Gsdmd (gasdermin D) - Rat Genome Database

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Gene: Gsdmd (gasdermin D) Rattus norvegicus
Analyze
Symbol: Gsdmd
Name: gasdermin D
RGD ID: 1307261
Description: Predicted to enable phospholipid binding activity; transcription coactivator activity; and wide pore channel activity. Predicted to be involved in several processes, including defense response to bacterium; positive regulation of cytokine production; and protein-containing complex assembly. Predicted to act upstream of or within several processes, including ceramide biosynthetic process; plasma membrane repair; and positive regulation of inflammatory response. Predicted to be located in several cellular components, including extracellular space; mitochondrial membrane; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in plasma membrane. Orthologous to human GSDMD (gasdermin D); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gasdermin domain containing 1; gasdermin-D; Gsdmdc1; LOC315084
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,423,209 - 109,427,771 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7109,422,910 - 109,430,722 (+)EnsemblGRCr8
mRatBN7.27107,542,489 - 107,547,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,542,083 - 107,547,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7109,281,502 - 109,286,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,505,178 - 111,509,740 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,451,127 - 111,455,689 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7111,422,861 - 111,427,423 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive7112,380,615 - 112,385,177 (+)NCBILyon_Normotensive
Lyon_Hypertensive7112,506,202 - 112,510,764 (+)NCBILyon_Hypertensive
F344_StmMcwi7110,994,772 - 110,999,334 (+)NCBIF344_StmMcwi
Rnor_6.07116,889,147 - 116,894,134 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,889,572 - 116,894,134 (+)Ensemblrn6Rnor6.0
Rnor_5.07116,781,947 - 116,786,875 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,832,420 - 113,837,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,902,119 - 103,906,706 (+)NCBICelera
RGSC_v3.17113,847,420 - 113,871,239 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxybenzoic acid  (ISO)
4-phenylbutyric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
aluminium hydroxide  (ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
baicalein  (ISO)
Bavachinin  (ISO)
bellidifolin  (ISO)
Belnacasan  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-cyclodextrin  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chitosan  (EXP)
chloroquine  (ISO)
chlorquinaldol  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dimethyl fumarate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
divinyl sulfone  (ISO)
eritoran  (ISO)
fenpropathrin  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
ginsenoside Rb1  (EXP,ISO)
glafenine  (EXP)
glucose  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycidol  (EXP)
graphene oxide  (ISO)
GW 4064  (ISO)
hyaluronic acid  (EXP)
hydroquinone  (ISO)
hydroxysafflor yellow A  (ISO)
icariin  (EXP)
imiquimod  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lonidamine  (ISO)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (ISO)
melatonin  (ISO)
mesalamine  (ISO)
methapyrilene  (ISO)
Mitoquinone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nigericin  (EXP,ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (EXP)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
patulin  (ISO)
Pentoxifylline  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
Ruscogenin  (ISO)
SB 203580  (ISO)
scutellarin  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Torularhodin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma. Peng LS, etal., Front Oncol. 2022 Nov 25;12:1043862. doi: 10.3389/fonc.2022.1043862. eCollection 2022.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10322635   PMID:26611636   PMID:27383986   PMID:30161099   PMID:30600840   PMID:34920032   PMID:35775127   PMID:36040608   PMID:36224321   PMID:36988259   PMID:37549514   PMID:37578618  


Genomics

Comparative Map Data
Gsdmd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,423,209 - 109,427,771 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7109,422,910 - 109,430,722 (+)EnsemblGRCr8
mRatBN7.27107,542,489 - 107,547,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,542,083 - 107,547,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7109,281,502 - 109,286,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,505,178 - 111,509,740 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,451,127 - 111,455,689 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7111,422,861 - 111,427,423 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive7112,380,615 - 112,385,177 (+)NCBILyon_Normotensive
Lyon_Hypertensive7112,506,202 - 112,510,764 (+)NCBILyon_Hypertensive
F344_StmMcwi7110,994,772 - 110,999,334 (+)NCBIF344_StmMcwi
Rnor_6.07116,889,147 - 116,894,134 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,889,572 - 116,894,134 (+)Ensemblrn6Rnor6.0
Rnor_5.07116,781,947 - 116,786,875 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,832,420 - 113,837,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,902,119 - 103,906,706 (+)NCBICelera
RGSC_v3.17113,847,420 - 113,871,239 (+)NCBI
Cytogenetic Map7q34NCBI
GSDMD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,553,387 - 143,563,062 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,553,207 - 143,563,062 (+)Ensemblhg38GRCh38
GRCh378144,635,557 - 144,645,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,711,635 - 144,716,375 (+)NCBIBuild 36Build 36hg18NCBI36
Build 348144,712,102 - 144,716,372NCBI
Celera8140,945,843 - 140,955,486 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,886,817 - 139,896,607 (+)NCBIHuRef
CHM1_18144,675,788 - 144,685,442 (+)NCBICHM1_1
T2T-CHM13v2.08144,702,722 - 144,712,453 (+)NCBIT2T-CHM13v2.0
Gsdmd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,733,990 - 75,739,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,734,176 - 75,739,257 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381575,862,144 - 75,867,408 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,862,327 - 75,867,408 (+)Ensemblmm10GRCm38
MGSCv371575,692,769 - 75,697,834 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361575,689,594 - 75,694,659 (+)NCBIMGSCv36mm8
Celera1577,363,199 - 77,368,383 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.0NCBI
Gsdmd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,265,753 - 2,271,655 (+)Ensembl
ChiLan1.0NW_0049554542,265,759 - 2,270,569 (+)NCBIChiLan1.0ChiLan1.0
GSDMD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,039,881 - 161,046,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,557,568 - 136,563,849 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,311,042 - 140,316,084 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,321,800 - 143,331,455 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,326,319 - 143,331,455 (+)EnsemblpanPan2panpan1.1
GSDMD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,221,219 - 37,226,912 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,193,022 - 37,228,360 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1337,178,091 - 37,183,803 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01337,693,423 - 37,699,140 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,693,447 - 37,700,588 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,367,765 - 37,373,478 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,484,726 - 37,490,434 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,965,884 - 37,971,607 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gsdmd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,141,008 - 1,145,358 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,567,091 - 8,571,467 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364708,567,085 - 8,571,448 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSDMD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4995,763 - 1,000,271 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14995,753 - 1,001,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,054,277 - 1,057,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSDMD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,778,290 - 137,783,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660392,110,335 - 2,115,465 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsdmd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473513,187,687 - 13,192,736 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473513,187,810 - 13,192,843 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gsdmd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11248,175,688 - 248,180,356 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gsdmd
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:35
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000045475
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH133888  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map7781.4UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 356 192 11 137 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000075917   ⟹   ENSRNOP00000067951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,423,146 - 109,427,761 (+)Ensembl
mRatBN7.2 Ensembl7107,542,418 - 107,547,051 (+)Ensembl
Rnor_6.0 Ensembl7116,889,572 - 116,894,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095149   ⟹   ENSRNOP00000095279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,422,910 - 109,430,722 (+)Ensembl
mRatBN7.2 Ensembl7107,542,083 - 107,547,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150594   ⟹   ENSRNOP00000111311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,422,910 - 109,429,239 (+)Ensembl
RefSeq Acc Id: NM_001400993   ⟹   NP_001387922
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,423,209 - 109,427,771 (+)NCBI
mRatBN7.27107,542,489 - 107,547,051 (+)NCBI
Dahl_SR_JrHsd7111,422,861 - 111,427,423 (+)NCBI
Lyon_Normotensive7112,380,615 - 112,385,177 (+)NCBI
Lyon_Hypertensive7112,506,202 - 112,510,764 (+)NCBI
F344_StmMcwi7110,994,772 - 110,999,334 (+)NCBI
RefSeq Acc Id: NM_001400994   ⟹   NP_001387923
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,423,209 - 109,427,771 (+)NCBI
mRatBN7.27107,542,489 - 107,547,051 (+)NCBI
Dahl_SR_JrHsd7111,422,861 - 111,427,423 (+)NCBI
Lyon_Normotensive7112,380,615 - 112,385,177 (+)NCBI
Lyon_Hypertensive7112,506,202 - 112,510,764 (+)NCBI
F344_StmMcwi7110,994,772 - 110,999,334 (+)NCBI
Ensembl Acc Id: ENSRNOP00000067951   ⟸   ENSRNOT00000075917
Ensembl Acc Id: ENSRNOP00000095279   ⟸   ENSRNOT00000095149
RefSeq Acc Id: NP_001387922   ⟸   NM_001400993
- UniProtKB: A0A096MJ11 (UniProtKB/TrEMBL),   A6HS22 (UniProtKB/TrEMBL),   A6HS23 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387923   ⟸   NM_001400994
- UniProtKB: A0A096MJ11 (UniProtKB/TrEMBL),   A6HS22 (UniProtKB/TrEMBL),   A6HS23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111311   ⟸   ENSRNOT00000150594
Protein Domains
Gasdermin pore forming   Gasdermin PUB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJ11-F1-model_v2 AlphaFold A0A096MJ11 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695391
Promoter ID:EPDNEW_R5916
Type:initiation region
Name:Gsdmd_1
Description:gasdermin D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07116,889,589 - 116,889,649EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307261 AgrOrtholog
BioCyc Gene G2FUF-32979 BioCyc
Ensembl Genes ENSRNOG00000007728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075917 ENTREZGENE
  ENSRNOT00000075917.3 UniProtKB/TrEMBL
  ENSRNOT00000095149.2 UniProtKB/TrEMBL
  ENSRNOT00000150594.1 UniProtKB/TrEMBL
InterPro Gasdermin UniProtKB/TrEMBL
  Gasdermin_pore UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/TrEMBL
NCBI Gene 315084 ENTREZGENE
PANTHER DFNA5 UniProtKB/TrEMBL
  GASDERMIN-D UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/TrEMBL
PhenoGen Gsdmd PhenoGen
RatGTEx ENSRNOG00000007728 RatGTEx
UniProt A0A096MJ11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B2B6_RAT UniProtKB/TrEMBL
  A0ABK0LK31_RAT UniProtKB/TrEMBL
  A6HS22 ENTREZGENE, UniProtKB/TrEMBL
  A6HS23 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Gsdmd  gasdermin D  Gsdmdc1_predicted  gasdermin domain containing 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Gsdmdc1_predicted  gasdermin domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED