Ap1s1 (adaptor related protein complex 1 subunit sigma 1) - Rat Genome Database

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Gene: Ap1s1 (adaptor related protein complex 1 subunit sigma 1) Rattus norvegicus
Analyze
Symbol: Ap1s1
Name: adaptor related protein complex 1 subunit sigma 1
RGD ID: 1305911
Description: Predicted to be involved in vesicle-mediated transport. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adaptor protein complex AP-1, sigma 1; adaptor-related protein complex 1, sigma 1 subunit; E2 ubiquitin-conjugating enzyme W; LOC360785; MGC188494; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ube2w; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2 W; ubiquitin-protein ligase W
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,261,958 - 25,272,483 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,262,036 - 25,272,483 (+)EnsemblGRCr8
mRatBN7.21219,625,267 - 19,635,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,625,332 - 19,756,713 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,762,948 - 20,773,387 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,375,661 - 21,386,100 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,440,199 - 20,450,638 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1226,531,114 - 26,541,553 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1226,458,390 - 26,468,825 (+)NCBILyon_Normotensive
Lyon_Hypertensive1225,316,233 - 25,326,672 (+)NCBILyon_Hypertensive
F344_StmMcwi1235,767,712 - 35,778,154 (+)NCBIF344_StmMcwi
Rnor_6.01222,665,128 - 22,676,079 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)Ensemblrn6Rnor6.0
Rnor_5.01224,677,410 - 24,688,360 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,907,855 - 20,918,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,401,021 - 21,411,455 (+)NCBICelera
RGSC_v3.11220,897,466 - 20,907,910 (-)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flecainide  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
levofloxacin  (EXP)
loratadine  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perhexiline  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
thiram  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. Montpetit A, etal., PLoS Genet. 2008 Dec;4(12):e1000296. doi: 10.1371/journal.pgen.1000296. Epub 2008 Dec 5.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, etal., J Cell Biol 1999 Sep 6;146(5):993-1004.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:16548883   PMID:19946888   PMID:20203623   PMID:23376485   PMID:24928897   PMID:25378584  


Genomics

Comparative Map Data
Ap1s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,261,958 - 25,272,483 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1225,262,036 - 25,272,483 (+)EnsemblGRCr8
mRatBN7.21219,625,267 - 19,635,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,625,332 - 19,756,713 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,762,948 - 20,773,387 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,375,661 - 21,386,100 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01220,440,199 - 20,450,638 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1226,531,114 - 26,541,553 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1226,458,390 - 26,468,825 (+)NCBILyon_Normotensive
Lyon_Hypertensive1225,316,233 - 25,326,672 (+)NCBILyon_Hypertensive
F344_StmMcwi1235,767,712 - 35,778,154 (+)NCBIF344_StmMcwi
Rnor_6.01222,665,128 - 22,676,079 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)Ensemblrn6Rnor6.0
Rnor_5.01224,677,410 - 24,688,360 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,907,855 - 20,918,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1221,401,021 - 21,411,455 (+)NCBICelera
RGSC_v3.11220,897,466 - 20,907,910 (-)NCBI
Cytogenetic Map12q12NCBI
AP1S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,154,476 - 101,161,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,154,352 - 101,161,596 (+)Ensemblhg38GRCh38
GRCh377100,797,757 - 100,804,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,584,406 - 100,591,277 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347100,391,201 - 100,397,991NCBI
Celera795,806,042 - 95,812,913 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,390,854 - 95,397,722 (+)NCBIHuRef
CHM1_17100,728,140 - 100,735,019 (+)NCBICHM1_1
T2T-CHM13v2.07102,477,198 - 102,484,025 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,156,073 - 100,162,944 (+)NCBI
Ap1s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,063,852 - 137,074,917 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,063,847 - 137,074,989 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385137,034,993 - 137,046,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,034,993 - 137,046,135 (-)Ensemblmm10GRCm38
MGSCv375137,510,864 - 137,521,930 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365137,319,621 - 137,330,687 (-)NCBIMGSCv36mm8
Celera5134,051,733 - 134,062,892 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.13NCBI
Ap1s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,127,877 - 16,134,039 (-)Ensembl
ChiLan1.0NW_00495545616,127,877 - 16,134,039 (-)NCBIChiLan1.0ChiLan1.0
AP1S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,166,703 - 119,173,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,431,334 - 167,438,233 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,294,826 - 93,301,202 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,536,450 - 106,543,317 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,536,452 - 106,543,316 (+)EnsemblpanPan2panpan1.1
AP1S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,705,294 - 8,711,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,705,647 - 8,711,190 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha610,402,619 - 10,408,611 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.068,524,828 - 8,530,831 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,524,828 - 8,530,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,484,889 - 8,490,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,455,351 - 8,461,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,620,013 - 8,626,010 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap1s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,978,078 - 132,983,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365431,052,732 - 1,058,483 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365431,052,692 - 1,058,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,881,107 - 8,887,566 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.138,880,993 - 8,887,806 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AP1S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,022,376 - 12,029,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,022,201 - 12,029,181 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660704,321,127 - 4,327,918 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,111,004 - 16,116,992 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474016,111,004 - 16,117,075 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ap1s1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11616,972,148 - 16,982,667 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ap1s1
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:169
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000001918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
BI280199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,635,251 - 19,635,402 (+)MAPPERmRatBN7.2
Rnor_6.01222,675,539 - 22,675,689NCBIRnor6.0
Rnor_5.01224,687,820 - 24,687,970UniSTSRnor5.0
RGSC_v3.41220,908,245 - 20,908,395UniSTSRGSC3.4
Celera1221,410,915 - 21,411,065UniSTS
RH 3.4 Map12277.8UniSTS
Cytogenetic Map12q12UniSTS
UniSTS:235344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,635,431 - 19,635,637 (+)MAPPERmRatBN7.2
Rnor_6.01222,675,719 - 22,675,924NCBIRnor6.0
Rnor_5.01224,688,000 - 24,688,205UniSTSRnor5.0
RGSC_v3.41220,908,010 - 20,908,215UniSTSRGSC3.4
Celera1221,411,095 - 21,411,300UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001918   ⟹   ENSRNOP00000001918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,262,036 - 25,272,483 (+)Ensembl
mRatBN7.2 Ensembl1219,625,332 - 19,635,784 (+)Ensembl
Rnor_6.0 Ensembl1222,665,112 - 22,676,075 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099813   ⟹   ENSRNOP00000096668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,385 - 19,756,713 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110980   ⟹   ENSRNOP00000082199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,332 - 19,634,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119520   ⟹   ENSRNOP00000082325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,625,816 - 19,634,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120650   ⟹   ENSRNOP00000106358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,262,507 - 25,270,115 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000166568   ⟹   ENSRNOP00000099473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1225,264,929 - 25,271,976 (+)Ensembl
RefSeq Acc Id: NM_001108331   ⟹   NP_001101801
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,262,036 - 25,272,483 (+)NCBI
mRatBN7.21219,625,345 - 19,635,792 (+)NCBI
Dahl_SR_JrHsd1226,531,114 - 26,541,553 (+)NCBI
Lyon_Normotensive1226,458,390 - 26,468,825 (+)NCBI
Lyon_Hypertensive1225,316,233 - 25,326,672 (+)NCBI
F344_StmMcwi1235,767,712 - 35,778,154 (+)NCBI
Rnor_6.01222,665,158 - 22,676,079 (+)NCBI
Rnor_5.01224,677,410 - 24,688,360 (+)NCBI
RGSC_v3.41220,907,855 - 20,918,301 (-)RGD
Celera1221,401,021 - 21,411,455 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249179   ⟹   XP_006249241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,261,958 - 25,272,478 (+)NCBI
mRatBN7.21219,625,267 - 19,633,551 (+)NCBI
Rnor_6.01222,665,128 - 22,673,832 (+)NCBI
Rnor_5.01224,677,410 - 24,688,360 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001101801   ⟸   NM_001108331
- UniProtKB: B5DFI3 (UniProtKB/TrEMBL),   A0A8I6ASY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249241   ⟸   XM_006249179
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZW78 (UniProtKB/TrEMBL),   A6J050 (UniProtKB/TrEMBL),   A0A8I5ZUR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001918   ⟸   ENSRNOT00000001918
Ensembl Acc Id: ENSRNOP00000096668   ⟸   ENSRNOT00000099813
Ensembl Acc Id: ENSRNOP00000082325   ⟸   ENSRNOT00000119520
Ensembl Acc Id: ENSRNOP00000082199   ⟸   ENSRNOT00000110980
Ensembl Acc Id: ENSRNOP00000106358   ⟸   ENSRNOT00000120650
Ensembl Acc Id: ENSRNOP00000099473   ⟸   ENSRNOT00000166568
Protein Domains
AP complex mu/sigma subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFI3-F1-model_v2 AlphaFold B5DFI3 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698525
Promoter ID:EPDNEW_R9050
Type:initiation region
Name:Ap1s1_1
Description:adaptor-related protein complex 1, sigma 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,665,205 - 22,665,265EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305911 AgrOrtholog
BioCyc Gene G2FUF-19677 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000001415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001918 ENTREZGENE
  ENSRNOT00000001918.9 UniProtKB/TrEMBL
  ENSRNOT00000120650.2 UniProtKB/TrEMBL
  ENSRNOT00000166568.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/TrEMBL
InterPro AP1_sigma UniProtKB/TrEMBL
  AP_complex_ssu UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  Clathrin_sigma/coatomer_zeta UniProtKB/TrEMBL
  Longin-like UniProtKB/TrEMBL
KEGG Report rno:360785 UniProtKB/TrEMBL
NCBI Gene 360785 ENTREZGENE
PANTHER PTHR11753 UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/TrEMBL
PhenoGen Ap1s1 PhenoGen
PIRSF AP_complex_sigma UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001415 RatGTEx
Superfamily-SCOP Longin_like UniProtKB/TrEMBL
UniProt A0A8I5ZUR0 ENTREZGENE
  A0A8I5ZW78 ENTREZGENE
  A0A8I6ASY6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEE5_RAT UniProtKB/TrEMBL
  A0ABK0LKT1_RAT UniProtKB/TrEMBL
  A6J050 ENTREZGENE, UniProtKB/TrEMBL
  B5DFI3 ENTREZGENE
  F7EZ57_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1s1  adaptor related protein complex 1 subunit sigma 1  Ap1s1  adaptor-related protein complex 1, sigma 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ap1s1  adaptor-related protein complex 1, sigma 1 subunit  Ap1s1  adaptor protein complex AP-1, sigma 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap1s1  adaptor protein complex AP-1, sigma 1   Ap1s1_predicted  adaptor protein complex AP-1, sigma 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ap1s1_predicted  adaptor protein complex AP-1, sigma 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED