Fcsk (fucose kinase) - Rat Genome Database

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Gene: Fcsk (fucose kinase) Rattus norvegicus
Analyze
Symbol: Fcsk
Name: fucose kinase
RGD ID: 1307000
Description: Predicted to enable fucokinase activity. Involved in response to dopamine. Orthologous to human FCSK (fucose kinase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 2,6-dinitrotoluene; acrylamide; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fucokinase; Fuk; L-fucose kinase; LOC307848
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,743,746 - 55,783,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,739,842 - 55,800,496 (-)EnsemblGRCr8
mRatBN7.21938,849,130 - 38,874,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,659,229 - 45,678,857 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,312,597 - 46,332,215 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,623,549 - 48,643,224 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,338,146 - 43,357,826 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,338,166 - 43,357,822 (+)Ensemblrn6Rnor6.0
Rnor_5.01954,149,422 - 54,190,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41940,803,644 - 40,823,587 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,247,827 - 38,267,268 (-)NCBICelera
RGSC_v3.11940,808,531 - 40,863,816 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Dopamine stimulated L-fucose incorporation into brain proteins is related to an increase in fucokinase activity. Jork R, etal., Biomed Biochim Acta. 1984;43(3):261-70.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14686921   PMID:30503518  


Genomics

Comparative Map Data
Fcsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,743,746 - 55,783,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,739,842 - 55,800,496 (-)EnsemblGRCr8
mRatBN7.21938,849,130 - 38,874,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,659,229 - 45,678,857 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,312,597 - 46,332,215 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,623,549 - 48,643,224 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,338,146 - 43,357,826 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,338,166 - 43,357,822 (+)Ensemblrn6Rnor6.0
Rnor_5.01954,149,422 - 54,190,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41940,803,644 - 40,823,587 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,247,827 - 38,267,268 (-)NCBICelera
RGSC_v3.11940,808,531 - 40,863,816 (-)NCBI
Cytogenetic Map19q12NCBI
FCSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,454,595 - 70,480,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,454,398 - 70,480,274 (+)Ensemblhg38GRCh38
GRCh371670,488,498 - 70,514,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361669,045,999 - 69,071,678 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341669,045,998 - 69,071,677NCBI
Celera1655,014,116 - 55,039,795 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1656,320,614 - 56,346,293 (+)NCBIHuRef
CHM1_11671,895,869 - 71,921,551 (+)NCBICHM1_1
T2T-CHM13v2.01676,265,623 - 76,291,305 (+)NCBIT2T-CHM13v2.0
Fcsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,609,088 - 111,629,120 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,609,088 - 111,629,120 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388110,882,456 - 110,902,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8110,882,456 - 110,902,488 (-)Ensemblmm10GRCm38
MGSCv378113,406,363 - 113,426,359 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368113,769,140 - 113,789,136 (-)NCBIMGSCv36mm8
Celera8115,106,085 - 115,126,168 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.79NCBI
Fcsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,263,795 - 3,278,078 (+)Ensembl
ChiLan1.0NW_0049554843,259,165 - 3,278,621 (+)NCBIChiLan1.0ChiLan1.0
FCSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21883,682,691 - 83,709,163 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,612,075 - 89,637,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,534,064 - 54,559,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11670,294,061 - 70,318,493 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,294,061 - 70,318,493 (+)EnsemblpanPan2panpan1.1
FCSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,442,597 - 76,463,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,443,411 - 76,462,771 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha576,403,883 - 76,424,449 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,879,027 - 76,899,580 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,879,210 - 76,951,921 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,705,672 - 76,721,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,524,033 - 76,544,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0577,016,091 - 77,036,654 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fcsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,452,464 - 36,472,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,116,646 - 23,136,604 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,116,638 - 23,136,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,471,833 - 13,506,419 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1613,471,771 - 13,492,581 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FCSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,606,693 - 53,634,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,615,958 - 53,637,550 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604716,402,617 - 16,430,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,694,660 - 12,714,574 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,695,007 - 12,715,173 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fcsk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11730,588,202 - 30,608,100 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fcsk
203 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084739   ⟹   ENSRNOP00000069893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,764,133 - 55,800,496 (-)Ensembl
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)Ensembl
Rnor_6.0 Ensembl1943,338,171 - 43,357,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091720   ⟹   ENSRNOP00000069496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,764,133 - 55,783,788 (-)Ensembl
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)Ensembl
Rnor_6.0 Ensembl1943,338,166 - 43,357,505 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125369   ⟹   ENSRNOP00000102085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,763,883 - 55,783,788 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138498   ⟹   ENSRNOP00000101537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,758,654 - 55,783,788 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141627   ⟹   ENSRNOP00000112541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,764,133 - 55,799,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143513   ⟹   ENSRNOP00000100748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1955,739,842 - 55,783,788 (-)Ensembl
RefSeq Acc Id: NM_001395146   ⟹   NP_001382075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,764,133 - 55,783,788 (-)NCBI
mRatBN7.21938,854,762 - 38,874,416 (-)NCBI
RefSeq Acc Id: XM_039097766   ⟹   XP_038953694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,743,746 - 55,783,873 (-)NCBI
mRatBN7.21938,849,130 - 38,874,497 (-)NCBI
RefSeq Acc Id: XM_039097768   ⟹   XP_038953696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,764,149 - 55,774,834 (-)NCBI
mRatBN7.21938,854,772 - 38,865,450 (-)NCBI
Ensembl Acc Id: ENSRNOP00000069893   ⟸   ENSRNOT00000084739
Ensembl Acc Id: ENSRNOP00000069496   ⟸   ENSRNOT00000091720
RefSeq Acc Id: XP_038953694   ⟸   XM_039097766
- Peptide Label: isoform X1
- UniProtKB: A6IZ73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953696   ⟸   XM_039097768
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001382075   ⟸   NM_001395146
- UniProtKB: A0A0G2JVI4 (UniProtKB/TrEMBL),   A6IZ73 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102085   ⟸   ENSRNOT00000125369
Ensembl Acc Id: ENSRNOP00000101537   ⟸   ENSRNOT00000138498
Ensembl Acc Id: ENSRNOP00000100748   ⟸   ENSRNOT00000143513
Ensembl Acc Id: ENSRNOP00000112541   ⟸   ENSRNOT00000141627
Protein Domains
GDP-fucose pyrophosphorylase   GHMP kinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVI4-F1-model_v2 AlphaFold A0A0G2JVI4 1-1090 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701144
Promoter ID:EPDNEW_R11668
Type:single initiation site
Name:Fuk_1
Description:fucokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,338,174 - 43,338,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307000 AgrOrtholog
BioCyc Gene G2FUF-5672 BioCyc
BioCyc Pathway PWY-6 [GDP-L-fucose biosynthesis II (from L-fucose)] BioCyc
BioCyc Pathway Image PWY-6 BioCyc
Ensembl Genes ENSRNOG00000059453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084739.3 UniProtKB/TrEMBL
  ENSRNOT00000091720 ENTREZGENE
  ENSRNOT00000091720.3 UniProtKB/TrEMBL
  ENSRNOT00000125369.1 UniProtKB/TrEMBL
  ENSRNOT00000138498 ENTREZGENE
  ENSRNOT00000138498.1 UniProtKB/TrEMBL
  ENSRNOT00000141627.1 UniProtKB/TrEMBL
  ENSRNOT00000143513.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.120 UniProtKB/TrEMBL
InterPro Fucokinase UniProtKB/TrEMBL
  GHMP_kinase UniProtKB/TrEMBL
  GHMP_Kinase-Related UniProtKB/TrEMBL
  GHMP_kinase_C_dom UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
NCBI Gene 307848 ENTREZGENE
PANTHER L-FUCOSE KINASE UniProtKB/TrEMBL
  L-FUCOSE KINASE UniProtKB/TrEMBL
Pfam Fucokinase UniProtKB/TrEMBL
  GHMP_kinases_C UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/TrEMBL
PhenoGen Fcsk PhenoGen
PRINTS MEVGALKINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059453 RatGTEx
Superfamily-SCOP Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF55060 UniProtKB/TrEMBL
UniProt A0A0G2JVI4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L1G3_RAT UniProtKB/TrEMBL
  A0ABK0LD62_RAT UniProtKB/TrEMBL
  A0ABK0LJ27_RAT UniProtKB/TrEMBL
  A0ABK0LNN2_RAT UniProtKB/TrEMBL
  A6IZ73 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDZ7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Fcsk  fucose kinase  Fuk  fucokinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fuk  fucokinase   Fuk_predicted  fucokinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fuk_predicted  fucokinase (predicted)      Symbol and Name status set to approved 70820 APPROVED