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Gene: Supv3l1 (Suv3 like RNA helicase) Rattus norvegicus

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Symbol:

Supv3l1

Name:

Suv3 like RNA helicase

RGD ID:

1305565

Description:

Predicted to enable several functions, including double-stranded RNA binding activity; helicase activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA metabolic process; positive regulation of cell growth; and positive regulation of mitochondrial RNA catabolic process. Predicted to be located in mitochondrial nucleoid and nucleus. Predicted to be part of mitochondrial degradosome. Orthologous to human SUPV3L1 (Suv3 like RNA helicase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ATP-dependent RNA helicase SUPV3L1, mitochondrial; LOC294385; MGC109049; suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1 (S. cerevisiae); SUV3-like helicase; SUV3-like protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SUPV3L1 (Suv3 like RNA helicase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Supv3l1 (suppressor of var1, 3-like 1 (S. cerevisiae))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Supv3l1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SUPV3L1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SUPV3L1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Supv3l1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SUPV3L1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SUPV3L1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Supv3l1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Supv3l1 (Suv3 like RNA helicase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SUPV3L1 (Suv3 like RNA helicase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Supv3l1 (suppressor of var1, 3-like 1 (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	supv3l1 (SUV3-like helicase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C08F8.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C08F8.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SUV3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SUV3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Suv3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	supv3l1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	30,921,248 - 30,941,779 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	30,921,249 - 30,941,723 (-)	Ensembl				GRCr8
mRatBN7.2	20	30,378,542 - 30,399,076 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	30,378,550 - 30,399,054 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	31,389,464 - 31,409,939 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	30,780,364 - 30,800,843 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	31,516,952 - 31,537,595 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	32,057,530 - 32,080,170 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	32,057,454 - 32,080,088 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	33,844,945 - 33,865,381 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	29,681,431 - 29,714,796 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	31,798,626 - 31,819,177 (-)	NCBI		Celera
RGSC_v3.1	20	29,695,230 - 29,714,461 (-)	NCBI
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alopecia (ISO)

ichthyosis (ISO)

Sarcopenia (ISO)

Skin Abnormalities (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

5-fluorouracil (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

atrazine (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

doxorubicin (EXP,ISO)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (EXP)

indometacin (ISO)

ivermectin (ISO)

methidathion (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP)

rotenone (ISO)

silicon dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA recombination (IEA,ISO,ISS)

mitochondrial mRNA catabolic process (IEA,ISO,ISS)

mitochondrial mRNA surveillance (IEA,ISO,ISS)

mitochondrial ncRNA surveillance (IEA,ISO,ISS)

mitochondrial RNA 3'-end processing (IBA,IEA,ISO,ISS)

mitochondrial RNA catabolic process (IEA,ISO)

mitochondrial RNA surveillance (IEA,ISO,ISS)

mitochondrion organization (IEA,ISO,ISS)

negative regulation of apoptotic process (IEA,ISO,ISS)

positive regulation of cell growth (IEA,ISO,ISS)

positive regulation of mitochondrial RNA catabolic process (IEA,ISO,ISS)

RNA catabolic process (IEA,ISO,ISS)

Cellular Component

mitochondrial degradosome (IBA,IEA,ISO,ISS)

mitochondrial matrix (IEA,ISO,ISS)

mitochondrial nucleoid (IEA,ISO)

mitochondrion (IEA,ISO,ISS)

nucleus (IEA,ISO,ISS)

Molecular Function

3'-5' RNA helicase activity (IEA,ISO,ISS)

3'-5'-RNA exonuclease activity (IEA,ISO)

ATP binding (IEA)

ATP hydrolysis activity (IEA)

DNA binding (IEA,ISO,ISS)

DNA helicase activity (IEA,ISO,ISS)

double-stranded RNA binding (IEA,ISO,ISS)

helicase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

RNA helicase activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12466530	PMID:17352692	PMID:17961633	PMID:18063578	PMID:18614015	PMID:18678873	PMID:19509288	PMID:19864255	PMID:22658674	PMID:22681889	PMID:29967381

Genomics

Comparative Map Data

Supv3l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	30,921,248 - 30,941,779 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	30,921,249 - 30,941,723 (-)	Ensembl				GRCr8
mRatBN7.2	20	30,378,542 - 30,399,076 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	30,378,550 - 30,399,054 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	31,389,464 - 31,409,939 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	30,780,364 - 30,800,843 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	31,516,952 - 31,537,595 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	32,057,530 - 32,080,170 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	32,057,454 - 32,080,088 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	33,844,945 - 33,865,381 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	29,681,431 - 29,714,796 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	31,798,626 - 31,819,177 (-)	NCBI		Celera
RGSC_v3.1	20	29,695,230 - 29,714,461 (-)	NCBI
Cytogenetic Map	20	q11	NCBI

SUPV3L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	69,180,234 - 69,209,093 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	69,180,234 - 69,209,108 (+)	Ensembl			hg38	GRCh38
GRCh37	10	70,939,990 - 70,968,849 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	70,609,999 - 70,638,855 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	70,609,998 - 70,638,855	NCBI
Celera	10	64,215,826 - 64,244,691 (+)	NCBI		Celera
Cytogenetic Map	10	q22.1	NCBI
HuRef	10	64,939,986 - 64,968,855 (+)	NCBI		HuRef
CHM1_1	10	71,221,740 - 71,250,602 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	70,048,571 - 70,077,444 (+)	NCBI		T2T-CHM13v2.0

Supv3l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	62,265,000 - 62,287,294 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	62,264,988 - 62,285,517 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	62,429,221 - 62,451,515 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	62,429,209 - 62,449,738 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	61,892,126 - 61,912,441 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	61,824,735 - 61,845,050 (-)	NCBI		MGSCv36	mm8
Celera	10	63,532,543 - 63,552,858 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	32.4	NCBI

Supv3l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	21,877,666 - 21,906,362 (-)	Ensembl
ChiLan1.0	NW_004955437	21,880,778 - 21,905,540 (-)	NCBI	ChiLan1.0	ChiLan1.0

SUPV3L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	81,326,442 - 81,355,348 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	81,331,765 - 81,360,670 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	65,647,273 - 65,676,179 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	68,180,665 - 68,209,538 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	68,180,671 - 68,209,538 (+)	Ensembl			panPan2	panpan1.1

SUPV3L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	20,313,902 - 20,342,375 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	20,313,814 - 20,340,882 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	20,444,181 - 20,471,207 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	20,585,901 - 20,612,932 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	20,585,723 - 20,614,352 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	20,486,562 - 20,513,580 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	20,689,769 - 20,716,783 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	21,033,217 - 21,060,241 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Supv3l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	60,744,355 - 60,771,693 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	9,237,120 - 9,264,358 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936521	9,237,081 - 9,264,441 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SUPV3L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	72,245,600 - 72,273,688 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	72,245,526 - 72,272,948 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	78,262,471 - 78,290,268 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SUPV3L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	62,111,702 - 62,141,092 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	62,111,648 - 62,141,045 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	22,851,896 - 22,881,275 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Supv3l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	3,474,298 - 3,500,170 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624754	3,474,235 - 3,500,215 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Supv3l1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	28,257,599 - 28,278,105 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Supv3l1
280 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	27
Count of miRNA genes:	25
Interacting mature miRNAs:	27
Transcripts:	ENSRNOT00000000441
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26689362	56021148	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	26689362	56021148	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26792353	56021148	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26689362	56021148	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26689362	56021148	Rat

Markers in Region

RH130695

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	30,401,909 - 30,402,094 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	32,083,055 - 32,083,239	NCBI	Rnor6.0
Rnor_5.0	20	33,871,309 - 33,871,493	UniSTS	Rnor5.0
RGSC_v3.4	20	29,705,409 - 29,705,593	UniSTS	RGSC3.4
Celera	20	31,822,062 - 31,822,246	UniSTS
RH 3.4 Map	20	307.77	UniSTS
Cytogenetic Map	20	q11	UniSTS

RH131421

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	30,378,689 - 30,378,873 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	32,057,670 - 32,057,853	NCBI	Rnor6.0
Rnor_5.0	20	33,845,085 - 33,845,268	UniSTS	Rnor5.0
RGSC_v3.4	20	29,681,571 - 29,681,754	UniSTS	RGSC3.4
Celera	20	31,798,766 - 31,798,949	UniSTS
RH 3.4 Map	20	307.58	UniSTS
Cytogenetic Map	20	q11	UniSTS

RH140138

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	30,404,615 - 30,404,825 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	32,085,761 - 32,085,970	NCBI	Rnor6.0
Rnor_5.0	20	33,874,015 - 33,874,224	UniSTS	Rnor5.0
RGSC_v3.4	20	29,708,115 - 29,708,324	UniSTS	RGSC3.4
Celera	20	31,824,767 - 31,824,976	UniSTS
Cytogenetic Map	20	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000441 ⟹ ENSRNOP00000000441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	32,057,454 - 32,076,503 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080773 ⟹ ENSRNOP00000075096

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	30,921,249 - 30,941,723 (-)	Ensembl
mRatBN7.2 Ensembl	20	30,378,550 - 30,399,054 (-)	Ensembl
Rnor_6.0 Ensembl	20	32,057,573 - 32,080,088 (-)	Ensembl

RefSeq Acc Id:

NM_001012462 ⟹ NP_001012480

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	30,921,248 - 30,941,723 (-)	NCBI
mRatBN7.2	20	30,378,550 - 30,399,025 (-)	NCBI
Rnor_6.0	20	32,057,530 - 32,080,170 (-)	NCBI
Rnor_5.0	20	33,844,945 - 33,865,381 (-)	NCBI
RGSC_v3.4	20	29,681,431 - 29,714,796 (-)	RGD
Celera	20	31,798,626 - 31,819,177 (-)	RGD

Sequence:

show sequence

CGAGCCGCGGCCTCAATGTCCTTGCCTAGATGTGCCCTGCTGTGGGCTCGGCTCCCGGCGGGGC
GCGGGGCTGGGCCCCGGGCGGCTCCTTGCTCCGCTCTTCGCGCTCTCGTGGGGTCGTTCCCCGG
GGCTTCAGGACGCGTTCCCTGCCTGGCCGCCTCCTCCTCTGCCTCTGGTGGCTCCAAAGCCCCG
AACACGTCCTTGTTCGTGCCGCTGACAGTGAAGCCTCAGGGTCCCAGCGCCGATGGCGACGTAG
GCGCCGAGCTTACTCGGCCTCTGGACAAGAATGAAGTAAAGAAGATCTTAGACAAGTTCTATAA
GCGGCAAGAAATTCAGAAGCTGAGTGCTGACTATGGACTTGATGCTCGTCTCTTCCACCAAGCT
TTCATAAGCTTCAGAAATTACATCATGCAGTCTCATTCCCTGGACGTGGACATCCACATTGTCT
TGAATGACATCTGCTTCAGTGCAGCTCATGTGGACGATTTGTTTCCGTTTTTCTTGAGACATGC
CAAACAGATATTTCCTGTATTGGAATGCAAGGATGACCTACGTCAAATCAGTGACCTGAGGAGA
CCGCCCAACTGGTACCCAGAAGCCAGAGCCATACAGCGGAAGATAATATTCCACTCAGGTCCCA
CCAACAGTGGGAAGACCTACCACGCAATCCAGAGATACTTGTCAGCGACCTCCGGCGTGTACTG
CGGCCCTCTGAAGCTGCTGGCGCATGAGATCTTTGAGAAGAGCAATGCCGCTGGTGTGCCGTGT
GACTTGGTGACAGGTGAAGAGCGGCTGACGGTTGAACCTGAGGGGAAACAAGCCACCCATGTCT
CTTGTACTGTGGAGATGTGCAACGTTGCAACTCCTTATGAAGTGGCTGTGATCGATGAAATCCA
GATGATTCGGGACCCAGCCAGAGGATGGGCTTGGACCAGAGCTCTGCTAGGACTCTGTGCTGAG
GAAGTCCACCTGTGCGGAGAATCTGCTGCCATTGACCTGGTCACTGAGCTCCTGTACACCACTG
GGGAGGAGGTGGAGGTTCAGAAGTACGAGAGGCTTACCCCCATTTCTGTGCTGGACCGTGCACT
GGAGTCTTTAGACAACCTTCGGCCTGGGGACTGCATTGTCTGCTTTAGCAAGAATGACATTTAT
TCTGTGAGCCGACAGATTGAAATTCGGGGCCTGGAATCCGCAGTGATATACGGCAGCCTGCCGC
CTGGAACCAAACTTGCTCAAGCAAGAAAGTTTAATGACCCCAATGATCCGTGCAAAATCCTCGT
AGCTACAGATGCGATTGGCATGGGACTTAATTTGAGCATAAGGAGAATTATTTTTTACTCCCTT
ATAAAGCCCAGCATCAATGAAAAGGGAGAGAAGGAGCTGGAGCCCATCACCACCTCCCAAGCCC
TGCAGATCGCGGGCAGAGCCGGCAGATTCAGCTCACACTTTAAAGAGGGGGAGGTGACCACAAT
GCACCGAGACGACTTGGCTTTATTGAAGGAGATTTTGAATAGACCTGTGGATCCTATACAGGCC
GCTGGACTTCACCCAACTGCTGAGCAGATCGAGATGTTTGCCTACCACCTCCCCGAGACAACGC
TGTCCAATCTCATTGATATTTTTGTAGACTTTGCACAAGTCGATGGGCAGTACTTTGTCTGCAA
CATGGATGATTTTAAGTTCTCTGCAGAGCTGATCCAGCATATTCCACTCAGTCTCCGGGTGAGG
TATGTGTTCTGCACAGCCCCCATCAATAAGAAACAGCCTTTCGTCTGCTCGTCGCTCTTACAGT
TTGCCAGGCAGTACAGCAGGAATGAGCCCCTGACCTTTGCCTGGCTACGCCGGTACATCAAGTG
GCCTCTGCTTCCACCTAAGAACATTAAAGACCTCATGGATCTTGAAGCTGTCCATGATGTCTTT
GATCTTTACCTGTGGCTAAGCTACCGATTTATTGATATGTTTCCAGACTCCAGCTTTGTTCGGA
GTCTCCAGAAAGAACTGGATGTCATTATCCAAGAAGGTGTGCACAATATCACCAAACTGATTAA
AATCTCTGAGTCACACAAGCTCTTGAATCTGGAGCCATCAGGGAGCCAGTCACGTTTGCCAGGA
GCCTCCAAGAGCCCAGCTAGAAGGACACGTGGCACTAAAACAGGGAATAAGGCGGCAGAGCCAC
CCAGCCCCAGTGACAAGGAGCTGCCCCTTGCCTCTAGGCTGGTGCAGCAAGGACTCCTCACTGC
AGACATGCTGAAGCAGCTTCAGAAGGAGTGGCTGACACAACGGCCAGAACAAGGCAAAGAGAAA
GTGGGGACACGGAGAAAGAAGAAGGACCCCAACTCTGATTAGTCTTTTTTTAATTTTGCAAATA
AAAATCAATTTTAAATCCTTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039098587 ⟹ XP_038954515

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	30,921,248 - 30,941,779 (-)	NCBI
mRatBN7.2	20	30,378,542 - 30,399,073 (-)	NCBI

RefSeq Acc Id:

XM_039098588 ⟹ XP_038954516

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	30,921,248 - 30,935,609 (-)	NCBI
mRatBN7.2	20	30,378,542 - 30,392,909 (-)	NCBI

RefSeq Acc Id:

XR_005497211

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	30,924,756 - 30,941,779 (-)	NCBI
mRatBN7.2	20	30,382,058 - 30,399,076 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012480	(Get FASTA)	NCBI Sequence Viewer
	XP_038954515	(Get FASTA)	NCBI Sequence Viewer
	XP_038954516	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89883	(Get FASTA)	NCBI Sequence Viewer
	EDL92978	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075096
GenBank Protein	Q5EBA1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001012480 ⟸ NM_001012462
- Peptide Label:	precursor
- UniProtKB:	Q5EBA1 (UniProtKB/Swiss-Prot), A0A0G2K9R3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLPRCALLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVPCLAASSSASGGSKAPNTSLF VPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYKRQEIQKLSADYGLDARLFHQAFISFR NYIMQSHSLDVDIHIVLNDICFSAAHVDDLFPFFLRHAKQIFPVLECKDDLRQISDLRRPPNWY PEARAIQRKIIFHSGPTNSGKTYHAIQRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTG EERLTVEPEGKQATHVSCTVEMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLC GESAAIDLVTELLYTTGEEVEVQKYERLTPISVLDRALESLDNLRPGDCIVCFSKNDIYSVSRQ IEIRGLESAVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSI NEKGEKELEPITTSQALQIAGRAGRFSSHFKEGEVTTMHRDDLALLKEILNRPVDPIQAAGLHP TAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCT APINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVFDLYLW LSYRFIDMFPDSSFVRSLQKELDVIIQEGVHNITKLIKISESHKLLNLEPSGSQSRLPGASKSP ARRTRGTKTGNKAAEPPSPSDKELPLASRLVQQGLLTADMLKQLQKEWLTQRPEQGKEKVGTRR KKKDPNSD hide sequence

Ensembl Acc Id:

ENSRNOP00000075096 ⟸ ENSRNOT00000080773

Ensembl Acc Id:

ENSRNOP00000000441 ⟸ ENSRNOT00000000441

RefSeq Acc Id:	XP_038954515 ⟸ XM_039098587
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K9R3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954516 ⟸ XM_039098588
- Peptide Label:	isoform X2

Protein Domains

Helicase ATP-binding Helicase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5EBA1-F1-model_v2	AlphaFold	Q5EBA1	1-776	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701622

Promoter ID:

EPDNEW_R12136

Type:

initiation region

Name:

Supv3l1_1

Description:

Suv3 like RNA helicase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	32,080,159 - 32,080,219	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305565	AgrOrtholog
BioCyc Gene	G2FUF-3693	BioCyc
Ensembl Genes	ENSRNOG00000000392	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000080773	ENTREZGENE
Gene3D-CATH	1.10.1740.140	UniProtKB/Swiss-Prot
	1.20.272.40	UniProtKB/Swiss-Prot
	1.20.58.1080	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7369752	IMAGE-MGC_LOAD
InterPro	DEXQc_Suv3	UniProtKB/Swiss-Prot
	Helicase_C	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	RNA-DNA_Helicase	UniProtKB/Swiss-Prot
	SUV3_C	UniProtKB/Swiss-Prot
	Suv3_C_1	UniProtKB/Swiss-Prot
	Suv3_DEXQc	UniProtKB/Swiss-Prot
	Suv3_N	UniProtKB/Swiss-Prot
KEGG Report	rno:294385	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109049	IMAGE-MGC_LOAD
NCBI Gene	294385	ENTREZGENE
PANTHER	ATP-DEPENDENT RNA AND DNA HELICASE	UniProtKB/Swiss-Prot
	ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL	UniProtKB/Swiss-Prot
Pfam	DEXQc_Suv3	UniProtKB/Swiss-Prot
	Helicase_C	UniProtKB/Swiss-Prot
	SUV3_C	UniProtKB/Swiss-Prot
	Suv3_C_1	UniProtKB/Swiss-Prot
	Suv3_N	UniProtKB/Swiss-Prot
PhenoGen	Supv3l1	PhenoGen
PROSITE	HELICASE_CTER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000392	RatGTEx
SMART	HELICc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A0G2K9R3	ENTREZGENE, UniProtKB/TrEMBL
	A6K444_RAT	UniProtKB/TrEMBL
	Q5EBA1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-13	Supv3l1	Suv3 like RNA helicase	Supv3l1	SUV3-like helicase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-10-01	Supv3l1	SUV3-like helicase	Supv3l1	suppressor of var1, 3-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Supv3l1	suppressor of var1, 3-like 1 (S. cerevisiae)	Supv3l1_predicted	suppressor of var1, 3-like 1 (S. cerevisiae) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Supv3l1_predicted	suppressor of var1, 3-like 1 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD