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Gene: Zic4 (Zic family zinc finger 4) Rattus norvegicus

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Symbol:

Zic4

Name:

Zic family zinc finger 4 (Ensembl:Zic family member 4)

RGD ID:

1307298

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZIC4 (Zic family zinc finger 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315882; Zic family member 4; zinc finger protein of the cerebellum 4; zinc finger protein ZIC 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZIC4 (Zic family zinc finger 4)	HGNC	Ensembl, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Zic4 (zinc finger protein of the cerebellum 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Zic4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZIC4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZIC4 (Zic family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Zic4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZIC4 (Zic family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZIC4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Zic4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Zic4 (Zic family zinc finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI)	HGNC	OMA
Homo sapiens (human):	PRR18 (proline rich 18)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ZIC4 (Zic family zinc finger 4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zic4 (zinc finger protein of the cerebellum 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zic4 (zic family member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	zic4 (zic family member 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ref-2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ref-2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	opa	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	opa	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	zic4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	100,795,860 - 100,816,276 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	100,796,102 - 100,816,271 (+)	Ensembl				GRCr8
mRatBN7.2	8	91,916,356 - 91,936,525 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	91,920,015 - 91,935,368 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	97,595,121 - 97,615,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	95,794,372 - 95,814,514 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	93,608,259 - 93,628,430 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	101,725,104 - 101,745,253 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	103,830,492 - 103,850,637 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	102,319,734 - 102,339,879 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	93,780,580 - 93,800,696 (+)	NCBI		F344_StmMcwi
Rnor_6.0	8	98,755,104 - 98,760,737 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	98,745,310 - 98,761,840 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	98,246,887 - 98,252,520 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	96,335,974 - 96,341,607 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	91,456,811 - 91,462,444 (+)	NCBI		Celera
RGSC_v3.1	8	96,341,959 - 96,360,689 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Dandy-Walker syndrome (ISS)

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetohydrazide (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (EXP,ISO)

ethylparaben (ISO)

gentamycin (EXP)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methylazoxymethanol (ISO)

okadaic acid (ISO)

paracetamol (ISO)

PCB138 (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

testosterone (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system development (IBA)

regulation of transcription by RNA polymerase II (IBA,IEA)

Cellular Component

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15465018	PMID:18298960

Genomics

Comparative Map Data

Zic4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	100,795,860 - 100,816,276 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	100,796,102 - 100,816,271 (+)	Ensembl				GRCr8
mRatBN7.2	8	91,916,356 - 91,936,525 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	91,920,015 - 91,935,368 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	97,595,121 - 97,615,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	95,794,372 - 95,814,514 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	93,608,259 - 93,628,430 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	101,725,104 - 101,745,253 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	103,830,492 - 103,850,637 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	102,319,734 - 102,339,879 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	93,780,580 - 93,800,696 (+)	NCBI		F344_StmMcwi
Rnor_6.0	8	98,755,104 - 98,760,737 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	98,745,310 - 98,761,840 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	98,246,887 - 98,252,520 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	96,335,974 - 96,341,607 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	91,456,811 - 91,462,444 (+)	NCBI		Celera
RGSC_v3.1	8	96,341,959 - 96,360,689 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

ZIC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	147,386,046 - 147,406,543 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	147,386,046 - 147,406,809 (-)	Ensembl			hg38	GRCh38
GRCh37	3	147,103,833 - 147,124,330 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	148,586,527 - 148,607,097 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	148,586,534 - 148,607,105	NCBI
Celera	3	145,516,286 - 145,536,859 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI
HuRef	3	144,480,047 - 144,500,765 (-)	NCBI		HuRef
CHM1_1	3	147,066,847 - 147,087,608 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	150,141,298 - 150,161,796 (-)	NCBI		T2T-CHM13v2.0

Zic4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	91,247,636 - 91,271,404 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	91,244,466 - 91,271,401 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	91,365,631 - 91,389,351 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	91,362,413 - 91,389,348 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	91,263,810 - 91,284,186 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	91,166,877 - 91,187,253 (+)	NCBI		MGSCv36	mm8
Celera	9	90,959,885 - 90,980,292 (+)	NCBI		Celera
Cytogenetic Map	9	E3.2	NCBI
cM Map	9	48.26	NCBI

Zic4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	10,033,804 - 10,056,870 (+)	Ensembl
ChiLan1.0	NW_004955474	10,021,777 - 10,056,870 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZIC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	145,283,717 - 145,304,168 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	145,288,448 - 145,310,491 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	144,411,069 - 144,437,019 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	151,995,980 - 152,018,963 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	151,995,375 - 152,016,777 (-)	Ensembl			panPan2	panpan1.1

ZIC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	42,509,742 - 42,527,918 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	42,512,186 - 42,529,112 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	42,381,742 - 42,400,792 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	43,129,902 - 43,148,999 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	43,132,347 - 43,149,312 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	42,726,995 - 42,746,068 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	42,779,515 - 42,798,572 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	43,031,158 - 43,050,246 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Zic4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	81,708,157 - 81,731,660 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936519	8,004,926 - 8,025,831 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936519	8,007,605 - 8,025,831 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZIC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	87,722,146 - 87,740,921 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	87,725,642 - 87,740,724 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	95,436,858 - 95,454,547 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZIC4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	43,285,711 - 43,309,197 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	43,291,014 - 43,309,187 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	16,153,135 - 16,176,296 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zic4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	24,416,490 - 24,439,579 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	24,416,601 - 24,436,312 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Zic4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	83,108,373 - 83,129,837 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Zic4
128 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	1293
Count of miRNA genes:	289
Interacting mature miRNAs:	388
Transcripts:	ENSRNOT00000019938, ENSRNOT00000056562
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

RH130967

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	91,934,659 - 91,934,874 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	98,760,029 - 98,760,243	NCBI	Rnor6.0
Rnor_5.0	8	98,251,812 - 98,252,026	UniSTS	Rnor5.0
RGSC_v3.4	8	96,340,899 - 96,341,113	UniSTS	RGSC3.4
Celera	8	91,461,736 - 91,461,950	UniSTS
RH 3.4 Map	8	1021.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

BF409650

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	91,927,470 - 91,927,621 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	98,752,836 - 98,752,986	NCBI	Rnor6.0
Rnor_5.0	8	98,244,619 - 98,244,769	UniSTS	Rnor5.0
RGSC_v3.4	8	96,333,706 - 96,333,856	UniSTS	RGSC3.4
Celera	8	91,454,543 - 91,454,693	UniSTS
RH 3.4 Map	8	1024.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH143995

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	91,936,181 - 91,936,311 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	98,761,551 - 98,761,680	NCBI	Rnor6.0
Rnor_5.0	8	98,253,334 - 98,253,463	UniSTS	Rnor5.0
RGSC_v3.4	8	96,342,421 - 96,342,550	UniSTS	RGSC3.4
Celera	8	91,463,258 - 91,463,387	UniSTS
RH 3.4 Map	8	1021.6	UniSTS
Cytogenetic Map	8	q31	UniSTS

BE110060

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	91,930,414 - 91,930,567 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	98,755,784 - 98,755,936	NCBI	Rnor6.0
Rnor_5.0	8	98,247,567 - 98,247,719	UniSTS	Rnor5.0
RGSC_v3.4	8	96,336,654 - 96,336,806	UniSTS	RGSC3.4
Celera	8	91,457,491 - 91,457,643	UniSTS
RH 3.4 Map	8	1021.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
4	9	7	142	29	34	11	20	11	6	78	48	10	123	8	52	23	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001394128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019938 ⟹ ENSRNOP00000019938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	100,796,102 - 100,816,271 (+)	Ensembl
mRatBN7.2 Ensembl	8	91,920,015 - 91,935,368 (+)	Ensembl
Rnor_6.0 Ensembl	8	98,745,310 - 98,761,840 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000056562 ⟹ ENSRNOP00000053401

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	91,929,735 - 91,935,368 (+)	Ensembl
Rnor_6.0 Ensembl	8	98,755,104 - 98,760,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100286 ⟹ ENSRNOP00000097909

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	100,798,970 - 100,816,271 (+)	Ensembl
mRatBN7.2 Ensembl	8	91,926,082 - 91,935,368 (+)	Ensembl

RefSeq Acc Id:

NM_001394128 ⟹ NP_001381057

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	100,796,102 - 100,816,271 (+)	NCBI
mRatBN7.2	8	91,916,356 - 91,936,525 (+)	NCBI
Dahl_SR_JrHsd	8	101,725,104 - 101,745,253 (+)	NCBI
Lyon_Normotensive	8	103,830,492 - 103,850,637 (+)	NCBI
Lyon_Hypertensive	8	102,319,734 - 102,339,879 (+)	NCBI
F344_StmMcwi	8	93,780,580 - 93,800,696 (+)	NCBI

RefSeq Acc Id:

XM_063265568 ⟹ XP_063121638

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	100,805,828 - 100,813,486 (+)	NCBI

RefSeq Acc Id:

XM_063265569 ⟹ XP_063121639

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	100,805,828 - 100,816,276 (+)	NCBI

RefSeq Acc Id:

XM_063265570 ⟹ XP_063121640

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	100,795,860 - 100,816,276 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001381057	(Get FASTA)	NCBI Sequence Viewer
	XP_063121638	(Get FASTA)	NCBI Sequence Viewer
	XP_063121639	(Get FASTA)	NCBI Sequence Viewer
	XP_063121640	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77542	(Get FASTA)	NCBI Sequence Viewer
	EDL77543	(Get FASTA)	NCBI Sequence Viewer
	EDL77544	(Get FASTA)	NCBI Sequence Viewer
	EDL77545	(Get FASTA)	NCBI Sequence Viewer
	EDL77546	(Get FASTA)	NCBI Sequence Viewer
	EDL77547	(Get FASTA)	NCBI Sequence Viewer
	EDL77548	(Get FASTA)	NCBI Sequence Viewer
	EDL77549	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019938
	ENSRNOP00000019938.6
	ENSRNOP00000097909
	ENSRNOP00000097909.2

Ensembl Acc Id:

ENSRNOP00000053401 ⟸ ENSRNOT00000056562

Ensembl Acc Id:

ENSRNOP00000019938 ⟸ ENSRNOT00000019938

Ensembl Acc Id:

ENSRNOP00000097909 ⟸ ENSRNOT00000100286

RefSeq Acc Id:	NP_001381057 ⟸ NM_001394128
- UniProtKB:	D4A6Z4 (UniProtKB/TrEMBL), A6I228 (UniProtKB/TrEMBL), A6I233 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121640 ⟸ XM_063265570
- Peptide Label:	isoform X3
- UniProtKB:	A6I233 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121639 ⟸ XM_063265569
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6ATI6 (UniProtKB/TrEMBL), A6I233 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121638 ⟸ XM_063265568
- Peptide Label:	isoform X1
- UniProtKB:	A6I234 (UniProtKB/TrEMBL), A6I233 (UniProtKB/TrEMBL)

Protein Domains

C2H2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A6Z4-F1-model_v2	AlphaFold	D4A6Z4	1-326	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307298	AgrOrtholog
BioCyc Gene	G2FUF-29562	BioCyc
Ensembl Genes	ENSRNOG00000014871	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019938	ENTREZGENE
	ENSRNOT00000019938.9	UniProtKB/TrEMBL
	ENSRNOT00000100286	ENTREZGENE
	ENSRNOT00000100286.2	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	GLI-like	UniProtKB/TrEMBL
	Znf-C2H2_ZIC1-5/GLI1-3-like	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
	Znf_ZIC	UniProtKB/TrEMBL
NCBI Gene	315882	ENTREZGENE
PANTHER	GLIS FAMILY ZINC FINGER 2	UniProtKB/TrEMBL
	TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_15	UniProtKB/TrEMBL
	zf_ZIC	UniProtKB/TrEMBL
PhenoGen	Zic4	PhenoGen
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014871	RatGTEx
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A8I6ATI6	ENTREZGENE, UniProtKB/TrEMBL
	A6I228	ENTREZGENE, UniProtKB/TrEMBL
	A6I233	ENTREZGENE, UniProtKB/TrEMBL
	A6I234	ENTREZGENE, UniProtKB/TrEMBL
	D4A6Z4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Zic4	Zic family zinc finger 4	Zic4	Zic family member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Zic4	Zic family member 4	Zic4	zinc finger protein of the cerebellum 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-03	Zic4	zinc finger protein of the cerebellum 4	Zic4_predicted	Zic family member 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Zic4_predicted	Zic family member 4 (predicted)		zinc finger protein of the cerebellum 4 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Zic4_predicted	zinc finger protein of the cerebellum 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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Imported Disease Annotations - CTD

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