Pcnx2 (pecanex 2) - Rat Genome Database

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Gene: Pcnx2 (pecanex 2) Rattus norvegicus
Analyze
Symbol: Pcnx2
Name: pecanex 2
RGD ID: 1305883
Description: Predicted to be located in membrane. Orthologous to human PCNX2 (pecanex 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307949; LOC307974; LOC365028; Pcnxl2; pecanex 1; pecanex homolog 2; pecanex homolog 2 (Drosophila); pecanex-like 2; pecanex-like 2 (Drosophila); pecanex-like protein 2; RGD1305883; similar to cDNA sequence AF096286; similar to pecanex-like 2 isoform 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,616,240 - 70,766,869 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,616,240 - 70,766,869 (-)EnsemblGRCr8
mRatBN7.21953,718,920 - 53,869,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,718,655 - 53,871,364 (-)EnsemblmRatBN7.2
Rnor_6.01958,583,000 - 58,736,069 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,583,632 - 58,735,173 (-)Ensemblrn6Rnor6.0
Rnor_5.01969,280,242 - 69,430,377 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,957,098 - 56,012,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,079,999 - 53,230,150 (-)NCBICelera
RGSC_v3.11955,961,944 - 56,017,740 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Pcnx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,616,240 - 70,766,869 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1970,616,240 - 70,766,869 (-)EnsemblGRCr8
mRatBN7.21953,718,920 - 53,869,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,718,655 - 53,871,364 (-)EnsemblmRatBN7.2
Rnor_6.01958,583,000 - 58,736,069 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,583,632 - 58,735,173 (-)Ensemblrn6Rnor6.0
Rnor_5.01969,280,242 - 69,430,377 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41955,957,098 - 56,012,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1953,079,999 - 53,230,150 (-)NCBICelera
RGSC_v3.11955,961,944 - 56,017,740 (-)NCBI
Cytogenetic Map19q12NCBI
PCNX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,983,435 - 233,327,329 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,983,435 - 233,295,729 (-)Ensemblhg38GRCh38
GRCh371233,119,181 - 233,431,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,186,505 - 231,498,082 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1206,390,263 - 206,701,642 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1203,609,792 - 203,921,197 (-)NCBIHuRef
CHM1_11234,393,427 - 234,704,993 (-)NCBICHM1_1
T2T-CHM13v2.01232,369,777 - 232,713,706 (-)NCBIT2T-CHM13v2.0
Pcnx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398126,478,243 - 126,625,056 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8126,478,247 - 126,625,056 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388125,751,504 - 125,898,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,751,508 - 125,898,317 (-)Ensemblmm10GRCm38
MGSCv378128,275,408 - 128,422,193 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368128,637,601 - 128,777,201 (-)NCBIMGSCv36mm8
Celera8130,064,419 - 130,211,590 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.65NCBI
Pcnx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554926,043,754 - 6,248,730 (+)Ensembl
ChiLan1.0NW_0049554926,043,577 - 6,249,483 (+)NCBIChiLan1.0ChiLan1.0
PCNX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,914,777 - 16,224,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,117,751 - 16,430,378 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01208,521,531 - 208,830,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,548,309 - 213,858,649 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,549,162 - 213,858,398 (-)EnsemblpanPan2panpan1.1
PCNX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.146,434,582 - 6,701,344 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl46,418,843 - 6,699,683 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha46,401,180 - 6,689,985 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.046,433,890 - 6,723,644 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl46,433,899 - 6,722,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.146,444,209 - 6,733,677 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.046,564,828 - 6,853,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.046,788,317 - 7,078,104 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcnx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,210,799 - 42,388,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648418,376,025 - 18,552,545 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648418,376,025 - 18,553,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCNX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11457,505,806 - 57,799,860 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21461,675,795 - 61,941,829 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCNX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12570,195,775 - 70,508,881 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605572,150,099 - 72,461,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcnx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477516,774,920 - 17,004,285 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477516,774,716 - 17,005,008 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcnx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11745,268,262 - 45,418,937 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:134
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000030077, ENSRNOT00000072170
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat

Markers in Region
BE097197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,836,161 - 53,836,496 (+)MAPPERmRatBN7.2
mRatBN7.21953,836,323 - 53,836,496 (+)MAPPERmRatBN7.2
Rnor_6.01958,702,081 - 58,702,253NCBIRnor6.0
Rnor_6.01958,701,795 - 58,702,253NCBIRnor6.0
Rnor_5.01969,396,843 - 69,397,015UniSTSRnor5.0
Rnor_5.01969,396,557 - 69,397,015UniSTSRnor5.0
Celera1953,196,823 - 53,196,995UniSTS
Cytogenetic Map19q12UniSTS
RH134915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,719,050 - 53,719,262 (+)MAPPERmRatBN7.2
Rnor_6.01958,583,131 - 58,583,342NCBIRnor6.0
Rnor_5.01969,280,373 - 69,280,584UniSTSRnor5.0
RGSC_v3.41955,956,600 - 55,956,811UniSTSRGSC3.4
Celera1953,080,130 - 53,080,341UniSTS
RH 3.4 Map19747.8UniSTS
Cytogenetic Map19q12UniSTS
RH136790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,769,017 - 53,769,091 (+)MAPPERmRatBN7.2
Rnor_6.01958,632,913 - 58,632,986NCBIRnor6.0
Rnor_5.01969,330,155 - 69,330,228UniSTSRnor5.0
Celera1953,130,083 - 53,130,156UniSTS
RH 3.4 Map19742.5UniSTS
Cytogenetic Map19q12UniSTS
RH137613  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1953,229,746 - 53,229,935UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 40 143 66 65 35 73 35 6 270 137 6 123 76 91 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030077   ⟹   ENSRNOP00000038464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,616,240 - 70,766,869 (-)Ensembl
mRatBN7.2 Ensembl1953,718,655 - 53,871,364 (-)Ensembl
Rnor_6.0 Ensembl1958,583,632 - 58,735,173 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126207   ⟹   ENSRNOP00000106882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1970,616,240 - 70,766,869 (-)Ensembl
RefSeq Acc Id: NM_001427189   ⟹   NP_001414118
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,616,240 - 70,766,869 (-)NCBI
RefSeq Acc Id: XM_039098293   ⟹   XP_038954221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,665,405 - 70,766,867 (-)NCBI
mRatBN7.21953,768,099 - 53,869,559 (-)NCBI
RefSeq Acc Id: XM_063278079   ⟹   XP_063134149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,616,240 - 70,766,869 (-)NCBI
RefSeq Acc Id: XM_063278080   ⟹   XP_063134150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,616,240 - 70,766,867 (-)NCBI
RefSeq Acc Id: XM_063278081   ⟹   XP_063134151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,627,178 - 70,766,867 (-)NCBI
RefSeq Acc Id: XM_063278082   ⟹   XP_063134152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,634,630 - 70,766,867 (-)NCBI
RefSeq Acc Id: XM_063278083   ⟹   XP_063134153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,616,240 - 70,727,050 (-)NCBI
Ensembl Acc Id: ENSRNOP00000038464   ⟸   ENSRNOT00000030077
RefSeq Acc Id: XP_038954221   ⟸   XM_039098293
- Peptide Label: isoform X5
RefSeq Acc Id: NP_001414118   ⟸   NM_001427189
- UniProtKB: D4AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134149   ⟸   XM_063278079
- Peptide Label: isoform X1
- UniProtKB: D4AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134150   ⟸   XM_063278080
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063134153   ⟸   XM_063278083
- Peptide Label: isoform X6
- UniProtKB: A6KJ41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134151   ⟸   XM_063278081
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063134152   ⟸   XM_063278082
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000106882   ⟸   ENSRNOT00000126207
Protein Domains
Pecanex C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB99-F1-model_v2 AlphaFold D4AB99 1-2125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305883 AgrOrtholog
BioCyc Gene G2FUF-5202 BioCyc
Ensembl Genes ENSRNOG00000028580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030077 ENTREZGENE
  ENSRNOT00000030077.9 UniProtKB/TrEMBL
  ENSRNOT00000126207.1 UniProtKB/TrEMBL
InterPro Pecanex UniProtKB/TrEMBL
  Pecanex UniProtKB/TrEMBL
NCBI Gene 307949 ENTREZGENE
PANTHER PECANEX-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR12372 UniProtKB/TrEMBL
Pfam Pecanex_C UniProtKB/TrEMBL
PhenoGen Pcnx2 PhenoGen
RatGTEx ENSRNOG00000028580 RatGTEx
UniProt A0ABK0LPR7_RAT UniProtKB/TrEMBL
  A6KJ41 ENTREZGENE, UniProtKB/TrEMBL
  D4AB99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Pcnx2  pecanex 2  Pcnx2  pecanex homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-20 Pcnx2  pecanex homolog 2  Pcnx2  pecanex homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Pcnx2  pecanex homolog 2 (Drosophila)  Pcnxl2  pecanex-like 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Pcnxl2  pecanex-like 2 (Drosophila)  LOC365028  similar to pecanex-like 2 isoform 1  Data merged from RGD:1586124 737654 PROVISIONAL
2015-07-29 Pcnxl2  pecanex-like 2 (Drosophila)  LOC307974  similar to pecanex-like 2 isoform 1  Data merged from RGD:1584975 737654 PROVISIONAL
2008-03-07 Pcnxl2  pecanex-like 2 (Drosophila)  RGD1305883_predicted  similar to cDNA sequence AF096286; pecanex 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC365028  similar to pecanex-like 2 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC307974  similar to pecanex-like 2 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1305883_predicted  similar to cDNA sequence AF096286; pecanex 1 (predicted)  LOC307949_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307949_predicted  similar to cDNA sequence AF096286; pecanex 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL