 | Zfp521 | Rat | glucose | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA] | CTD | PMID:33448797 | Zfp521 | Rat | glucose | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Glucose results in decreased expression of ZFP521 mRNA | CTD | PMID:33448797 | Zfp521 | Rat | lipopolysaccharide | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of ZNF521 mRNA | CTD | PMID:35811015 | Zfp521 | Rat | lipopolysaccharide | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of ZNF521 mRNA | CTD | PMID:35811015 | Zfp521 | Rat | melphalan | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of ZNF521 mRNA | CTD | PMID:22363485 | Zfp521 | Rat | mercury dibromide | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of ZNF521 mRNA | CTD | PMID:26272509 | Zfp521 | Rat | mercury dibromide | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Zfp521 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of ZFP521 gene | CTD | PMID:35440735 | Zfp521 | Rat | methylmercury chloride | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ZNF521 mRNA | CTD | PMID:28001369 | Zfp521 | Rat | Moniliformin | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | moniliformin results in increased expression of ZFP521 mRNA | CTD | PMID:39984025 | Zfp521 | Rat | nickel atom | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ZNF521 mRNA | CTD | PMID:24768652|PMID:25583101 | Zfp521 | Rat | O-methyleugenol | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of ZNF521 mRNA | CTD | PMID:32234424 | Zfp521 | Rat | okadaic acid | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of ZNF521 mRNA | CTD | PMID:38832940 | Zfp521 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of ZNF521 mRNA | CTD | PMID:25729387 | Zfp521 | Rat | ozone | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Zfp521 | Rat | p-chloromercuribenzoic acid | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of ZNF521 mRNA | CTD | PMID:26272509 | Zfp521 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Zfp521 | Rat | panobinostat | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | panobinostat results in decreased expression of ZNF521 mRNA | CTD | PMID:26272509 | Zfp521 | Rat | panobinostat | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Zfp521 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of ZFP521 mRNA | CTD | PMID:33387578 | Zfp521 | Rat | PCB138 | decreases expression | EXP | | 6480464 | 2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of ZNF521 mRNA | CTD | PMID:23829299 | Zfp521 | Rat | pentanal | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | pentanal results in increased expression of ZNF521 mRNA | CTD | PMID:26079696 | Zfp521 | Rat | phenylmercury acetate | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of ZNF521 mRNA | CTD | PMID:26272509 | Zfp521 | Rat | phenylmercury acetate | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Zfp521 | Rat | pioglitazone | multiple interactions | ISO | Zfp521 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ZFP521 mRNA | CTD | PMID:27935865 | Zfp521 | Rat | pirinixic acid | increases expression | ISO | Zfp521 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of ZFP521 mRNA | CTD | PMID:23811191 | Zfp521 | Rat | progesterone | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of ZNF521 mRNA | CTD | PMID:21795739 | Zfp521 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of ZNF521 mRNA | CTD | PMID:35811015 | Zfp521 | Rat | SB 431542 | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Zfp521 | Rat | sevoflurane | increases methylation | ISO | Zfp521 (Mus musculus) | 6480464 | Sevoflurane results in increased methylation of ZNF521 mRNA | CTD | PMID:35249202 | Zfp521 | Rat | silver atom | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Silver results in decreased expression of ZFP521 mRNA | CTD | PMID:27131904 | Zfp521 | Rat | silver(0) | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | Silver results in decreased expression of ZFP521 mRNA | CTD | PMID:27131904 | Zfp521 | Rat | sulforaphane | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of ZNF521 mRNA | CTD | PMID:31838189 | Zfp521 | Rat | testosterone | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Testosterone results in increased expression of ZNF521 mRNA | CTD | PMID:33359661 | Zfp521 | Rat | titanium dioxide | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of ZFP521 mRNA | CTD | PMID:29264374 | Zfp521 | Rat | titanium dioxide | decreases methylation | ISO | Zfp521 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of ZFP521 gene | CTD | PMID:35295148 | Zfp521 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of ZNF521 mRNA | CTD | PMID:25729387 | Zfp521 | Rat | trichostatin A | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ZNF521 mRNA | CTD | PMID:24935251 | Zfp521 | Rat | trichostatin A | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Zfp521 | Rat | trichostatin A | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ZNF521 mRNA | CTD | PMID:24935251|PMID:26272509 | Zfp521 | Rat | trimellitic anhydride | decreases expression | ISO | Zfp521 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of ZFP521 mRNA | CTD | PMID:19042947 | Zfp521 | Rat | valproic acid | affects expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ZNF521 mRNA | CTD | PMID:25979313 | Zfp521 | Rat | valproic acid | increases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ZNF521 mRNA | CTD | PMID:24935251 | Zfp521 | Rat | valproic acid | decreases expression | ISO | ZNF521 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ZNF521 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:24935251|PMID:25192806|PMID:26272509|PMID:28001369 | Zfp521 | Rat | valproic acid | multiple interactions | ISO | ZNF521 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | |






















