Antxr1 (ANTXR cell adhesion molecule 1) - Rat Genome Database

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Gene: Antxr1 (ANTXR cell adhesion molecule 1) Rattus norvegicus
Analyze
Symbol: Antxr1
Name: ANTXR cell adhesion molecule 1
RGD ID: 1307144
Description: Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Predicted to be involved in actin cytoskeleton organization; positive regulation of epidermal growth factor receptor signaling pathway; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within blood vessel development; epidermal growth factor receptor signaling pathway; and negative regulation of extracellular matrix assembly. Predicted to be located in external side of plasma membrane; filopodium membrane; and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: anthrax toxin receptor 1; LOC362393; tumor endothelial marker 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,148,102 - 121,335,549 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4121,148,103 - 121,336,892 (-)EnsemblGRCr8
mRatBN7.24119,590,770 - 119,778,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,590,771 - 119,778,232 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4125,063,963 - 125,249,842 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,838,704 - 121,024,595 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,462,951 - 119,648,840 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,946,267 - 119,131,202 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,946,268 - 119,131,202 (-)Ensemblrn6Rnor6.0
Rnor_5.04183,514,051 - 183,699,805 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44121,297,955 - 121,483,876 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4108,561,084 - 108,748,509 (-)NCBICelera
RGSC_v3.14121,543,680 - 121,728,345 (-)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-ethyl-N-nitrosourea  (ISO)
naled  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cullen M, etal., Cancer Res. 2009 Aug 1;69(15):6021-6. doi: 10.1158/0008-5472.CAN-09-1086. Epub 2009 Jul 21.
2. Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical significance. Davies G, etal., Int J Oncol. 2006 Nov;29(5):1311-7.
3. Targeting tumor endothelial marker 8 in the tumor vasculature of colorectal carcinomas in mice. Fernando S and Fletcher BS, Cancer Res. 2009 Jun 15;69(12):5126-32. doi: 10.1158/0008-5472.CAN-09-0725.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Tumor endothelial marker 8 expression in triple-negative breast cancer. Gutwein LG, etal., Anticancer Res. 2011 Oct;31(10):3417-22.
6. Expression pattern of tumor endothelial marker 8 protein in gallbladder carcinomas. Maurya SK, etal., Asian Pac J Cancer Prev. 2011;12(2):507-12.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Tumor endothelial marker 8 overexpression in breast cancer cells enhances tumor growth and metastasis. Opoku-Darko M, etal., Cancer Invest. 2011 Dec;29(10):676-82. doi: 10.3109/07357907.2011.626474.
10. Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients. Raeisossadati R, etal., Int J Colorectal Dis. 2011 Oct;26(10):1265-70. doi: 10.1007/s00384-011-1230-8. Epub 2011 May 15.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. DNA vaccine against tumor endothelial marker 8 inhibits tumor angiogenesis and growth. Ruan Z, etal., J Immunother. 2009 Jun;32(5):486-91. doi: 10.1097/CJI.0b013e3181a1d134.
15. Mutations in ANTXR1 cause GAPO syndrome. Stranecky V, etal., Am J Hum Genet. 2013 May 2;92(5):792-9. doi: 10.1016/j.ajhg.2013.03.023. Epub 2013 Apr 18.
16. Dendritic cells transduced with TEM8 recombinant adenovirus prevents hepatocellular carcinoma angiogenesis and inhibits cells growth. Yang X, etal., Vaccine. 2010 Oct 8;28(43):7130-5. doi: 10.1016/j.vaccine.2010.07.014. Epub 2010 Sep 16.
Additional References at PubMed
PMID:12477932   PMID:16762926   PMID:19581412   PMID:19617532   PMID:21129411   PMID:23376485   PMID:25572963   PMID:31477767  


Genomics

Comparative Map Data
Antxr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,148,102 - 121,335,549 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4121,148,103 - 121,336,892 (-)EnsemblGRCr8
mRatBN7.24119,590,770 - 119,778,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,590,771 - 119,778,232 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4125,063,963 - 125,249,842 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,838,704 - 121,024,595 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,462,951 - 119,648,840 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,946,267 - 119,131,202 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,946,268 - 119,131,202 (-)Ensemblrn6Rnor6.0
Rnor_5.04183,514,051 - 183,699,805 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44121,297,955 - 121,483,876 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4108,561,084 - 108,748,509 (-)NCBICelera
RGSC_v3.14121,543,680 - 121,728,345 (-)NCBI
Cytogenetic Map4q34NCBI
ANTXR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38269,013,144 - 69,249,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl269,013,176 - 69,249,327 (+)Ensemblhg38GRCh38
GRCh37269,240,276 - 69,476,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,093,993 - 69,329,806 (+)NCBIBuild 36Build 36hg18NCBI36
Celera269,091,094 - 69,326,525 (+)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,976,485 - 69,212,089 (+)NCBIHuRef
CHM1_1269,169,599 - 69,405,781 (+)NCBICHM1_1
T2T-CHM13v2.0269,025,553 - 69,261,692 (+)NCBIT2T-CHM13v2.0
Antxr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,110,835 - 87,312,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,110,835 - 87,312,803 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38687,133,853 - 87,335,809 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,133,853 - 87,335,821 (-)Ensemblmm10GRCm38
MGSCv37687,083,847 - 87,285,769 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36687,099,487 - 87,301,349 (-)NCBIMGSCv36mm8
Celera689,073,161 - 89,274,792 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.94NCBI
Antxr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,824,435 - 16,033,946 (-)Ensembl
ChiLan1.0NW_00495542415,820,734 - 16,034,278 (-)NCBIChiLan1.0ChiLan1.0
ANTXR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,166,003 - 57,402,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,169,950 - 57,406,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,054,253 - 69,290,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,176,051 - 70,412,454 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,175,982 - 70,412,454 (+)EnsemblpanPan2panpan1.1
ANTXR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,829,573 - 68,021,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,829,225 - 68,019,127 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1067,715,413 - 67,912,796 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01068,847,827 - 69,045,692 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,847,772 - 69,045,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,529,210 - 68,726,343 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,830,407 - 69,027,760 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,125,652 - 69,323,525 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Antxr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,054,414 - 15,282,299 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,288,717 - 13,516,984 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,288,986 - 13,516,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANTXR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,157,747 - 73,398,379 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1373,157,744 - 73,398,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,588,817 - 76,839,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANTXR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,849,911 - 38,116,339 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1437,877,436 - 38,115,938 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604573,876,615 - 74,142,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Antxr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247624,128,127 - 4,377,278 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247624,051,479 - 4,377,237 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Antxr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1658,983,031 - 59,177,979 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Antxr1
527 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:166
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000011675
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
D4Got85  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,615,498 - 119,615,629 (+)MAPPERmRatBN7.2
Rnor_6.04118,971,019 - 118,971,147NCBIRnor6.0
Rnor_5.04183,538,751 - 183,538,879UniSTSRnor5.0
RGSC_v3.44121,324,656 - 121,324,785RGDRGSC3.4
RGSC_v3.44121,324,657 - 121,324,785UniSTSRGSC3.4
Celera4108,585,845 - 108,585,973UniSTS
RGSC_v3.14121,569,138 - 121,569,266RGD
RH 3.4 Map4703.2UniSTS
RH 3.4 Map4703.2RGD
RH 2.0 Map4733.1RGD
Cytogenetic Map4q34UniSTS
D4Got86  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,620,464 - 119,620,654 (+)MAPPERmRatBN7.2
Rnor_6.04118,975,983 - 118,976,170NCBIRnor6.0
Rnor_5.04183,543,715 - 183,543,902UniSTSRnor5.0
RGSC_v3.44121,329,620 - 121,329,808RGDRGSC3.4
RGSC_v3.44121,329,621 - 121,329,808UniSTSRGSC3.4
Celera4108,590,809 - 108,590,978UniSTS
RGSC_v3.14121,574,102 - 121,574,289RGD
RH 3.4 Map4701.1RGD
RH 3.4 Map4701.1UniSTS
Cytogenetic Map4q34UniSTS
D4Uia1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84121,334,540 - 121,334,721 (+)Marker Load Pipeline
mRatBN7.24119,777,225 - 119,777,404 (+)MAPPERmRatBN7.2
Rnor_6.04119,130,196 - 119,130,374NCBIRnor6.0
Rnor_5.04183,698,799 - 183,698,977UniSTSRnor5.0
RGSC_v3.44121,482,869 - 121,483,048RGDRGSC3.4
RGSC_v3.44121,482,870 - 121,483,048UniSTSRGSC3.4
Celera4108,747,503 - 108,747,681UniSTS
RGSC_v3.14121,727,350 - 121,727,529RGD
Cytogenetic Map4q34UniSTS
RH139141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,590,738 - 119,590,898 (+)MAPPERmRatBN7.2
Rnor_6.04118,946,236 - 118,946,395NCBIRnor6.0
Rnor_5.04183,514,020 - 183,514,179UniSTSRnor5.0
RGSC_v3.44121,297,924 - 121,298,083UniSTSRGSC3.4
Celera4108,561,053 - 108,561,212UniSTS
RH 3.4 Map4700.1UniSTS
Cytogenetic Map4q34UniSTS
RH142653  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,761,883 - 119,762,098 (+)MAPPERmRatBN7.2
Rnor_6.04119,114,854 - 119,115,068NCBIRnor6.0
Rnor_5.04183,683,427 - 183,683,641UniSTSRnor5.0
RGSC_v3.44121,467,528 - 121,467,742UniSTSRGSC3.4
RGSC_v3.44121,467,116 - 121,467,742UniSTSRGSC3.4
Celera4108,732,161 - 108,732,375UniSTS
RH 3.4 Map4701.1UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 56 59 6 319 156 11 134 80 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000011675   ⟹   ENSRNOP00000011675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4121,148,103 - 121,335,549 (-)Ensembl
mRatBN7.2 Ensembl4119,590,771 - 119,778,232 (-)Ensembl
Rnor_6.0 Ensembl4118,946,268 - 119,131,202 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109957   ⟹   ENSRNOP00000077883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4121,148,103 - 121,335,549 (-)Ensembl
mRatBN7.2 Ensembl4119,590,771 - 119,778,232 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149308   ⟹   ENSRNOP00000108555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4121,148,103 - 121,335,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170449   ⟹   ENSRNOP00000102973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4121,148,103 - 121,336,892 (-)Ensembl
RefSeq Acc Id: NM_001044249   ⟹   NP_001037714
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84121,148,102 - 121,335,549 (-)NCBI
mRatBN7.24119,590,770 - 119,778,232 (-)NCBI
Rnor_6.04118,946,267 - 119,131,202 (-)NCBI
Rnor_5.04183,514,051 - 183,699,805 (-)NCBI
RGSC_v3.44121,297,955 - 121,483,876 (-)RGD
Celera4108,561,084 - 108,748,509 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001037714 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI31854 (Get FASTA)   NCBI Sequence Viewer  
  AAV29939 (Get FASTA)   NCBI Sequence Viewer  
  ABH03702 (Get FASTA)   NCBI Sequence Viewer  
  EDL91270 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011675
GenBank Protein Q0PMD2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037714   ⟸   NM_001044249
- UniProtKB: A0A0G2JSJ5 (UniProtKB/TrEMBL),   A0A8I5Y8B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011675   ⟸   ENSRNOT00000011675
Ensembl Acc Id: ENSRNOP00000077883   ⟸   ENSRNOT00000109957
Ensembl Acc Id: ENSRNOP00000102973   ⟸   ENSRNOT00000170449
Ensembl Acc Id: ENSRNOP00000108555   ⟸   ENSRNOT00000149308
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q0PMD2-F1-model_v2 AlphaFold Q0PMD2 1-562 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693218
Promoter ID:EPDNEW_R3743
Type:multiple initiation site
Name:Antxr1_1
Description:anthrax toxin receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04119,131,084 - 119,131,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307144 AgrOrtholog
BioCyc Gene G2FUF-43874 BioCyc
Ensembl Genes ENSRNOG00000008678 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011675 ENTREZGENE
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7320366 IMAGE-MGC_LOAD
InterPro Anthrax_toxin_rcpt UniProtKB/Swiss-Prot
  Anthrax_toxin_rcpt_C UniProtKB/Swiss-Prot
  Anthrax_toxin_rcpt_extracel UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:362393 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156827 IMAGE-MGC_LOAD
NCBI Gene 362393 ENTREZGENE
PANTHER ANTHRAX TOXIN RECEPTOR UniProtKB/Swiss-Prot
  PTHR16059:SF11 UniProtKB/Swiss-Prot
Pfam Ant_C UniProtKB/Swiss-Prot
  Anth_Ig UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PhenoGen Antxr1 PhenoGen
PIRSF Anthrax_toxin_receptor_2 UniProtKB/Swiss-Prot
PRINTS PRICHEXTENSN UniProtKB/Swiss-Prot
PROSITE VWFA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008678 RatGTEx
SMART VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot
UniProt A0A0G2JSJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8B0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LE97_RAT UniProtKB/TrEMBL
  A0ABK0M202_RAT UniProtKB/TrEMBL
  A6IB02_RAT UniProtKB/TrEMBL
  ANTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Antxr1  ANTXR cell adhesion molecule 1  Antxr1  anthrax toxin receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Antxr1  anthrax toxin receptor 1  Antxr1_predicted  anthrax toxin receptor 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Antxr1_predicted  anthrax toxin receptor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED