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Gene: Cyria (CYFIP related Rac1 interactor A) Rattus norvegicus

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Symbol:

Cyria

Name:

CYFIP related Rac1 interactor A

RGD ID:

1305961

Description:

Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be located in membrane. Orthologous to human CYRIA (CYFIP related Rac1 interactor A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CYFIP-related Rac1 interactor A; Fam49a; family with sequence similarity 49, member A; LOC298890; RGD1305961; similar to hypothetical protein DKFZp566A1524

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYRIA (CYFIP related Rac1 interactor A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Cyria (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cyria (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CYRIA (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYRIA (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cyria (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYRIA (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYRIA (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cyria (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cyria (CYFIP related Rac1 interactor A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CYRIB (CYFIP related Rac1 interactor B)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CYRIA (CYFIP related Rac1 interactor A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cyria (CYFIP related Rac1 interactor A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fam49al (family with sequence similarity 49 member A, like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R07G3.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R07G3.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32066	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cyria	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cyria	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	40,774,165 - 40,883,005 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	40,774,171 - 40,881,860 (+)	Ensembl				GRCr8
mRatBN7.2	6	35,045,208 - 35,150,669 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	35,045,208 - 35,150,668 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	35,346,881 - 35,452,349 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	35,661,507 - 35,766,973 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	35,123,999 - 35,229,298 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	37,555,167 - 37,661,196 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	37,555,182 - 37,665,064 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	50,682,248 - 50,788,038 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	35,830,497 - 35,936,574 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	34,410,256 - 34,515,470 (+)	NCBI		Celera
RGSC_v3.1	6	35,875,817 - 35,940,028 (+)	NCBI
Cytogenetic Map	6	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-diaminodiphenylmethane (EXP)

acetamide (EXP)

aflatoxin B1 (EXP)

Aflatoxin B2 alpha (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

butanal (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

celastrol (ISO)

choline (ISO)

cyclosporin A (ISO)

DDT (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

Heliotrine (EXP)

L-methionine (ISO)

Lasiocarpine (EXP)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

melphalan (ISO)

methapyrilene (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

poly(I:C) (EXP)

propanal (ISO)

SB 431542 (ISO)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of actin filament polymerization (IEA)

Cellular Component

membrane (IEA)

Molecular Function

protein binding (ISO)

small GTPase binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22871113

Genomics

Comparative Map Data

Cyria
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	40,774,165 - 40,883,005 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	40,774,171 - 40,881,860 (+)	Ensembl				GRCr8
mRatBN7.2	6	35,045,208 - 35,150,669 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	35,045,208 - 35,150,668 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	35,346,881 - 35,452,349 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	35,661,507 - 35,766,973 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	35,123,999 - 35,229,298 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	37,555,167 - 37,661,196 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	37,555,182 - 37,665,064 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	50,682,248 - 50,788,038 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	35,830,497 - 35,936,574 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	34,410,256 - 34,515,470 (+)	NCBI		Celera
RGSC_v3.1	6	35,875,817 - 35,940,028 (+)	NCBI
Cytogenetic Map	6	q15	NCBI

CYRIA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	16,549,459 - 16,665,834 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	16,549,459 - 16,666,331 (-)	Ensembl			hg38	GRCh38
GRCh37	2	16,730,727 - 16,847,102 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	16,597,382 - 16,710,580 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	16,655,528 - 16,768,724	NCBI
Celera	2	16,610,797 - 16,684,917 (-)	NCBI		Celera
Cytogenetic Map	2	p24.2	NCBI
HuRef	2	16,505,559 - 16,621,967 (-)	NCBI		HuRef
CHM1_1	2	16,660,180 - 16,734,676 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	16,581,160 - 16,697,534 (-)	NCBI		T2T-CHM13v2.0

Cyria
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	12,312,136 - 12,430,966 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	12,312,140 - 12,430,966 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	12,262,134 - 12,380,965 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	12,262,139 - 12,380,965 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	12,268,945 - 12,383,169 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	12,302,329 - 12,402,349 (+)	NCBI		MGSCv36	mm8
Celera	12	12,607,335 - 12,720,232 (+)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	5.63	NCBI

Cyria
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	9,545,639 - 9,636,243 (-)	Ensembl
ChiLan1.0	NW_004955487	9,545,639 - 9,636,183 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYRIA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	109,868,729 - 109,979,134 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	109,872,697 - 109,982,420 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	16,532,230 - 16,642,397 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	16,660,464 - 16,728,797 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	16,660,469 - 16,728,797 (-)	Ensembl			panPan2	panpan1.1

CYRIA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	12,208,319 - 12,311,775 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	12,211,494 - 12,270,152 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	12,154,659 - 12,258,045 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	12,338,751 - 12,442,231 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	12,338,753 - 12,442,261 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	12,196,811 - 12,300,249 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	12,208,493 - 12,311,876 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	12,234,516 - 12,296,349 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cyria
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	56,700,509 - 56,758,417 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	14,081,148 - 14,139,780 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	14,081,178 - 14,139,054 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYRIA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	120,968,060 - 121,069,240 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	120,968,016 - 121,069,372 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	129,216,661 - 129,316,473 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYRIA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	90,990,100 - 91,076,449 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	90,961,862 - 91,074,560 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	21,141,542 - 21,251,039 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cyria
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624865	343,954 - 429,915 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624865	303,124 - 430,426 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cyria
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	32,099,417 - 32,166,598 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cyria
562 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
8693632	Alc27	Alcohol consumption QTL 27	2.2	0.791	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	40052411	56848866	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Markers in Region

D6Rat36

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	35,098,709 - 35,098,849 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	37,608,980 - 37,609,119	NCBI	Rnor6.0
Rnor_5.0	6	50,735,827 - 50,735,966	UniSTS	Rnor5.0
RGSC_v3.4	6	35,883,625 - 35,883,996	RGD	RGSC3.4
RGSC_v3.4	6	35,883,847 - 35,883,986	UniSTS	RGSC3.4
Celera	6	34,463,599 - 34,463,738	UniSTS
RGSC_v3.1	6	35,886,800 - 35,886,939	RGD
RH 3.4 Map	6	139.1	RGD
RH 3.4 Map	6	139.1	UniSTS
RH 2.0 Map	6	284.1	RGD
FHH x ACI Map	6	29.28	RGD
Cytogenetic Map	6	q14	UniSTS

D6Rat228

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	40,857,957 - 40,858,199 (+)	Marker Load Pipeline
mRatBN7.2	6	35,128,974 - 35,129,218 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	37,639,217 - 37,639,458	NCBI	Rnor6.0
Rnor_5.0	6	50,766,059 - 50,766,300	UniSTS	Rnor5.0
RGSC_v3.4	6	35,914,889 - 35,915,131	RGD	RGSC3.4
RGSC_v3.4	6	35,914,890 - 35,915,131	UniSTS	RGSC3.4
Celera	6	34,493,789 - 34,494,030	UniSTS
RGSC_v3.1	6	35,917,842 - 35,918,084	RGD
SHRSP x BN Map	6	27.3798	UniSTS
SHRSP x BN Map	6	27.3798	RGD
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	352	192	11	144	77	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082616 ⟹ ENSRNOP00000068675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	40,774,171 - 40,881,860 (+)	Ensembl
mRatBN7.2 Ensembl	6	35,045,208 - 35,150,668 (+)	Ensembl
Rnor_6.0 Ensembl	6	37,555,182 - 37,665,064 (+)	Ensembl

RefSeq Acc Id:

NM_001106718 ⟹ NP_001100188

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	40,774,194 - 40,879,646 (+)	NCBI
mRatBN7.2	6	35,045,208 - 35,150,669 (+)	NCBI
Rnor_6.0	6	37,555,210 - 37,661,196 (+)	NCBI
Rnor_5.0	6	50,682,248 - 50,788,038 (+)	NCBI
RGSC_v3.4	6	35,830,497 - 35,936,574 (+)	RGD
Celera	6	34,410,256 - 34,515,470 (+)	RGD

Sequence:

show sequence

CTGAGCAGGAGCGAGGCGGCGACAGCGGCTGCGACTCTGTACCACTCCCATAAGCACAGAGACC
AGACCCGCCGGGACCAGACTTGATTTGGAGAGCTCCTTCCTGTGGCCTCATAGCTGCTCTGCTG
GTTTGCCCCTTCAGTCTGGATTGGTGACACGCAACCACTGGAGATATTTCCAGGTTTGCTGGCA
TGGGAAACTTGCTCAAAGTCCTGACCCGGGAAATTGAGAATTATCCACACTTCTTCCTGGATTT
TGAAAATGCCCAGCCTACGGAAGGAGAGCGAGAAATATGGAACCAGATCAGTGCTGTCCTCCAA
GATTCCGAGAGCATCCTCTCAGACCTGCAGGCTTACAAAGGCGCAGGACCGGAGATTCGAGATG
CAATTCAAAATCCCAATGACATTCAACTTCAGGAAAAGGCTTGGAATGCAGTCTGTCCTCTGGT
CGTGAGGCTGAAGAGGTTTTACGAATTTTCTATTCGTCTTGAGAAAGCACTACAGAGTTTATTG
GAATCTCTGACGTGTCCACCCTATACACCAACCCAGCACCTCGAACGGGAGCAAGCCCTGGCAA
AGGAATTTGCAGAAATCTTACATTTTACCCTTCGATTCGATGAGCTGAAGATGAGGAACCCAGC
TATTCAGAATGACTTCAGTTACTACAGAAGAACAATAAGTCGTAACCGCATCAACAACATGCAC
CTAGACATTGAGAATGAAGTTAATAATGAGATGGCCAATCGAATGTCCCTCTTCTATGCAGAAG
CCACGCCCATGCTGAAGACTCTTAGCAACGCCACAATGCACTTTGTCTCAGAAAATAAAACCCT
GCCCATAGAGAATACCACAGACTGCCTCAGTACGATGACAAGTGTCTGTAAAGTCATGCTGGAG
ACACCGGAGTACAGGAGCAGGTTTACAAGTGAGGAGACACTGATGTTCTGCATGAGGGTGATGG
TGGGGGTCATCATCCTCTATGACCATGTGCACCCCGTGGGAGCTTTCTGCAAGACATCTAAGAT
TGATATGAAAGGCTGCATAAAGGTGCTGAAGGAACAGGCGCCAGACAGTGTGGAAGGGCTGCTG
AATGCTCTCAGGTTCACTACAAAGCACTTGAATGATGAATCGACTTCCAAACAGATTCGAGCGA
TGCTTCAGTAGAACCCTGCTCAGAGAGGAGGATCTGTGCTGACCTCAGATGTATATGTTTACAT
AATTTAATACAGATTGATGTTAATACTTGTGTATTTACATAACCATTTCCTTCTTGTCACTGAA
ATATATGGACCTTAATTTGTATCCTGACTGATTCAACCCAGCAGAGCATAACTTGACTTGAGAG
CCTTACCTTTGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008764585 ⟹ XP_008762807

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	40,774,165 - 40,883,005 (+)	NCBI
mRatBN7.2	6	35,045,224 - 35,150,664 (+)	NCBI
Rnor_6.0	6	37,555,167 - 37,661,141 (+)	NCBI

Sequence:

show sequence

GCGGCTGCCGGGGGAGAGGCATCCACAGCGGCGGAGCGGACGGCTGAGCAGGAGCGAGGCGGCG
ACAGCGGCTGCGACTCTGGTTTGCTGGCATGGGAAACTTGCTCAAAGTCCTGACCCGGGAAATT
GAGAATTATCCACACTTCTTCCTGGATTTTGAAAATGCCCAGCCTACGGAAGGAGAGCGAGAAA
TATGGAACCAGATCAGTGCTGTCCTCCAAGATTCCGAGAGCATCCTCTCAGACCTGCAGGCTTA
CAAAGGCGCAGGACCGGAGATTCGAGATGCAATTCAAAATCCCAATGACATTCAACTTCAGGAA
AAGGCTTGGAATGCAGTCTGTCCTCTGGTCGTGAGGCTGAAGAGGTTTTACGAATTTTCTATTC
GTCTTGAGAAAGCACTACAGAGTTTATTGGAATCTCTGACGTGTCCACCCTATACACCAACCCA
GCACCTCGAACGGGAGCAAGCCCTGGCAAAGGAATTTGCAGAAATCTTACATTTTACCCTTCGA
TTCGATGAGCTGAAGATGAGGAACCCAGCTATTCAGAATGACTTCAGTTACTACAGAAGAACAA
TAAGTCGTAACCGCATCAACAACATGCACCTAGACATTGAGAATGAAGTTAATAATGAGATGGC
CAATCGAATGTCCCTCTTCTATGCAGAAGCCACGCCCATGCTGAAGACTCTTAGCAACGCCACA
ATGCACTTTGTCTCAGAAAATAAAACCCTGCCCATAGAGAATACCACAGACTGCCTCAGTACGA
TGACAAGTGTCTGTAAAGTCATGCTGGAGACACCGGAGTACAGGAGCAGGTTTACAAGTGAGGA
GACACTGATGTTCTGCATGAGGGTGATGGTGGGGGTCATCATCCTCTATGACCATGTGCACCCC
GTGGGAGCTTTCTGCAAGACATCTAAGATTGATATGAAAGGCTGCATAAAGGTGCTGAAGGAAC
AGGCGCCAGACAGTGTGGAAGGGCTGCTGAATGCTCTCAGGTTCACTACAAAGCACTTGAATGA
TGAATCGACTTCCAAACAGATTCGAGCGATGCTTCAGTAGAACCCTGCTCAGAGAGGAGGATCT
GTGCTGACCTCAGATGTATATGTTTACATAATTTAATACAGATTGATGTTAATACTTGTGTATT
TACATAACCATTTCCTTCTTGTCACTGAAATATATGGACCTTAATTTGTA

hide sequence

RefSeq Acc Id:

XM_063261651 ⟹ XP_063117721

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	40,774,182 - 40,883,005 (+)	NCBI

RefSeq Acc Id:

XM_063261652 ⟹ XP_063117722

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	40,779,945 - 40,883,005 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100188	(Get FASTA)	NCBI Sequence Viewer
	XP_008762807	(Get FASTA)	NCBI Sequence Viewer
	XP_063117721	(Get FASTA)	NCBI Sequence Viewer
	XP_063117722	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58701	(Get FASTA)	NCBI Sequence Viewer
	EDM03107	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068675
	ENSRNOP00000068675.1

RefSeq Acc Id:

NP_001100188 ⟸ NM_001106718

- UniProtKB:

B0BN65 (UniProtKB/TrEMBL), A6HAQ2 (UniProtKB/TrEMBL), A0A0G2JTE1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGNLLKVLTREIENYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILSDLQAYKGAGPEIRD
AIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALA
KEFAEILHFTLRFDELKMRNPAIQNDFSYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAE
ATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRFTSEETLMFCMRVM
VGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRA
MLQ

hide sequence

RefSeq Acc Id:	XP_008762807 ⟸ XM_008764585
- Peptide Label:	isoform X1
- UniProtKB:	B0BN65 (UniProtKB/TrEMBL), A6HAQ2 (UniProtKB/TrEMBL), A0A0G2JTE1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGNLLKVLTREIENYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILSDLQAYKGAGPEIRD AIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALA KEFAEILHFTLRFDELKMRNPAIQNDFSYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAE ATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRFTSEETLMFCMRVM VGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQIRA MLQ hide sequence

Ensembl Acc Id:

ENSRNOP00000068675 ⟸ ENSRNOT00000082616

RefSeq Acc Id:	XP_063117721 ⟸ XM_063261651
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JTE1 (UniProtKB/TrEMBL), A6HAQ2 (UniProtKB/TrEMBL), B0BN65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117722 ⟸ XM_063261652
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JTE1 (UniProtKB/TrEMBL), A6HAQ2 (UniProtKB/TrEMBL), B0BN65 (UniProtKB/TrEMBL)

Protein Domains

CYRIA/CYRIB Rac1 binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0BN65-F1-model_v2	AlphaFold	B0BN65	1-323	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694497

Promoter ID:

EPDNEW_R5021

Type:

multiple initiation site

Name:

Fam49a_1

Description:

family with sequence similarity 49, member A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	37,555,187 - 37,555,247	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305961	AgrOrtholog
BioCyc Gene	G2FUF-38133	BioCyc
Ensembl Genes	ENSRNOG00000052758	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082616	ENTREZGENE
	ENSRNOT00000082616.3	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9028479	IMAGE-MGC_LOAD
InterPro	DUF1394	UniProtKB/TrEMBL
	FAM49	UniProtKB/TrEMBL
KEGG Report	rno:298890	UniProtKB/TrEMBL
MGC_CLONE	MGC:187774	IMAGE-MGC_LOAD
NCBI Gene	298890	ENTREZGENE
PANTHER	PTHR12422	UniProtKB/TrEMBL
Pfam	DUF1394	UniProtKB/TrEMBL
PhenoGen	Cyria	PhenoGen
RatGTEx	ENSRNOG00000052758	RatGTEx
UniProt	A0A0G2JTE1	ENTREZGENE, UniProtKB/TrEMBL
	A6HAQ2	ENTREZGENE, UniProtKB/TrEMBL
	B0BN65	ENTREZGENE
UniProt Secondary	B0BN65	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Cyria	CYFIP related Rac1 interactor A	Fam49a	family with sequence similarity 49, member A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Fam49a	family with sequence similarity 49, member A	RGD1305961_predicted	similar to hypothetical protein DKFZp566A1524 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305961_predicted	similar to hypothetical protein DKFZp566A1524 (predicted)	LOC298890_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC298890_predicted	similar to hypothetical protein DKFZp566A1524 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD