Slc22a13 (solute carrier family 22 member 13) - Rat Genome Database

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Gene: Slc22a13 (solute carrier family 22 member 13) Rattus norvegicus
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Symbol: Slc22a13 (Ensembl: LOC120094289)
Name: solute carrier family 22 member 13 (Ensembl:solute carrier family 22 member 13-like)
RGD ID: 1306840
Description: Predicted to enable nicotinate transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in several processes, including nicotinate transport; positive regulation of T cell mediated cytotoxicity directed against tumor cell target; and urate transport. Predicted to be located in Golgi apparatus; apical plasma membrane; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human SLC22A13 (solute carrier family 22 member 13); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; INTERACTS WITH bisphenol A; cyclosporin A; methamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316062; OAT10; ORCTL-3; organic anion transporter 10; organic cation transporter-like 3; solute carrier family 22 (organic anion transporter), member 13; solute carrier family 22 (organic anion/urate transporter), member 13; solute carrier family 22 (organic cation transporter), member 13
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,800,097 - 127,811,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,800,097 - 127,811,724 (-)EnsemblGRCr8
mRatBN7.28118,922,367 - 118,934,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,922,367 - 118,953,635 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,523,764 - 124,535,564 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,722,731 - 122,734,583 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,555,873 - 120,567,444 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,885,268 - 127,900,829 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,092,455 - 127,107,283 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,159,275 - 124,174,462 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,095,450 - 118,105,170 (-)NCBICelera
RGSC_v3.18124,179,329 - 124,209,653 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. The human NAD metabolome: Functions, metabolism and compartmentalization. Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10072596   PMID:12477932   PMID:18411268   PMID:19056867   PMID:19282870   PMID:23376485   PMID:24147638   PMID:24769897  


Genomics

Comparative Map Data
Slc22a13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,800,097 - 127,811,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8127,800,097 - 127,811,724 (-)EnsemblGRCr8
mRatBN7.28118,922,367 - 118,934,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,922,367 - 118,953,635 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,523,764 - 124,535,564 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,722,731 - 122,734,583 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,555,873 - 120,567,444 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,885,268 - 127,900,829 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,092,455 - 127,107,283 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,159,275 - 124,174,462 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,095,450 - 118,105,170 (-)NCBICelera
RGSC_v3.18124,179,329 - 124,209,653 (-)NCBI
Cytogenetic Map8q32NCBI
SLC22A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,265,812 - 38,278,757 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,265,812 - 38,278,757 (+)Ensemblhg38GRCh38
GRCh37338,307,303 - 38,320,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,282,335 - 38,294,810 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34338,282,334 - 38,294,810NCBI
Celera338,242,927 - 38,255,435 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,349,252 - 38,361,760 (+)NCBIHuRef
CHM1_1338,258,992 - 38,271,500 (+)NCBICHM1_1
T2T-CHM13v2.0338,271,525 - 38,284,466 (+)NCBIT2T-CHM13v2.0
Slc22a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,020,618 - 119,038,171 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,022,040 - 119,038,164 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,192,966 - 119,209,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,192,974 - 119,209,098 (-)Ensemblmm10GRCm38
MGSCv379119,102,092 - 119,118,223 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369119,041,672 - 119,057,784 (-)NCBIMGSCv36mm8
Celera9119,660,862 - 119,676,484 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:115
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000045105
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
RH141526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,922,448 - 118,922,642 (+)MAPPERmRatBN7.2
Rnor_6.08127,885,350 - 127,885,543NCBIRnor6.0
Rnor_5.08127,092,632 - 127,092,825UniSTSRnor5.0
RGSC_v3.48124,159,357 - 124,159,550UniSTSRGSC3.4
Celera8118,095,532 - 118,095,725UniSTS
RH 3.4 Map81289.2UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 9 50 126 83 81 51 44 51 6 256 118 2 105 69 76 30 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000078303   ⟹   ENSRNOP00000075628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,800,097 - 127,811,724 (-)Ensembl
mRatBN7.2 Ensembl8118,922,367 - 118,953,609 (-)Ensembl
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094542   ⟹   ENSRNOP00000085528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,942,695 - 118,953,635 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099503   ⟹   ENSRNOP00000076627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,922,367 - 118,933,994 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104015   ⟹   ENSRNOP00000088097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8127,800,415 - 127,811,724 (-)Ensembl
mRatBN7.2 Ensembl8118,922,685 - 118,933,994 (-)Ensembl
RefSeq Acc Id: NM_001126285   ⟹   NP_001119757
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,800,097 - 127,811,750 (-)NCBI
mRatBN7.28118,922,367 - 118,934,020 (-)NCBI
Rnor_6.08127,885,268 - 127,900,463 (-)NCBI
Rnor_5.08127,092,455 - 127,107,283 (-)NCBI
RGSC_v3.48124,159,275 - 124,174,462 (-)RGD
Celera8118,095,450 - 118,105,170 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119757 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66511 (Get FASTA)   NCBI Sequence Viewer  
  B2GV36 (Get FASTA)   NCBI Sequence Viewer  
  EDL76920 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075628
  ENSRNOP00000075628.1
  ENSRNOP00000076627.1
RefSeq Acc Id: NP_001119757   ⟸   NM_001126285
- UniProtKB: B2GV36 (UniProtKB/TrEMBL),   A0A8I6A5H4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075628   ⟸   ENSRNOT00000078303
Ensembl Acc Id: ENSRNOP00000076627   ⟸   ENSRNOT00000099503
Ensembl Acc Id: ENSRNOP00000088097   ⟸   ENSRNOT00000104015
Ensembl Acc Id: ENSRNOP00000085528   ⟸   ENSRNOT00000094542
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV36-F1-model_v2 AlphaFold B2GV36 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306840 AgrOrtholog
BioCyc Gene G2FUF-28798 BioCyc
Ensembl Genes ENSRNOG00000056476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078303 ENTREZGENE
  ENSRNOT00000078303.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099503.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128568 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:316062 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188079 IMAGE-MGC_LOAD
NCBI Gene 316062 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc22a13 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056476 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A8I6A5H4 ENTREZGENE, UniProtKB/TrEMBL
  B2GV36 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a13  solute carrier family 22 member 13  Slc22a13  solute carrier family 22 (organic anion/urate transporter), member 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc22a13  solute carrier family 22 (organic anion/urate transporter), member 13  Slc22a13  solute carrier family 22 (organic anion transporter), member 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc22a13  solute carrier family 22 (organic anion transporter), member 13  Slc22a13  solute carrier family 22 (organic cation transporter), member 13   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc22a13  solute carrier family 22 (organic cation transporter), member 13   Slc22a13_predicted  solute carrier family 22 (organic cation transporter), member 13 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc22a13_predicted  solute carrier family 22 (organic cation transporter), member 13 (predicted)      Symbol and Name status set to approved 70820 APPROVED