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Gene: Otud4 (OTU deubiquitinase 4) Rattus norvegicus

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Symbol:

Otud4

Name:

OTU deubiquitinase 4

RGD ID:

1305606

Description:

Predicted to enable K63-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and molecular adaptor activity. Predicted to be involved in several processes, including DNA alkylation repair; negative regulation of signal transduction; and protein deubiquitination. Predicted to act upstream of or within antiviral innate immune response and protein K27-linked ubiquitination. Orthologous to human OTUD4 (OTU deubiquitinase 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC307774; OTU domain containing 4; OTU domain-containing protein 4; RGD1305606; similar to mKIAA1046 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OTUD4 (OTU deubiquitinase 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Otud4 (OTU domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Otud4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OTUD4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OTUD4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Otud4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OTUD4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OTUD4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Otud4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Otud4 (OTU deubiquitinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Otud4 (OTU domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	OTUD4 (OTU deubiquitinase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	otud4 (OTU deubiquitinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	otud4 (OTU deubiquitinase 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	otu	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	otu	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3251	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3251	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	snca	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	otud4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	otud4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	45,141,043 - 45,184,136 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	45,141,043 - 45,184,136 (-)	Ensembl				GRCr8
mRatBN7.2	19	28,236,713 - 28,279,815 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	28,236,713 - 28,279,815 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	35,097,012 - 35,140,127 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	35,751,086 - 35,794,201 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	37,985,978 - 38,029,120 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	31,895,753 - 31,942,509 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	31,899,087 - 31,942,180 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	42,799,728 - 42,846,155 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	30,124,849 - 30,167,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	27,744,764 - 27,787,846 (-)	NCBI		Celera
RGSC_v3.1	19	30,129,291 - 30,172,543 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

dorsomorphin (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

FR900359 (ISO)

geldanamycin (ISO)

hypochlorous acid (ISO)

leflunomide (ISO)

paracetamol (ISO)

PCB138 (ISO)

pentanal (ISO)

phorone (EXP)

potassium dichromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium dichromate (EXP)

succimer (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

torcetrapib (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (ISO)

DNA alkylation repair (ISO)

negative regulation of interleukin-1-mediated signaling pathway (IBA,ISO)

negative regulation of toll-like receptor signaling pathway (IBA,ISO)

protein K11-linked deubiquitination (ISO)

protein K48-linked deubiquitination (ISO)

protein K63-linked deubiquitination (ISO)

proteolysis (IEA)

regulation of protein K48-linked deubiquitination (ISO)

Cellular Component

cytosol (ISO)

Molecular Function

cysteine-type deubiquitinase activity (IBA,IEA,ISO)

cysteine-type peptidase activity (IEA)

hydrolase activity (IEA)

K63-linked deubiquitinase activity (IBA,ISO)

molecular adaptor activity (ISO)

peptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22681889	PMID:23827681	PMID:25931508	PMID:25944111	PMID:29395066	PMID:37162556

Genomics

Comparative Map Data

Otud4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	45,141,043 - 45,184,136 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	45,141,043 - 45,184,136 (-)	Ensembl				GRCr8
mRatBN7.2	19	28,236,713 - 28,279,815 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	28,236,713 - 28,279,815 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	35,097,012 - 35,140,127 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	35,751,086 - 35,794,201 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	37,985,978 - 38,029,120 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	31,895,753 - 31,942,509 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	31,899,087 - 31,942,180 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	42,799,728 - 42,846,155 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	30,124,849 - 30,167,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	27,744,764 - 27,787,846 (-)	NCBI		Celera
RGSC_v3.1	19	30,129,291 - 30,172,543 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

OTUD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	145,133,650 - 145,180,589 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	145,110,838 - 145,180,621 (-)	Ensembl			hg38	GRCh38
GRCh37	4	146,054,802 - 146,101,741 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	146,274,252 - 146,320,282 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	143,382,143 - 143,428,339 (-)	NCBI		Celera
Cytogenetic Map	4	q31.21	NCBI
HuRef	4	141,786,122 - 141,832,147 (-)	NCBI		HuRef
CHM1_1	4	146,031,068 - 146,077,284 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	148,451,040 - 148,497,987 (-)	NCBI		T2T-CHM13v2.0

Otud4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	80,366,305 - 80,404,384 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	80,366,247 - 80,404,353 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	79,639,676 - 79,677,755 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	79,639,618 - 79,677,724 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	82,163,575 - 82,201,654 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	82,535,748 - 82,573,827 (+)	NCBI		MGSCv36	mm8
Celera	8	83,915,553 - 83,953,642 (+)	NCBI		Celera
Cytogenetic Map	8	C1	NCBI
cM Map	8	37.74	NCBI

Otud4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	1,062,998 - 1,115,415 (-)	Ensembl
ChiLan1.0	NW_004955428	1,062,998 - 1,108,711 (-)	NCBI	ChiLan1.0	ChiLan1.0

OTUD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	143,014,271 - 143,065,786 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	143,379,154 - 143,430,674 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	137,480,809 - 137,527,651 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	149,141,513 - 149,187,333 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	149,135,900 - 149,182,476 (-)	Ensembl			panPan2	panpan1.1

OTUD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	43,816,656 - 43,861,813 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	43,818,196 - 43,861,784 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	44,208,727 - 44,253,896 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	44,485,491 - 44,530,755 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	44,488,609 - 44,531,432 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	43,758,510 - 43,803,683 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	43,845,139 - 43,890,348 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	44,109,586 - 44,154,745 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Otud4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	46,475,249 - 46,513,834 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936535	3,912,606 - 3,951,503 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936535	3,911,904 - 3,950,675 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTUD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	83,240,754 - 83,288,234 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	83,240,759 - 83,288,237 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	88,519,444 - 88,558,932 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTUD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	91,709,184 - 91,756,437 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	91,708,767 - 91,756,793 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	71,349,422 - 71,397,341 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otud4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624853	4,091,316 - 4,140,201 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624853	4,091,591 - 4,145,344 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Otud4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	20,419,260 - 20,467,219 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Otud4
386 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	25
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000024924
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
61328	Eae8	Experimental allergic encephalomyelitis QTL 8	4		nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	19	41720609	49971820	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	40727092	54856850	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	40727092	54856850	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	40727092	54856850	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat

Markers in Region

AI449692

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	28,236,821 - 28,237,050 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	31,899,196 - 31,899,424	NCBI	Rnor6.0
Rnor_5.0	19	42,803,171 - 42,803,399	UniSTS	Rnor5.0
RGSC_v3.4	19	30,124,958 - 30,125,186	UniSTS	RGSC3.4
Celera	19	27,744,873 - 27,745,101	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF284741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024924 ⟹ ENSRNOP00000024924

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	45,141,043 - 45,184,136 (-)	Ensembl
mRatBN7.2 Ensembl	19	28,236,713 - 28,279,815 (-)	Ensembl
Rnor_6.0 Ensembl	19	31,899,087 - 31,942,180 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155869 ⟹ ENSRNOP00000107345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	45,141,043 - 45,184,136 (-)	Ensembl

RefSeq Acc Id:

NM_001191700 ⟹ NP_001178629

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	45,141,043 - 45,184,136 (-)	NCBI
mRatBN7.2	19	28,236,713 - 28,279,815 (-)	NCBI
Rnor_6.0	19	31,899,087 - 31,942,180 (-)	NCBI
Rnor_5.0	19	42,799,728 - 42,846,155 (-)	NCBI
Celera	19	27,744,764 - 27,787,846 (-)	NCBI

Sequence:

show sequence

GCGGCCGCGTGCGGATGGCCATGCACTAGGCTGGGCTCCCCTATGCTCCGGGAGAGCGCCGGCC
ACCGCCTCGGGCCGCCGCCGCCTCTTCCTGCCGCCGCTCGCAGTGTCCGCGTCGGAGCCGGAGC
CCGAGCCACAGCCTGCCCCAGGCCCGGGCGTCGAGCAGCCGGCGGCGCGGCCATGTGGGGCTAG
TCCGCCCCGCGCACGCTGCAGCGGACCGGCAACATGGAGGCAGCTGTCGGCGCGCCCGACGGCG
TGGACCAGGGCGGCGCGGGACCGCTGGAGGATGCGACGCCCATGGACGCCTATCTGCGCAAGCT
GGGATTGTATCGGAAATTGGTCGCCAAGGACGGGTCGTGCTTGTTCCGGGCTGTGGCCGAGCAG
GTATTACACTCTCAGTCTCGACATGTGGAAGTTAGAATGGCTTGTATTCGCTACCTTCGAGATA
ACAGAGAGAAATTTGAAGCGTTTATAGAAGGGTCATTTGAAGAATATTTAAAACGTTTGGAAAA
CCCACAGGAATGGGTAGGACAAGTGGAGATAAGCGCCCTCTCTCTTATGTACAGGAAAGATTTT
GTAATATATCAGGAGCCAAATGTTTCTCCTTCGCATGTAACTGAAAATAATTTTCCTGAGAAGG
TGTTACTGTGCTTTTCGAATGGAAATCATTATGACATTGTCTATCCTATAACATACAGAGATAG
TTCTGCTGTGTGTCAGTCTCTCCTTTATGAATTGCTGTATGAGAAGGTATTTAAAACTGACGTC
AGTAAAATCATGATGGGACTAGAAACTTCTGAAGTGGCTGATGAAAGCAACAGTGAAATATCAG
ATTCTGAGGATGACAGTTGCAAGAGTAAAAGCACTGCTGCTACTGATGTGAATGGATTTAAGTC
CTCAGGCAGTGAGAACCCTAAGAACCATGGGAACTCAGCTGACCTTCCTTTGTCCAGAAAGGTT
CTTAAGTCCCTCAGCCCAGCAGTCTATAGAAATGTGGAGTATGAAATTTGGTTGAAGTCTAAGC
AAGCTCAACAAAAACGTGATTATTCCATTGCTGCTGGCTTACAATATGAAGGAGGAGAGAGATG
CCATGTTAGATTGGATCATAATGGGAAGTTATCTAATGCAGACATTCATGGGGTTCACTCTGAG
AATGGACCGGTTTTGTCTGAAGAACTGGGGAAAAAGCAAACACCGAAGAACCTCAAGCCACCTC
CCCCAGAAAGCTGGAACACGGTGTCCGGAAAGAAGATGAAAAAACCTAATTCTGGGCAAAATTT
CCATTCAGATACGGATTACAGAGGGCCAAAGAATCTAAACAAGCCAATCAAAGCCCCGTCTGCA
CTACCTCCTCGCCTGCAGCATCCTCCAGCGGGTGTAAGGCAGCACGCGCTCTCCAGTCATTCTA
CGGGGCCCCAGTCTCAGAAATCCTCCAGTGAGCATAAGAATCTAAGTCGGGTGCCATCACAGAT
CACAAGAAAACCTGATCGTGAAAGAGCTGAGGACTTTGATCATGTGAGTCGTGAATCTTACTAT
TTTGGCCTCTCGCCAGAAGAACGCAGAGAGAAGCAAGCTATTGAAGAGTCTCGGCTACTCTATG
AGATTCAGAACCGGGATGAACAGGCTTTTCCGGCTCTTTCTAGTTCATCAGTCAGTCAGTCACC
TCAGAATAGCAACGCGTGCGTCCCAAGGAAGTCTTCACATGCGAGGGACAGGAAAGGAAGCATG
CGGAGAGTAGATGCAGAGGAACGGAAGGACAAAGACTCTCTACGTGGCCATACTCACATGGATA
AAAAACCCGAGCCAAGCACACTGGAGATCAGCGATGATAAATGTACAAGAGTTTCATCACCATC
TAAGTCAAAGAAAGAGTGCCCATCTCCTGTAGAACAAAAGCCAGCAGAACATATACCTTTGTCA
AATCCAGCCCCCCTCCTAGTCTCTCCAGAAGTTCATCTCACTCCTGCGGTGCCTTCTTTACCAG
CCACTGTGCCAGCCTGGCCAAGTGAACCCACAACTTTCGGACCAACAGGTGTCCCTGCTCAGAT
TCCCATTTTGTCAGTGACACAGACCACTGGACCTGATGCTGCCGTGTCACAAGCGCATTTAACA
CCCTCTCCGGTTCCTGTGTCAATTCAGGCAGTTAACCAGCCCTTGATGCCTTTGCCTCAGACAA
TGAGCCTCTATCAAGACCCACTCTATCCTGGGTTTCCTTGTAGTGAGAAGGGAGATCGAGCCAT
TGCACCACCCTATTCACTGTGTCAGACCGGCGAGGACCTGCCTAAAGATAAGAATATTCTTCGA
TTCTTCTTCAATCTTGGTGTAAAGGCATATAGTTGCCCTATGTGGGCCCCACACTCTTACCTGT
ATCCTCTGCACCAGGCGTACATGGCAGCCTGCAGGGTGTACCCAAAGGTCCCTGTTCCTGTGTA
TCCTCAGAGTACTTGGTTCCAAGAAGCCCCTCCTGCTCAGAGTGAAAGTGACTGCCCCTGTGCT
GACGCCCACTACTCTATGCACCCTGAGGCCAGTGTTAATGGCCAGATGCCACAGGCAGAGATCG
GACCACCTGCGTTTTCTTCCCCTCTGGTTATCCCTCCATCTCAGGTGTCTGAAGGTCATGGACA
GTTGTCTTACCAACCTGAACTGGAGTCTGAGAGCCCAGGGCAGCTTCTTCACGCTGAGTATGAA
GAGTCACTTAGCGGCAAGAACATGTACCCACAGCAGTCCTTTGGGCCTAATCCATTCTTAGGTC
CTGTTCCCATTGCACCTCCTTTCTTCCCTCATGTTTGGTATGGGTATCCTTTTCAGGGATTTGT
GGAAAATCCTGTAATGAGGCAAAATATTGTCCTGCCCCCTGATGATAAAGGAGAGTTGGATTTG
CCTTTGGAAAATCTAGATCTGTCTAAAGAGTGCGATTCTGTCTCAGCAGTAGACGAGTTCCCAG
AAGCCAGAGTTGAAGGCGCACATTCTCTCTCTGAAGCAAGTGTGAGCAGCAAGCATGAAGGCCG
GGTGGAGCAGTCGTCCCAGACGCGGAAGGCAGACATAGACTTGTCTTCAGGTTCTTCTGGAGTG
GAGGGAAAGGCTCACCCCCCTACTCAGATTCTAAACCGAGAGAGAGAGGCTGTGTCTGCTGAAC
CTGAGCCTAAGAGGACCATTCAAAGTCTGAAAGAAAAACCAGAGAAAGTCAAAGACCCCAAGAC
TGCTGCCGATGTGCTCAGCTCTGGGGCCAACTCTGTGGATAGATTGCAAAGACCAAAAGAAGAG
AGTTCAGAAGATGAGAACGAAGTGTCTAATATTTTGAGAAGTGGCAGATCCAAGCAGTTTTATA
ATCAAACTTATGGAAGCAGGAAGTACAAAAGTGATTGGGGCTCTTCTGGTAGAGGTGGCTATCA
ACATGTGAGAGGCGAGGAGTCCTGGAAAGGGCAGCCTAACAGAAGCCGGGATGAAGGTTATCAG
TACCATCGACATGTTAGAGGACGCCCTTACAGGGGAGATAGGAGGAGGTCAGGGATGGGAGATG
GCCACAGGGGACAACACACTTAATGGCTGGTTGTCGCTCGTACTGTAGAGCTCTAGCCTTTTCT
TAGGTGGAATATTTCTGAAGGCTTTAAAATCATTATAATAAAAACCCAAATTGGAACTATCTCC
TCCCCTCCCCTTTTCCCCTTAATTTCCTATTCTGATGAGACTTTGGACATAAGTTTAAGGGGCA
GATGAATTTTTGGCATTGTGGTTTTTTCTTACTCAGAATCTGTTTATTGGGTTACTGCCCCCAT
AAGAAGTAAACATGACTTTTAAGTATTTTTTTATAAACAGCTCAATATAAAACATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178629	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83886	(Get FASTA)	NCBI Sequence Viewer
	AAI00160	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024924.6
	ENSRNOP00000107345
	ENSRNOP00000107345.1

RefSeq Acc Id:

NP_001178629 ⟸ NM_001191700

- UniProtKB:

F1M7Q7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAAVGAPDGVDQGGAGPLEDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEV
RMACIRYLRDNREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPS
HVTENNFPEKVLLCFSNGNHYDIVYPITYRDSSAVCQSLLYELLYEKVFKTDVSKIMMGLETSE
VADESNSEISDSEDDSCKSKSTAATDVNGFKSSGSENPKNHGNSADLPLSRKVLKSLSPAVYRN
VEYEIWLKSKQAQQKRDYSIAAGLQYEGGERCHVRLDHNGKLSNADIHGVHSENGPVLSEELGK
KQTPKNLKPPPPESWNTVSGKKMKKPNSGQNFHSDTDYRGPKNLNKPIKAPSALPPRLQHPPAG
VRQHALSSHSTGPQSQKSSSEHKNLSRVPSQITRKPDRERAEDFDHVSRESYYFGLSPEERREK
QAIEESRLLYEIQNRDEQAFPALSSSSVSQSPQNSNACVPRKSSHARDRKGSMRRVDAEERKDK
DSLRGHTHMDKKPEPSTLEISDDKCTRVSSPSKSKKECPSPVEQKPAEHIPLSNPAPLLVSPEV
HLTPAVPSLPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVSQAHLTPSPVPVSIQAV
NQPLMPLPQTMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTGEDLPKDKNILRFFFNLGVKAYS
CPMWAPHSYLYPLHQAYMAACRVYPKVPVPVYPQSTWFQEAPPAQSESDCPCADAHYSMHPEAS
VNGQMPQAEIGPPAFSSPLVIPPSQVSEGHGQLSYQPELESESPGQLLHAEYEESLSGKNMYPQ
QSFGPNPFLGPVPIAPPFFPHVWYGYPFQGFVENPVMRQNIVLPPDDKGELDLPLENLDLSKEC
DSVSAVDEFPEARVEGAHSLSEASVSSKHEGRVEQSSQTRKADIDLSSGSSGVEGKAHPPTQIL
NREREAVSAEPEPKRTIQSLKEKPEKVKDPKTAADVLSSGANSVDRLQRPKEESSEDENEVSNI
LRSGRSKQFYNQTYGSRKYKSDWGSSGRGGYQHVRGEESWKGQPNRSRDEGYQYHRHVRGRPYR
GDRRRSGMGDGHRGQHT

hide sequence

Ensembl Acc Id:

ENSRNOP00000024924 ⟸ ENSRNOT00000024924

Ensembl Acc Id:

ENSRNOP00000107345 ⟸ ENSRNOT00000155869

Protein Domains

OTU

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M7Q7-F1-model_v2	AlphaFold	F1M7Q7	1-1105	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701051

Promoter ID:

EPDNEW_R11574

Type:

single initiation site

Name:

Otud4_1

Description:

OTU deubiquitinase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	31,942,095 - 31,942,155	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305606	AgrOrtholog
BioCyc Gene	G2FUF-5955	BioCyc
Ensembl Genes	ENSRNOG00000018477	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024924.8	UniProtKB/TrEMBL
	ENSRNOT00000155869	ENTREZGENE
	ENSRNOT00000155869.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.70.80	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131208	IMAGE-MGC_LOAD
	IMAGE:7131897	IMAGE-MGC_LOAD
InterPro	OTU	UniProtKB/TrEMBL
	OTU_ubiquitin_thioesterase	UniProtKB/TrEMBL
	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
MGC_CLONE	MGC:114579	IMAGE-MGC_LOAD
	MGC:95198	IMAGE-MGC_LOAD
NCBI Gene	307774	ENTREZGENE
PANTHER	OTU DOMAIN CONTAINING PROTEIN	UniProtKB/TrEMBL
	OTU DOMAIN-CONTAINING PROTEIN 4	UniProtKB/TrEMBL
Pfam	OTU	UniProtKB/TrEMBL
PhenoGen	Otud4	PhenoGen
PROSITE	OTU	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018477	RatGTEx
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0ABK0LA32_RAT	UniProtKB/TrEMBL
	F1M7Q7	ENTREZGENE, UniProtKB/TrEMBL
	Q498M3_RAT	UniProtKB/TrEMBL
	Q5XI11_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-13	Otud4	OTU deubiquitinase 4	Otud4	OTU domain containing 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Otud4	OTU domain containing 4	RGD1305606	similar to mKIAA1046 protein	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1305606	similar to mKIAA1046 protein	RGD1305606_predicted	similar to mKIAA1046 protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305606_predicted	similar to mKIAA1046 protein (predicted)	LOC307774_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC307774_predicted	similar to mKIAA1046 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar