Prss29 (serine protease 29) - Rat Genome Database

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Gene: Prss29 (serine protease 29) Rattus norvegicus
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Symbol: Prss29
Name: serine protease 29
RGD ID: 1305856
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within blastocyst hatching and embryo implantation. Predicted to be active in extracellular space. Orthologous to human PRSS29P (serine protease 29, pseudogene); INTERACTS WITH sodium fluoride; 1,2-dichloroethane (ortholog); 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC287136; protease, serine, 29; Tpsd1; tryptase delta 1
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Prss29-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,841,808 - 14,845,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,841,905 - 14,845,332 (+)EnsemblGRCr8
mRatBN7.21014,337,315 - 14,341,038 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,339,036 - 14,341,038 (+)EnsemblmRatBN7.2
Rnor_6.01014,678,286 - 14,681,877 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,678,278 - 14,681,888 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,496,269 - 14,499,834 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,569,722 - 14,571,558 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,009,512 - 14,013,103 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17156484   PMID:18831529  


Genomics

Comparative Map Data
Prss29
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,841,808 - 14,845,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,841,905 - 14,845,332 (+)EnsemblGRCr8
mRatBN7.21014,337,315 - 14,341,038 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,339,036 - 14,341,038 (+)EnsemblmRatBN7.2
Rnor_6.01014,678,286 - 14,681,877 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,678,278 - 14,681,888 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,496,269 - 14,499,834 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,569,722 - 14,571,558 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,009,512 - 14,013,103 (+)NCBICelera
Cytogenetic Map10q12NCBI
PRSS29P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,261,003 - 1,264,004 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,261,313 - 1,263,212 (-)Ensemblhg38GRCh38
GRCh37161,311,004 - 1,314,005 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,251,005 - 1,254,006 (-)NCBIBuild 36Build 36hg18NCBI36
Celera161,525,335 - 1,528,339 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,239,925 - 1,242,931 (-)NCBIHuRef
CHM1_1161,310,165 - 1,313,165 (-)NCBICHM1_1
T2T-CHM13v2.0161,277,044 - 1,280,044 (-)NCBIT2T-CHM13v2.0
Prss29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,537,628 - 25,541,658 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,537,620 - 25,541,659 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,318,654 - 25,322,684 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,318,654 - 25,322,684 (+)Ensemblmm10GRCm38
MGSCv371725,455,599 - 25,459,629 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,047,883 - 25,050,280 (+)NCBIMGSCv36mm8
Celera1725,847,250 - 25,851,234 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI

Variants

.
Variants in Prss29
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:44
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000060387
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 1 22 18 49 52 40 33 40 1 127 66 8 8 18 22 12 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000060387   ⟹   ENSRNOP00000057130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,841,905 - 14,845,332 (+)Ensembl
mRatBN7.2 Ensembl1014,339,036 - 14,341,038 (+)Ensembl
Rnor_6.0 Ensembl1014,678,278 - 14,681,888 (+)Ensembl
RefSeq Acc Id: XM_017597837   ⟹   XP_017453326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,841,808 - 14,845,531 (+)NCBI
mRatBN7.21014,337,315 - 14,341,038 (+)NCBI
Rnor_6.01014,678,286 - 14,681,877 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597838   ⟹   XP_017453327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,843,044 - 14,845,531 (+)NCBI
mRatBN7.21014,338,550 - 14,341,038 (+)NCBI
Rnor_6.01014,679,441 - 14,681,877 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017453326 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453327 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057130
  ENSRNOP00000057130.2
RefSeq Acc Id: XP_017453326   ⟸   XM_017597837
- UniProtKB: D4AEK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453327   ⟸   XM_017597838
- UniProtKB: D4AEK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057130   ⟸   ENSRNOT00000060387

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEK6-F1-model_v2 AlphaFold D4AEK6 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305856 AgrOrtholog
BioCyc Gene G2FUF-25787 BioCyc
Ensembl Genes ENSRNOG00000039405 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060387 ENTREZGENE
  ENSRNOT00000060387.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:287136 UniProtKB/TrEMBL
NCBI Gene 287136 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE PROTEASE CTRL-1-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss29 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039405 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt D4AEK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Prss29  serine protease 29  Prss29  protease, serine, 29  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Prss29  protease, serine, 29  Tpsd1_predicted  tryptase delta 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Tpsd1_predicted  tryptase delta 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED