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Gene: Rpf2 (ribosome production factor 2 homolog) Rattus norvegicus

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Symbol:

Rpf2

Name:

ribosome production factor 2 homolog

RGD ID:

1306906

Description:

Predicted to enable 5S rRNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein localization to nucleolus; and regulation of signal transduction by p53 class mediator. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human RPF2 (ribosome production factor 2 homolog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

brix domain containing 1; Bxdc1; LOC294436; ribosome production factor 2 homolog (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPF2 (ribosome production factor 2 homolog)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rpf2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rpf2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPF2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RPF2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpf2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPF2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPF2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpf2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rpf2 (ribosome production factor 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RPF2 (ribosome production factor 2 homolog)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rpf2 (ribosome production factor 2 homolog)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rpf2 (ribosome production factor 2 homolog)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y54E10A.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Non3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPF2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rpf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	45,184,511 - 45,205,983 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	45,184,512 - 45,206,001 (-)	Ensembl				GRCr8
mRatBN7.2	20	43,630,003 - 43,651,477 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,629,951 - 43,651,509 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	45,379,014 - 45,400,466 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,038,205 - 45,059,655 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	45,782,530 - 45,803,288 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	20	45,231,211 - 45,252,983 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	20	46,297,727 - 46,319,499 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	20	46,360,684 - 46,382,460 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	20	45,182,048 - 45,203,820 (-)	NCBI		F344_StmMcwi
Rnor_6.0	20	45,321,381 - 45,342,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,321,405 - 45,342,948 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	47,041,336 - 47,062,600 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	44,388,637 - 44,410,093 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	44,336,784 - 44,358,198 (-)	NCBI		Celera
RGSC_v3.1	20	44,411,626 - 44,433,112 (-)	NCBI
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

endosulfan (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

glafenine (EXP)

indometacin (ISO)

ketamine (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylparaben (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rimonabant (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

Triptolide (EXP)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maturation of LSU-rRNA (IEA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IBA)

protein localization to nucleolus (IEA,ISO)

regulation of signal transduction by p53 class mediator (IEA,ISO)

ribosomal large subunit assembly (IEA)

ribosomal large subunit biogenesis (IEA,ISO)

rRNA processing (IEA)

Cellular Component

chromosome (IEA,ISO)

nucleolus (IBA,IEA,ISO)

Molecular Function

5S rRNA binding (IEA,ISO)

protein binding (ISO)

rRNA binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22658674	PMID:22681889	PMID:24120868

Genomics

Comparative Map Data

Rpf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	45,184,511 - 45,205,983 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	45,184,512 - 45,206,001 (-)	Ensembl				GRCr8
mRatBN7.2	20	43,630,003 - 43,651,477 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,629,951 - 43,651,509 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	45,379,014 - 45,400,466 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,038,205 - 45,059,655 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	45,782,530 - 45,803,288 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	20	45,231,211 - 45,252,983 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	20	46,297,727 - 46,319,499 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	20	46,360,684 - 46,382,460 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	20	45,182,048 - 45,203,820 (-)	NCBI		F344_StmMcwi
Rnor_6.0	20	45,321,381 - 45,342,865 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,321,405 - 45,342,948 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	47,041,336 - 47,062,600 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	44,388,637 - 44,410,093 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	44,336,784 - 44,358,198 (-)	NCBI		Celera
RGSC_v3.1	20	44,411,626 - 44,433,112 (-)	NCBI
Cytogenetic Map	20	q12	NCBI

RPF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	110,982,038 - 111,028,263 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	110,982,015 - 111,028,263 (+)	Ensembl			hg38	GRCh38
GRCh37	6	111,303,241 - 111,349,466 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	111,409,984 - 111,453,487 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	6	112,049,860 - 112,093,367 (+)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	108,874,129 - 108,917,809 (+)	NCBI		HuRef
CHM1_1	6	111,566,361 - 111,609,868 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	112,160,651 - 112,206,881 (+)	NCBI		T2T-CHM13v2.0

Rpf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	40,099,242 - 40,123,035 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	40,099,242 - 40,123,032 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	40,223,246 - 40,247,039 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	40,223,246 - 40,247,036 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	39,943,052 - 39,966,845 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	39,906,567 - 39,936,447 (-)	NCBI		MGSCv36	mm8
Celera	10	41,110,053 - 41,133,833 (-)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	21.76	NCBI

Rpf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	35,627,209 - 35,662,557 (+)	Ensembl
ChiLan1.0	NW_004955411	35,627,127 - 35,663,903 (+)	NCBI	ChiLan1.0	ChiLan1.0

RPF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	130,986,693 - 131,033,395 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	128,872,719 - 128,919,468 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	108,781,082 - 108,827,783 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	112,862,627 - 112,908,059 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	112,862,627 - 112,908,061 (+)	Ensembl			panPan2	panpan1.1

RPF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	67,516,991 - 67,566,287 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	67,490,780 - 67,557,609 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	67,335,580 - 67,376,101 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	68,395,291 - 68,436,015 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	68,395,357 - 68,438,309 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	67,746,416 - 67,787,450 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	67,592,889 - 67,642,532 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	67,870,432 - 67,910,925 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rpf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	102,459,974 - 102,490,507 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	6,734,942 - 6,765,099 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936564	6,734,872 - 6,765,370 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	76,917,185 - 76,963,831 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	76,917,114 - 76,959,227 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	86,305,739 - 86,345,805 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	62,856,730 - 62,890,934 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	35,150,972 - 35,192,345 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624916	1,932,881 - 1,967,656 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624916	1,932,773 - 1,967,935 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rpf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	40,001,069 - 40,022,519 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rpf2
142 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	294
Count of miRNA genes:	197
Interacting mature miRNAs:	215
Transcripts:	ENSRNOT00000000717
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26689362	56021148	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26792353	56021148	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26689362	56021148	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	26689362	56021148	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26689362	56021148	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	32156967	45978663	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000717 ⟹ ENSRNOP00000000717

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	45,184,512 - 45,206,001 (-)	Ensembl
mRatBN7.2 Ensembl	20	43,629,951 - 43,651,470 (-)	Ensembl
Rnor_6.0 Ensembl	20	45,321,405 - 45,342,948 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095674 ⟹ ENSRNOP00000093895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	45,184,512 - 45,206,001 (-)	Ensembl
mRatBN7.2 Ensembl	20	43,630,265 - 43,651,509 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099652 ⟹ ENSRNOP00000079814

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,629,999 - 43,649,912 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105691 ⟹ ENSRNOP00000079370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	45,184,512 - 45,204,316 (-)	Ensembl
mRatBN7.2 Ensembl	20	43,629,999 - 43,649,810 (-)	Ensembl

RefSeq Acc Id:

NM_001106391 ⟹ NP_001099861

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	45,184,528 - 45,205,983 (-)	NCBI
mRatBN7.2	20	43,630,019 - 43,651,477 (-)	NCBI
Dahl_SR_JrHsd	20	45,231,211 - 45,252,983 (-)	NCBI
Lyon_Normotensive	20	46,297,727 - 46,319,499 (-)	NCBI
Lyon_Hypertensive	20	46,360,684 - 46,382,460 (-)	NCBI
F344_StmMcwi	20	45,182,048 - 45,203,820 (-)	NCBI
Rnor_6.0	20	45,321,381 - 45,342,865 (-)	NCBI
Rnor_5.0	20	47,041,336 - 47,062,600 (-)	NCBI
RGSC_v3.4	20	44,388,637 - 44,410,093 (-)	RGD
Celera	20	44,336,784 - 44,358,198 (-)	RGD

Sequence:

show sequence

CACTAGGAGATCCAGCAGCGATGGATGCTTTGGACAAAGTCCTAAAGCCTAAAACAAAAAGGGC
TAAGAGATTCCTTGAGAAGAGAGAACCAAAACTCAGTGAGAACATTAAGAATGCCATGCTGATT
AAAGGCGGGAATGCGAATGCAACGGTGACGCAAGTACTGAGAGACGTGTATGCACTGAAGAAAC
CGTATGGAGTTCTCTATAAAAAGAAAAACATTACAAGACCATTTGAGGATCAGACGTCACTGGA
GTTCTTTTCAAAGAAGTCGGACTGTTCTCTGTTCATGTTTGGCTCCCACAATAAGAAGAGGCCC
AATAATCTCGTGATAGGTCGTATGTATGACTACCATGTGCTGGATATGATTGAACTAGGGATTG
AGAAATTCGTGTCTCTGAAAGATATTAAGACAAGTAAGTGCCCTGAGGGAACAAAGCCCATGTT
GATATTTGCTGGTGATGATTTTGATGTAACAGAAGACTACAGAAGACTGAAAAATCTTCTTATT
GATTTCTTCAGAGGCCCCACAGTGTCAAACGTCCGTCTGGCTGGATTAGAGTATGTTCTGCACT
TCACGGCACTGAATGGGAAGGTTTACTTTCGAAGCTATAAGCTGCTGCTGAAGAAATCTGGGTG
CAGAACACCGAGAATCGAGCTAGAAGAGATGGGGCCATCGTTGGATCTGGTTGTGAGGAGGACA
CACTTAGCATCGGACGACCTTTATAAACTGTCCATGAAAGTGCCCAAAGCTCTCAAGCCGAAGA
AGAGGAAGAATATCTCTCAGGATACTTTTGGTACAACGTTTGGAAGGATTCATATGCAGAAGCA
AGACCTAAGCAAACTACAGACGAGGAAAGTGAAGGGGTTGAAGAAGCGGCCTGCAGAGAATGGA
GTAGAAGACCAGGGGAAGAAATCAAAGAGAATTAAGAAAAGTTAGTGAACCTGACTGACAGACA
GCATCACCTTCTTGTGTCGTTTACTAAAGAGAATTTTTCTGCTTGAGGCTGTTTGGTTTTCTGA
TAAGACTTTGTGGCTTATTTGGATGGGGTGAGGGTGTGACAAAATTTCACACTGTAGCCCAGGC
TGGCCCCAGCCTCCCAAGTGCTGTGATATACCATCAGAGCCAGCACACTGTATATTTCTATAAC
ATTATTTATTACGTAAAACTTTTTTTTAAAAAATTGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039098599 ⟹ XP_038954527

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	45,184,511 - 45,204,266 (-)	NCBI
mRatBN7.2	20	43,630,003 - 43,649,760 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099861	(Get FASTA)	NCBI Sequence Viewer
	XP_038954527	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58720	(Get FASTA)	NCBI Sequence Viewer
	EDL87840	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000717
	ENSRNOP00000000717.7
	ENSRNOP00000079370.1
	ENSRNOP00000093895.2

RefSeq Acc Id:

NP_001099861 ⟸ NM_001106391

- UniProtKB:

B0BN82 (UniProtKB/TrEMBL), A0A8I6AJR1 (UniProtKB/TrEMBL), F7ENM1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDALDKVLKPKTKRAKRFLEKREPKLSENIKNAMLIKGGNANATVTQVLRDVYALKKPYGVLYK
KKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDMIELGIEKFVSLK
DIKTSKCPEGTKPMLIFAGDDFDVTEDYRRLKNLLIDFFRGPTVSNVRLAGLEYVLHFTALNGK
VYFRSYKLLLKKSGCRTPRIELEEMGPSLDLVVRRTHLASDDLYKLSMKVPKALKPKKRKNISQ
DTFGTTFGRIHMQKQDLSKLQTRKVKGLKKRPAENGVEDQGKKSKRIKKS

hide sequence

Ensembl Acc Id:

ENSRNOP00000000717 ⟸ ENSRNOT00000000717

RefSeq Acc Id:	XP_038954527 ⟸ XM_039098599
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000093895 ⟸ ENSRNOT00000095674

Ensembl Acc Id:

ENSRNOP00000079814 ⟸ ENSRNOT00000099652

Ensembl Acc Id:

ENSRNOP00000079370 ⟸ ENSRNOT00000105691

Protein Domains

Brix

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0BN82-F1-model_v2	AlphaFold	B0BN82	1-306	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701657

Promoter ID:

EPDNEW_R12180

Type:

initiation region

Name:

Rpf2_1

Description:

ribosome production factor 2 homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	45,342,868 - 45,342,928	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306906	AgrOrtholog
BioCyc Gene	G2FUF-3438	BioCyc
Ensembl Genes	ENSRNOG00000000587	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000717	ENTREZGENE
	ENSRNOT00000000717.9	UniProtKB/TrEMBL
	ENSRNOT00000095674.2	UniProtKB/TrEMBL
	ENSRNOT00000105691.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9089752	IMAGE-MGC_LOAD
InterPro	Brix	UniProtKB/TrEMBL
	Rpf2	UniProtKB/TrEMBL
KEGG Report	rno:294436	UniProtKB/TrEMBL
MGC_CLONE	MGC:187864	IMAGE-MGC_LOAD
NCBI Gene	294436	ENTREZGENE
PANTHER	PTHR12728	UniProtKB/TrEMBL
	RIBOSOME PRODUCTION FACTOR 2 HOMOLOG	UniProtKB/TrEMBL
Pfam	Brix	UniProtKB/TrEMBL
PhenoGen	Rpf2	PhenoGen
PROSITE	BRIX	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000587	RatGTEx
SMART	Brix	UniProtKB/TrEMBL
UniProt	A0A8I5ZMX0_RAT	UniProtKB/TrEMBL
	A0A8I6AJR1	ENTREZGENE, UniProtKB/TrEMBL
	B0BN82	ENTREZGENE, UniProtKB/TrEMBL
	F7ENM1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-30	Rpf2	ribosome production factor 2 homolog	Rpf2	ribosome production factor 2 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-28	Rpf2	ribosome production factor 2 homolog (S. cerevisiae)	Bxdc1	brix domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Bxdc1	brix domain containing 1	Bxdc1_predicted	brix domain containing 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Bxdc1_predicted	brix domain containing 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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