Krit1 (KRIT1, ankyrin repeat containing) - Rat Genome Database

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Gene: Krit1 (KRIT1, ankyrin repeat containing) Rattus norvegicus
Analyze
Symbol: Krit1
Name: KRIT1, ankyrin repeat containing
RGD ID: 1305929
Description: Predicted to enable microtubule binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including cell redox homeostasis; integrin activation; and negative regulation of endothelial cell apoptotic process. Predicted to be located in cell-cell junction and cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebral cavernous malformation and cerebral cavernous malformation 1. Orthologous to human KRIT1 (KRIT1 ankyrin repeat containing); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Krev interaction trapped protein 1; LOC362317; LOC362318; RGD1305929; RGD1305929_predicted; similar to Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog); similar to KRIT1; similar to KRIT1 (predicted)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,253,918 - 31,288,066 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl431,253,918 - 31,288,073 (-)EnsemblGRCr8
mRatBN7.2430,299,203 - 30,333,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,299,203 - 30,333,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx435,271,948 - 35,306,096 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,198,032 - 31,232,180 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,594,018 - 29,628,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,438,609 - 27,473,150 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,438,609 - 27,473,150 (-)Ensemblrn6Rnor6.0
Rnor_5.0427,341,835 - 27,376,376 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4427,014,488 - 27,048,636 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera425,724,169 - 25,758,310 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
2. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, etal., Nat Rev Mol Cell Biol. 2013 Aug;14(8):503-17. doi: 10.1038/nrm3624. Epub 2013 Jul 17.
3. Clinical features of cerebral cavernous malformations patients with KRIT1 mutations. Denier C, etal., Ann Neurol 2004 Feb;55(2):213-20.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. CCM1 mutation screen of sporadic cases with cerebral cavernous malformations. Verlaan DJ, etal., Neurology. 2004 Apr 13;62(7):1213-5.
Additional References at PubMed
PMID:12477932   PMID:12810002   PMID:12877753   PMID:16239636   PMID:16769843   PMID:17916086   PMID:19151727   PMID:20332120   PMID:20616044   PMID:20668652   PMID:22664934   PMID:22970292  
PMID:23007647  


Genomics

Comparative Map Data
Krit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,253,918 - 31,288,066 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl431,253,918 - 31,288,073 (-)EnsemblGRCr8
mRatBN7.2430,299,203 - 30,333,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,299,203 - 30,333,359 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx435,271,948 - 35,306,096 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,198,032 - 31,232,180 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,594,018 - 29,628,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,438,609 - 27,473,150 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,438,609 - 27,473,150 (-)Ensemblrn6Rnor6.0
Rnor_5.0427,341,835 - 27,376,376 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4427,014,488 - 27,048,636 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera425,724,169 - 25,758,310 (-)NCBICelera
Cytogenetic Map4q13NCBI
KRIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,198,969 - 92,246,100 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,197,498 - 92,246,166 (-)Ensemblhg38GRCh38
GRCh37791,828,283 - 91,875,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,666,219 - 91,713,350 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34791,472,933 - 91,520,065NCBI
Celera786,532,835 - 86,579,965 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,435,945 - 86,483,492 (-)NCBIHuRef
CHM1_1791,758,320 - 91,805,450 (-)NCBICHM1_1
T2T-CHM13v2.0793,440,257 - 93,487,387 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,157,516 - 91,204,647 (-)NCBI
Krit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,853,156 - 3,894,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,853,184 - 3,895,564 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3853,803,156 - 3,844,515 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,803,184 - 3,845,564 (+)Ensemblmm10GRCm38
MGSCv3753,803,165 - 3,844,515 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3653,809,195 - 3,847,365 (+)NCBIMGSCv36mm8
Celera53,739,452 - 3,780,804 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.26NCBI
Krit1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,171,216 - 9,219,946 (-)Ensembl
ChiLan1.0NW_0049554329,168,678 - 9,219,947 (-)NCBIChiLan1.0ChiLan1.0
KRIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26110,085,447 - 110,131,571 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,350,089 - 158,396,176 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,197,200 - 84,244,050 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,794,527 - 97,841,099 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,794,531 - 97,840,895 (-)EnsemblpanPan2panpan1.1
KRIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,836,513 - 17,872,514 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,832,625 - 17,872,190 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1417,398,065 - 17,433,896 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01417,643,248 - 17,679,106 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,643,248 - 17,679,291 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,803,905 - 17,839,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,516,013 - 17,552,078 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,789,641 - 17,825,471 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Krit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,240,278 - 31,280,063 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,088,802 - 2,128,657 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,088,606 - 2,128,579 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,142,835 - 72,185,661 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1972,143,652 - 72,184,774 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,874,130 - 78,913,770 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,770,694 - 56,816,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,774,487 - 56,816,049 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604247,456,063 - 47,502,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krit1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624809978,789 - 1,039,091 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624809978,391 - 1,036,313 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Krit1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16136,092,373 - 136,125,581 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Krit1
283 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:313
Count of miRNA genes:201
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000032505
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42228845340471598Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42228845345429897Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
06.MHAa81T_M13Rev.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,331,584 - 30,331,724 (+)MAPPERmRatBN7.2
Rnor_6.0427,471,384 - 27,471,523NCBIRnor6.0
Rnor_5.0427,374,610 - 27,374,749UniSTSRnor5.0
RGSC_v3.4427,046,870 - 27,047,009UniSTSRGSC3.4
Celera425,756,544 - 25,756,683UniSTS
Cytogenetic Map4q13UniSTS
RH143170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,304,726 - 30,304,917 (+)MAPPERmRatBN7.2
Rnor_6.0427,444,290 - 27,444,480NCBIRnor6.0
Rnor_5.0427,347,516 - 27,347,706UniSTSRnor5.0
RGSC_v3.4427,020,012 - 27,020,202UniSTSRGSC3.4
Celera425,729,693 - 25,729,883UniSTS
RH 3.4 Map4169.19UniSTS
Cytogenetic Map4q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032505   ⟹   ENSRNOP00000031502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl431,253,918 - 31,288,066 (-)Ensembl
mRatBN7.2 Ensembl430,299,203 - 30,333,351 (-)Ensembl
Rnor_6.0 Ensembl427,438,609 - 27,473,150 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099540   ⟹   ENSRNOP00000081308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl431,254,407 - 31,288,073 (-)Ensembl
mRatBN7.2 Ensembl430,299,692 - 30,333,359 (-)Ensembl
RefSeq Acc Id: NM_001108618   ⟹   NP_001102088
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,253,918 - 31,288,066 (-)NCBI
mRatBN7.2430,299,203 - 30,333,351 (-)NCBI
Rnor_6.0427,438,609 - 27,473,150 (-)NCBI
Rnor_5.0427,341,835 - 27,376,376 (-)NCBI
RGSC_v3.4427,014,488 - 27,048,636 (-)RGD
Celera425,724,169 - 25,758,310 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107762   ⟹   XP_038963690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,264,094 - 31,285,477 (-)NCBI
mRatBN7.2430,309,379 - 30,333,366 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963690 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68923 (Get FASTA)   NCBI Sequence Viewer  
  EDL84359 (Get FASTA)   NCBI Sequence Viewer  
  EDL84360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031502
  ENSRNOP00000031502.4
  ENSRNOP00000081308.1
RefSeq Acc Id: NP_001102088   ⟸   NM_001108618
- UniProtKB: A6K277 (UniProtKB/TrEMBL),   B5DF47 (UniProtKB/TrEMBL),   G3V8Z6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031502   ⟸   ENSRNOT00000032505
RefSeq Acc Id: XP_038963690   ⟸   XM_039107762
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G7T1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081308   ⟸   ENSRNOT00000099540
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8Z6-F1-model_v2 AlphaFold G3V8Z6 1-736 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692844
Promoter ID:EPDNEW_R3369
Type:multiple initiation site
Name:Krit1_1
Description:KRIT1, ankyrin repeat containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0427,473,172 - 27,473,232EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305929 AgrOrtholog
BioCyc Gene G2FUF-45769 BioCyc
Ensembl Genes ENSRNOG00000007937 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032505 ENTREZGENE
  ENSRNOT00000032505.6 UniProtKB/TrEMBL
  ENSRNOT00000099540.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.70.2240 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ARM_KRIT1 UniProtKB/TrEMBL
  Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_domain_containing UniProtKB/TrEMBL
  KRIT1_FERM_C UniProtKB/TrEMBL
  KRIT1_FRMD8_FERM_C UniProtKB/TrEMBL
  NUDIX UniProtKB/TrEMBL
  NUDIX_sf UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
KEGG Report rno:362317 UniProtKB/TrEMBL
NCBI Gene Krit1 ENTREZGENE
PANTHER KREV INTERACTION TRAPPED 1-RELATED UniProtKB/TrEMBL
  KREV INTERACTION TRAPPED PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank_KRIT1 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  KRIT1_FRMD8_FERM_C UniProtKB/TrEMBL
  NUDIX_5 UniProtKB/TrEMBL
PhenoGen Krit1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007937 RatGTEx
SMART ANK UniProtKB/TrEMBL
  B41 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  FERM_3-hlx UniProtKB/TrEMBL
UniProt A0A8I6G7T1 ENTREZGENE, UniProtKB/TrEMBL
  A6K277 ENTREZGENE, UniProtKB/TrEMBL
  B5DF47 ENTREZGENE, UniProtKB/TrEMBL
  G3V8Z6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Krit1  KRIT1, ankyrin repeat containing   Krit1_predicted  KRIT1, ankyrin repeat containing (predicted)  'predicted' is removed 2292626 APPROVED
2007-01-29 Krit1  KRIT1, ankyrin repeat containing  RGD1305929_predicted  similar to KRIT1 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-01-29 RGD1305929_predicted  similar to KRIT1 (predicted)  LOC362317  similar to Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog)  Data merged from RGD:1587328 737654 APPROVED
2006-11-19 LOC362317  similar to Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1305929_predicted  similar to KRIT1 (predicted)  LOC362318_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362318_predicted  similar to KRIT1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL